BR112017002053A2 - composto de acordo com a fórmula (i), composição farmacêutica, e usos de um composto - Google Patents

composto de acordo com a fórmula (i), composição farmacêutica, e usos de um composto

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Publication number
BR112017002053A2
BR112017002053A2 BR112017002053-0A BR112017002053A BR112017002053A2 BR 112017002053 A2 BR112017002053 A2 BR 112017002053A2 BR 112017002053 A BR112017002053 A BR 112017002053A BR 112017002053 A2 BR112017002053 A2 BR 112017002053A2
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BR
Brazil
Prior art keywords
compound
formula
pharmaceutical composition
compound according
compounds
Prior art date
Application number
BR112017002053-0A
Other languages
English (en)
Inventor
GERNER SEITZBERG Jimmi
Titilola Akinleminu Kronborg Tine
Poljak Visnja
FRIBERG Gitte
Teuber Lene
Original Assignee
Nuevolution A/S
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Publication date
Application filed by Nuevolution A/S filed Critical Nuevolution A/S
Publication of BR112017002053A2 publication Critical patent/BR112017002053A2/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Abstract

a presente invenção trata de compostos em relação a bromodomínios, composições farmacêuticas contendo os compostos e uso dos compostos em terapia.
BR112017002053-0A 2014-08-01 2015-07-29 composto de acordo com a fórmula (i), composição farmacêutica, e usos de um composto BR112017002053A2 (pt)

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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990403A1 (en) 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
CA2992698A1 (en) 2015-07-17 2017-01-26 Toyama Chemical Co., Ltd. Nitrogen-containing heterocyclic compound
AU2017220611A1 (en) 2016-02-15 2018-08-30 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh TAF1 inhibitors for the therapy of cancer
CA3018358A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property (No.2) Limited Pyridyl derivatives as bromodomain inhibitors
CN116478131A (zh) 2016-07-12 2023-07-25 锐新医药公司 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪
WO2018075908A1 (en) * 2016-10-21 2018-04-26 University Of Miami Materials and methods for treating ophthalmic inflammation
BR112019013273A2 (pt) 2016-12-27 2019-12-17 Fujifilm Corp agente antitumoral e inibidor de bromodomínio
KR20190111079A (ko) 2017-01-23 2019-10-01 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 이환 화합물
BR112019014527A2 (pt) 2017-01-23 2020-02-27 Revolution Medicines, Inc. Compostos de piridina como inibidores de shp2 alostéricos
CN110300579A (zh) * 2017-02-07 2019-10-01 詹森药业有限公司 氨磺酰基芳基衍生物及其作为药物用于治疗肝纤维化的用途
JP2020525490A (ja) 2017-06-27 2020-08-27 ヤンセン ファーマシューティカ エヌ．ベー． ヘテロアリールジヒドロピリミジン誘導体及びｂ型肝炎感染を治療する方法
JP2020536881A (ja) * 2017-10-12 2020-12-17 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としてのピリジン、ピラジンおよびトリアジン化合物
MX2020006273A (es) 2017-12-15 2020-09-14 Revolution Medicines Inc Compuestos policiclicos como inhibidores alostericos de shp2.
