NO20050514L - Sammensetning og antiviral aktivitet til substituerte azaindoloksoeddikpiperazinderivater - Google Patents

Sammensetning og antiviral aktivitet til substituerte azaindoloksoeddikpiperazinderivater

Info

Publication number
NO20050514L
NO20050514L NO20050514A NO20050514A NO20050514L NO 20050514 L NO20050514 L NO 20050514L NO 20050514 A NO20050514 A NO 20050514A NO 20050514 A NO20050514 A NO 20050514A NO 20050514 L NO20050514 L NO 20050514L
Authority
NO
Norway
Prior art keywords
antiviral activity
derivatives
oxoaceticpiperazine
azaindolo
substituted
Prior art date
Application number
NO20050514A
Other languages
English (en)
Other versions
NO331591B1 (no
Inventor
Yasutsugu Ueda
John F Kadow
Nicholas A Meanwell
Tao Wang
Zhongxing Zhang
John D Matiskella
Zhiwei Yin
Qiufen May Xue
Alicia Regueiro-Ren
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31714265&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20050514(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20050514L publication Critical patent/NO20050514L/no
Publication of NO331591B1 publication Critical patent/NO331591B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Abstract

2005 -03- I 8 591 SAMMENDRAG Foreliggende oppfinnelse tilveiebringer forbindelser som har medikament egenskaper og bio-påvirkende egenskaper, deres farmasøytiske preparater og fremgangsmåter for anvendelse. Spesielt omfatter oppfinnelsen azaindoloksoacetyl piperazin-derivater. Disse forbindelser har unik antiviral aktivitet, hvorvidt anvendt alene eller i kombinasjon med andre antiviraler, antiinfeksjonsmidler, inimunomodulatorer eller HIV entry inhibitorer. Mer spesielt angår foreliggende oppfinnelse behandling av HIV og AIDS.
NO20050514A 2002-08-07 2005-01-28 Azaindoloksoeddikpiperazinderivater, farmasøytiske formuleringer omfattende slike samt anvendelse av slike for fremstilling av medikament for behandling av pattedyr NO331591B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/214,982 US20030207910A1 (en) 2001-02-02 2002-08-07 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
PCT/US2003/024415 WO2004014380A1 (en) 2002-08-07 2003-08-05 Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

Publications (2)

Publication Number Publication Date
NO20050514L true NO20050514L (no) 2005-03-18
NO331591B1 NO331591B1 (no) 2012-01-30

Family

ID=31714265

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050514A NO331591B1 (no) 2002-08-07 2005-01-28 Azaindoloksoeddikpiperazinderivater, farmasøytiske formuleringer omfattende slike samt anvendelse av slike for fremstilling av medikament for behandling av pattedyr

Country Status (31)

Country Link
US (1) US20030207910A1 (no)
EP (4) EP2975038B1 (no)
KR (1) KR101045154B1 (no)
CN (2) CN100379421C (no)
AR (1) AR041190A1 (no)
AU (2) AU2003261367B2 (no)
BR (1) BRPI0313286B8 (no)
CA (1) CA2494832C (no)
CY (3) CY1113413T1 (no)
DK (3) DK2801576T3 (no)
ES (4) ES2388919T3 (no)
GE (1) GEP20084284B (no)
HK (4) HK1072731A1 (no)
HR (1) HRP20050123B8 (no)
HU (1) HUE027396T2 (no)
IL (1) IL166512A (no)
IS (1) IS2919B (no)
MX (1) MXPA05001441A (no)
MY (1) MY146549A (no)
NO (1) NO331591B1 (no)
NZ (1) NZ537930A (no)
PE (1) PE20040772A1 (no)
PL (1) PL219566B1 (no)
PT (3) PT2497770E (no)
RS (1) RS53428B (no)
RU (1) RU2325389C2 (no)
SI (3) SI2801576T1 (no)
TW (1) TWI328452B (no)
UA (1) UA82199C2 (no)
WO (1) WO2004014380A1 (no)
ZA (1) ZA200501018B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307834D0 (en) * 2003-04-04 2003-05-14 Ta Contrast Ab Composition
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US20050124623A1 (en) * 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7776863B2 (en) * 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
US20050215544A1 (en) * 2004-03-24 2005-09-29 Pin-Fang Lin Methods of treating HIV infection
DE602005010698D1 (de) 2004-06-09 2008-12-11 Glaxo Group Ltd Pyrrolopyridinderivate
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
EP2046753A2 (en) * 2006-07-06 2009-04-15 Brystol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
GB0910667D0 (en) * 2009-06-19 2009-08-05 Glaxo Wellcome Mfg Pte Ltd Novel compounds
WO2012019003A1 (en) * 2010-08-06 2012-02-09 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
EP2646439B1 (en) * 2010-12-02 2016-05-25 Bristol-Myers Squibb Company Alkyl amides as hiv attachment inhibitors
CN102718692B (zh) * 2012-07-03 2014-01-08 苏州和健医药科技有限公司 一种7位甲基-5位氧取代吲哚化合物的制备方法
WO2016004272A1 (en) 2014-07-02 2016-01-07 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
EP3194387B1 (en) * 2014-09-17 2019-07-31 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
EP3291813A4 (en) 2015-05-06 2019-01-02 The Regents of The University of California K-ras modulators
EP4340839A1 (fr) * 2021-05-21 2024-03-27 Centre National de la Recherche Scientifique (CNRS) Nouveaux derives azaindole en tant qu'agents antiviraux

