MX2020006273A - Compuestos policiclicos como inhibidores alostericos de shp2. - Google Patents

Compuestos policiclicos como inhibidores alostericos de shp2.

Info

Publication number
MX2020006273A
MX2020006273A MX2020006273A MX2020006273A MX2020006273A MX 2020006273 A MX2020006273 A MX 2020006273A MX 2020006273 A MX2020006273 A MX 2020006273A MX 2020006273 A MX2020006273 A MX 2020006273A MX 2020006273 A MX2020006273 A MX 2020006273A
Authority
MX
Mexico
Prior art keywords
polycyclic compounds
shp2 inhibitors
allosteric shp2
inhibitors
allosteric
Prior art date
Application number
MX2020006273A
Other languages
English (en)
Inventor
Elena S Koltun
Andreas Buckl
Jennifer Pitzen
Walter S Won
Jie Jack Li
Adrian Liam Gill
James Joseph Cregg
Naing N Aay
Kevin T Mellem
Blank Brian R
Gang Wang
Ashutosh S Jogalekar
Christos Tzitzilonis
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of MX2020006273A publication Critical patent/MX2020006273A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente divulgación está dirigida a inhibidores de SHP2 y a su uso en el tratamiento de enfermedades. También se divulgan composiciones farmacéuticas que los comprenden.
MX2020006273A 2017-12-15 2018-12-14 Compuestos policiclicos como inhibidores alostericos de shp2. MX2020006273A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762599583P 2017-12-15 2017-12-15
US201862678891P 2018-05-31 2018-05-31
PCT/US2018/065817 WO2019118909A1 (en) 2017-12-15 2018-12-14 Polycyclic compounds as allosteric shp2 inhibitors

Publications (1)

Publication Number Publication Date
MX2020006273A true MX2020006273A (es) 2020-09-14

Family

ID=65003535

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006273A MX2020006273A (es) 2017-12-15 2018-12-14 Compuestos policiclicos como inhibidores alostericos de shp2.

Country Status (16)

Country Link
US (2) US11673901B2 (es)
EP (1) EP3724189B1 (es)
JP (1) JP7361693B2 (es)
KR (1) KR20200099530A (es)
CN (1) CN111433205B (es)
AU (1) AU2018385713A1 (es)
BR (1) BR112020009757A2 (es)
CA (1) CA3084058A1 (es)
CO (1) CO2020005887A2 (es)
IL (1) IL275089A (es)
MX (1) MX2020006273A (es)
PH (1) PH12020550857A1 (es)
RU (1) RU2020123241A (es)
SG (1) SG11202004090YA (es)
TW (1) TW201927791A (es)
WO (1) WO2019118909A1 (es)

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