CN101583286B - 含有类胡萝卜素的液体配制剂 - Google Patents

含有类胡萝卜素的液体配制剂 Download PDF

Info

Publication number
CN101583286B
CN101583286B CN2008800024418A CN200880002441A CN101583286B CN 101583286 B CN101583286 B CN 101583286B CN 2008800024418 A CN2008800024418 A CN 2008800024418A CN 200880002441 A CN200880002441 A CN 200880002441A CN 101583286 B CN101583286 B CN 101583286B
Authority
CN
China
Prior art keywords
carotenoid
preparaton
weight
glycerine
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2008800024418A
Other languages
English (en)
Other versions
CN101583286A (zh
Inventor
C·克普泽尔
J·费德图森延森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39570485&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101583286(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BASF SE filed Critical BASF SE
Publication of CN101583286A publication Critical patent/CN101583286A/zh
Application granted granted Critical
Publication of CN101583286B publication Critical patent/CN101583286B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种包含至少一种类胡萝卜素、至少一种亲水性保护胶体和至少一种水混溶性醇的液体配制剂。本发明配制剂可以直接加入含水或不含水制剂中。

Description

含有类胡萝卜素的液体配制剂
本发明涉及液体配制剂，其生产方法及其作为动物饲料和人类食品的添加剂的用途。
类胡萝卜素由于其微溶于水和化学不稳定性而特别难配制。因此已做出很多努力以提供一方面稳定且另一方面显示出良好的生物利用率并在使用时具有所需给色量的类胡萝卜素配制剂。液体类胡萝卜素配制剂特别重要，因为获得粉末形式类胡萝卜素及使用者制备液体配制剂变得不必要。
具有纳米级粒度的类胡萝卜素初级颗粒的生产对于获得足够的生物利用率和给色量是关键的。为了生产这类颗粒，现有技术中使用研磨法，例如如WO 91/06292和WO 94/19411中所述。使用胶体磨在水性或油性介质中研磨类胡萝卜素，获得纳米级粒度。
EP 1 460 060 A描述了通过在油中研磨而生产叶黄素分散体。还描述了通过将叶黄素溶解于水混溶性有机溶剂中并在乳化剂的存在下在改性淀粉中包封而生产的可冷水分散的叶黄素配制剂。
US 2005/0084462描述了通过在作为载体的***树胶的存在下在水中研磨色料并随后加热至30-60℃而生产用于食品、药品和化妆品中的色料混合物。
US 5,827,539描述了在油中研磨类胡萝卜素分散体，与淀粉、糖和抗氧化剂的混合物形成乳液并且随后喷雾干燥。
WO 9613178描述了通过在其中番茄红素基本上不溶的液体介质中研磨番茄红素而生产稳定的番茄红素提浓物。所用液体介质为甘油、丙二醇或乙醇。然而，不使用亲水胶体。
WO 96/23429描述了通过研磨虾青素，在研磨过程中或之后添加油而生产粒度＜2μm的油性虾青素悬浮液。保护胶体和乳化剂的使用未公开。它指出颗粒易于团聚。因此，考虑通过在固化温度以下贮存该悬浮液而进一步稳定。
WO 93/04598描述了在油、水分散性基体成型剂如糖的分散体和稳定剂如明胶或酪蛋白的分散体、乳化剂及合适的话非油性溶剂如甘油中生产包含类胡萝卜素的类胡萝卜素组合物。
本发明的目的为提供能够容易生产并且使用者无需额外努力便能够使用的液体类胡萝卜素配制剂。
目前已惊人地发现该目的通过除类胡萝卜素和亲水性保护胶体之外还包含至少一种水混溶性醇的液体配制剂实现。
本发明因此涉及一种包含至少一种类胡萝卜素、至少一种亲水性保护胶体和至少一种水混溶性醇的液体配制剂。
