CN102361561A - 部分无定形类胡萝卜素颗粒的即用稳定悬浮液 - Google Patents
部分无定形类胡萝卜素颗粒的即用稳定悬浮液 Download PDFInfo
- Publication number
- CN102361561A CN102361561A CN2010800132049A CN201080013204A CN102361561A CN 102361561 A CN102361561 A CN 102361561A CN 2010800132049 A CN2010800132049 A CN 2010800132049A CN 201080013204 A CN201080013204 A CN 201080013204A CN 102361561 A CN102361561 A CN 102361561A
- Authority
- CN
- China
- Prior art keywords
- weight
- carotenoid
- stable suspension
- particle
- promptly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001747 carotenoids Chemical class 0.000 title claims abstract description 85
- 239000000725 suspension Substances 0.000 title claims abstract description 85
- 235000021466 carotenoid Nutrition 0.000 title claims abstract description 84
- 239000002245 particle Substances 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 claims abstract description 17
- 241001465754 Metazoa Species 0.000 claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 claims abstract description 12
- 235000015872 dietary supplement Nutrition 0.000 claims abstract description 11
- 239000000654 additive Substances 0.000 claims abstract description 9
- 230000000996 additive effect Effects 0.000 claims abstract description 9
- 239000002537 cosmetic Substances 0.000 claims abstract description 9
- 235000013734 beta-carotene Nutrition 0.000 claims description 47
- 239000011648 beta-carotene Substances 0.000 claims description 47
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 39
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 39
- 229960002747 betacarotene Drugs 0.000 claims description 39
- 239000000084 colloidal system Substances 0.000 claims description 36
- 239000008157 edible vegetable oil Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 26
- 229920002472 Starch Polymers 0.000 claims description 25
- 239000008107 starch Substances 0.000 claims description 25
- 235000019698 starch Nutrition 0.000 claims description 25
- 235000013361 beverage Nutrition 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 22
- 235000013305 food Nutrition 0.000 claims description 20
- 239000003960 organic solvent Substances 0.000 claims description 15
- 150000005846 sugar alcohols Polymers 0.000 claims description 15
- 230000010148 water-pollination Effects 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 11
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 9
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 claims description 8
- 239000006185 dispersion Substances 0.000 claims description 8
- -1 orange element Chemical compound 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 5
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 4
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 4
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 239000001168 astaxanthin Substances 0.000 claims description 4
- 235000013793 astaxanthin Nutrition 0.000 claims description 4
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 4
- 229940022405 astaxanthin Drugs 0.000 claims description 4
- 235000012682 canthaxanthin Nutrition 0.000 claims description 4
- 239000001659 canthaxanthin Substances 0.000 claims description 4
- 229940008033 canthaxanthin Drugs 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 239000001656 lutein Substances 0.000 claims description 4
- 235000012680 lutein Nutrition 0.000 claims description 4
- 229960005375 lutein Drugs 0.000 claims description 4
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 4
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 4
- 239000001751 lycopene Substances 0.000 claims description 4
- 235000012661 lycopene Nutrition 0.000 claims description 4
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 4
- 229960004999 lycopene Drugs 0.000 claims description 4
- 238000005728 strengthening Methods 0.000 claims description 4
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 4
