CN102429963B - Method for preparing ultrafine powder Houyanjing San at normal temperature - Google Patents
Method for preparing ultrafine powder Houyanjing San at normal temperature Download PDFInfo
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Abstract
The invention discloses a method for preparing ultrafine powder Houyanjing San at normal temperature, which comprises the following steps of: mixing indigowoad root and liquoric root serving as Chinese herbal medicines, toad venom, realgar, bile paste and borneol, and grinding to obtain coarse powder; uniformly mixing the coarse powder, artificial bezoar, natural indigo and refined mirabilite in a ratio, putting the mixed coarse powder into a rod mill for grinding, feeding into a special bidirectional airflow sieving machine through air, sieving with a 500-mesh screen, conveying powder which is obtained by sieving and has the particle size of less than or equal to 25 micrometers to a cyclone collector through airflow generated by a draught fan, and collecting to obtain a finished ultrafine powder Houyanjing San product; and collecting powder which does not pass through the 500-mesh screen by using a funnel, conveying to the rod mill through a pipeline, and performing cyclic grinding. The method has the advantages that: the whole preparation process is performed at normal temperature, the particle size of the prepared finished product medicine is less than or equal to 25 micrometers, the cell wall breaking rate and bioavailability are greatly improved, and the pharmacological effect is enhanced; and by the bidirectional airflow sieving machine used in the method, the preparation process for the ultrafine powder Houyanjing San is simplified.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder HOUYANJING SAN normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine for this method.
Background technology
The HOUYANJING SAN that is applied to poultry at present mostly is the powder of making by after the coarse pulverizations such as crude drug Radix Isatidis, Venenum Bufonis, artificial Calculus Bovis, gallbladder cream, Radix Glycyrrhizae, Indigo Naturalis, Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Realgar; have that dosage is big, dosage form is thick, appearance poor; effective ingredient can not fully discharge; the low deficiency that waits of bioavailability has had a strong impact on Chinese medicine quality and therapeutic effect.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder HOUYANJING SAN normal temperature preparation method, efficiently solve that the energy consumption that exists in the present production is big, the medicine maximum particle diameter is difficult to accurate control, can't produce continuously, difficult problems such as dust is many in the production process, make the finished medicines of preparation have rapid-action, good effect, bioavailability height, effect that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder HOUYANJING SAN normal temperature preparation method.
Superfine powder HOUYANJING SAN normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Radix Isatidis, licorice piece, clean, dry or dry to moisture≤10%;
Second step, pulverizing after with above-mentioned raw materials medicine and Venenum Bufonis, Realgar, gallbladder cream, Borneolum Syntheticum mix homogeneously under 20 ℃～25 ℃ temperature, obtain granularity 60～120 purpose coarse powder;
The 3rd goes on foot, gained coarse powder and artificial Calculus Bovis, Indigo Naturalis, Matrii Sulfas Exsiccatus in second step is mixed together evenly, and the weight portion proportioning of its Chinese medicine powder is Radix Isatidis: Venenum Bufonis: artificial Calculus Bovis: gallbladder cream: Radix Glycyrrhizae: Indigo Naturalis: Matrii Sulfas Exsiccatus: Borneolum Syntheticum: Realgar=42:4:3:6:2:1.2:2:1.4:4.5;
The 4th step, the 3rd step gained mixings coarse powder is placed in the rod mill after the pulverizing, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets superfine powder HOUYANJING SAN finished product; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, also improve simultaneously abnormal smells from the patient and the mouthfeel of medicine, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder HOUYANJING SAN greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
1. experimental animal: the chicken house 90 ages in days morbidity blue brown chicken group in sea, be diagnosed as infectious laryngotracheitis of chicken by clinical symptoms, pathological anatomy and pathogen separation and evaluation, from morbidity chicken group, randomly draw and select 300, be divided into 6 groups, from healthy chicken flock, extract 50 and do blank, carry out therapeutic test.
2. trial drug and grouping:
The superfine powder HOUYANJING SAN: by the inventive method preparation,
HOUYANJING SAN fine powder: preparation according to a conventional method.