可以使用的类胡萝卜素为可由天然源或通过合成获得的已知代表。此外，可以使用可由天然源或通过合成获得的已知代表。其实例单独或作为混合物为β-胡萝卜素、番茄红素、叶黄素、虾青素、玉米黄质、隐黄质、柠黄质(citranaxanthin)、斑蝥黄、海胆酮、红木素、β-阿朴-4-胡萝卜素醛、β-阿朴-8-胡萝卜素醛、β-阿朴-4-胡萝卜素酯。优选虾青素、β-胡萝卜素、β-阿朴-8-胡萝卜素醛、β-阿朴-8′-胡萝卜素酸乙酯、斑蝥黄、柠黄质、海胆酮、叶黄素、番茄红素和玉米黄质。特别优选虾青素和斑蝥黄，尤其是虾青素。
类胡萝卜素的粒度通常为50nm-10μm，优选为100nm-5μm，特别优选为100nm-3μm、150nm-2μm，尤其是200nm-1μm。
水溶性或水溶胀性胶体适合作为亲水性保护胶体。保护胶体优选为蛋白质基保护胶体、改性淀粉衍生物和改性纤维素衍生物。蛋白质基保护胶体特别是酪蛋白、酪蛋白酸盐、牛明胶、猪明胶或鱼明胶，尤其是勃鲁姆数(Bloom number)为0-250的酸降解或碱降解明胶及其混合物。改性淀粉衍生物和改性纤维素衍生物特别是酯如淀粉辛烯基琥珀酸酯。相应的产品由National Starch以名称Purity Gum 2000或者由Roquette以Clear GumCO 01、由National Starch以Hi Cap 100或Capsul市售。
优选将改性淀粉用作亲水性保护胶体。
合适的水混溶性醇为一元醇和多元醇。一元醇为链烷醇如甲醇、乙醇、异丙醇等。然而，优选使用多元醇。这些特别是二元醇或三元醇。其实例为乙二醇、丙二醇、丁二醇、聚乙二醇、聚丙二醇、甘油、甘油与C1-C5单羧酸的单酯或甘油的单醚。本发明配制剂特别优选包含甘油。
类胡萝卜素通常以基于配制剂总重为0.1-50重量％，优选0.2-30重量％，尤其是1.0-15重量％的量存在于本发明配制剂中。
亲水性保护胶体的量通常为1-40重量％，优选为2-30重量％，特别是3-25重量％。
类胡萝卜素与亲水性保护胶体的重量比通常为5∶1-1∶5，优选3∶1-1∶3。水混溶性醇的量基于配制剂总重通常为30-95重量％，特别是30-90重量％，特别优选35-90重量％。
本发明配制剂可以包含基于配制剂总重为至多40重量％，优选至多35重量％的水。
本发明配制剂优选不包含油。
为了增加活性成分相对于氧化降解的稳定性，有利的是添加稳定剂如α-生育酚、叔丁基羟基甲苯、叔丁基羟基茴香醚、抗坏血酸或乙氧喹。
本发明配制剂可以额外包含辅助物质如增稠剂，硬脂，螯合剂如柠檬酸、肌醇六磷酸或膦酸的碱金属或碱土金属盐和/或乳化剂。乳化剂的实例为棕榈酸抗坏血酸酯，聚甘油脂肪酸酯如聚甘油3多聚蓖酸酯(PGPR 90)，脱水山梨醇脂肪酸酯如脱水山梨醇单硬脂酸酯(span 60)、PEG(20)脱水山梨醇单油酸酯，丙二醇脂肪酸酯或磷脂如卵磷脂。
通过研磨类胡萝卜素和亲水性保护胶体在所用水混溶性醇中的分散体而制备本发明配制剂。然而，还可以在研磨过程中添加部分醇。继续研磨直到类胡萝卜素晶体和亲水性保护胶体的平均粒度达到＜5μm，优选＜1μm。可以使用本领域技术人员已知的常规装置，例如胶体磨、球磨机如KDL或Multilab类型的Dynomill作为研磨装置。
可以将本发明配制剂直接加入含水或不含水制剂中。然而，它们也可以在加入前进一步用所用醇稀释。
所述配制剂尤其适合作为动物饲料添加剂和人类食品制剂添加剂或配合饲料添加剂，适合作为生产药品和化妆品制剂的组合物并适合生产人类和动物领域的膳食补充剂产品。悬浮液例如可优选通过在挤出时混入饲料颗粒或通过施加或喷雾至饲料颗粒上而用作家畜营养品中的饲料添加剂。特别通过例如如所谓的后造粒施加那样直接喷雾本发明配制剂而用作饲料添加剂。饲料颗粒优选在降低的压力下加载配制剂。
在人类食品领域的一般应用范围例如为饮料，乳制品如酸乳酪、牛奶饮料或牛奶冰和牛奶冻粉，蛋制品，烘烤混合料和糖果的维生素化和着色。在化妆品领域，可以将油性悬浮液用于例如装饰性个人护理组合物，例如以面霜、乳液的形式，或作为唇膏或彩妆。
本发明还涉及包含本发明配制剂的膳食补充剂、动物饲料、人类食品和药品及化妆品制剂。优选加载有配制剂的动物饲料，尤其是饲料颗粒。
膳食补充剂产品和药品制剂尤其指包含本发明配制剂的片剂、包覆片剂及优选硬和软明胶胶囊。
以下实施例用于解释本发明而不限制本发明。
实施例1
生产10.5％浓度的β-胡萝卜素分散体
将784.16g甘油引入2L玻璃烧杯中并搅拌加入110.84g(水含量5.27％)Purity Gum 2000(辛烯基琥珀酸酯-淀粉)。随后，搅拌加入105.0g晶体β-胡萝卜素直到完全润湿(30-40分钟)。然后将由此获得的分散体用来自Siegmund Lindner的Dynomill Multilab使用钇稳定且直径为0.4-0.6mm的SiLi珠Zr珠研磨。研磨容器装有400ml这些研磨珠。在54-70℃的温度、0.10mm的研磨狭缝和2986rpm的磨机转速下进行研磨。
实施例2
制备7.0％浓度的β-胡萝卜素分散体
通过实施例1描述的方法研磨210.0g晶体β-胡萝卜素、221.68g PurityGum 2000(水含量5.27％)和2568.32g甘油的分散体。在52-68℃的温度下进行研磨。1.5小时后，获得其中β-胡萝卜素粒度为438nm的低粘度分散体。