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 4
- GVJHHUAWPYXKBD-QLVXXPONSA-N (S,R,R)-alpha-tocopherol Chemical compound [H][C@@](C)(CCCC(C)C)CCC[C@@]([H])(C)CCC[C@@]1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C GVJHHUAWPYXKBD-QLVXXPONSA-N 0.000 claims description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 17
- 235000019198 oils Nutrition 0.000 description 17
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 150000002148 esters Chemical class 0.000 description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 235000011496 sports drink Nutrition 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000004040 coloring Methods 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 244000000626 Daucus carota Species 0.000 description 4
- 235000002767 Daucus carota Nutrition 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 239000011668 ascorbic acid Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 4
- 229960004592 isopropanol Drugs 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000004368 Modified starch Substances 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 229910001425 magnesium ion Inorganic materials 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 235000019426 modified starch Nutrition 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000015205 orange juice Nutrition 0.000 description 3
- 239000003346 palm kernel oil Substances 0.000 description 3
- 235000019865 palm kernel oil Nutrition 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- XDLYMKFUPYZCMA-UHFFFAOYSA-M sodium;4-oct-1-enoxy-4-oxobutanoate Chemical compound [Na+].CCCCCCC=COC(=O)CCC([O-])=O XDLYMKFUPYZCMA-UHFFFAOYSA-M 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- QXNWZXMBUKUYMD-ITUXNECMSA-N 4-keto-beta-carotene Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C QXNWZXMBUKUYMD-ITUXNECMSA-N 0.000 description 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 244000024675 Eruca sativa Species 0.000 description 2
- 235000014755 Eruca sativa Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000012343 cottonseed oil Nutrition 0.000 description 2
- 239000002385 cottonseed oil Substances 0.000 description 2
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 235000021323 fish oil Nutrition 0.000 description 2
- 235000002864 food coloring agent Nutrition 0.000 description 2
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 2
- 229940011051 isopropyl acetate Drugs 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 150000004668 long chain fatty acids Chemical class 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 235000009973 maize Nutrition 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 235000020124 milk-based beverage Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 230000006209 tert-butylation Effects 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- RAFGELQLHMBRHD-VFYVRILKSA-N Bixin Natural products COC(=O)C=CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)/C)C RAFGELQLHMBRHD-VFYVRILKSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 241000415246 Callisia navicularis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004217 Citranaxanthin Substances 0.000 description 1
- SLQHGWZKKZPZEK-JKEZLOPUSA-N Citranaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)C)C=CC=C(/C)C=CC1=C(C)CCCC1(C)C SLQHGWZKKZPZEK-JKEZLOPUSA-N 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 239000004258 Ethoxyquin Substances 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- RAFGELQLHMBRHD-UHFFFAOYSA-N alpha-Fuc-(1-2)-beta-Gal-(1-3)-(beta-GlcNAc-(1-6))-GalNAc-ol Natural products COC(=O)C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC(O)=O RAFGELQLHMBRHD-UHFFFAOYSA-N 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000001670 anatto Substances 0.000 description 1