CN111683932A (zh) * 2018-02-06 2020-09-18 上海海和药物研究开发有限公司 具有bet抑制活性的化合物及其制备方法和用途
CN110386927B (zh) * 2018-04-20 2022-09-23 中国科学院上海药物研究所 组蛋白乙酰转移酶（hat）抑制剂及其用途
CN109053542A (zh) * 2018-07-25 2018-12-21 南通大学 一种6-溴-5-羟基异吲哚啉-1-酮的化学合成方法
JP2021532158A (ja) * 2018-07-31 2021-11-25 ザ、トラスティーズ オブ プリンストン ユニバーシティ 転移性癌および化学療法抵抗性癌の治療のためのテトラヒドロキノリノ誘導体
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
MA54076A (fr) * 2018-11-02 2022-02-09 Merck Sharp & Dohme 2-amino-n-hétéroaryl-nicotinamides utilisés en tant qu'inhibiteurs de nav1.8
CN114728936A (zh) * 2019-10-29 2022-07-08 豪夫迈·罗氏有限公司 用于治疗癌症的双功能化合物
GB201918587D0 (en) * 2019-12-17 2020-01-29 Artios Pharma Ltd Novel compounds
AU2021209962A1 (en) * 2020-01-24 2022-09-15 Kayothera Inc. Heterocyclic compounds and uses thereof
WO2022103899A1 (en) * 2020-11-10 2022-05-19 Foghorn Therapeutics Inc. Compounds and uses thereof
GB202019475D0 (en) 2020-12-10 2021-01-27 Cancer Research Tech Ltd Therapeutic compounds and their use
WO2022159445A1 (en) * 2021-01-19 2022-07-28 Metrea Biosciences, Inc. Compounds and methods of activating lipoprotein lipase
WO2022222890A1 (en) * 2021-04-19 2022-10-27 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease
WO2023274418A1 (zh) * 2021-07-02 2023-01-05 南京明德新药研发有限公司 蛋白降解靶向嵌合体类化合物
WO2023006893A1 (en) * 2021-07-30 2023-02-02 Confo Therapeutics N.V. Compounds for the treatment of pain, in particular neuropathic pain, and/or other diseases or disorders that are associated with at2r and/or at2r mediated signaling
WO2023205251A1 (en) 2022-04-19 2023-10-26 Nuevolution A/S Compounds active towards bromodomains
WO2023205475A1 (en) * 2022-04-21 2023-10-26 Nimbus Clotho, Inc. Ctps1 inhibitors and uses thereof
WO2023248193A1 (en) * 2022-06-24 2023-12-28 Zydus Lifesciences Limited Treatment for glomerular diseases

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5328935B2 (pt) 1972-01-20 1978-08-17
JPS56104333A (en) 1980-01-23 1981-08-20 Fuji Photo Film Co Ltd Color photographic sensitive material
DE3445669A1 (de) 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS6232459A (ja) 1985-08-05 1987-02-12 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS6238463A (ja) 1985-08-14 1987-02-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−感光材料の画像形成方法
JPH067250B2 (ja) 1985-10-18 1994-01-26 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料
JPS6292939A (ja) 1985-10-19 1987-04-28 Fuji Photo Film Co Ltd 熱現像感光材料
JPH0756566B2 (ja) 1985-11-06 1995-06-14 富士写真フイルム株式会社 ハロゲン化銀カラ−写真感光材料の処理方法
JPS62129853A (ja) 1985-11-30 1987-06-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
JPS62153953A (ja) 1985-12-27 1987-07-08 Fuji Photo Film Co Ltd カラ−写真感光材料
JPS62173466A (ja) 1986-01-28 1987-07-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
JPS62222251A (ja) 1986-02-17 1987-09-30 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62257158A (ja) 1986-04-30 1987-11-09 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料
DE3788600T2 (de) 1986-07-22 1994-04-28 Fuji Photo Film Co Ltd Verfahren zur Behandlung eines farbphotographischen Silberhalogenidmaterials.