Claims (5)

1.一种包含至少一种类胡萝卜素、淀粉辛烯基琥珀酸酯和甘油的液体配制剂，其中类胡萝卜素以基于配制剂总重为1.0-15重量％的量存在，并且通过研磨类胡萝卜素和淀粉辛烯基琥珀酸酯在甘油中的分散体直到类胡萝卜素晶体和淀粉辛烯基琥珀酸酯的平均粒度达到＜5μm而制备所述配制剂。
2.根据权利要求1的配制剂，其包含0-40重量％的水。
3.根据权利要求1或2的配制剂，其中类胡萝卜素为单独或作为混合物的β-胡萝卜素、叶黄素、虾青素、玉米黄质、隐黄质、柠黄质、斑蝥黄、海胆酮、红木素、β-阿朴-8-胡萝卜素醛。
4.根据权利要求1或2的配制剂，其中所述类胡萝卜素为虾青素。
5.根据权利要求1-4中任一项的配制剂作为动物饲料、人类食品和膳食补充剂及药品和化妆品组合物的添加剂的用途。
CN2008800024418A 2007-01-16 2008-01-15 含有类胡萝卜素的液体配制剂 Active CN101583286B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07100633.2 2007-01-16
EP07100633 2007-01-16
EP07105349.0 2007-03-30
EP07105349 2007-03-30
PCT/EP2008/050401 WO2008087140A2 (de) 2007-01-16 2008-01-15 Flüssige formulierungen enthaltend ein carotinoid

Publications (2)

Publication Number Publication Date
CN101583286A CN101583286A (zh) 2009-11-18
CN101583286B true CN101583286B (zh) 2013-08-21

Family

ID=39570485

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800024418A Active CN101583286B (zh) 2007-01-16 2008-01-15 含有类胡萝卜素的液体配制剂

Country Status (10)