- 235000012665 annatto Nutrition 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- DMASLKHVQRHNES-FKKUPVFPSA-N beta-cryptoxanthin Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C DMASLKHVQRHNES-FKKUPVFPSA-N 0.000 description 1
- RAFGELQLHMBRHD-SLEZCNMESA-N bixin Chemical compound COC(=O)\C=C\C(\C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O RAFGELQLHMBRHD-SLEZCNMESA-N 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical group NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 229940071162 caseinate Drugs 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 235000019247 citranaxanthin Nutrition 0.000 description 1
- PRDJTOVRIHGKNU-ZWERVMMHSA-N citranaxanthin Chemical compound CC(=O)\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C PRDJTOVRIHGKNU-ZWERVMMHSA-N 0.000 description 1
- PRDJTOVRIHGKNU-UHFFFAOYSA-N citranaxanthine Natural products CC(=O)C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C PRDJTOVRIHGKNU-UHFFFAOYSA-N 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000019244 cryptoxanthin Nutrition 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000006932 echinenone Nutrition 0.000 description 1
- YXPMCBGFLULSGQ-YHEDCBSUSA-N echinenone Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(=O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CCCC2(C)C YXPMCBGFLULSGQ-YHEDCBSUSA-N 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 description 1
- 229940093500 ethoxyquin Drugs 0.000 description 1
- 235000019285 ethoxyquin Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 108010059642 isinglass Proteins 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
- 229960000201 isosorbide dinitrate Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- 229910052627 muscovite Inorganic materials 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 235000010958 polyglycerol polyricinoleate Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 235000014438 salad dressings Nutrition 0.000 description 1
- 229940119224 salmon oil Drugs 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0053—Compositions other than spreads
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/60—Salad dressings; Mayonnaise; Ketchup
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/10—Puddings; Dry powder puddings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其生产方法及其作为动物饲料、食品和食品增补剂以及化妆品和药物组合物的添加剂的用途。
Description
本发明涉及一种部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其生产方法及其作为动物饲料、食品和食品增补剂以及化妆品和药物组合物的添加剂的用途。
类胡萝卜素类物质被分成两大类:胡萝卜素和胡萝卜醇类。与为纯多烯烃的胡萝卜素如β-胡萝卜素或番茄红素相反,氧官能团如羟基、环氧和/或羰基也出现在胡萝卜醇类中。该组的典型成员尤其是虾青素、角黄素、叶黄素和玉米黄素。
不仅可以通过合成得到而且还可以由天然源分离的这些多烯对食品和饲料工业以及还对药物领域而言是重要的着色剂和活性成分且例如由于其维生素A原活性而令人感兴趣。
胡萝卜素和胡萝卜醇类均不溶于水中,但发现在脂肪和油中同样仅具有低溶解性。该受限的溶解性以及对氧化的高敏感性对在食品和饲料着色中直接应用通过化学合成得到的相对粗颗粒产物构成障碍,因为粗结晶形式的物质不是储存稳定的且仅得到不良着色结果。对于类胡萝卜素的实际应用不利的这些效果尤其体现在含水介质中,因为它们在其中基本不溶。
改进的得色率在食品着色中仅可通过特别生产的配制剂实现,其中类胡萝卜素以细碎形式存在且任选由保护胶体保护以防氧化。此外,用于饲料中的这些配制剂导致作为胡萝卜素或胡萝卜醇类的类胡萝卜素具有更高的生物利用率,并因此间接导致更好的着色效果,例如在蛋黄或鱼的着色中。
为了改进得色率并提高可吸收性和/或生物利用率,已经描述了各种方法,它们的目的全部在于降低活性成分的晶粒尺寸并使它们具有小于10μm的粒度范围。
尤其在Chimia 21,329(1967),WO 91/06292以及WO 94/19411中所描述的许多方法在此使用胶体磨研磨类胡萝卜素并由此部分实现小于2μm的粒度。
WO 2007/003543例如描述了一种研磨方法,其中通过在蔗糖或葡萄糖和改性淀粉存在下研磨并随后将包含类胡萝卜素的悬浮液转化成干粉而将β-胡萝卜素作为悬浮液粉碎至粒度约0.6μm。
除了研磨方法外,存在许多组合的乳化/喷雾干燥方法,例如如DE-A-1211911或EP-A-0410236中所述那些。
根据欧洲专利EP-B-0065193,细碎的粉状类胡萝卜素制剂按如下生产:在升高的温度下,需要的话在升高的压力下,将类胡萝卜素溶于挥发性水溶混性有机溶剂中,通过将该溶液与保护胶体的水溶液混合而沉淀类胡萝卜素并随后喷雾干燥该溶液。
使用水不溶混性溶剂生产细碎粉状类胡萝卜素制剂的类似方法描述于EP-A-0937412中。
在饮料工业中,通常将添加剂以液体浓缩物形式加入饮料中。不仅提供着色剂如类胡萝卜素的液体配制剂,而且提供相应的水溶性粉状配制剂,在饮料制造商现场采用的生产方法中首先由它们生产着色剂的水分散体。
EP 0239086描述了溶于油中的类胡萝卜素乳液,其中为了稳定油滴,使用中链脂肪酸与抗坏血酸的酯和冷水可溶性淀粉产品如淀粉辛烯基琥珀酸盐的混合物。这些乳液中的类胡萝卜素浓度为0.1-2%。
在EP 0551638中制备了脂溶性维生素或类胡萝卜素的稳定液体乳液,其中外相为甘油或甘油/水混合物且作为乳化剂和稳定剂使用抗坏血酸与长链脂肪酸的酯。在β-胡萝卜素的情况下,该制剂的特征在于明亮的黄色调。
WO 93/04598描述了类胡萝卜素组合物的生产,该组合物包含处于油中的类胡萝卜素,水分散性基质形成剂如糖类和稳定剂如明胶或酪蛋白的分散体,以及乳化剂和任选的非油性溶剂如甘油。
WO 97/26802描述了即用水分散性颜料组合物,其中天然来源的疏水性颜料以分散形式存在,无需在包含亲水胶体的水相中加入表面活性剂。
EP 0795585描述了含水的细碎类胡萝卜素悬浮液,其不包含保护胶体,但包含至少一种特殊乳化剂。所得悬浮液的色调由于不同粒度而变化。
EP 0832569描述了包含类胡萝卜素的冷水分散性干粉的生产,其中热处理细碎类胡萝卜素的分散体以设定所需色调。