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2761201A (en) 1952-05-02 1956-09-04 Griffin Wheel Co Renewing molds
US3830602A (en) 1973-03-14 1974-08-20 Commercial Shearing Rotary pumps and motors
US5023265A (en) * 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
IL99843A0 (en) 1990-11-01 1992-08-18 Merck & Co Inc Synergistic combination of hiv reverse transcriptase inhibitors
US5811432A (en) 1990-11-09 1998-09-22 Pfizer Inc Azaoxindole derivatives
KR100236808B1 (ko) 1991-07-03 2000-02-01 로렌스 티. 마이젠헬더 에이즈 치료약제로서의 치환된 인돌
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
IT1265057B1 (it) 1993-08-05 1996-10-28 Dompe Spa Tropil 7-azaindolil-3-carbossiamidi
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9420521D0 (en) 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
BR0011274A (pt) 1999-05-21 2002-02-26 Scios Inc Derivados tipo indol como inibidores de p38 quinase
US6469006B1 (en) 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
US20020061892A1 (en) 2000-02-22 2002-05-23 Tao Wang Antiviral azaindole derivatives
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
DK1299382T3 (da) 2000-07-10 2006-01-16 Bristol Myers Squibb Co Præparat og antiviral virkning af substituerede indoloxoeddikesyrepiperazinderivater
US6403211B1 (en) 2000-07-18 2002-06-11 3M Innovative Properties Company Liquid crystal polymer for flexible circuits
EP1363705B9 (en) * 2001-02-02 2012-11-07 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
EP1476163A4 (en) * 2002-02-23 2009-05-27 Bristol Myers Squibb Co METHOD FOR TREATING HIV INFECTION BY PREVENTING INTERACTION OF CD4 AND GP120

