BRPI0411126A - derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno - Google Patents
derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenalenoInfo
- Publication number
- BRPI0411126A BRPI0411126A BRPI0411126-5A BRPI0411126A BRPI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- phenalene
- triaza
- treatment
- control
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Abstract
"DERIVADOS DE 1,3,4-TRIAZA-FENALENO E 1,3,4,6-TETRAAZAFENALENO". A presente invenção refere-se a novos derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno da fórmula (I). Estes compostos inibem a tirosina cinase de receptor de fator de crescimento epidérmico ('EGFR'). Estes compostos e seus ésteres e sais farmaceuticamente aceitáveis têm atividade antiproliferativa e são úteis, entre outros, no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção da mesma forma se refere a composições farmacêuticas que contêm tais compostos e aos métodos de tratar ou controlar câncer, mais particularmente o tratamento ou controle de tumores de mama, pulmão, cólon e próstata.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47731803P | 2003-06-10 | 2003-06-10 | |
PCT/EP2004/050608 WO2004111055A1 (en) | 2003-06-10 | 2004-04-26 | 1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0411126A true BRPI0411126A (pt) | 2006-07-18 |
Family
ID=33551702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411126-5A BRPI0411126A (pt) | 2003-06-10 | 2004-04-26 | derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno |
Country Status (15)
Country | Link |
---|---|
US (1) | US7217717B2 (pt) |
EP (1) | EP1680426B1 (pt) |
JP (1) | JP2006527235A (pt) |
KR (1) | KR100753385B1 (pt) |
CN (1) | CN100378101C (pt) |
AT (1) | ATE373661T1 (pt) |
AU (1) | AU2004247418B2 (pt) |
BR (1) | BRPI0411126A (pt) |
CA (1) | CA2527832A1 (pt) |
DE (1) | DE602004009097T2 (pt) |
ES (1) | ES2293251T3 (pt) |
MX (1) | MXPA05013145A (pt) |
PL (1) | PL1680426T3 (pt) |
RU (1) | RU2346946C2 (pt) |
WO (1) | WO2004111055A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2485122C2 (ru) * | 2007-10-03 | 2013-06-20 | Эйсэй Инк. | Соединения и композиции, ингибирующие parp, и способы их применения |
RU2498986C2 (ru) * | 2011-07-20 | 2013-11-20 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
CN104945406B (zh) * | 2015-05-25 | 2017-10-10 | 苏州康润医药有限公司 | 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用 |
CN115894486B (zh) * | 2021-09-30 | 2024-02-09 | 北京赛特明强医药科技有限公司 | 一种氢化吡啶并喹唑啉类化合物、组合物及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
ES2183817T3 (es) * | 1992-09-11 | 2003-04-01 | Univ California | Inibidores de proteasas de parasatiso metazoarios. |
US5739170A (en) * | 1992-09-11 | 1998-04-14 | The Regents Of The University Of California | Inhibitors of metazoan parasite proteases |
EP2295415A1 (en) | 1995-03-30 | 2011-03-16 | OSI Pharmaceuticals, Inc. | Quinazoline derivatives |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
TW436485B (en) * | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
AU759691C (en) | 1998-04-29 | 2004-04-29 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4- quinazolinamine mesylate anhydrate and monohydrate |
UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
DE60126134T2 (de) * | 2000-11-03 | 2007-10-18 | Neurocrine Biosciences, Inc., San Diego | CRF-Rezeptorantagonisten und Verfahren, die damit in Beziehung stehen |
JP2010532758A (ja) * | 2007-07-06 | 2010-10-14 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 組み合わせ抗癌療法 |
-
2004
- 2004-04-26 DE DE602004009097T patent/DE602004009097T2/de not_active Expired - Fee Related
- 2004-04-26 CN CNB2004800162458A patent/CN100378101C/zh not_active Expired - Fee Related
- 2004-04-26 CA CA002527832A patent/CA2527832A1/en not_active Abandoned
- 2004-04-26 RU RU2006100034/04A patent/RU2346946C2/ru active
- 2004-04-26 KR KR1020057023531A patent/KR100753385B1/ko not_active IP Right Cessation
- 2004-04-26 BR BRPI0411126-5A patent/BRPI0411126A/pt not_active IP Right Cessation
- 2004-04-26 AT AT04729442T patent/ATE373661T1/de not_active IP Right Cessation
- 2004-04-26 AU AU2004247418A patent/AU2004247418B2/en not_active Expired - Fee Related
- 2004-04-26 ES ES04729442T patent/ES2293251T3/es not_active Expired - Lifetime
- 2004-04-26 WO PCT/EP2004/050608 patent/WO2004111055A1/en active IP Right Grant
- 2004-04-26 JP JP2006516102A patent/JP2006527235A/ja active Pending
- 2004-04-26 PL PL04729442T patent/PL1680426T3/pl unknown
- 2004-04-26 MX MXPA05013145A patent/MXPA05013145A/es active IP Right Grant
- 2004-04-26 EP EP04729442A patent/EP1680426B1/en not_active Expired - Lifetime
- 2004-05-24 US US10/852,735 patent/US7217717B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1680426B1 (en) | 2007-09-19 |
ATE373661T1 (de) | 2007-10-15 |
MXPA05013145A (es) | 2006-03-17 |
CN100378101C (zh) | 2008-04-02 |
WO2004111055A1 (en) | 2004-12-23 |
PL1680426T3 (pl) | 2008-02-29 |
KR20060017854A (ko) | 2006-02-27 |
RU2006100034A (ru) | 2006-08-27 |
US20040254205A1 (en) | 2004-12-16 |
RU2346946C2 (ru) | 2009-02-20 |
EP1680426A1 (en) | 2006-07-19 |
DE602004009097D1 (de) | 2007-10-31 |
AU2004247418B2 (en) | 2009-11-05 |
DE602004009097T2 (de) | 2008-06-19 |
AU2004247418A1 (en) | 2004-12-23 |
KR100753385B1 (ko) | 2007-08-30 |
US7217717B2 (en) | 2007-05-15 |
CA2527832A1 (en) | 2004-12-23 |
ES2293251T3 (es) | 2008-03-16 |
JP2006527235A (ja) | 2006-11-30 |
CN1805964A (zh) | 2006-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |