CY1122399T1 - Αγωνιστικοι παραγοντες δεσμευσης του υποδοχεα tnf - Google Patents

Αγωνιστικοι παραγοντες δεσμευσης του υποδοχεα tnf

Info

Publication number
CY1122399T1
CY1122399T1 CY20191101191T CY191101191T CY1122399T1 CY 1122399 T1 CY1122399 T1 CY 1122399T1 CY 20191101191 T CY20191101191 T CY 20191101191T CY 191101191 T CY191101191 T CY 191101191T CY 1122399 T1 CY1122399 T1 CY 1122399T1
Authority
CY
Cyprus
Prior art keywords
competitive
receptor binding
tnf receptor
binding factors
binding agents
Prior art date
Application number
CY20191101191T
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English (en)
Inventor
Ugur Sahin
Friederike GIESEKE
Isil Altintas
David Satijn
Paul Parren
Original Assignee
BioNTech SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioNTech SE filed Critical BioNTech SE
Publication of CY1122399T1 publication Critical patent/CY1122399T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε παράγοντες δέσμευσης που δεσμεύονται σε υποδοχείς της υπεροικογένειας του TNF και πιο συγκεκριμένα παράγοντες δέσμευσης που δεσμεύονται σε τουλάχιστον δύο διαφορετικούς υποδοχείς της υπεροικογένειας του TNF, καθώς και στη χρήση τους στην ιατρική. Η παρούσα εφεύρεση αναφέρεται περαιτέρω σε μόρια νουκλεϊκού οξέος που κωδικοποιούν τέτοιους παράγοντες δέσμευσης, σε κύτταρα που περιλαμβάνουν τέτοια μόρια νουκλεϊκού οξέος και σε φαρμακευτικές συνθέσεις και κιτ.
CY20191101191T 2015-01-08 2019-11-13 Αγωνιστικοι παραγοντες δεσμευσης του υποδοχεα tnf CY1122399T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015050255 2015-01-08
PCT/EP2016/050308 WO2016110584A1 (en) 2015-01-08 2016-01-08 Agonistic tnf receptor binding agents

Publications (1)

Publication Number Publication Date
CY1122399T1 true CY1122399T1 (el) 2020-11-25

Family

ID=55072677

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101191T CY1122399T1 (el) 2015-01-08 2019-11-13 Αγωνιστικοι παραγοντες δεσμευσης του υποδοχεα tnf

Country Status (24)

Country Link
US (3) US10457735B2 (el)
EP (3) EP3242890B1 (el)
JP (4) JP6744326B2 (el)
KR (3) KR102238326B1 (el)
CN (3) CN111499752B (el)
AU (2) AU2016205974B2 (el)
BR (1) BR112017013189B1 (el)
CA (2) CA3224830A1 (el)
CY (1) CY1122399T1 (el)
DK (2) DK3242890T3 (el)
ES (2) ES2922398T3 (el)
HR (2) HRP20220811T1 (el)
HU (2) HUE059219T2 (el)
LT (1) LT3623386T (el)
ME (1) ME03576B (el)
MX (2) MX2017008917A (el)
PL (2) PL3242890T3 (el)
PT (2) PT3242890T (el)
RS (2) RS63384B1 (el)
RU (1) RU2723131C2 (el)
SG (2) SG11201704597WA (el)
SI (2) SI3623386T1 (el)
WO (1) WO2016110584A1 (el)
ZA (1) ZA201704797B (el)

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RS63384B1 (sr) 2022-08-31
SI3623386T1 (sl) 2022-09-30
AU2016205974B2 (en) 2021-11-04
US10927181B2 (en) 2021-02-23
US20180194849A1 (en) 2018-07-12
NZ733157A (en) 2021-10-29
US10457735B2 (en) 2019-10-29
EP3242890A1 (en) 2017-11-15
JP6950056B2 (ja) 2021-10-13
CN109476761A (zh) 2019-03-15
KR102640769B1 (ko) 2024-02-27
JP2023085435A (ja) 2023-06-20
KR102238326B1 (ko) 2021-04-12
JP2020188797A (ja) 2020-11-26
HRP20191824T1 (hr) 2020-01-24
US11814411B2 (en) 2023-11-14
MX2017008917A (es) 2018-02-09
DK3242890T3 (da) 2019-10-21
JP7487376B2 (ja) 2024-05-20
DK3623386T3 (da) 2022-07-04
ES2755527T3 (es) 2020-04-22
BR112017013189B1 (pt) 2024-03-05
RU2017127792A3 (el) 2019-06-17
RU2723131C2 (ru) 2020-06-08
EP3623386B1 (en) 2022-04-13
CN111499752B (zh) 2024-05-31
CN109476761B (zh) 2020-01-10
EP3623386A1 (en) 2020-03-18
KR20240028548A (ko) 2024-03-05
PT3242890T (pt) 2019-12-10
HUE048532T2 (hu) 2020-07-28
PL3242890T3 (pl) 2020-04-30
MX2020012240A (es) 2021-02-22
RS59693B1 (sr) 2020-01-31
KR20170132717A (ko) 2017-12-04
SI3242890T1 (sl) 2020-01-31
CN117843799A (zh) 2024-04-09
AU2016205974A1 (en) 2017-07-13
JP6744326B2 (ja) 2020-08-19
ME03576B (me) 2020-07-20
EP4071176A2 (en) 2022-10-12
CA2969888A1 (en) 2016-07-14
CN111499752A (zh) 2020-08-07
SG11201704597WA (en) 2017-07-28
PT3623386T (pt) 2022-07-18
JP2022025064A (ja) 2022-02-09
LT3623386T (lt) 2022-08-10
BR112017013189A2 (pt) 2018-04-10
RU2017127792A (ru) 2019-02-08
ES2922398T3 (es) 2022-09-14
JP2018506298A (ja) 2018-03-08
AU2022200571A1 (en) 2022-02-17
CA3224830A1 (en) 2016-07-14
US20200079866A1 (en) 2020-03-12
HRP20220811T1 (hr) 2022-09-30
JP7390345B2 (ja) 2023-12-01
PL3623386T3 (pl) 2022-08-08
SG10202003171TA (en) 2020-05-28
HUE059219T2 (hu) 2022-10-28
EP4071176A3 (en) 2022-12-14
ZA201704797B (en) 2019-05-29
WO2016110584A1 (en) 2016-07-14
US20210253725A1 (en) 2021-08-19
RU2020115901A (ru) 2020-08-05
KR20210041634A (ko) 2021-04-15
EP3242890B1 (en) 2019-09-04

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