Country Link
US (1) US8809398B2 (zh)
EP (1) EP2111125B2 (zh)
JP (2) JP5368316B2 (zh)
CN (1) CN101583286B (zh)
AT (1) ATE501644T1 (zh)
CL (1) CL2008000129A1 (zh)
DE (1) DE502008002872D1 (zh)
DK (1) DK2111125T4 (zh)
ES (1) ES2361276T5 (zh)
WO (1) WO2008087140A2 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502008002872D1 (de) 2007-01-16 2011-04-28 Basf Se Flüssige formulierungen enthaltend carotinoide
ATE494799T1 (de) * 2007-02-23 2011-01-15 Brain Biotechnology Res & Information Network Ag Verwendung von wasserdispergierbaren carotinoid- nanopartikeln als geschmacksmodulatoren, geschmacksmodulatoren, enthaltend wasserdispergierbare carotinoid-nanopartikel, und verfahren zur geschmacksmodulation
DE502008002299D1 (de) * 2007-02-23 2011-02-24 Brain Biotechnology Res & Information Network Ag Verfahren zur geschmacksmodulation von stofflichen zusammensetzungen, die mindestens einen high intensity sweetener (his) enthalten
ES2540222T5 (es) * 2007-11-29 2022-04-19 Basf Se Preparado de carotinoide en forma de polvo para el teñido de bebidas
US9375387B2 (en) 2008-10-07 2016-06-28 Basf Se Ready-to-use, stable emulsion
CN102361561A (zh) 2009-03-30 2012-02-22 巴斯夫欧洲公司 部分无定形类胡萝卜素颗粒的即用稳定悬浮液
CN102796398B (zh) * 2012-07-31 2013-11-27 浙江新维普添加剂有限公司 一种用于着色的β-胡萝卜素微胶囊的制备方法
USD805728S1 (en) 2016-09-06 2017-12-26 Mars, Incorporated Food product
USD806351S1 (en) 2016-09-06 2018-01-02 Mars, Incorporated Food product
GB201701417D0 (en) 2017-01-27 2017-03-15 Mars Inc Pet food
CN111714466A (zh) 2019-03-18 2020-09-29 浙江医药股份有限公司新昌制药厂 一种高生物利用度高稳定性的类胡萝卜素制剂的制备方法
CN115736158A (zh) * 2022-12-30 2023-03-07 广州百花香料股份有限公司 一种稳定的乳化香精及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252238A (zh) * 1998-09-14 2000-05-10 Basf公司 稳定的、含有结晶度大于20%的番茄红素的粉状番茄红素制剂
CN1374035A (zh) * 2001-01-31 2002-10-16 巴斯福股份公司 生产一种或多种类胡萝卜素的干粉的方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2661349A (en) * 1949-02-18 1953-12-01 Nat Starch Products Inc Polysaccharide derivatives of substituted dicarboxylic acids
US3110598A (en) * 1959-09-08 1963-11-12 Hoffmann La Roche Process of making a carotenoid preparation
DE1211911B (de) 1959-09-08 1966-03-03 Hoffmann La Roche Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates
BE599795A (fr) 1960-02-04 1961-05-29 Knud Abildgaard Procédé de préparation de compositions contenant des substances douées d'activité vitaminique et produits obtenus
GB970363A (en) 1960-02-04 1964-09-23 Knud Abildgaard Improvements in vitamin preparations and process for producing them
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
DE3610191A1 (de) 1986-03-26 1987-10-01 Basf Ag Verfahren zur herstellung von feinteiligen, wasserdispergierbaren carotinoid-praeparationen
JPH0783684B2 (ja) 1986-11-28 1995-09-13 三栄源エフ・エフ・アイ株式会社 塩化カリウムの苦味除去の方法
JP2649175B2 (ja) 1988-07-12 1997-09-03 富山化学工業株式会社 苦味の軽減方法および苦味軽減組成物
US5028625A (en) * 1989-06-20 1991-07-02 American Home Products Corporation Acid addition salt of ibuprofen and meglumine
DK0410236T3 (da) 1989-07-25 1993-12-13 Hoffmann La Roche Fremgangsmåde til fremstilling af caratenoidpræparater
ATE129987T1 (de) 1989-07-28 1995-11-15 Chemie Linz Gmbh Verfahren zur abtrennung von isocyansäure aus einem gemisch von isocyansäure und ammoniak.
DK546289D0 (da) 1989-11-02 1989-11-02 Danochemo As Carotenoidpulvere
US5637618A (en) * 1990-06-01 1997-06-10 Bioresearch, Inc. Specific eatable taste modifiers
JP3073544B2 (ja) 1991-02-18 2000-08-07 三栄源エフ・エフ・アイ株式会社 塩化カリウムの脱苦味方法
WO1993004598A1 (en) 1991-09-06 1993-03-18 Betatene Limited Carotenoid composition
DE4200728A1 (de) 1992-01-14 1993-07-15 Basf Ag Stabile, fluessige praeparate fettloeslicher substanzen
DK19393D0 (da) 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
JPH0767574A (ja) * 1993-08-31 1995-03-14 Takeda Chem Ind Ltd カロチノイド類組成物
JPH0799924A (ja) 1993-09-30 1995-04-18 Nippon Suisan Kaisha Ltd アスタキサンチンを主要成分とするファフィア色素油の安定な粉末化物及びその製造方法