DE3803775A1 (de) 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPH02234158A (ja) 1989-03-07 1990-09-17 Fuji Photo Film Co Ltd カラー感光材料
JPH02264946A (ja) 1989-04-05 1990-10-29 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JPH02267548A (ja) 1989-04-10 1990-11-01 Fuji Photo Film Co Ltd 画像形成法
DE3925584A1 (de) 1989-08-02 1991-02-07 Boehringer Mannheim Gmbh Neue n-(dimethyloxophosphinylmethyl-)-lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4027592A1 (de) 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JPH04315148A (ja) 1991-04-15 1992-11-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
GB9205702D0 (en) 1992-03-16 1992-04-29 Fujisawa Pharmaceutical Co A new use of a quinazoline derivative
EP0598216B1 (en) 1992-10-15 1997-04-23 Fuji Photo Film Co., Ltd. Method for processing silver halide color photographic material
US5741796A (en) 1994-05-27 1998-04-21 Merck & Co., Inc. Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption
US5756502A (en) 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
TW381092B (en) 1995-07-07 2000-02-01 Otsuka Pharma Co Ltd Novel benzimidazole derivatives for use in treating arteriosclerotic diseases
US5747235A (en) 1996-01-26 1998-05-05 Eastman Kodak Company Silver halide light sensitive emulsion layer having enhanced photographic sensitivity
US5780480A (en) 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1997031910A1 (en) 1996-02-28 1997-09-04 Merck & Co., Inc. Fibrinogen receptor antagonists
EP1003374A1 (en) 1996-12-30 2000-05-31 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
JP2002508366A (ja) 1997-12-12 2002-03-19 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー キノリンピペラジンおよびキノリンピペリジン誘導体、それらの製造方法、ならびに複合的５−ｈｔ１ａ、５−ｈｔ１ｂおよび５−ｈｔ１ｄ受容体アンタゴニストとしてのそれらの用途
NZ505843A (en) 1997-12-22 2003-06-30 Bayer Ag Diphenyl ureas compounds for treating cancer and raf kinase related diseases
DE19839499A1 (de) 1998-08-29 2000-03-02 Merck Patent Gmbh 2-Oxo-2H-chinolinderivate
WO2001057021A2 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. 2-[1H]-QUINOLONE AND 2-[1H]-QUINOXALONE INHIBITORS OF FACTOR Xa
JP2002341484A (ja) 2001-03-12 2002-11-27 Fuji Photo Film Co Ltd 熱現像感光材料
JP2002296731A (ja) 2001-03-30 2002-10-09 Fuji Photo Film Co Ltd 熱現像カラー画像記録材料
WO2002090347A1 (en) 2001-04-30 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Amide compounds
PL367200A1 (en) 2001-05-15 2005-02-21 E.I.Du Pont De Nemours And Company Pyridinyl fused bicyclic amide as fungicides
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
EP1388342A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
CA2496164C (en) 2002-08-23 2010-11-09 Chiron Corporation Benzimidazole quinolinones and uses thereof
WO2004026794A2 (en) 2002-09-17 2004-04-01 Merck & Co., Inc. Removal of aldehyde impurity by reactive polystyrene resin
AU2003287880A1 (en) 2002-12-11 2004-06-30 7Tm Pharma A/S Cyclic quinoline compounds for use in mch receptor related disorders
US20040142950A1 (en) 2003-01-17 2004-07-22 Bunker Amy Mae Amide and ester matrix metalloproteinase inhibitors
US7205318B2 (en) 2003-03-18 2007-04-17 Bristol-Myers Squibb Company Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors
WO2004110350A2 (en) 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
JP4728962B2 (ja) 2003-05-19 2011-07-20 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
KR101224410B1 (ko) 2003-11-07 2013-01-23 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 퀴놀리논 화합물을 합성하는 방법
WO2005087742A1 (en) 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
WO2005094805A1 (ja) 2004-04-01 2005-10-13 Institute Of Medicinal Molecular Design. Inc. イミン誘導体及びアミド誘導体
KR20070024667A (ko) 2004-06-03 2007-03-02 브랜데이스 유니버시티 이작용성 신코나-알칼로이드 기재 촉매를 사용하는 비대칭마이클 및 알돌 부가반응
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
EP1655295A1 (en) * 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
US20060281763A1 (en) 2005-03-25 2006-12-14 Axon Jonathan R Carboxamide inhibitors of TGFbeta
GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
GB0509224D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
WO2006130437A2 (en) 2005-05-27 2006-12-07 Brandeis University Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids
CA2623541A1 (en) 2005-09-23 2007-03-29 Coley Pharmaceutical Group, Inc. Method for 1h-imidazo[4,5-c]pyridines and analogs thereof
ES2331437T3 (es) 2006-02-16 2010-01-04 Syngenta Participations Ag Pesticidas que contienen una estructura de bisamida biciclica.
