BR112016030447A2 - diacorpo biespecífico de fc capaz de ligação imunoespecífica a um epítopo de pd-1 e a um epítopo de lag-3, composição farmacêutica, método para tratamento de câncer, e, método para tratamento de uma doença associada com a presença de um patógeno - Google Patents
diacorpo biespecífico de fc capaz de ligação imunoespecífica a um epítopo de pd-1 e a um epítopo de lag-3, composição farmacêutica, método para tratamento de câncer, e, método para tratamento de uma doença associada com a presença de um patógenoInfo
- Publication number
- BR112016030447A2 BR112016030447A2 BR112016030447-0A BR112016030447A BR112016030447A2 BR 112016030447 A2 BR112016030447 A2 BR 112016030447A2 BR 112016030447 A BR112016030447 A BR 112016030447A BR 112016030447 A2 BR112016030447 A2 BR 112016030447A2
- Authority
- BR
- Brazil
- Prior art keywords
- epitope
- lag
- bispecific
- treating
- bodies
- Prior art date
Links
- 101100510617 Caenorhabditis elegans sel-8 gene Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 244000052769 pathogen Species 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Abstract
a presente invenção é direcionada a diacorpos biespecíficos que compreendem duas ou mais cadeias polipeptídicas e que possuem pelo menos um sítio de ligação ao epítopo que é imunoespecífico para um epítopo de pd-1 e pelo menos um sítio de ligação ao epítopo que é imunoespecífico para um epítopo de lag-3 (ou seja, um ?diacorpo biespecífico pd-1 x lag-3?). mais preferivelmente, a presente invenção é direcionada a diacorpos biespecíficos que compreendem quatro cadeias polipeptídicas e que possuem dois sítios de ligação ao epítopo que são imunoespecíficos para um (ou dois) epítopo(s) de pd-1 e dois sítios de ligação ao epítopo que são imunoespecífico para um (ou dois) epítopo(s) de lag-3 (ou seja, um ?diacorpo tetravalente biespecífico pd-1 x lag-3?). a presente invenção também é direcionada a tais diacorpos que, adicionalmente, compreendem um domínio fc de imunoglobulina (?diacorpos fc biespecíficos e diacorpos fc tetravalentes biespecíficos?). os diacorpos da presente invenção são capazes de ligar simultaneamente a pd-1 e a lag-3, particularmente tais moléculas são colocadas nas superfícies de células humanas. a invenção é direcionada a composições farmacêuticas que contêm tais diacorpos e a métodos que envolvem o uso de tais diacorpos no tratamento de câncer e outras doenças e condições.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462017467P | 2014-06-26 | 2014-06-26 | |
| US62/017,467 | 2014-06-26 | ||
| PCT/US2015/036634 WO2015200119A1 (en) | 2014-06-26 | 2015-06-19 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016030447A2 true BR112016030447A2 (pt) | 2018-01-16 |
Family
ID=54938685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016030447-0A BR112016030447A2 (pt) | 2014-06-26 | 2015-06-19 | diacorpo biespecífico de fc capaz de ligação imunoespecífica a um epítopo de pd-1 e a um epítopo de lag-3, composição farmacêutica, método para tratamento de câncer, e, método para tratamento de uma doença associada com a presença de um patógeno |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US10160806B2 (pt) |
| EP (1) | EP3161004B1 (pt) |
| JP (2) | JP6890421B2 (pt) |
| KR (1) | KR102514330B1 (pt) |
| CN (1) | CN106715470B (pt) |
| AR (1) | AR101009A1 (pt) |
| AU (1) | AU2015280392B2 (pt) |
| BR (1) | BR112016030447A2 (pt) |
| CA (1) | CA2953818C (pt) |
| CL (1) | CL2016003335A1 (pt) |
| CR (1) | CR20160599A (pt) |
| CY (1) | CY1123917T1 (pt) |
| DK (1) | DK3161004T3 (pt) |
| EA (1) | EA036737B1 (pt) |
| EC (1) | ECSP16096342A (pt) |
| ES (1) | ES2843269T3 (pt) |
| GE (1) | GEP20197034B (pt) |
| HR (1) | HRP20210041T1 (pt) |
| HU (1) | HUE052615T2 (pt) |
| IL (1) | IL249764B (pt) |
| LT (1) | LT3161004T (pt) |
| MX (1) | MX369486B (pt) |
| MY (1) | MY177324A (pt) |
| NZ (1) | NZ727772A (pt) |
| PE (1) | PE20170767A1 (pt) |
| PH (1) | PH12016502590A1 (pt) |
| PL (1) | PL3161004T3 (pt) |
| PT (1) | PT3161004T (pt) |
| RS (1) | RS61284B1 (pt) |
| SA (1) | SA516380600B1 (pt) |
| SG (1) | SG11201610715SA (pt) |
| SI (1) | SI3161004T1 (pt) |
| TW (1) | TWI693232B (pt) |
| UA (1) | UA119673C2 (pt) |
| WO (1) | WO2015200119A1 (pt) |
| ZA (1) | ZA201608768B (pt) |
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