BR112017002811A2 - compostos de pirrolopirimidina usados como agonista de tlr7 - Google Patents
compostos de pirrolopirimidina usados como agonista de tlr7Info
- Publication number
- BR112017002811A2 BR112017002811A2 BR112017002811A BR112017002811A BR112017002811A2 BR 112017002811 A2 BR112017002811 A2 BR 112017002811A2 BR 112017002811 A BR112017002811 A BR 112017002811A BR 112017002811 A BR112017002811 A BR 112017002811A BR 112017002811 A2 BR112017002811 A2 BR 112017002811A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds used
- tlr7 agonist
- pyrrolopyrimidine compounds
- compounds
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
a presente invenção fornece compostos de pirrolopirimidina usados como um agonista de tlr7 e, especificamente, refere-se a compostos de formula (i) (i) ou sais farmaceuticamente aceitáveis dos mesmos, um método de preparação dos mesmos, composições farmacêuticas que contêm tais compostos e uso dos mesmos na preparação de medicamentos antivirais.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410405136.0 | 2014-08-15 | ||
| CN201410405136.0A CN105367576A (zh) | 2014-08-15 | 2014-08-15 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| CN201510392499 | 2015-07-06 | ||
| CN201510392499.X | 2015-07-06 | ||
| PCT/CN2015/086909 WO2016023511A1 (zh) | 2014-08-15 | 2015-08-14 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017002811A2 true BR112017002811A2 (pt) | 2017-12-19 |
| BR112017002811B1 BR112017002811B1 (pt) | 2022-09-06 |
Family
ID=55303885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017002811-5A BR112017002811B1 (pt) | 2014-08-15 | 2015-08-14 | Compostos de pirrolopirimidina usados como agonista de tlr7 e seu uso, composição farmacêutica e kit |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9962388B2 (pt) |
| EP (1) | EP3190113B1 (pt) |
| JP (2) | JP6328341B2 (pt) |
| KR (2) | KR20190098277A (pt) |
| CN (4) | CN110759916B (pt) |
| AU (3) | AU2015303558B2 (pt) |
| BR (1) | BR112017002811B1 (pt) |
| CA (1) | CA2958097C (pt) |
| CL (1) | CL2017000379A1 (pt) |
| DK (1) | DK3190113T3 (pt) |
| EA (1) | EA032824B1 (pt) |
| ES (1) | ES2875313T3 (pt) |
| HR (1) | HRP20210927T1 (pt) |
| HU (1) | HUE054672T2 (pt) |
| IL (2) | IL250586B (pt) |
| LT (1) | LT3190113T (pt) |
| MX (1) | MX2017002028A (pt) |
| MY (1) | MY190026A (pt) |
| PH (2) | PH12017500281B1 (pt) |
| PL (1) | PL3190113T3 (pt) |
| PT (1) | PT3190113T (pt) |
| SG (2) | SG10201809918RA (pt) |
| SI (1) | SI3190113T1 (pt) |
| UA (1) | UA117634C2 (pt) |
| WO (1) | WO2016023511A1 (pt) |
| ZA (1) | ZA201803736B (pt) |
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| CN101304748A (zh) * | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
| EA019151B1 (ru) * | 2007-02-07 | 2014-01-30 | Дзе Регентс Оф Дзе Юниверсити Оф Калифорния | Конъюгаты синтетических агонистов tlr и их применение |
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| WO2009019553A2 (en) | 2007-08-03 | 2009-02-12 | Pfizer Limited | Imidazopyridinones |
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| EP2674170B1 (en) * | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
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| KR20150085080A (ko) * | 2012-11-20 | 2015-07-22 | 글락소스미스클라인 엘엘씨 | 신규 화합물 |
| US9428512B2 (en) * | 2012-11-20 | 2016-08-30 | Glaxosmithkline Llc | Compounds |
| UA114645C2 (uk) * | 2012-11-20 | 2017-07-10 | Ґлаксосмітклайн Ллк | Піролопіримідини як індуктори інтерферону людини |
| CN106029668B (zh) | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
| SG11201608299TA (en) | 2014-05-01 | 2016-11-29 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
| PL3137470T3 (pl) | 2014-05-01 | 2021-10-11 | Novartis Ag | Związki i kompozycje jako agonisty receptora toll-like 7 |
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| CN105732635A (zh) | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
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