Also Published As

Publication number Publication date
HRP20050123B8 (hr) 2015-04-10
DK2801576T3 (en) 2016-03-07
EP2497770B1 (en) 2014-05-14
EP2801576A1 (en) 2014-11-12
ZA200501018B (en) 2006-09-27
AU2009202361A1 (en) 2009-07-02
ES2641893T3 (es) 2017-11-14
MXPA05001441A (es) 2005-06-06
HUE027396T2 (en) 2016-09-28
HK1202530A1 (en) 2015-10-02
SI2497770T1 (sl) 2014-11-28
DK2497770T3 (da) 2014-07-28
BRPI0313286A2 (pt) 2005-07-05
UA82199C2 (uk) 2008-03-25
CY1115580T1 (el) 2017-01-04
ES2481044T3 (es) 2014-07-29
IL166512A0 (en) 2006-01-15
EP1549313B9 (en) 2012-11-21
GEP20084284B (en) 2008-01-10
RU2005106350A (ru) 2005-11-20
PT2801576E (pt) 2016-03-03
CA2494832C (en) 2012-07-10
CN101229164B (zh) 2013-01-02
HRP20050123B1 (hr) 2014-04-25
KR20060021811A (ko) 2006-03-08
EP2497770A1 (en) 2012-09-12
CN100379421C (zh) 2008-04-09
CN101229164A (zh) 2008-07-30
RS20050108A (en) 2007-09-21
MY146549A (en) 2012-08-15
AU2003261367B2 (en) 2009-03-12
ES2560844T3 (es) 2016-02-23
CA2494832A1 (en) 2004-02-19
JP4430539B2 (ja) 2010-03-10
HK1174037A1 (en) 2013-05-31
EP1549313B1 (en) 2012-06-27
RS53428B (en) 2014-12-31
AU2003261367A1 (en) 2004-02-25
IS2919B (is) 2015-01-15
DK1549313T3 (da) 2012-10-01
EP1549313A4 (en) 2010-08-04
NZ537930A (en) 2008-01-31
EP2801576B1 (en) 2015-12-09
IS7682A (is) 2005-02-01
AU2009202361B2 (en) 2011-10-13
ES2388919T3 (es) 2012-10-19
US20030207910A1 (en) 2003-11-06
CY1117217T1 (el) 2017-04-05
SI2801576T1 (sl) 2016-03-31
EP2975038B1 (en) 2017-07-12
CN1688311A (zh) 2005-10-26
HK1220181A1 (zh) 2017-04-28
PT1549313E (pt) 2012-09-05
EP2975038A1 (en) 2016-01-20
PL219566B1 (pl) 2015-05-29
BRPI0313286A8 (pt) 2018-05-08
WO2004014380A1 (en) 2004-02-19
PL375360A1 (en) 2005-11-28
KR101045154B1 (ko) 2011-07-04
IL166512A (en) 2014-12-31
CY1113413T1 (el) 2016-06-22
SI1549313T1 (sl) 2013-01-31
TWI328452B (en) 2010-08-11
BRPI0313286B1 (pt) 2019-02-05
HRP20050123A2 (en) 2006-02-28
TW200410696A (en) 2004-07-01
RU2325389C2 (ru) 2008-05-27
JP2006504669A (ja) 2006-02-09
PT2497770E (pt) 2014-07-18
PE20040772A1 (es) 2004-11-20
BRPI0313286B8 (pt) 2021-05-25
AR041190A1 (es) 2005-05-04
EP1549313A1 (en) 2005-07-06
NO331591B1 (no) 2012-01-30
HK1072731A1 (en) 2005-09-09

Similar Documents

Publication Publication Date Title
NO20050514L (no) Sammensetning og antiviral aktivitet til substituerte azaindoloksoeddikpiperazinderivater
NO20010743L (no) Antivirale indoloksoacetyl-piperazin-derivater
NO20053144L (no) Chk-, Pdk- og Akt-inhibitorpyrimidiner, deres fremstilling og anvendelse som famasoytiske midler.
MY137480A (en) Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
NO20082269L (no) Nye piperaziner som antimalariamidler
NO20045677L (no) Inhibitorer av JAK- og CDK2-proteinkinaser
NO20084257L (no) Diketopiperazin og piperidin derivater som antivirale midler
ECSP067076A (es) Derivados de pirimidina urea como inhibidores de la quinasa
BRPI0410078A (pt) uso de efetuadores de ciclases de glutaminila e glutamato
NO20062726L (no) Nye pyridazin-3(2H)-on derivater
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
DK1791830T3 (da) Diaminotriazol-forbindelser der er nyttige som protein-kinase-inhibitorer
ES2195785A1 (es) Nuevos derivados de piridazin-3(2h)-ona.
NO20064584L (no) Tetrahydropyridoindolderivater
BR0309557A (pt) Inibidores da transcriptase reversa não nucleosìdeos
NO20054083L (no) Nye sammenkoblede triazoloner og deres anvendelse
NO20051165L (no) Benzotiazolderivater som har -adrenoerseptorantagonist aktivitet
NO20080675L (no) P38-Map kinaseinhibitorer og metoder for deres anvendelse
NO20062020L (no) 1-amino-2-oksysubstituerte tetrahydronaftalenderivater, fremgangsmate for fremstilling derav, og deres anvendelse som antiflogistika
ATE371656T1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
NO20054312L (no) HIV-replikasjonsinhiberende pyrimidiner og triaziner
DE60223262D1 (de) Verwendung von fucanen in der behandlung von adhäsion, arthritis und psoriasis
NO20070334L (no) 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
DE60113543D1 (de) Zusammensetzung und antivirale wirkung von substituierten indol-oxo-aceto-piperidin-derivaten

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: VIIV HEALTHCARE UK (NO. 5) LIMITED, GB

MM1K Lapsed by not paying the annual fees