GB0605689D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic compounds
US7601716B2 (en) 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
US20090306103A1 (en) 2006-05-19 2009-12-10 Stephen Boyer Pyridonecarboxamide derivatives useful in treating hyper-proliferative and angiogenesis disorders
WO2008029152A2 (en) 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
CA2665438C (en) 2006-10-04 2014-12-02 Tibotec Pharmaceuticals Ltd. Carboxamide 4-[(4-pyridyl)amino]pyrimidines useful as hcv inhibitors
US20080186971A1 (en) 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
EP2114898A2 (en) 2007-02-16 2009-11-11 Amgen Inc. Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
WO2008109177A2 (en) * 2007-03-07 2008-09-12 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
JP2008280341A (ja) 2007-04-12 2008-11-20 Sumitomo Chemical Co Ltd ヒドラジド化合物およびその防除用途
WO2009020677A2 (en) 2007-04-27 2009-02-12 University Of Rochester Compositions and methods for inhibiting g protein signaling
EP2008658A1 (en) 2007-06-28 2008-12-31 Bayer Schering Pharma Aktiengesellschaft Synergistic combination of anthranilamide pyridinureas and benzamide derivatives
NZ584720A (en) 2007-09-17 2012-07-27 Abbott Lab Uracil or thymine derivative for treating hepatitis c
EP2297097A2 (en) 2008-06-11 2011-03-23 Irm Llc Compounds and compositions useful for the treatment of malaria
US20100068204A1 (en) 2008-09-12 2010-03-18 Wyeth 4-aryloxyquinolin-2(1h)-ones as mtor kinase and pi3 kinase inhibitors, for use as anti-cancer agents
US20100267752A1 (en) 2008-10-15 2010-10-21 Gilead Palo Alto, Inc. 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
WO2010072597A1 (en) 2008-12-23 2010-07-01 F. Hoffmann-La Roche Ag Dihydropyridone amides as p2x7 modulators
WO2010101949A1 (en) 2009-03-02 2010-09-10 Sirtris Pharmaceuticals, Inc. 8-substituted quinolines and related analogs as sirtuin modulators
US8278302B2 (en) * 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
ME02360B (me) * 2009-11-05 2016-06-20 Glaxosmithkline Llc Inhibitor bromodomena benzodiazepina
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
EP2571878B1 (en) 2010-05-17 2018-10-17 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases
WO2011156632A2 (en) 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
JPWO2012020820A1 (ja) 2010-08-11 2013-10-28 大正製薬株式会社 ヘテロアリール−ピラゾール誘導体
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
MX2013006101A (es) 2010-12-17 2013-07-02 Hoffmann La Roche Compuestos heterociclicos nitrogenados sustituidos fusionados en posicion 6,6 y usos de los mismos.
TW201309639A (zh) 2011-02-17 2013-03-01 Lg Life Sciences Ltd 作為ｇｐｒ１１９促效劑之肟衍生物
WO2012125668A1 (en) 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
GB201106743D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106750D0 (en) * 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
JP5742439B2 (ja) 2011-05-02 2015-07-01 信越化学工業株式会社 蛍光性化合物及び蛍光性樹脂組成物
PT2713722T (pt) 2011-05-31 2017-06-27 Receptos Llc Novos estabilizadores e moduladores do receptor glp-1
CN102887895B (zh) 2011-07-22 2016-08-24 山东轩竹医药科技有限公司 吡啶并嘧啶类mTOR抑制剂
US20140315881A1 (en) 2011-07-29 2014-10-23 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013027168A1 (en) * 2011-08-22 2013-02-28 Pfizer Inc. Novel heterocyclic compounds as bromodomain inhibitors
CN103987697B (zh) * 2011-10-14 2017-04-26 百时美施贵宝公司 作为因子xia抑制剂的取代的四氢异喹啉化合物
EP2770993A2 (en) 2011-10-26 2014-09-03 The United States of America, as represented by The Secretary, Department of Health and Human Services Method of treating hcv infection with a small molecule chk2 inhibitor
JP6175673B2 (ja) 2012-04-25 2017-08-09 ラクオリア創薬株式会社 Ｔｔｘ−ｓ遮断薬としてのアミド誘導体
JPWO2014034719A1 (ja) 2012-08-29 2016-08-08 興和株式会社 Ｔｌｒ阻害作用を有するキノリン誘導体
EP2935260A1 (de) 2012-12-20 2015-10-28 Bayer Pharma Aktiengesellschaft Bet-proteininhibitorische dihydropyridopyrazinone
CA2895426A1 (en) 2012-12-20 2014-06-26 Bayer Pharma Aktiengesellschaft Bet-protein-inhibiting dihydroquinoxalinones

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