EA201270528A1 - Композиции цитокинов семейства il-17 и их применение - Google Patents
Композиции цитокинов семейства il-17 и их применениеInfo
- Publication number
- EA201270528A1 EA201270528A1 EA201270528A EA201270528A EA201270528A1 EA 201270528 A1 EA201270528 A1 EA 201270528A1 EA 201270528 A EA201270528 A EA 201270528A EA 201270528 A EA201270528 A EA 201270528A EA 201270528 A1 EA201270528 A1 EA 201270528A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- families
- cytokines
- compositions
- application
- molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
В изобретении предложены связывающие белки, в том числе не встречающиеся в природе и модифицированные рекомбинатные белки, которые связываются с IL-17R, в том числе белки, содержащие мутантную последовательность цитокина IL-17, способы получения таких молекул и способы применения таких молекул в качестве терапевтических, профилактических и диагностических агентов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27877909P | 2009-10-10 | 2009-10-10 | |
PCT/US2010/052194 WO2011044563A2 (en) | 2009-10-10 | 2010-10-11 | Il-17 family cytokine compositions and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201270528A1 true EA201270528A1 (ru) | 2012-12-28 |
Family
ID=43857433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270528A EA201270528A1 (ru) | 2009-10-10 | 2010-10-11 | Композиции цитокинов семейства il-17 и их применение |
Country Status (11)
Country | Link |
---|---|
US (1) | US20130064788A1 (ru) |
EP (1) | EP2485763A4 (ru) |
JP (1) | JP2013507132A (ru) |
KR (1) | KR20120093932A (ru) |
CN (1) | CN102648002A (ru) |
AU (1) | AU2010303166A1 (ru) |
BR (1) | BR112012008444A2 (ru) |
CA (1) | CA2777222A1 (ru) |
EA (1) | EA201270528A1 (ru) |
IL (1) | IL219209A0 (ru) |
WO (1) | WO2011044563A2 (ru) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
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US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
CN106986933A (zh) | 2009-02-11 | 2017-07-28 | 阿尔布梅迪克斯医疗公司 | 白蛋白变体和缀合物 |
RU2607374C2 (ru) | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
DK2598526T3 (en) | 2010-07-29 | 2018-11-19 | Eleven Biotherapeutics Inc | CHEMICAL IL-1 RECEPTOR TYPE-I AGONISTS AND ANTAGONISTS |
US20140105855A1 (en) * | 2011-04-06 | 2014-04-17 | Kenan Christopher Garcia | Structural based design of il-17 dominant negative mutants |
US20140234330A1 (en) * | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
AU2012324895B2 (en) | 2011-10-19 | 2017-03-16 | Galapagos Nv | Antagonists of IL17C for the treatment of inflammatory disorders |
WO2013059644A1 (en) * | 2011-10-21 | 2013-04-25 | Baylor College Of Medicine | Method to measure inflammation in the conjunctiva of patients with tear dysfunction |
US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
CA2861592A1 (en) | 2012-03-16 | 2013-09-19 | Novozymes Biopharma Dk A/S | Albumin variants |
JP2013253842A (ja) | 2012-06-06 | 2013-12-19 | Univ Of Tokyo | pH依存的に標的分子に結合するペプチドのスクリーニング方法 |
EP3417878A1 (en) * | 2012-06-12 | 2018-12-26 | Orega Biotech | Antagonists of il-17 isoforms and their uses |
WO2013186236A1 (en) * | 2012-06-12 | 2013-12-19 | Orega Biotech | Antagonists of il-17 isoforms and their uses |
WO2014072481A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
WO2014160371A1 (en) | 2013-03-13 | 2014-10-02 | Eleven Biotherapeutics, Inc. | Chimeric cytokine formulations for ocular delivery |
CN115715797A (zh) * | 2013-04-17 | 2023-02-28 | 建新公司 | 用于治疗和预防黄斑变性的组合物和方法 |
EP3337816B1 (en) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin variants and conjugates |
JP6941321B2 (ja) * | 2016-03-25 | 2021-09-29 | 国立大学法人大阪大学 | 疾患の要因となる生体内タンパク質を標的とするコンジュゲートワクチン |
CA3020713A1 (en) * | 2016-04-19 | 2017-10-26 | Azura Ophthalmics Ltd. | Compositions for the treatment of hyperkeratosis disorders |
CN111093678A (zh) * | 2017-07-21 | 2020-05-01 | 克利夫兰诊所基金会 | 用于治疗IL-17a相关疾病和病状的SBE适体 |
CN113840832A (zh) | 2018-05-14 | 2021-12-24 | 狼人治疗公司 | 可活化白介素-2多肽及其使用方法 |
JP2021523741A (ja) | 2018-05-14 | 2021-09-09 | ウェアウルフ セラピューティクス, インコーポレイテッド | 活性化可能なインターロイキン12ポリペプチド及びその使用方法 |
JP2022527345A (ja) | 2019-04-03 | 2022-06-01 | オレガ・バイオテック | Pd1阻害剤及びil-17b阻害剤に基づく複合療法 |
KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
