BRPI0410078A - uso de efetuadores de ciclases de glutaminila e glutamato - Google Patents

uso de efetuadores de ciclases de glutaminila e glutamato

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Publication number
BRPI0410078A
BRPI0410078A BRPI0410078-6A BRPI0410078A BRPI0410078A BR PI0410078 A BRPI0410078 A BR PI0410078A BR PI0410078 A BRPI0410078 A BR PI0410078A BR PI0410078 A BRPI0410078 A BR PI0410078A
Authority
BR
Brazil
Prior art keywords
effectors
glutaminyl
modulation
activity
treated
Prior art date
Application number
BRPI0410078-6A
Other languages
English (en)
Inventor
Hans-Ulrich Demuth
Torsten Hoffmann
Andre J Niestroj
Stephan Schilling
Ulrich Heiser
Original Assignee
Probiodrug Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiodrug Ag filed Critical Probiodrug Ag
Publication of BRPI0410078A publication Critical patent/BRPI0410078A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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Abstract

"USO DE EFETUADORES DE CICLASES DE GLUTAMINILA E GLUTAMATO". A presente invenção proporciona novos substratos fisiológicos de ciclase de glutaminila de mamífero (QC, EC 2.3.2.5), novos efetuadores de QC, métodos para tais efetuadores e o uso de tais efetuadores e composições farmacêuticas compreendendo tais efetuadores para o tratamento de condições que podem ser tratadas através de modulação de atividade de QC. Composições preferidas compreendem, adicionalmente, inibidores de DP IV ou enzimas semelhantes à DP IV para o tratamento ou alívio de condições que podem ser tratadas através de modulação de atividade de QC e DP IV.
BRPI0410078-6A 2003-05-05 2004-05-05 uso de efetuadores de ciclases de glutaminila e glutamato BRPI0410078A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46804303P 2003-05-05 2003-05-05
US46801403P 2003-05-05 2003-05-05
US51203803P 2003-10-15 2003-10-15
PCT/EP2004/004778 WO2004098625A2 (en) 2003-05-05 2004-05-05 Medical use of inhibitors of glutaminyl and glutamate cyclases

Publications (1)

Publication Number Publication Date
BRPI0410078A true BRPI0410078A (pt) 2006-05-16

Family

ID=42827350

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410078-6A BRPI0410078A (pt) 2003-05-05 2004-05-05 uso de efetuadores de ciclases de glutaminila e glutamato

Country Status (15)

Country Link
EP (1) EP1620082B9 (pt)
JP (1) JP5690463B2 (pt)
CN (1) CN1784220B (pt)
AT (1) ATE464889T1 (pt)
AU (2) AU2004237408C9 (pt)
BR (1) BRPI0410078A (pt)
CA (1) CA2524009C (pt)
DK (1) DK1620082T3 (pt)
EA (1) EA009291B1 (pt)
HK (1) HK1089964A1 (pt)
IL (2) IL171339A (pt)
MX (1) MXPA05011861A (pt)
NZ (1) NZ543146A (pt)
PL (1) PL1620082T3 (pt)
WO (1) WO2004098625A2 (pt)

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KR20120035203A (ko) 2003-05-05 2012-04-13 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
NZ546322A (en) * 2003-10-15 2008-11-28 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
WO2005049027A2 (en) * 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
ATE541835T1 (de) * 2004-02-05 2012-02-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
WO2005075436A2 (en) * 2004-02-05 2005-08-18 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
GEP20135838B (en) 2005-09-14 2013-06-10 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors usage at diabetes treatment
CA2622642C (en) 2005-09-16 2013-12-31 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7572614B2 (en) 2006-02-24 2009-08-11 Academia Sinica Crystal structure of soluble glutaminyl cyclase
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
NZ597498A (en) 2006-06-23 2013-06-28 Abbvie Bahamas Ltd Cyclopropyl amine derivatives as histamin H3 receptor modulators
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
WO2008034891A2 (en) * 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase
US8889709B2 (en) 2006-09-21 2014-11-18 Probiodrug Ag Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
US9277737B2 (en) 2006-09-21 2016-03-08 Probiodrug Ag Mouse models carrying a knock-out mutation of the QPCTL-gene
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
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