BRPI1013877A2 - Sequências de aminoácidos melhoradas contra il-6r e polipeptídeos que compreendem os mesmos para o tratamento de doenças e distúrbios relacionados com il-6r - Google Patents

Sequências de aminoácidos melhoradas contra il-6r e polipeptídeos que compreendem os mesmos para o tratamento de doenças e distúrbios relacionados com il-6r

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Publication number
BRPI1013877A2
BRPI1013877A2 BRPI1013877A BRPI1013877A BRPI1013877A2 BR PI1013877 A2 BRPI1013877 A2 BR PI1013877A2 BR PI1013877 A BRPI1013877 A BR PI1013877A BR PI1013877 A BRPI1013877 A BR PI1013877A BR PI1013877 A2 BRPI1013877 A2 BR PI1013877A2
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amino acid
polypeptides
sequences
disorders
treatment
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BRPI1013877A
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English (en)
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Alice Els Beirnaert Anna
Jozef Néotère Ververken Cedric
Alexander Kolkman Joost
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Ablynx Nv
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Abstract

SEQUÊNCIAS DE AMINOÁCIDOS MELHORADAS CONTRA IL-6R E POLIPEPTÍDEOS QUE COMPREENDEM OS MESMOS PARA O TRATAMENTO DE DOENÇAS E DISTÚRBIOS RELACIONADOS COM IL-6R. A presente invenção se refere às sequências de aminoácidos que são direcionadas contra e/ou que podem se ligar especificamente ao receptor de interleucina-6 (IL-6R) com afinidade e/ou avidez melhorada, e/ou que têm uma maior eficácia e/ou potência, e que são capazes de (parcialmente ou de preferência totalmente) bloquear a interação de IL-6/IL-6R e/ou inibir a sinalização através de IL-6, IL-6R e/ou do complexo IL6/IL-6R. A invenção também se relaciona aos compostos ou construtos, e especialmente às proteínas e polipeptídeos que compreendem ou essencialmente consistem em uma ou mais sequências de aminoácidos. A invenção também se refere aos ácidos nucléicos que codificam tais sequências de aminoácidos e polipeptídeos, aos métodos para preparar tais sequências de aminoácidos e polipeptídeos, as células hospedeiras que expressam ou são capazes de expressar tais sequências de aminoácidos ou polipeptídeos, as composições e, em particular as composições farmacêuticas, que compõem tais sequências de aminoácidos, polipeptídeos, ácidos nucléicos e/ou células hospedeiras, e ao uso de tais sequências de aminoácidos ou polipeptídeos, ácidos nucléicos, células hospedeiras e/ou composições, em particular para fins profiláticos, terapêuticos ou de diagnósticos.
BRPI1013877A 2009-04-10 2010-04-12 Sequências de aminoácidos melhoradas contra il-6r e polipeptídeos que compreendem os mesmos para o tratamento de doenças e distúrbios relacionados com il-6r BRPI1013877A2 (pt)

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Application Number Priority Date Filing Date Title
US16841009P 2009-04-10 2009-04-10
PCT/EP2010/054764 WO2010115998A2 (en) 2009-04-10 2010-04-12 Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders

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BRPI1013877A2 true BRPI1013877A2 (pt) 2017-08-15

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US (5) US8748581B2 (pt)
EP (2) EP2417163B1 (pt)
JP (2) JP5647222B2 (pt)
KR (2) KR101470690B1 (pt)
CN (2) CN105399828B (pt)
AU (1) AU2010233658B2 (pt)
BR (1) BRPI1013877A2 (pt)
CA (1) CA2758191C (pt)
HK (1) HK1222863A1 (pt)
IL (2) IL215525B (pt)
MX (1) MX2011010681A (pt)
NZ (1) NZ595461A (pt)
RU (1) RU2539798C2 (pt)
SG (1) SG174862A1 (pt)
WO (1) WO2010115998A2 (pt)
ZA (1) ZA201107055B (pt)

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AU2010233658B2 (en) 2009-04-10 2013-11-28 Ablynx Nv Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders
US10618964B2 (en) 2009-04-10 2020-04-14 Ablynx N.V. Nanobody against IL-6R
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
DK2632946T3 (en) 2010-10-29 2018-03-12 Ablynx Nv PROCEDURE FOR MANUFACTURING VARIABLE IMMUNGLOBULIN SINGLE DOMAINS
KR20220114104A (ko) * 2011-06-23 2022-08-17 아블린쓰 엔.브이. 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법
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WO2016062766A1 (en) * 2014-10-21 2016-04-28 Ablynx Nv Treatment of il-6r related diseases
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NO2768984T3 (pt) 2015-11-12 2018-06-09
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