WO 2008/087140描述了包含至少一种类胡萝卜素、至少一种亲水性保护胶体和至少一种水溶混性醇的液体配制剂。
类胡萝卜素的市售粉状配制剂具有良好的储存稳定性且在各种饮料应用如果汁、柠檬汁饮料、运动饮料、牛奶饮料或维生素饮料中显示出良好的着色性能。为了用于富含矿物质的运动饮料或当使用具有高含量钙离子或镁离子的饮用水时,瓶装饮料必须不出现任何结圈(分出乳油)且不能在瓶壁上出现类胡萝卜素组分的沉积物。
使用类胡萝卜素的粉状配制剂的缺点是形成粉尘以及由其连带的污染环境的风险,粉末在输送工艺过程中静电荷电的风险以及在将粉末溶于水中时起泡或形成团块的风险。同样不利的是类胡萝卜素的粉状配制剂通常以类胡萝卜素含量为约0.1重量%的含水储备溶液使用,结果也总是向待着色食品中提供显著量的水。
本发明的目的是提供一种类胡萝卜素的即用稳定配制剂,该配制剂具有市售粉状配制剂的所需性能,例如就微生物侵染而言良好的储存稳定性,储存过程中的色调稳定性,对于在包含钙或镁的饮料中使用或当使用具有高含量钙离子或镁离子的饮用水时的良好的热稳定性和不敏感性,但不具有粉状配制剂的加工缺点。本发明的另一目的是提供一种具有上述性能的类胡萝卜素配制剂,其中该配制剂可以用于生产着橙色且富含维生素A原的食品,尤其是饮料,并且其中色调应由黄橙色经橙色扩展至红橙色。
该目的由部分无定形类胡萝卜素颗粒的即用稳定悬浮液实现,该悬浮液包含:
1-20重量% 至少一种类胡萝卜素,
0.2-20重量% 食用油,
3-60重量% 亲水性保护胶体,
5-60重量% 生理上耐受的多元醇,和
5-60重量% 水,
其中重量百分数相对于所述即用稳定悬浮液,类胡萝卜素、食用油、保护胶体、生理上耐受的多元醇和水一起的比例总和为至少80重量%并且类胡萝卜素与食用油的重量比为1∶0.01-1∶2。
在本发明上下文中,特征“即用”是指本发明悬浮液可以由用户直接用于其目的的性能,因此它可以直接计量加入,例如在食品工业中用于食品着色或用于用维生素A原(β-胡萝卜素)强化食品,其中在β-胡萝卜素的情况下可以产生黄橙色至红橙色的色调。
在本发明上下文中特征“稳定”是指微生物、胶体和化学稳定性。微生物稳定性为抑菌效果。胶体稳定性涉及不出现相分离和颜色特性不出现变化。化学稳定性涉及稳定的颜色特性和类胡萝卜素含量。
本发明的即用稳定悬浮液包含1-20重量%,优选3-15重量%,特别优选5-10重量%类胡萝卜素。
可以用于本发明即用稳定悬浮液中的类胡萝卜素是可以由天然源得到或通过合成得到的已知代表物。其实例是单独或作为混合物的β-胡萝卜素、番茄红素、叶黄素、虾青素、玉米黄素、隐黄素、桔黄素(citranaxanthin)、角黄素、海胆酮、胭脂树素、β-阿朴-4-胡萝卜醛、β-阿朴-8-胡萝卜醛、β-阿朴-4-胡萝卜素酸的酯。优选使用合成制备且提纯的类胡萝卜素。特别优选存在于本发明即用稳定悬浮液中的类胡萝卜素选自β-胡萝卜素、虾青素、角黄素、桔黄素、番茄红素和叶黄素。非常特别优选本发明即用稳定悬浮液中存在的类胡萝卜素为尤其通过合成生产的β-胡萝卜素。
本发明即用稳定悬浮液包含0.2-20重量%,优选0.5-10重量%,特别优选1-5重量%食用油。
可以考虑的食用油原则上是生理上耐受的合成、矿物、植物或动物来源的油。实例是芝麻油、玉米胚芽油、棉籽油、豆油、花生油、中链植物脂肪酸酯、油硬脂、石蜡油、硬脂酸甘油酯、肉豆蔻酸异丙酯、己二酸二异丙酯、鲸蜡硬脂醇2-乙基己酸酯、氢化聚异丁烯、辛酸/癸酸甘油三酯、棕榈油、棕榈仁油、羊毛脂和PUFA(多不饱和脂肪酸,如二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)和α-亚麻酸)。
优选本发明即用稳定悬浮液中的食用油是植物或动物来源的,其中它在30℃下为液体,如葵花油、棕榈油、棕榈仁油、芝麻油、玉米胚芽油、棉籽油、豆油、花生油、中链甘油三酯(称为MCT油),鱼油,如鲭鱼油、黍鲱鱼油或鲑鱼油。
特别优选本发明即用稳定悬浮液中的食用油为植物油。非常特别优选地,该食用油为中链甘油三酯(MCT油)。中链甘油三酯基本仅包括例如存在于棕榈仁油或椰子油中的饱和脂肪酸。
在本发明的即用稳定悬浮液中,类胡萝卜素和食用油的重量比为1∶0.01-1∶2,优选1∶0.05-1∶1.5,特别优选1∶0.2-1∶1,尤其是1∶0.3-1∶0.7。在类胡萝卜素与食用油的上述重量比情况下,通常大于50%的所用类胡萝卜素作为固体存在,且小部分,即小于50%的所用类胡萝卜素溶于存在的食用油中。
类胡萝卜素和食用油形成本发明悬浮液疏水相的主组分,其中根据现有的知识,一部分该油伴有固体类胡萝卜素颗粒且一部分该油以液滴形式存在,其中这些油滴仅包含分子溶解的类胡萝卜素其不包含类胡萝卜素颗粒。
固体类胡萝卜素颗粒并不是完全结晶的,而是部分无定形的。在本发明中,部分无定形是指结晶度小于95%,优选结晶度小于70%。类胡萝卜素颗粒中的结晶和无定形比例例如可以通过X射线衍射测量法测定。本发明悬浮液的类胡萝卜素颗粒中X射线无定形比例优选为50-100%,尤其是60-100%。
本发明即用稳定悬浮液包含3-60重量%,优选5-40重量%,尤其是7-30重量%亲水性保护胶体。
作为亲水性保护胶体,可以考虑水溶性或水溶胀性胶体。优选保护胶体为蛋白基保护胶体,改性淀粉衍生物和改性纤维素衍生物。蛋白基保护胶体尤其为酪蛋白、酪蛋白酸盐、牛明胶、猪明胶或鱼明胶,尤其是在酸性或碱性条件下分解的Bloom值为0-250的明胶,以及它们的混合物。改性淀粉衍生物和纤维素衍生物尤其为酯,例如淀粉辛烯基琥珀酸酯。相应产物以名称Purity Gum 2000由National Starch市购或以Clear Gum CO 01由Roquette市购,以Hi Cap 100或Capsul由National Starch市购。
优选本发明的即用稳定悬浮液包含化学改性淀粉作为亲水性保护胶体。
化学改性淀粉是指化学和/或酶催生产的淀粉转化产物。这些可以是淀粉醚,淀粉酯或淀粉磷酸酯。该组的优选代表是淀粉酯,尤其是辛烯基琥珀酸盐淀粉,例如来自National Starch的(辛烯基琥珀酸钠淀粉),来自Roquette的Cleargum CO 01或来自National Starch的Gum2000(辛烯基琥珀酸钠淀粉),尤其是辛烯基琥珀酸钠淀粉如Gum2000。
特别优选本发明即用稳定悬浮液包含辛烯基琥珀酸盐淀粉作为亲水性保护胶体。
本发明即用稳定悬浮液包含5-60重量%,优选15-50重量%,特别优选25-45重量%,尤其是30-40重量%生理上耐受的多元醇。
在本发明悬浮液中存在的生理上耐受的多元醇通常在大气压力下具有高于150℃,优选高于180℃,尤其高于200℃的沸点。
生理上耐受的多元醇优选为甘油、甘油与C1-C5单羧酸的单酯、甘油的单醚、丙二醇或山梨醇。特别优选甘油为生理上耐受的多元醇。
本发明的即用稳定悬浮液包含5-60重量%,优选15-50重量%,特别优选25-45重量%,尤其是30-40重量%水。
在本发明的即用稳定悬浮液中,类胡萝卜素、食用油、保护胶体、生理上耐受的多元醇和水一起的比例总和至少为80重量%,优选至少90重量%,尤其是至少95重量%。
在本发明的即用稳定悬浮液中,除了亲水性保护胶体(高分子量化合物或聚合物)外,选自表面活性剂类别(低分子量化合物)的具有乳化活性的其他物质的含量通常小于2重量%,优选小于1重量%。作为具有乳化活性的物质的表面活性剂例如为抗坏血酰棕榈酸酯,脂肪酸的聚甘油酯如聚甘油3-聚蓖麻醇酸酯(PGPR 90),脂肪酸的脱水山梨醇酯如脱水山梨醇单硬脂酸酯(Span 60),PEG(20)-山梨醇单油酸酯,脂肪酸的丙二醇酯,长链脂肪酸的蔗糖酯,如蔗糖单棕榈酸酯,或磷脂,如卵磷脂。
若具有乳化活性的其他物质为抗坏血酰棕榈酸酯,则抗坏血酰棕榈酸酯的含量优选小于0.5重量%,特别优选小于0.25重量%,尤其小于0.1重量%,其中重量百分数相对于该悬浮液的总重量。
为了提高类胡萝卜素在本发明即用稳定悬浮液中对氧化腐败的稳定性,有利的是加入稳定剂如d,l-α-生育酚、叔丁基化羟基甲苯、叔丁基化羟基茴香醚、抗坏血酸、抗坏血酸盐或和乙氧基喹作为抗氧化剂。
优选本发明部分无定形类胡萝卜素颗粒的即用稳定悬浮液额外包含0.1-5重量%,优选0.2-4重量%的至少一种抗氧化剂,其中重量百分数相对于所述即用稳定悬浮液。特别优选将0.5-2.0重量%的d,l-α-生育酚作为抗氧化剂加入本发明的即用稳定悬浮液中。
特别优选包含如下组分的本发明即用稳定悬浮液:
3-10重量% β-胡萝卜素作为类胡萝卜素,
1-5重量% 中链甘油三酯作为食用油,
0.5-2.0重量% d,l-α-生育酚,
10-24重量% 辛烯基琥珀酸盐淀粉作为亲水性保护胶体,
30-40重量% 甘油作为生理上耐受的多元醇,和
30-40重量% 水,
其中β-胡萝卜素、中链甘油三酯、d,l-α-生育酚、辛烯基琥珀酸盐淀粉、甘油和水一起的比例总和为至少95重量%并且β-胡萝卜素和中链甘油三酯的重量比为1∶0.3-1∶0.7。
在本发明部分无定形类胡萝卜素颗粒的即用稳定悬浮液中,所述部分无定形类胡萝卜素颗粒优选作为纳米颗粒状颗粒存在。