JP3516737B2 (ja) * 1994-09-30 2004-04-05 長谷川香料株式会社 異臭のない安定なカロチノイド製剤の製造法
IL111477A (en) * 1994-10-31 1999-07-14 Makhteshim Chem Works Ltd Stable lycophene concentrates and process for their preparation
AT408073B (de) 1995-01-30 2001-08-27 Mrk Handels Ag Einspuriger rollschuh
EP0812135A1 (en) 1995-01-31 1997-12-17 Neurosearch A/S Astaxanthin suspension
DE69613164T2 (de) 1995-03-15 2001-09-27 Kao Corp Verwendung eines Zusatzstoffes zur Verminderung von Bittergeschmack
US5827539A (en) * 1995-12-28 1998-10-27 Amway Corporation Dry carotenoid-oil powder and process for making same
DE19609477A1 (de) * 1996-03-11 1997-09-18 Basf Ag Stabile wäßrige Solubilisate von Carotinoiden und Vitamine
DE19637517A1 (de) * 1996-09-13 1998-03-19 Basf Ag Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen
DE19653410A1 (de) 1996-12-20 1998-06-25 Basf Ag Verwendung von Carotinoid-Solubilisaten zum Färben von Lebensmitteln und pharmazeutischen Zubereitungen
DE19802134A1 (de) * 1998-01-21 1999-07-22 Basf Ag Verwendung von Carotinoid-Aggregaten als Färbemittel
CA2261456A1 (en) 1998-02-23 1999-08-23 F. Hoffmann-La Roche Ag Preparation of a finely divided pulverous carotenoid preparation
US6224876B1 (en) * 1998-08-04 2001-05-01 Biyani Milind Kesharlal Isolation and formulations of nutrient-rich carotenoids
ES2255206T3 (es) 1998-08-05 2006-06-16 Dsm Ip Assets B.V. Preparacion de 4,4'-diceto-carotenoides.
DE19838636A1 (de) * 1998-08-26 2000-03-02 Basf Ag Carotinoid-Formulierungen, enthaltend ein Gemisch aus beta-Carotin, Lycopin und Lutein
JP2001226293A (ja) 2000-02-17 2001-08-21 Kotaro Kanpo Seiyaku Kk 服用補助剤
ATE259351T1 (de) 2000-07-13 2004-02-15 Vitatene Sa Verfahren für die produktion einer in wasser dispersiblen carotenoid-haltigen formulierung
US7105176B2 (en) * 2000-11-29 2006-09-12 Basf Aktiengesellschaft Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds
DE10059213A1 (de) 2000-11-29 2002-06-13 Basf Ag Verfahren zur Herstellung fester Zubereitungen wasserunlöslicher oder schwer wasserlöslicher Wirkstoffe
DK1213013T3 (da) 2000-11-29 2007-07-02 Basf Ag Fremgangsmåde til fremstilling af faste præparater af vandoplöselige, tungt vandoplöselige eller vanduoplöselige aktive stoffer
JP2002187837A (ja) * 2000-12-20 2002-07-05 Kuraray Co Ltd 微粉化カロテノイドを含有する水溶性製剤の製造方法
DE10064387A1 (de) 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
DE10122898A1 (de) 2001-05-11 2002-11-14 Haarmann & Reimer Gmbh Verwendung von Hydroxyflavanonen zur Maskierung des bitteren Geschmacks
JP4859006B2 (ja) * 2001-05-25 2012-01-18 富士化学工業株式会社 安定なアスタキサンチン−シクロデキストリン包接化合物及びその製造方法、並びに該包接化合物を含有する液剤、飲食物、飼料、医薬品及び化粧品
CN1274246C (zh) 2001-08-23 2006-09-13 Dsmip资产有限公司 新的经稳定化处理的类胡萝卜素组合物
ES2189697B1 (es) 2001-12-28 2005-02-01 Antibioticos, S.A.U. Procedimiento para obtener nuevas formulaciones a base de luteina.
EP1474388B2 (en) 2002-02-06 2013-03-06 DSM IP Assets B.V. Astaxanthin esters
JP2005522488A (ja) 2002-04-09 2005-07-28 大正製薬株式会社 味マスキングするための製剤
CN1656178A (zh) 2002-05-30 2005-08-17 化尔氏制药研究公司 油溶性色素合成物
US20040033246A1 (en) * 2002-06-25 2004-02-19 Kose Corporation Cosmetic for prevention of skin aging and agent for prevention of skin aging
ATE442104T1 (de) * 2002-10-22 2009-09-15 Medtronic Vascular Inc Stent mit exzentrischer beschichtung
DE10253111A1 (de) * 2002-11-13 2004-05-27 Basf Ag Pulverförmige Phytosterol-Formulierungen
JP3969652B2 (ja) 2002-12-16 2007-09-05 東洋酵素化学株式会社 カロテノイド含有パウダーの製造方法
ES2542687T3 (es) † 2003-03-27 2015-08-10 Dsm Ip Assets B.V. Proceso para la producción de microglóbulos de gelatina reticulados
US20050084462A1 (en) * 2003-10-16 2005-04-21 Andreas Klingenberg Method for manufacturing a colour mixture for use in food products, pharmaceuticals and cosmetics and colour mixture obtained according to this method
