EP0812135A1 - Astaxanthin suspension - Google Patents
Astaxanthin suspensionInfo
- Publication number
- EP0812135A1 EP0812135A1 EP96902947A EP96902947A EP0812135A1 EP 0812135 A1 EP0812135 A1 EP 0812135A1 EP 96902947 A EP96902947 A EP 96902947A EP 96902947 A EP96902947 A EP 96902947A EP 0812135 A1 EP0812135 A1 EP 0812135A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- astaxanthin
- suspension
- oil
- feed
- particle size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
Definitions
- This invention relates to a stable oil suspension of astaxanthin with high bioavailability, and the use thereof.
- Astaxanthin belongs to the carotenoids, which is a group of compounds exhibiting a wide range of yellow to red colour nuances. Carotenoids give rise to several of the colour characteristics of plants, and aquatic animals, for example.
- Carotenoids are insoluble in water and are only slightly fat soluble which means that solutions of carotenoids for direct application are unavailable. Furthermore, carotenoids are very sensible to oxidation.
- Astaxanthin is used in fish-farming to impart a pink colour to shrimp, trout, salmon etc.
- the invention comprises thus the following:
- the suspension according to the invention can be prepared by milling of astaxanthin, if desired in the presence of oil.
- astaxanthin is milled without oil, whereafter oil is added and the milling continued, if desired. Oxidation of astaxanthin during the dry milling operation can be reduced by the application of an inert gas atmosphere.
- the astaxanthin particles in the suspension of the invention have a particle size less than 2 ⁇ m, especially less than 1 ⁇ m. More preferred is an astaxanthin particle size less than 0.5 ⁇ m, especially less than 0J ⁇ m.
- the oil can be any animal or vegetable oil suitable for use in feed for aquatic animals.
- oil includes fish oil, such as for example mackerel oil, sprat oil and launce oil.
- Antioxidants such as for example tocopherols, especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin, can be added to the suspension to avoid oxidation.
- tocopherols especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin
- BHA butylhydroxyanisole
- BHT butylhydroxytoluene
- ascorbylpalmitate or ethoxyquin can be added to the suspension to avoid oxidation.
- Feed for aquatic animals suitably contains 15-30 % fat. Fat can be added by absorption of oil into the feed after extrusion, if desired using vacuum.
- the oil suspension of the invention could suitably be added to the feed using the same procedure, whereby an addition of fat and astaxanthin is obtained in one step.
- the suspension of the invention has a high concentration of astaxanthin and is diluted with additional oil before use.
- the final concentration of astaxanthin in fish feed is suitable between 25 and 100 ppm.
- Astaxanthin OJ g is milled for one hour totally in a Fritsen planetary micro mill pulverisette 7, speed 6. 5 ml of Launce oil ( Esbjerg Fiskeindustri ) is added and milling is continued for 15 min, speed 1.5. Particle size is measured by microscopy and found to be less than 2 ⁇ m for the majority of the particles. This suspension is poured on to a glass and placed in the dark at room temperature for 14 days.
- the small particles show a tendency to agglomeration but nothing indicates that the particles grow when standing. There is no sedimentation of astaxanthin.