纳米颗粒状颗粒是指由Fraunhofer衍射测定的平均粒度D[4,3]为0.02-100μm,优选0.05-50μm,特别优选0.05-20μm,非常特别优选0.05-5μm,尤其是0.05-1.0μm的那些颗粒。表述D[4,3]表示体积加权平均直径(参见Malvern Mastersizer S的手册,Malvern Instruments Ltd.,UK),其可以借助Fraunhofer衍射测定。
优选处于本发明悬浮液中的类胡萝卜素颗粒具有的平均粒度D[4,3]为0.05-0.8μm,优选0.1-0.7μm,尤其是0.4-0.6μm。
特别优选处于本发明即用稳定悬浮液中的类胡萝卜素颗粒具有的平均粒度为0.05-0.8μm,优选0.1-0.7μm,尤其是0.4-0.6μm并且具有的平均X射线无定形比例为50-100%,优选60-100%。
本发明还进一步涉及一种生产包含如下组分的部分无定形类胡萝卜素颗粒的即用稳定悬浮液的方法:
1-20重量% 至少一种类胡萝卜素,
0.2-20重量% 食用油,
3-60重量% 亲水性保护胶体,
5-60重量% 生理上耐受的多元醇,和
5-60重量% 水,
其中重量百分数相对于所述即用稳定悬浮液,类胡萝卜素、食用油、保护胶体、生理上耐受的多元醇和水一起的比例总和为至少80重量%并且类胡萝卜素和食用油的重量比为1∶0.01-1∶2,
所述方法包括:
a1)在高于30℃的温度下将类胡萝卜素与食用油一起溶于水溶混性有机溶剂或水和水溶混性有机溶剂的混合物中,或
a2)将类胡萝卜素与食用油一起溶于水不溶混性有机溶剂中,
b)将根据a1)或a2)得到的溶液与保护胶体在水和生理上耐受的多元醇的混合物中的分子分散或胶体分散溶液混合,其中产生作为纳米分散相的包含类胡萝卜素的疏水相,
c)除去a1)或a2)中所用的有机溶剂并将形成的悬浮液浓缩至所需类胡萝卜素含量。
有关组分类胡萝卜素、食用油、亲水性保护胶体、生理上耐受的多元醇和水及其用量的优选实施方案可参见在开头已经给出的解释。
在本发明方法步骤a1)中使用的水溶混性溶剂主要是仅包含碳、氢和氧的水溶混性、热稳定的挥发性溶剂,如醇、醚、酯、酮或缩醛。有利的是使用至少10%水溶混、沸点低于200℃和/或具有少于10个碳原子的那些溶剂。特别优选使用甲醇、乙醇、正丙醇、异丙醇、1,2-丁二醇1-甲基醚(1-甲氧基-2-丁醇)、1,2-丙二醇1-正丙基醚(1-丙氧基-2-丙醇)、四氢呋喃或丙酮。
本发明上下文中的表述“水不溶混性有机溶剂”是在大气压力下的水溶性小于10%的有机溶剂。此时可以考虑的可能溶剂尤其是卤代脂族烃类,如二氯甲烷、氯仿和四氯化碳,羧酸的酯如碳酸二甲酯、碳酸二乙酯、碳酸亚丙酯、甲酸乙酯、乙酸甲酯、乙酸乙酯或乙酸异丙酯以及醚类如甲基叔丁基醚。优选的水不溶混性有机溶剂是下列化合物:碳酸二甲酯、碳酸亚丙酯、甲酸乙酯、乙酸乙酯、乙酸异丙酯和甲基叔丁基醚。
根据本发明,优选进行工艺步骤a1),其中在高于30℃,优选50-240℃,尤其是100-200℃,特别优选140-180℃的温度下,需要的话在加压下,将类胡萝卜素与食用油一起溶于水溶混性有机溶剂或水和水溶混性有机溶剂的混合物中。
由于高温的作用在某些情况下可能降低类胡萝卜素,尤其还有β-胡萝卜素的所需高全反式异构体比例,因此尽可能快速地溶解类胡萝卜素,例如在几秒钟内,例如0.1-10秒,特别优选小于1秒钟。为了快速生产分子分散的溶液,使用升高的压力,例如20-80巴,优选30-60巴可能是有利的。
所得分子分散溶液随后在工艺步骤b)中直接与保护胶体在水和生理上耐受的多元醇的混合物中的可能冷却的分子分散或胶体分散溶液混合,其中来自工艺步骤a1)的溶剂组分转移到水相中并且形成作为纳米分散相的类胡萝卜素与该食用油一起的疏水相。优选在工艺步骤b)中产生约35-80℃的混合物温度。
对于上述分散的方法和设备的更详细描述,此时参考EP-B-0065193。
在本发明方法中,在工艺步骤c)中除去工艺步骤a1)或a2)中所用有机溶剂并通过除去过量水将形成的悬浮液浓缩至所需类胡萝卜素含量。所用生理上耐受的多元醇在该浓缩步骤中由于其高沸点而基本未被除去。
本发明部分无定形类胡萝卜素颗粒的即用稳定悬浮液的特征在于与可以由粉状类胡萝卜素配制剂生产的含水储备溶液相比,其在类胡萝卜素含量上显著更为浓缩,并且因此也可以加入仅容许非常少量水的饮料基质中。本发明悬浮液可以毫无问题地计量加入且没有出现不希望的沉降。
此外,本发明悬浮液就微生物侵染和储存过程中的色调稳定性而言具有良好的储存稳定性。此外,本发明悬浮液在包含钙或镁的饮料中使用或当使用具有高含量钙离子或镁离子的饮用水时显示出良好的热稳定性和所要求的不敏感性。与本发明悬浮液混合的饮料对不希望的结圈(分出乳油)具有良好稳定性。
本发明部分无定形类胡萝卜素颗粒的即用稳定悬浮液尤其适合作为食品制剂的添加剂,例如用于着色食品如饮料,作为生产药物和化妆品制剂的组合物以及还用于生产食品增补配制剂,例如人类和动物领域的多维生素配制剂。优选本发明的即用稳定悬浮液适合作为饮料添加剂。
本发明悬浮液在类胡萝卜素β-胡萝卜素的情况下具有橙色色调且适合在黄橙色至红橙色的颜色范围内着色食品。此外,该包含β-胡萝卜素的悬浮液用于用维生素A原强化食品。
因此,本发明进一步涉及本发明部分无定形类胡萝卜素颗粒的上述即用稳定悬浮液作为动物饲料、食品、食品增补剂以及化妆品和药物组合物的添加剂,尤其也在饮料生产中作为添加剂的用途,其中优选将本发明悬浮液直接加入饮料中。
本发明同样涉及动物饲料、食品和食品增补剂,尤其是饮料,其包含本发明的部分无定形类胡萝卜素颗粒的即用稳定悬浮液。
本发明进一步涉及其中类胡萝卜素为β-胡萝卜素的上述即用稳定悬浮液在用维生素A原强化动物饲料、食品和食品增补剂以及化妆品和药物组合物中的用途。
本发明同样还涉及一种通过向其中加入本发明的部分无定形类胡萝卜素颗粒的即用稳定悬浮液而用维生素A原强化动物饲料、食品和食品增补剂以及化妆品和药物组合物,尤其是饮料的方法,其中类胡萝卜素为β-胡萝卜素。
通过下列实施例解释本发明,但这些实施例并不限制本发明:
实施例
实施例1:生产β-胡萝卜素悬浮液
在可加热的接收烧瓶中,在30℃的温度下将57g结晶β-胡萝卜素,27gMCT油和8.4gα-生育酚悬浮于315g共沸异丙醇/水混合物中。然后将活性成分悬浮液加热至73℃并在3.4kg/h的流速下与温度为235℃且流速为4.8kg/h的另外异丙醇/水共沸物在混合室中混合,其中β-胡萝卜素在产生171℃的混合物温度和65巴的压力下溶解。将该活性成分溶液立即在第二混合室中与227g Purity Gum 2000、286g甘油在6646g蒸馏水中的水溶液在60kg/h的流速下混合。
在混合时得到的活性成分颗粒在异丙醇/水混合物中具有的粒度在115的E1/1值下为438nm(E1/1:浓度为1重量%的悬浮液在1cm比色杯中的消光)。
然后在薄膜蒸发器上将该活性成分悬浮液浓缩至约6.2重量%活性成分含量的浓度。
在实施例1中生产的β-胡萝卜素含量为约6.2重量%的悬浮液在随后的应用研究中以名称OL表示。
实施例2:不含果汁的运动饮料(15ppm β-胡萝卜素)
在掺合各组分后,将该饮料在90℃下巴氏杀菌60秒。
对比例2b
以与实施例2所述类似的方式制备运动饮料,其中代替本发明实施例1的悬浮液OL,使用B-胡萝卜素含量为0.1重量%的储备溶液作为B-胡萝卜素源,其由粉状市售产品10CWD/O(10重量%β-胡萝卜素)制备。
结果:
观察到在实施例2中生产的运动饮料的化学稳定性(β-胡萝卜素含量,颜色)与在对比例2b中生产的运动饮料相比没有缺点。
实施例3:牛奶饮料(5ppm β-胡萝卜素)
在掺合后将该饮料在200巴的高压下均化并在90℃下巴氏杀菌60秒。
实施例4:波普饮料(Alcopop)(3.5ppm β-胡萝卜素)
在掺合后将该饮料在200巴的高压下均化并在65℃下巴氏杀菌60秒。
对比例4b
结果:
观察到在实施例4中生产的波普饮料的化学稳定性(β-胡萝卜素含量,颜色)与在对比例4b中生产的波普饮料相比没有缺点。
实施例5:具有30%果汁的维生素饮料(15ppm β-胡萝卜素)
在掺合后将该饮料在200巴的高压下均化并在90℃下巴氏杀菌60秒。
实施例6:具有100%果汁的维生素饮料(30ppm β-胡萝卜素)
在掺合后将该饮料在100巴的高压下均化并在90℃下巴氏杀菌60秒。
实施例7:在冷掺合工艺中的橙汁基质(30ppm β-胡萝卜素)
在冷掺合工艺中,在-2℃下将用于生产橙汁基质的所有成分掺入橙汁浓缩物中。饮料介质的高粘度以及低温对β-胡萝卜素配制剂的稳定性和加工性具有特殊要求。
实施例8:色拉调料(6.2ppm β-胡萝卜素)
将各成分混合、用Ultra-Turrax均化并加热。
实施例9:布丁(2ppm β-胡萝卜素)
Claims (18)
1.一种部分无定形类胡萝卜素颗粒的即用稳定悬浮液,包含:
1-20重量% 至少一种类胡萝卜素,
0.2-20重量% 食用油,
3-60重量% 亲水性保护胶体,
5-60重量% 生理上耐受的多元醇,和
5-60重量% 水,
其中重量百分数相对于所述即用稳定悬浮液,类胡萝卜素、食用油、保护胶体、生理上耐受的多元醇和水一起的比例总和为至少80重量%并且类胡萝卜素和食用油的重量比为1∶0.01-1∶2。