BR0308051A (pt) * 2003-12-15 2005-09-06 Natura Cosmeticos Sa Composição base para preparação de formulações multifuncionais para o cuidado e proteção da pele e cabelo
US8119113B2 (en) * 2004-08-24 2012-02-21 Nisshin Pharma, Inc. Coenzyme Q10—containing composition
DE102004046026A1 (de) * 2004-09-21 2006-03-23 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinoide
US7851006B2 (en) * 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
EP1883315B1 (en) 2005-05-23 2010-12-22 Phares Drug Delivery AG Direct dissolution
DE102005030952A1 (de) 2005-06-30 2007-01-18 Basf Ag Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide
DE102005031468A1 (de) * 2005-07-04 2007-01-18 Basf Ag Wässrige Suspensionen schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe und daraus hergestellte Trockenpulver
US20080193539A1 (en) 2005-07-20 2008-08-14 Karl Manfred Voelker Novel Stabilized Carotenoid Compositions
ES2420155T3 (es) 2005-08-15 2013-08-22 Phares Drug Delivery Ag Formas de cristal de astaxantina
WO2007045488A1 (en) 2005-10-21 2007-04-26 Dsm Ip Assets B.V. Novel formulations of fat-soluble active ingredients with high bioavailability
DE202006010606U1 (de) 2006-07-07 2007-11-22 Sensient Food Colors Germany Gmbh & Co. Kg Zubereitung für Lebensmittel
US20080131515A1 (en) 2006-12-01 2008-06-05 Fujifilm Corporation Emulsion composition, and foods and cosmetics containing the emulsion composition
EP2124615A1 (de) 2007-01-16 2009-12-02 Basf Se Ölige formulierungen
DE502008002872D1 (de) 2007-01-16 2011-04-28 Basf Se Flüssige formulierungen enthaltend carotinoide
WO2008087090A1 (de) 2007-01-19 2008-07-24 Basf Se Kristallmodifikation von astaxanthin
EP1952845A1 (en) 2007-01-26 2008-08-06 DSMIP Assets B.V. Use of an astaxathin derivative for cosmetic purposes
ATE494799T1 (de) * 2007-02-23 2011-01-15 Brain Biotechnology Res & Information Network Ag Verwendung von wasserdispergierbaren carotinoid- nanopartikeln als geschmacksmodulatoren, geschmacksmodulatoren, enthaltend wasserdispergierbare carotinoid-nanopartikel, und verfahren zur geschmacksmodulation
DE502008002299D1 (de) * 2007-02-23 2011-02-24 Brain Biotechnology Res & Information Network Ag Verfahren zur geschmacksmodulation von stofflichen zusammensetzungen, die mindestens einen high intensity sweetener (his) enthalten
US7885788B2 (en) * 2007-06-15 2011-02-08 Abbott Cardiovascular Systems Inc. Method and apparatus for weighing a stent
US7812941B2 (en) * 2007-06-15 2010-10-12 Abbott Cardiovascular Systems Inc. Systems and methods for the inspection of cylinders
US8677650B2 (en) * 2007-06-15 2014-03-25 Abbott Cardiovascular Systems Inc. Methods and devices for drying coated stents
US7897195B2 (en) * 2007-06-15 2011-03-01 Abbott Cardiovascular Systems Inc. Devices for coating stents
US7606625B2 (en) * 2007-06-15 2009-10-20 Abbott Cardiovascular Systems Inc. Method and device for aligning a stent with a stent support
EP2188250B1 (de) 2007-08-31 2011-10-19 Basf Se Verfahren zur herstellung von öligen lösungen von astaxanthin-derivaten
ES2540222T5 (es) 2007-11-29 2022-04-19 Basf Se Preparado de carotinoide en forma de polvo para el teñido de bebidas
US9375387B2 (en) 2008-10-07 2016-06-28 Basf Se Ready-to-use, stable emulsion
CN102341006A (zh) 2009-03-05 2012-02-01 巴斯夫欧洲公司 虾青素衍生物的粉状组合物ii
ES2400223T3 (es) 2009-03-05 2013-04-08 Basf Se Formulación de derivados de astaxantina y su utilización II
EP2403364B1 (de) 2009-03-05 2013-01-09 Basf Se Verfahren zur herstellung von lösungen von astaxanthin-derivaten
CN102341004B (zh) 2009-03-05 2014-04-16 巴斯夫欧洲公司 虾青素衍生物的粉状组合物i
ES2602124T3 (es) 2009-03-05 2017-02-17 Basf Se Formulación de derivados de astaxantina y su uso III
DK2403354T3 (da) 2009-03-05 2013-04-08 Basf Se Formulering af astaxanthin-derivater og anvendelse heraf
CN102361561A (zh) 2009-03-30 2012-02-22 巴斯夫欧洲公司 部分无定形类胡萝卜素颗粒的即用稳定悬浮液
JP7083684B2 (ja) 2018-04-18 2022-06-13 株式会社三共 遊技機

