BR112018009312A2 - método para promover eficiência de purificação de polipeptídeo contendo região de fc - Google Patents

método para promover eficiência de purificação de polipeptídeo contendo região de fc

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Publication number
BR112018009312A2
BR112018009312A2 BR112018009312-2A BR112018009312A BR112018009312A2 BR 112018009312 A2 BR112018009312 A2 BR 112018009312A2 BR 112018009312 A BR112018009312 A BR 112018009312A BR 112018009312 A2 BR112018009312 A2 BR 112018009312A2
Authority
BR
Brazil
Prior art keywords
region
polypeptide containing
purification efficiency
resin
promote purification
Prior art date
Application number
BR112018009312-2A
Other languages
English (en)
Japanese (ja)
Other versions
BR112018009312A8 (pt
Inventor
Tanaka Nobuyuki
Momose Rumiko
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of BR112018009312A2 publication Critical patent/BR112018009312A2/pt
Publication of BR112018009312A8 publication Critical patent/BR112018009312A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/528—CH4 domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

é constatado que, quando uma região de fc em que uma primeira cadeia de polipeptídeo da mesma pode ligar-se a uma resina de proteína a, porém uma segunda cadeia de polipeptídeo da mesma pode não ligar-se à resina ou pode ligar-se à resina fracamente é empregada como o polipeptídeo contendo região de fc, a quantidade de ligação do polipeptídeo contendo região de fc por volume de unidade da resina pode ser aumentada e o polipeptídeo contendo região de fc pode ser purificada com eficiência mais alta.
BR112018009312A 2015-12-28 2016-12-27 método para promover eficiência de purificação de polipeptídeo contendo região de fc BR112018009312A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015-255726 2015-12-28
JP2015255726 2015-12-28
PCT/JP2016/088820 WO2017115773A1 (ja) 2015-12-28 2016-12-27 Ｆｃ領域含有ポリペプチドの精製を効率化するための方法

Publications (2)

Publication Number Publication Date
BR112018009312A2 true BR112018009312A2 (pt) 2018-11-06
BR112018009312A8 BR112018009312A8 (pt) 2019-02-26

Family

ID=59224731

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018009312A BR112018009312A8 (pt) 2015-12-28 2016-12-27 método para promover eficiência de purificação de polipeptídeo contendo região de fc

Country Status (13)

Country Link
US (1) US11649262B2 (pt)
EP (1) EP3398965A4 (pt)
JP (2) JP7219005B2 (pt)
KR (1) KR20180091918A (pt)
CN (1) CN108368166B (pt)
AU (1) AU2016381992B2 (pt)
BR (1) BR112018009312A8 (pt)
CA (1) CA3004288A1 (pt)
HK (1) HK1251237A1 (pt)
IL (1) IL259247B2 (pt)
MX (1) MX2018007781A (pt)
SG (1) SG11201803989WA (pt)
WO (1) WO2017115773A1 (pt)

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MY180713A (en) 2007-09-26 2020-12-07 Chugai Pharmaceutical Co Ltd Modified antibody constant region
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
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JP6013915B2 (ja) 2010-11-17 2016-10-25 中外製薬株式会社 血液凝固第ｖｉｉｉ因子の機能を代替する機能を有する多重特異性抗原結合分子
EP4279511A3 (en) 2010-11-30 2024-01-24 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
US11124576B2 (en) 2013-09-27 2021-09-21 Chungai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
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IL259247A (en) 2018-07-31
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