2.根据权利要求1的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中类胡萝卜素选自β-胡萝卜素、虾青素、角黄素、桔黄素、番茄红素和叶黄素。
3.根据权利要求1或2的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中类胡萝卜素为β-胡萝卜素。
4.根据权利要求1-3中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中食用油为植物油。
5.根据权利要求1-4中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中生理上耐受的多元醇为甘油。
6.根据权利要求1-5中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中亲水性保护胶体为化学改性淀粉。
7.根据权利要求6的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中亲水性保护胶体为辛烯基琥珀酸盐淀粉。
8.根据权利要求1-7中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,额外包含0.1-5重量%至少一种抗氧化剂。
9.根据权利要求1的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,包含:
3-10重量% β-胡萝卜素作为类胡萝卜素,
1-5重量% 中链甘油三酯作为食用油,
0.5-2.0重量% d,l-α-生育酚,
10-24重量% 辛烯基琥珀酸盐淀粉作为亲水性保护胶体,
30-40重量% 甘油作为生理上耐受的多元醇,和
30-40重量% 水,
其中β-胡萝卜素、中链甘油三酯、d,l-α-生育酚、辛烯基琥珀酸盐淀粉、甘油和水一起的比例总和为至少95重量%并且β-胡萝卜素和中链甘油三酯的重量比为1∶0.3-1∶0.7。
10.根据权利要求1-9中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液,其中类胡萝卜素颗粒的平均粒度为0.05-0.8μm且平均X射线无定形比例为50-100%。
11.一种生产包含如下组分的部分无定形类胡萝卜素颗粒的即用稳定悬浮液的方法:
1-20重量% 至少一种类胡萝卜素,
0.2-20重量% 食用油,
3-60重量% 亲水性保护胶体,
5-60重量% 生理上耐受的多元醇,和
5-60重量% 水,
其中重量百分数相对于所述即用稳定悬浮液,类胡萝卜素、食用油、保护胶体、生理上耐受的多元醇和水一起的比例总和为至少80重量%并且类胡萝卜素和食用油的重量比为1∶0.01-1∶2,
所述方法包括如下步骤:
a1)在高于30℃的温度下将类胡萝卜素与食用油一起溶于水溶混性有机溶剂或水和水溶混性有机溶剂的混合物中,或
a2)将类胡萝卜素与食用油一起溶于水不溶混性有机溶剂中,
b)将根据a1)或a2)得到的溶液与保护胶体在水和生理上耐受的多元醇的混合物中的分子分散或胶体分散溶液混合,其中产生作为纳米分散相的包含类胡萝卜素的疏水相,
c)除去a1)或a2)中所用的有机溶剂并将形成的悬浮液浓缩至所需类胡萝卜素含量。
12.根据权利要求1-10中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液作为动物饲料、食品和食品增补剂以及化妆品和药物组合物的添加剂的用途。
13.根据权利要求1-10中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液在饮料生产中作为添加剂的用途。
14.根据权利要求13的用途,其中将根据权利要求1-10中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液直接加入饮料中。
15.一种动物饲料、食品和食品增补剂,包含根据权利要求1-10中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液。
16.一种饮料,包含根据权利要求1-10中任一项的部分无定形类胡萝卜素颗粒的即用稳定悬浮液。
17.根据权利要求3的部分无定形类胡萝卜素颗粒的即用稳定悬浮液在用维生素A原强化动物饲料、食品和食品增补剂以及化妆品和药物组合物中的用途。
18.一种通过向其中加入根据权利要求3的部分无定形类胡萝卜素颗粒的即用稳定悬浮液而用维生素A原强化动物饲料、食品和食品增补剂以及化妆品和药物组合物,尤其是饮料的方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09156651.3 | 2009-03-30 | ||
EP09156651 | 2009-03-30 | ||
PCT/EP2010/053965 WO2010112406A1 (de) | 2009-03-30 | 2010-03-26 | Gebrauchsfertige, stabile suspension teilamorpher carotinoidpartikel |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102361561A true CN102361561A (zh) | 2012-02-22 |
Family
ID=42243439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800132049A Pending CN102361561A (zh) | 2009-03-30 | 2010-03-26 | 部分无定形类胡萝卜素颗粒的即用稳定悬浮液 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20120039970A1 (zh) |
EP (1) | EP2413710B1 (zh) |
JP (1) | JP2012521774A (zh) |
CN (1) | CN102361561A (zh) |
DK (1) | DK2413710T3 (zh) |
ES (1) | ES2621184T3 (zh) |
WO (1) | WO2010112406A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015003536A1 (zh) | 2013-07-09 | 2015-01-15 | 浙江新维普添加剂有限公司 | 油分散性类胡萝卜素制剂的制备方法 |
CN105578894A (zh) * | 2013-09-24 | 2016-05-11 | 帝斯曼知识产权资产管理有限公司 | 用于对饮料和食品进行着色的稳定的红色制剂 |
CN113208141A (zh) * | 2012-11-27 | 2021-08-06 | 帝斯曼知识产权资产管理有限公司 | 用于生产离散固体挤出颗粒的方法 |
CN115349630A (zh) * | 2022-06-20 | 2022-11-18 | 海宁凤鸣叶绿素有限公司 | 水分散性叶黄素微囊粉的制备方法 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2361276T5 (es) | 2007-01-16 | 2017-06-09 | Basf Se | Formulaciones líquidas, que contienen carotenoides |
CN105077203A (zh) | 2007-11-29 | 2015-11-25 | 巴斯夫欧洲公司 | 用于饮料着色的粉状类胡萝卜素制剂 |
CN102176833B (zh) † | 2008-10-07 | 2018-03-16 | 巴斯夫欧洲公司 | 即用型稳定乳液 |
ES2621184T3 (es) | 2009-03-30 | 2017-07-03 | Basf Se | Suspensión estable, lista para su uso, de partículas de beta-caroteno parcialmente amorfas |
JP5691037B2 (ja) * | 2009-11-10 | 2015-04-01 | 株式会社サウスプロダクト | 油性組成物 |
CN102552173B (zh) | 2010-12-23 | 2014-01-29 | 浙江医药股份有限公司新昌制药厂 | 一种高生物利用度的类胡萝卜素油悬浮液及其制备方法 |
JP5296118B2 (ja) * | 2011-02-18 | 2013-09-25 | 株式会社 伊藤園 | ビタミンc含有飲料及びその製造方法 |