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252238A (zh) * 1998-09-14 2000-05-10 Basf公司 稳定的、含有结晶度大于20%的番茄红素的粉状番茄红素制剂
CN1374035A (zh) * 2001-01-31 2002-10-16 巴斯福股份公司 生产一种或多种类胡萝卜素的干粉的方法

Also Published As

Publication number Publication date
ATE501644T1 (de) 2011-04-15
JP5368316B2 (ja) 2013-12-18
DK2111125T3 (da) 2011-06-20
DE502008002872D1 (de) 2011-04-28
US20100120922A1 (en) 2010-05-13
DK2111125T4 (en) 2017-02-27
EP2111125A2 (de) 2009-10-28
CL2008000129A1 (es) 2008-05-23
JP2013240337A (ja) 2013-12-05
ES2361276T3 (es) 2011-06-15
EP2111125B1 (de) 2011-03-16
US8809398B2 (en) 2014-08-19
EP2111125B2 (de) 2016-11-16
CN101583286A (zh) 2009-11-18
WO2008087140A3 (de) 2008-09-12
JP2010515447A (ja) 2010-05-13
WO2008087140A2 (de) 2008-07-24
JP5841974B2 (ja) 2016-01-13
ES2361276T5 (es) 2017-06-09

Similar Documents

Publication Publication Date Title
CN101583286B (zh) 含有类胡萝卜素的液体配制剂
CA2282184C (en) Stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%
CN100356868C (zh) 粉末状植物甾醇配方
CN1094326C (zh) 含有β－胡萝卜素、番茄红素和叶黄素的混合物的类胡萝卜素制剂
CN1104234C (zh) 液体、油可混类胡萝卜素制剂
JP4124821B2 (ja) キサントフィル類の安定な水性分散液および安定な水−分散性乾燥粉末、それらの製造および使用
ES2587016T3 (es) Nuevas composiciones de sustancias liposolubles
CN102361561A (zh) 部分无定形类胡萝卜素颗粒的即用稳定悬浮液
EP1794238A2 (de) Verfahren zur herstellung von trockenpulvern eines oder mehrerer carotinoide
JP3694268B2 (ja) １種以上のカロテノイドを含む乾燥粉末の製造方法
KR102049488B1 (ko) 카로테노이드 색소의 용기로의 부착 방지 방법
CN101217885A (zh) 微溶于水和不溶于水的活性成分的含水悬浮液和由其生产的干燥粉末
US20100041607A1 (en) Unctuous compositions
CN102176833A (zh) 即用型稳定乳液
EP3437488B1 (en) Carotenoid-containing particles
KR101948351B1 (ko) 카로테노이드를 포함하는 비들렛
CN100374041C (zh) 具有多芯结构的固体制剂
US20020052421A1 (en) Multicore type carotenoid beads
CN101583285A (zh) 油性组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant