PT2473527T - Formulações estáveis de polipéptidos e seus usos - Google Patents
Formulações estáveis de polipéptidos e seus usosInfo
- Publication number
- PT2473527T PT2473527T PT107478950T PT10747895T PT2473527T PT 2473527 T PT2473527 T PT 2473527T PT 107478950 T PT107478950 T PT 107478950T PT 10747895 T PT10747895 T PT 10747895T PT 2473527 T PT2473527 T PT 2473527T
- Authority
- PT
- Portugal
- Prior art keywords
- polypeptides
- stable formulations
- formulations
- stable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27581609P | 2009-09-03 | 2009-09-03 | |
US28450209P | 2009-12-18 | 2009-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2473527T true PT2473527T (pt) | 2017-02-27 |
Family
ID=42797362
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT107478950T PT2473527T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
PT181857723T PT3438126T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
PT10747896T PT2473528E (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT181857723T PT3438126T (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
PT10747896T PT2473528E (pt) | 2009-09-03 | 2010-09-03 | Formulações estáveis de polipéptidos e seus usos |
Country Status (12)
Country | Link |
---|---|
US (2) | US20120244158A1 (pt) |
EP (5) | EP2805731B1 (pt) |
CY (1) | CY1121411T1 (pt) |
DK (2) | DK2473527T3 (pt) |
ES (3) | ES2531083T3 (pt) |
HK (1) | HK1204284A1 (pt) |
HR (1) | HRP20190137T1 (pt) |
LT (1) | LT2805731T (pt) |
PL (2) | PL2473528T3 (pt) |
PT (3) | PT2473527T (pt) |
SI (1) | SI2805731T1 (pt) |
WO (2) | WO2011026948A1 (pt) |
Families Citing this family (27)
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WO2008020079A1 (en) * | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
KR20120125601A (ko) | 2007-05-24 | 2012-11-16 | 아블린쓰 엔.브이. | Rank-l에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
JP6113404B2 (ja) | 2008-10-29 | 2017-04-12 | アブリンクス エン.ヴェー. | 単一ドメイン抗原結合分子の精製方法 |
EP4104821A1 (en) | 2008-10-29 | 2022-12-21 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
US10005830B2 (en) | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
AU2010233658B2 (en) | 2009-04-10 | 2013-11-28 | Ablynx Nv | Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders |
WO2010115995A2 (en) | 2009-04-10 | 2010-10-14 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
DK2473527T3 (en) * | 2009-09-03 | 2017-03-06 | Ablynx Nv | STABLE FORMULATIONS OF POLYPEPTIDES AND APPLICATIONS THEREOF |
US20110059079A1 (en) * | 2009-09-04 | 2011-03-10 | Xoma Technology Ltd. | Antibody Coformulations |
DK2533761T3 (da) | 2010-02-11 | 2019-06-24 | Ablynx Nv | Fremgangsmåder og sammensætninger til fremstilling af aerosoler |
CA2976671C (en) | 2010-03-01 | 2021-01-12 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
WO2011161263A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Pharmaceutical compositions for cutaneous administration |
JP6034798B2 (ja) | 2010-12-02 | 2016-11-30 | オンコリティクス バイオテク,インコーポレーテッド | 液体ウイルス製剤 |
US9044498B2 (en) * | 2010-12-02 | 2015-06-02 | Oncolytics Biotech Inc. | Lyophilized viral formulations |
BR112013030298A2 (pt) * | 2011-05-27 | 2017-12-12 | Ablynx Nv | inibição da reabsorção óssea com peptídeos que se ligam ao rankl |
JP6178311B2 (ja) * | 2011-07-07 | 2017-08-09 | エルエフビー ユーエスエー インコーポレイテッドLfb Usa, Inc. | タンパク質を安定化する製剤 |
AU2012311443B2 (en) * | 2011-09-23 | 2016-12-01 | Ablynx Nv | Prolonged inhibition of interleukin-6 mediated signaling |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
US20160129112A1 (en) * | 2013-05-28 | 2016-05-12 | Momenta Pharmaceuticals, Inc. | Pharmaceutical Compositions Comprising Pyrophosphate |
AU2015334984A1 (en) | 2014-10-21 | 2017-04-13 | Ablynx Nv | Treatment of IL-6R related diseases |
WO2018007442A1 (en) | 2016-07-06 | 2018-01-11 | Ablynx N.V. | Treatment of il-6r related diseases |
WO2018029182A1 (en) | 2016-08-08 | 2018-02-15 | Ablynx N.V. | Il-6r single variable domain antibodies for treatment of il-6r related diseases |