BR112013031286B1 (pt) | 2011-06-06 | 2020-04-22 | Chr Hansen As | composição líquida de carotenoide para coloração, seu método de preparação e seu uso, método de coloração de queijo, produto alimentar, bebida, ração para animal, cosmético ou medicamento |
CN103945837B (zh) * | 2011-11-18 | 2016-04-27 | 富士胶片株式会社 | 含类胡萝卜素组合物及其制造方法 |
KR20150045445A (ko) | 2012-08-26 | 2015-04-28 | 라이코드 리미티드 | 색상-조절된 β-카로텐 포뮬레이션 |
US20160227827A1 (en) * | 2013-09-24 | 2016-08-11 | Dsm Ip Assets B.V. | Red colorant for beverages, food and pharmaceutical compositions |
WO2015052182A1 (en) * | 2013-10-08 | 2015-04-16 | Chr. Hansen Natural Colors A/S | Beta-carotene formulation and use thereof in coloring edible products |
JP6426902B2 (ja) * | 2014-03-20 | 2018-11-21 | 株式会社コーセー | カロテノイド含有組成物、並びにカロテノイドの劣化抑制剤及びカロテノイドの劣化抑制方法 |
WO2016083874A1 (en) | 2014-11-26 | 2016-06-02 | Omniactive Health Technologies Limited | Stable oil suspensions comprising lipophilic nutrient with enhanced bioavailability and process of preparation |
USD806351S1 (en) | 2016-09-06 | 2018-01-02 | Mars, Incorporated | Food product |
USD805728S1 (en) | 2016-09-06 | 2017-12-26 | Mars, Incorporated | Food product |
GB201701417D0 (en) | 2017-01-27 | 2017-03-15 | Mars Inc | Pet food |
MX2020004599A (es) * | 2017-10-31 | 2021-01-08 | Roquette America Inc | Método para la formulación de sustancias solubles en aceite, y polvos que se pueden obtener de las mismas. |
CN111714466A (zh) | 2019-03-18 | 2020-09-29 | 浙江医药股份有限公司新昌制药厂 | 一种高生物利用度高稳定性的类胡萝卜素制剂的制备方法 |
CN115023146A (zh) * | 2020-02-06 | 2022-09-06 | 奥特拉有限责任公司 | 基于藻蓝蛋白的稳定颜色配方 |
AU2022217083A1 (en) * | 2021-02-02 | 2023-09-21 | Aminorganix, Corp. | Amino acid fertilizer, feed, and soil amendment made from blood and feathers |
IT202100008465A1 (it) * | 2021-04-06 | 2022-10-06 | Orsana Italia S R L | Composizione analgesica per neonato |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364563A (en) * | 1989-07-25 | 1994-11-15 | Hoffmann-La Roche Inc. | Powdered aqueous carotenoid dispersions |
US5460823A (en) * | 1989-11-02 | 1995-10-24 | Danochemo A/S | Process of preparing a water dispersible hydrophobic or aerophilic solid |
CN1189489A (zh) * | 1996-09-13 | 1998-08-05 | 巴斯福股份公司 | 冷水可分散性粉末形态的类胡萝卜素制剂的制备及这种新类胡萝卜素制剂的应用 |
US5811609A (en) * | 1993-02-19 | 1998-09-22 | Danochemo A/S | Process for the preparation of a water dispersible carotenoid preparation in powder form |
CN1239977A (zh) * | 1996-12-12 | 1999-12-29 | Basf公司 | 叶黄素类的稳定水分散液及稳定的水分散性干粉,其制备以及用途 |
EP1964479A1 (en) * | 2007-02-14 | 2008-09-03 | DSMIP Assets B.V. | Process for the manufacture of a powder containing carotenoids |
CN101378668A (zh) * | 2006-02-06 | 2009-03-04 | 帝斯曼知识产权资产管理有限公司 | 含β-胡萝卜素的组合物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1211911B (de) | 1959-09-08 | 1966-03-03 | Hoffmann La Roche | Verfahren zur Herstellung eines insbesondere zum Faerben von Lebens- und Futtermitteln geeigneten Carotinoidpraeparates |
DE3119383A1 (de) | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten |
DE3610191A1 (de) | 1986-03-26 | 1987-10-01 | Basf Ag | Verfahren zur herstellung von feinteiligen, wasserdispergierbaren carotinoid-praeparationen |
EP0602137B1 (en) | 1991-09-06 | 2002-01-23 | Cognis Australia Pty Ltd | Carotenoid composition |
DE4200728A1 (de) | 1992-01-14 | 1993-07-15 | Basf Ag | Stabile, fluessige praeparate fettloeslicher substanzen |
DE19609538A1 (de) | 1996-03-11 | 1997-09-18 | Basf Ag | Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung |
WO1997026802A1 (en) | 1996-01-22 | 1997-07-31 | Chr. Hansen A/S | Water dispersible compositions containing natural hydrophobic pigment, method of preparing same and their use |
CA2261456A1 (en) | 1998-02-23 | 1999-08-23 | F. Hoffmann-La Roche Ag | Preparation of a finely divided pulverous carotenoid preparation |
US7105176B2 (en) * | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
DE50112285D1 (de) | 2000-11-29 | 2007-05-16 | Basf Ag | Verfahren zur Herstellung fester Zubereitungen wasserlöslicher, schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe |
