BR112018016396A2 - composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbio - Google Patents

composto, composição farmacêutica, uso de um composto, e, método para tratar um distúrbio

Info

Publication number
BR112018016396A2
BR112018016396A2 BR112018016396A BR112018016396A BR112018016396A2 BR 112018016396 A2 BR112018016396 A2 BR 112018016396A2 BR 112018016396 A BR112018016396 A BR 112018016396A BR 112018016396 A BR112018016396 A BR 112018016396A BR 112018016396 A2 BR112018016396 A2 BR 112018016396A2
Authority
BR
Brazil
Prior art keywords
compound
disorder
treating
pharmaceutical composition
compounds
Prior art date
Application number
BR112018016396A
Other languages
English (en)
Other versions
BR112018016396B1 (pt
Inventor
Sharpe Andrew
William James Cooper Anthony
Le Gall Arnelle
Paul Cannons Edward
Victoria White Gemma
George Adam Inglis Graham
Nicole Hamblin Julie
David DOWN Kenneth
James Doyle Kevin
Andrew Anderson Niall
Paul Barton Nicholas
Andre Campos Sebastien
Peace Simon
Kantibhai Patel Vipulkumar
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of BR112018016396A2 publication Critical patent/BR112018016396A2/pt
Publication of BR112018016396B1 publication Critical patent/BR112018016396B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached

Abstract

a invenção está direcionada a certos novos compostos. especificamente, a invenção está direcionada a compostos da fórmula (i): (i) e sais dos mesmos. os compostos da invenção são inibidores da atividade da cinase, em particular da atividade da pi3 cinase.
BR112018016396-1A 2016-02-12 2017-02-10 Composto, composição farmacêutica, e, uso de um composto BR112018016396B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1602527.2A GB201602527D0 (en) 2016-02-12 2016-02-12 Chemical compounds
GB1602527.2 2016-02-12
PCT/EP2017/052954 WO2017137535A1 (en) 2016-02-12 2017-02-10 Chemical compounds as inhibitors of kinase activity

Publications (2)

Publication Number Publication Date
BR112018016396A2 true BR112018016396A2 (pt) 2018-12-18
BR112018016396B1 BR112018016396B1 (pt) 2023-11-14

Family

ID=55697605

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018016396-1A BR112018016396B1 (pt) 2016-02-12 2017-02-10 Composto, composição farmacêutica, e, uso de um composto

Country Status (15)

Country Link
US (2) US10457674B2 (pt)
EP (1) EP3414228B1 (pt)
JP (1) JP6916195B2 (pt)
KR (1) KR20180105726A (pt)
CN (1) CN108884046B (pt)
AR (1) AR107570A1 (pt)
AU (1) AU2017218530A1 (pt)
BR (1) BR112018016396B1 (pt)
CA (1) CA3013404A1 (pt)
ES (1) ES2786948T3 (pt)
GB (1) GB201602527D0 (pt)
RU (1) RU2018127494A (pt)
TW (1) TW201738238A (pt)
UY (1) UY37121A (pt)
WO (1) WO2017137535A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201811766A (zh) * 2016-08-29 2018-04-01 瑞士商諾華公司 N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途
GB201712081D0 (en) * 2017-07-27 2017-09-13 Glaxosmithkline Ip Dev Ltd Chemical compounds
KR102130254B1 (ko) 2019-10-15 2020-07-03 주식회사 실리콘사피엔스 대상자 고유의 혈관에 대한 혈류 시뮬레이션 방법 및 장치

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Also Published As

Publication number Publication date
EP3414228A1 (en) 2018-12-19
US20200071311A1 (en) 2020-03-05
CN108884046B (zh) 2021-11-09
WO2017137535A1 (en) 2017-08-17
AU2017218530A1 (en) 2018-08-09
ES2786948T3 (es) 2020-10-14
CN108884046A (zh) 2018-11-23
AR107570A1 (es) 2018-05-09
GB201602527D0 (en) 2016-03-30
RU2018127494A (ru) 2020-03-12
EP3414228B1 (en) 2020-03-18
KR20180105726A (ko) 2018-09-28
JP2019504858A (ja) 2019-02-21
BR112018016396B1 (pt) 2023-11-14
US10457674B2 (en) 2019-10-29
UY37121A (es) 2017-09-29
JP6916195B2 (ja) 2021-08-11
CA3013404A1 (en) 2017-08-17
US10793559B2 (en) 2020-10-06
TW201738238A (zh) 2017-11-01
US20190040051A1 (en) 2019-02-07

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