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CA3063293A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Adamts binding immunoglobulins |
EA202192405A1 (ru) * | 2019-03-08 | 2022-01-13 | Бёрингер Ингельхайм Интернациональ Гмбх | Составы антител против il-36r |
CN114681592A (zh) * | 2020-12-31 | 2022-07-01 | 天境生物科技(杭州)有限公司 | 包含可溶性gp130二聚体的制剂和使用方法 |
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EP4104821A1 (en) * | 2008-10-29 | 2022-12-21 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
CA2744055A1 (en) * | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Polypeptides, antibody variable domains & antagonists |
DK2387583T3 (en) * | 2009-01-14 | 2019-01-14 | Ablynx Nv | PULMONAL ADMINISTRATION OF VARIABLE IMMUNGLOBULIN SINGLE DOMAINS AND CONSTRUCTIONS THEREOF. |
RU2650594C1 (ru) * | 2009-01-29 | 2018-04-17 | Медиммун, Ллк | Человеческие анти-il-6 антитела с пролонгированным периодом выведения in vivo и их применение при лечении онкологических, аутоиммунных заболеваний и воспалительных заболеваний |
US10005830B2 (en) * | 2009-03-05 | 2018-06-26 | Ablynx N.V. | Antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
DK2473527T3 (en) * | 2009-09-03 | 2017-03-06 | Ablynx Nv | STABLE FORMULATIONS OF POLYPEPTIDES AND APPLICATIONS THEREOF |
-
2010
- 2010-09-03 DK DK10747895.0T patent/DK2473527T3/en active
- 2010-09-03 EP EP14171120.0A patent/EP2805731B1/en active Active
- 2010-09-03 LT LTEP14171120.0T patent/LT2805731T/lt unknown
- 2010-09-03 EP EP10747895.0A patent/EP2473527B1/en active Active
- 2010-09-03 ES ES10747896T patent/ES2531083T3/es active Active
- 2010-09-03 WO PCT/EP2010/062975 patent/WO2011026948A1/en active Application Filing
- 2010-09-03 SI SI201031846T patent/SI2805731T1/sl unknown
- 2010-09-03 DK DK10747896T patent/DK2473528T3/en active
- 2010-09-03 US US13/393,636 patent/US20120244158A1/en not_active Abandoned
- 2010-09-03 ES ES18185772T patent/ES2831323T3/es active Active
- 2010-09-03 PT PT107478950T patent/PT2473527T/pt unknown
- 2010-09-03 PL PL10747896T patent/PL2473528T3/pl unknown
- 2010-09-03 PL PL18185772T patent/PL3438126T3/pl unknown
- 2010-09-03 ES ES10747895.0T patent/ES2617180T3/es active Active
- 2010-09-03 WO PCT/EP2010/062972 patent/WO2011026945A1/en active Application Filing
- 2010-09-03 PT PT181857723T patent/PT3438126T/pt unknown
- 2010-09-03 EP EP10747896.8A patent/EP2473528B1/en active Active
- 2010-09-03 EP EP18185772.3A patent/EP3438126B1/en active Active
- 2010-09-03 EP EP20176028.7A patent/EP3725330A1/en active Pending
- 2010-09-03 PT PT10747896T patent/PT2473528E/pt unknown
- 2010-09-03 US US13/393,679 patent/US9884117B2/en active Active
-
2015
- 2015-05-22 HK HK15104885.3A patent/HK1204284A1/xx not_active IP Right Cessation
-
2019
- 2019-01-21 HR HRP20190137TT patent/HRP20190137T1/hr unknown
- 2019-01-31 CY CY20191100137T patent/CY1121411T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT2473528E (pt) | 2015-03-04 |
LT2805731T (lt) | 2019-02-11 |
WO2011026945A1 (en) | 2011-03-10 |
ES2617180T3 (es) | 2017-06-15 |
ES2831323T3 (es) | 2021-06-08 |
EP2473527B1 (en) | 2016-11-30 |
EP3438126A1 (en) | 2019-02-06 |
EP3438126B1 (en) | 2020-08-19 |
EP2805731B1 (en) | 2018-10-31 |
EP2805731A2 (en) | 2014-11-26 |
DK2473527T3 (en) | 2017-03-06 |
US20120201812A1 (en) | 2012-08-09 |
EP2473528B1 (en) | 2014-12-03 |
ES2531083T3 (es) | 2015-03-10 |
EP2805731A3 (en) | 2015-04-01 |
HRP20190137T1 (hr) | 2019-03-22 |
EP2473527A1 (en) | 2012-07-11 |
PT3438126T (pt) | 2020-11-09 |
EP2473528A1 (en) | 2012-07-11 |
PL2473528T3 (pl) | 2015-05-29 |
EP3725330A1 (en) | 2020-10-21 |
CY1121411T1 (el) | 2020-05-29 |
US20120244158A1 (en) | 2012-09-27 |
SI2805731T1 (sl) | 2019-02-28 |
US9884117B2 (en) | 2018-02-06 |
HK1204284A1 (en) | 2015-11-13 |
PL3438126T3 (pl) | 2021-03-08 |
DK2473528T3 (en) | 2015-03-02 |
WO2011026948A1 (en) | 2011-03-10 |
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