DE102005030952A1 (de) | 2005-06-30 | 2007-01-18 | Basf Ag | Verfahren zur Herstellung einer wässrigen Suspension und einer pulverförmigen Zubereitung eines oder mehrerer Carotinoide |
PL1981915T3 (pl) | 2006-02-06 | 2018-09-28 | Dsm Ip Assets B.V. | Kompozycje składników aktywnych |
DE202006010606U1 (de) | 2006-07-07 | 2007-11-22 | Sensient Food Colors Germany Gmbh & Co. Kg | Zubereitung für Lebensmittel |
ES2361276T5 (es) | 2007-01-16 | 2017-06-09 | Basf Se | Formulaciones líquidas, que contienen carotenoides |
CN102176833B (zh) | 2008-10-07 | 2018-03-16 | 巴斯夫欧洲公司 | 即用型稳定乳液 |
ES2621184T3 (es) | 2009-03-30 | 2017-07-03 | Basf Se | Suspensión estable, lista para su uso, de partículas de beta-caroteno parcialmente amorfas |
-
2010
- 2010-03-26 ES ES10710346.7T patent/ES2621184T3/es active Active
- 2010-03-26 DK DK10710346.7T patent/DK2413710T3/en active
- 2010-03-26 JP JP2012502590A patent/JP2012521774A/ja not_active Withdrawn
- 2010-03-26 US US13/260,741 patent/US20120039970A1/en not_active Abandoned
- 2010-03-26 CN CN2010800132049A patent/CN102361561A/zh active Pending
- 2010-03-26 WO PCT/EP2010/053965 patent/WO2010112406A1/de active Application Filing
- 2010-03-26 EP EP10710346.7A patent/EP2413710B1/de not_active Revoked
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5364563A (en) * | 1989-07-25 | 1994-11-15 | Hoffmann-La Roche Inc. | Powdered aqueous carotenoid dispersions |
US5460823A (en) * | 1989-11-02 | 1995-10-24 | Danochemo A/S | Process of preparing a water dispersible hydrophobic or aerophilic solid |
US5811609A (en) * | 1993-02-19 | 1998-09-22 | Danochemo A/S | Process for the preparation of a water dispersible carotenoid preparation in powder form |
CN1189489A (zh) * | 1996-09-13 | 1998-08-05 | 巴斯福股份公司 | 冷水可分散性粉末形态的类胡萝卜素制剂的制备及这种新类胡萝卜素制剂的应用 |
CN1239977A (zh) * | 1996-12-12 | 1999-12-29 | Basf公司 | 叶黄素类的稳定水分散液及稳定的水分散性干粉,其制备以及用途 |
CN101378668A (zh) * | 2006-02-06 | 2009-03-04 | 帝斯曼知识产权资产管理有限公司 | 含β-胡萝卜素的组合物 |
EP1964479A1 (en) * | 2007-02-14 | 2008-09-03 | DSMIP Assets B.V. | Process for the manufacture of a powder containing carotenoids |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113208141A (zh) * | 2012-11-27 | 2021-08-06 | 帝斯曼知识产权资产管理有限公司 | 用于生产离散固体挤出颗粒的方法 |
WO2015003536A1 (zh) | 2013-07-09 | 2015-01-15 | 浙江新维普添加剂有限公司 | 油分散性类胡萝卜素制剂的制备方法 |
CN105578894A (zh) * | 2013-09-24 | 2016-05-11 | 帝斯曼知识产权资产管理有限公司 | 用于对饮料和食品进行着色的稳定的红色制剂 |
CN115349630A (zh) * | 2022-06-20 | 2022-11-18 | 海宁凤鸣叶绿素有限公司 | 水分散性叶黄素微囊粉的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US20120039970A1 (en) | 2012-02-16 |
EP2413710B1 (de) | 2017-01-04 |
DK2413710T3 (en) | 2017-04-03 |
ES2621184T3 (es) | 2017-07-03 |
JP2012521774A (ja) | 2012-09-20 |
EP2413710A1 (de) | 2012-02-08 |
WO2010112406A1 (de) | 2010-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102361561A (zh) | 部分无定形类胡萝卜素颗粒的即用稳定悬浮液 | |
EP2280611B1 (en) | Compositions of fat-soluble active ingredients containing gum ghatti | |
JP4988081B2 (ja) | 安定なリコピン粉末製剤、安定なリコピン水性分散液、それらの製法、それらの使用およびそれらを含有する栄養補助剤、動物飼料、食品、および医薬品および化粧品 | |
EP1448066B1 (en) | Process for preparation of finely dispersed carotenoid suspensions for use in foods | |
CA2739361C (en) | Ready-to-use, stable emulsion | |
JP5368316B2 (ja) | カロテノイドを含有する液体製剤 | |
CN101217885A (zh) | 微溶于水和不溶于水的活性成分的含水悬浮液和由其生产的干燥粉末 | |
JP2010515446A (ja) | 油性組成物 | |
JP6696037B2 (ja) | 固体色素の安定化方法 | |
JP5192356B2 (ja) | 飲料用乳化組成物 | |
US20180317523A1 (en) | Nanoparticles, nanoemulsions and their formation with mixing chamber micronization | |
CN102341006A (zh) | 虾青素衍生物的粉状组合物ii | |
WO2019069992A1 (ja) | 天然由来の水溶性色素又はその含有物の消泡及び/又は抑泡方法 | |
CN102341005A (zh) | 虾青素衍生物的配制剂及其应用iii | |
WO2012143492A1 (en) | Beadlets comprising carotenoids | |
JP4279319B2 (ja) | 粉末組成物及びその製造方法、並びにこれを含む食品組成物、化粧品組成物及び医薬品組成物 | |
CN112004422A (zh) | 乳化组合物 | |
CN110573027A (zh) | 乳化组合物 | |
CN101583285A (zh) | 油性组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120222 |