- Launce oil solidifies at -18°C.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK10895 | 1995-01-31 | ||
DK10895 | 1995-01-31 | ||
PCT/EP1996/000373 WO1996023420A1 (en) | 1995-01-31 | 1996-01-30 | Astaxanthin suspension |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0812135A1 true EP0812135A1 (en) | 1997-12-17 |
Family
ID=8089837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96902947A Withdrawn EP0812135A1 (en) | 1995-01-31 | 1996-01-30 | Astaxanthin suspension |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0812135A1 (en) |
JP (1) | JPH10511270A (en) |
AU (1) | AU4715696A (en) |
CA (1) | CA2211107A1 (en) |
FI (1) | FI972961A (en) |
NO (1) | NO973473L (en) |
NZ (1) | NZ301672A (en) |
WO (1) | WO1996023420A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19649062A1 (en) * | 1996-11-27 | 1998-05-28 | Basf Ag | Liquid, oil-miscible carotenoid preparations |
US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
GB0218932D0 (en) * | 2002-08-14 | 2002-09-25 | Zoolife Internat Ltd | Composition for dietary enrichment |
WO2006034556A1 (en) * | 2004-09-29 | 2006-04-06 | Michael Ary Bos | Caratenoid composition and method for preparation thereof |
CN101232820B (en) | 2005-05-23 | 2012-09-05 | 法雷斯药品研究公司 | Direct dissolution method |
ES2304835B1 (en) * | 2005-12-29 | 2009-10-23 | Universidad De Las Palmas De Gran Canaria | FEED AND FEEDING PROCEDURE FOR PINK-RED COLORED SKIN FISHES FROM AQUACULTURE, TO OBTAIN IN THE SAME AN EXTERNAL COLORATION AND APPEARANCE SIMILAR TO SUCH ORGANIZATIONS WHEN THEY ARE OBTAINED DIRECTLY FROM THE SEA THROUGH FISHING. |
ES2361276T5 (en) | 2007-01-16 | 2017-06-09 | Basf Se | Liquid formulations, which contain carotenoids |
CN101883498A (en) * | 2007-11-23 | 2010-11-10 | 巴斯夫欧洲公司 | Method for the production of carotenoid solutions |
CL2008003484A1 (en) * | 2007-11-23 | 2010-01-11 | Basf Se | Process for the preparation of solutions of carotenoids in an oil suitable for edibles which comprises providing a suspension of carotenoids in oil; ii. heat continuously; iii. Cool the solution with a colder solution of the carotenoids in a suitable edible oil. |
CN105077203A (en) | 2007-11-29 | 2015-11-25 | 巴斯夫欧洲公司 | Pulverulent carotenoid preparation for colouring drinks |
CN102176833B (en) | 2008-10-07 | 2018-03-16 | 巴斯夫欧洲公司 | Instant stable emulsion |
EP2792246A1 (en) * | 2013-04-17 | 2014-10-22 | Basf Se | Method for producing an astaxanthin suspension |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3611229A1 (en) * | 1986-04-04 | 1987-10-08 | Basf Ag | METHOD FOR PRODUCING FINE DISTRIBUTED, POWDERED CAROTINOID PREPARATIONS |
DK199887D0 (en) * | 1987-04-15 | 1987-04-15 | Danisco Bioteknologi As | yeast strain |
US4871551A (en) * | 1988-02-08 | 1989-10-03 | Microbio Resources, Inc. | Pigmentation supplements for animal feed compositions |
DK546289D0 (en) * | 1989-11-02 | 1989-11-02 | Danochemo As | carotenoid |
DE4200728A1 (en) * | 1992-01-14 | 1993-07-15 | Basf Ag | STABLE, LIQUID PREPARATIONS OF FAT-SOLUBLE SUBSTANCES |
JPH06505881A (en) * | 1992-01-24 | 1994-07-07 | ギスト ブロカデス ナムローゼ フェンノートシャップ | Method for producing feed pellets |
-
1996
- 1996-01-30 WO PCT/EP1996/000373 patent/WO1996023420A1/en not_active Application Discontinuation
- 1996-01-30 AU AU47156/96A patent/AU4715696A/en not_active Abandoned
- 1996-01-30 EP EP96902947A patent/EP0812135A1/en not_active Withdrawn
- 1996-01-30 NZ NZ301672A patent/NZ301672A/en unknown
- 1996-01-30 CA CA002211107A patent/CA2211107A1/en not_active Abandoned
- 1996-01-30 JP JP8523250A patent/JPH10511270A/en active Pending
-
1997
- 1997-07-11 FI FI972961A patent/FI972961A/en unknown
- 1997-07-28 NO NO973473A patent/NO973473L/en unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9623420A1 * |
Also Published As
Publication number | Publication date |
---|---|
FI972961A (en) | 1997-07-31 |
FI972961A0 (en) | 1997-07-11 |
WO1996023420A1 (en) | 1996-08-08 |
CA2211107A1 (en) | 1996-08-08 |
NO973473D0 (en) | 1997-07-28 |
JPH10511270A (en) | 1998-11-04 |
NZ301672A (en) | 1997-12-19 |
AU4715696A (en) | 1996-08-21 |
NO973473L (en) | 1997-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19970718 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: LT PAYMENT 970718;LV PAYMENT 970718;SI PAYMENT 970718 |
|
17Q | First examination report despatched |
Effective date: 19990126 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: NEUROSEARCH A/S |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19990608 |