Table 1 test grouping and medicining condition
| Group | Number of animals (only) | Medicining condition | Usage and dosage |
| 1 | 50 | Do not infect matched group | Do not infect not medication |
| 2 | 50 | Infect, do not treat group | Infect not medication |
| 3 | 50 | Infect the erythromycin for treating group | Infect 150ppm/ days |
| 4 | 50 | Infect HOUYANJING SAN fine powder high dose group | 0.6%/sky/ |
| 5 | 50 | Infect superfine powder HOUYANJING SAN high dose group | 0.3%/sky/spice |
| 6 | 50 | Infect dosage group in the superfine powder HOUYANJING SAN | 0.2%/sky/spice |
| 7 | 50 | Infect superfine powder HOUYANJING SAN low dose group | 0.1%/sky/spice |
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 2 is respectively organized Drug therapy infectious laryngotracheitis of chicken effect test result relatively
| Group | Cure rate (%) | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) |
| 1 | 0 | 0 | 0 | 0 |
| 2 | 0 | 0 | 0 | 100 |
| 3 | 62.3 | 3.5 | 65.8 | 34.2 |
| 4 | 82.9 | 11.6 | 94.5 | 4.5 |
| 5 | 87.0 | 10.2 | 97.2 | 2.8 |
| 6 | 80.8 | 12.7 | 93.5 | 6.5 |
| 7 | 73.1 | 14.0 | 87.1 | 12.9 |
The result of the test that shows from table 2 as can be seen, superfine powder HOUYANJING SAN high dose group therapeutic effect the best is 97.2%.HOUYANJING SAN fine powder group and superfine powder HOUYANJING SAN group cure rate are all apparently higher than erythromycin powder group (p＜0.05), superfine powder HOUYANJING SAN group therapeutic effect is apparently higher than HOUYANJING SAN fine powder group (p＜0.05), so can think that the superfine powder HOUYANJING SAN has good effect at the treatment infectious laryngotracheitis of chicken.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, superfine powder HOUYANJING SAN normal temperature preparation method of the present invention comprises the steps:
The first step, choose crude drug Radix Isatidis, licorice piece, clean, dry or dry to moisture≤10%;
Second step, pulverizing after with above-mentioned raw materials medicine and Venenum Bufonis, Realgar, gallbladder cream, Borneolum Syntheticum mix homogeneously under 20 ℃～25 ℃ temperature, obtain granularity 60～120 purpose coarse powder;
The 3rd goes on foot, gained coarse powder and artificial Calculus Bovis, Indigo Naturalis, Matrii Sulfas Exsiccatus in second step is mixed together evenly, and the weight portion proportioning of its Chinese medicine powder is Radix Isatidis: Venenum Bufonis: artificial Calculus Bovis: gallbladder cream: Radix Glycyrrhizae: Indigo Naturalis: Matrii Sulfas Exsiccatus: Borneolum Syntheticum: Realgar=42:4:3:6:2:1.2:2:1.4:4.5;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated that disperses in the screen drum 2 carries out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets superfine powder HOUYANJING SAN finished product.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder HOUYANJING SAN finished product of gained is sub-packed in the aluminium foil bag, every bag of 500g or 1000g storage.
Claims (2)
1. a superfine powder HOUYANJING SAN normal temperature preparation method is characterized in that: comprise the steps:
The first step, choose crude drug Radix Isatidis, licorice piece, clean, dry or dry to moisture≤10%;
Second step, pulverizing after with above-mentioned raw materials medicine and Venenum Bufonis, Realgar, gallbladder cream, Borneolum Syntheticum mix homogeneously under 20 ℃～25 ℃ temperature, obtain granularity 60～120 purpose coarse powder;
The 3rd goes on foot, gained coarse powder and artificial Calculus Bovis, Indigo Naturalis, Matrii Sulfas Exsiccatus in second step is mixed together evenly, and the weight portion proportioning of its Chinese medicine powder is Radix Isatidis: Venenum Bufonis: artificial Calculus Bovis: gallbladder cream: Radix Glycyrrhizae: Indigo Naturalis: Matrii Sulfas Exsiccatus: Borneolum Syntheticum: Realgar=42:4:3:6:2:1.2:2:1.4:4.5;
The 4th step, the 3rd step gained mixings coarse powder is placed in the rod mill (16) after the pulverizing, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to that collection namely gets superfine powder HOUYANJING SAN finished product in the tornado feeder set (17); The powder of not crossing 500 mesh sieves is transported to circulation pulverizing again in the described rod mill (16) through funnel (3) collection and by pipeline (18);
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. superfine powder HOUYANJING SAN normal temperature preparation method according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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| CN107008539B (en) * | 2017-05-24 | 2022-10-25 | 湖北馥雅食品科技有限公司 | Low-temperature pulverizer for high-grease materials |
| CN118045047A (en) * | 2024-01-30 | 2024-05-17 | 广州中冠动物药业有限公司 | Bufonis venenum granule prepared by superfine pulverizing technology |
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Non-Patent Citations (3)
| Title |
|---|
| 中国兽药典委员会.喉炎净散.《中华人民共和国兽药典》.2000,420. * |
| 分级技术在中药超细粉体生产中的应用;王劲等;《中国粉体技术》;20080225(第1期);36－38 * |
| 王劲等.分级技术在中药超细粉体生产中的应用.《中国粉体技术》.2008,(第1期),36－38. |
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Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
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