EP4007775A1 (en) * | 2019-08-02 | 2022-06-08 | Orega Biotech | Novel il-17b antibodies |
KR102265435B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
WO2021140417A2 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
JP2023514957A (ja) | 2020-02-28 | 2023-04-12 | オレガ・バイオテック | Ctla4阻害剤及びil-17b阻害剤に基づく複合療法 |
WO2022032592A1 (en) * | 2020-08-13 | 2022-02-17 | Tsinghua University | Interleukin-17d and cd93 as a new cytokine-receptor pair in the immune system |
CN113403259B (zh) * | 2021-06-04 | 2023-01-17 | 华南农业大学 | 一种提高克隆胚胎发育质量的添加剂及其应用 |
CN113563453A (zh) * | 2021-07-23 | 2021-10-29 | 四川大学 | 鸡白细胞介素17b重组乳酸菌免疫制剂的制备和应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
ATE279517T1 (de) * | 1995-03-23 | 2004-10-15 | Immunex Corp | Il-17 receptor |
US6569419B2 (en) * | 2000-02-29 | 2003-05-27 | Zymogenetics, Inc. | Methods for promoting production of myelin by Schwann cells |
US20030203451A1 (en) * | 2000-08-24 | 2003-10-30 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
AU2001296229A1 (en) * | 2000-10-13 | 2002-04-29 | Eli Lilly And Company | Methods of using a human il-17-related polypeptide to treat disease |
EP1328260A2 (en) | 2000-10-18 | 2003-07-23 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
US6793919B2 (en) * | 2000-10-18 | 2004-09-21 | Immunex Corporation | Methods for treating rheumatoid arthritis using IL-17 antagonists |
US20040115191A1 (en) * | 2002-01-24 | 2004-06-17 | Moore Emma E | Method for treating psoriasis |
US20040234500A1 (en) * | 2001-03-26 | 2004-11-25 | Moore Emma E. | Method for inducing proliferation of retinal stem cells |
US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
PL1641822T3 (pl) * | 2003-07-08 | 2013-10-31 | Genentech Inc | Heterologiczne polipeptydy IL-17 A/F i ich zastosowania terapeutyczne |
GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
WO2007117762A1 (en) * | 2006-02-10 | 2007-10-18 | Zymogenetics, Inc. | Truncated il-17ra soluble receptor and methods of using in inflammation |
JP2009534297A (ja) * | 2006-03-10 | 2009-09-24 | ザイモジェネティクス, インコーポレイテッド | Il−17aおよびil−17fの両方に結合する抗体ならびにその使用方法 |
GB0612928D0 (en) * | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
PE20080739A1 (es) * | 2006-08-11 | 2008-06-14 | Schering Corp | Anticuerpos para il-17a |
US7767206B2 (en) * | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
CN101679497A (zh) | 2007-03-26 | 2010-03-24 | 津莫吉尼蒂克斯公司 | 可溶性il-17ra/rc融合蛋白以及相关方法 |
US8460647B2 (en) * | 2007-04-20 | 2013-06-11 | Amgen Inc. | Pre-ligand assembly domain of the IL-17 receptor |
CA2682889C (en) * | 2007-04-27 | 2016-04-05 | Zymogenetics, Inc. | Antibodies that bind both il-17a and il-17f and methods of using the same |
ES2614735T3 (es) * | 2007-07-23 | 2017-06-01 | Janssen Biotech, Inc. | Métodos y composiciones para tratar los trastornos relacionados con fibrosis usando antagonistas de la IL-17 |
-
2010
- 2010-10-11 BR BR112012008444A patent/BR112012008444A2/pt not_active IP Right Cessation
- 2010-10-11 CN CN2010800536540A patent/CN102648002A/zh active Pending
- 2010-10-11 AU AU2010303166A patent/AU2010303166A1/en not_active Abandoned
- 2010-10-11 KR KR1020127011769A patent/KR20120093932A/ko not_active Application Discontinuation
- 2010-10-11 EP EP10822826.3A patent/EP2485763A4/en not_active Withdrawn
- 2010-10-11 US US13/501,244 patent/US20130064788A1/en not_active Abandoned
- 2010-10-11 JP JP2012533384A patent/JP2013507132A/ja active Pending
- 2010-10-11 CA CA2777222A patent/CA2777222A1/en not_active Abandoned
- 2010-10-11 WO PCT/US2010/052194 patent/WO2011044563A2/en active Application Filing
- 2010-10-11 EA EA201270528A patent/EA201270528A1/ru unknown
-
2012
- 2012-04-15 IL IL219209A patent/IL219209A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN102648002A (zh) | 2012-08-22 |
IL219209A0 (en) | 2012-06-28 |
BR112012008444A2 (pt) | 2019-09-24 |
KR20120093932A (ko) | 2012-08-23 |
EP2485763A4 (en) | 2013-10-30 |
WO2011044563A2 (en) | 2011-04-14 |
US20130064788A1 (en) | 2013-03-14 |
JP2013507132A (ja) | 2013-03-04 |
WO2011044563A3 (en) | 2011-06-03 |
AU2010303166A1 (en) | 2012-05-24 |
EP2485763A2 (en) | 2012-08-15 |
CA2777222A1 (en) | 2011-04-14 |
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