CN103566377A - 癌症的靶向免疫治疗 - Google Patents
癌症的靶向免疫治疗 Download PDFInfo
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- CN103566377A CN103566377A CN201210248481.9A CN201210248481A CN103566377A CN 103566377 A CN103566377 A CN 103566377A CN 201210248481 A CN201210248481 A CN 201210248481A CN 103566377 A CN103566377 A CN 103566377A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims (36)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011353424.8A CN112587671A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN202011353425.2A CN112587658A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN201210248481.9A CN103566377A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
MX2015000821A MX2015000821A (es) | 2012-07-18 | 2013-07-16 | Compuestos para inmunoterapia dirigida. |
EP13820359.1A EP2874651B1 (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
AU2013292894A AU2013292894A1 (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
BR112015001098A BR112015001098A2 (pt) | 2012-07-18 | 2013-07-16 | composto, composição farmacêutica e método para o tratamento de uma condição de doença. |
PCT/CN2013/079441 WO2014012479A1 (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
JP2015521961A JP6587936B2 (ja) | 2012-07-18 | 2013-07-16 | 標的免疫療法のための化合物 |
CN201380033552.6A CN104411329A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
CA2878989A CA2878989A1 (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
ES13820359T ES2953395T3 (es) | 2012-07-18 | 2013-07-16 | Compuestos para inmunoterapia dirigida |
KR1020157003785A KR20150054768A (ko) | 2012-07-18 | 2013-07-16 | 표적화된 면역 요법을 위한 화합물들 |
SG11201500399SA SG11201500399SA (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
CN202211286144.9A CN115611988A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
RU2015105186A RU2015105186A (ru) | 2012-07-18 | 2013-07-16 | Соединения для направленной иммунотерапии |
US14/408,268 US9878052B2 (en) | 2012-07-18 | 2013-07-16 | Compounds for targeted immunotherapy |
TW102125608A TW201408323A (zh) | 2012-07-18 | 2013-07-17 | 用於靶向免疫療法的化合物 |
ARP130102565A AR091837A1 (es) | 2012-07-18 | 2013-07-18 | Compuestos para inmunoterapia dirigida |
IN385DEN2015 IN2015DN00385A (zh) | 2012-07-18 | 2015-01-15 | |
ZA2015/00318A ZA201500318B (en) | 2012-07-18 | 2015-01-16 | Compounds for targeted immunotherapy |
IL236772A IL236772A0 (en) | 2012-07-18 | 2015-01-18 | Preparations for directed immunotherapy |
US15/849,436 US10548988B2 (en) | 2012-07-18 | 2017-12-20 | Compounds for targeted immunotherapy |
US15/849,470 US10660971B2 (en) | 2012-07-18 | 2017-12-20 | Compounds for targeted immunotherapy |
JP2019165174A JP7062298B2 (ja) | 2012-07-18 | 2019-09-11 | 標的免疫療法のための化合物 |
US16/794,069 US20200179527A1 (en) | 2012-07-18 | 2020-02-18 | Compounds for targeted immunotherapy |
US16/794,056 US20200246478A1 (en) | 2012-07-18 | 2020-02-18 | Compounds for targeted immunotherapy |
JP2022066294A JP2022092041A (ja) | 2012-07-18 | 2022-04-13 | 標的免疫療法のための化合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210248481.9A CN103566377A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011353424.8A Division CN112587671A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN202011353425.2A Division CN112587658A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103566377A true CN103566377A (zh) | 2014-02-12 |
Family
ID=49948284
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011353425.2A Pending CN112587658A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN201210248481.9A Pending CN103566377A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN202011353424.8A Pending CN112587671A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN202211286144.9A Pending CN115611988A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
CN201380033552.6A Pending CN104411329A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011353425.2A Pending CN112587658A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011353424.8A Pending CN112587671A (zh) | 2012-07-18 | 2012-07-18 | 癌症的靶向免疫治疗 |
CN202211286144.9A Pending CN115611988A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
CN201380033552.6A Pending CN104411329A (zh) | 2012-07-18 | 2013-07-16 | 用于靶向免疫疗法的化合物 |
Country Status (18)
Country | Link |
---|---|
US (5) | US9878052B2 (zh) |
EP (1) | EP2874651B1 (zh) |
JP (3) | JP6587936B2 (zh) |
KR (1) | KR20150054768A (zh) |
CN (5) | CN112587658A (zh) |
AR (1) | AR091837A1 (zh) |
AU (1) | AU2013292894A1 (zh) |
BR (1) | BR112015001098A2 (zh) |
CA (1) | CA2878989A1 (zh) |
ES (1) | ES2953395T3 (zh) |
IL (1) | IL236772A0 (zh) |
IN (1) | IN2015DN00385A (zh) |
MX (1) | MX2015000821A (zh) |
RU (1) | RU2015105186A (zh) |
SG (1) | SG11201500399SA (zh) |
TW (1) | TW201408323A (zh) |
WO (1) | WO2014012479A1 (zh) |
ZA (1) | ZA201500318B (zh) |
Cited By (20)
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WO2015200828A1 (en) * | 2014-06-27 | 2015-12-30 | H. Lee Moffit Cancer Center And Research Institute, Inc. | Conjugates for immunotherapy |
CN105233291A (zh) * | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
CN105820244A (zh) * | 2015-01-06 | 2016-08-03 | 珠海亿胜生物制药有限公司 | 抗vegf抗体 |
CN106714811A (zh) * | 2014-08-27 | 2017-05-24 | 佩普蒂梅德股份有限公司 | 抗肿瘤组合物和方法 |
WO2017118406A1 (en) * | 2016-01-07 | 2017-07-13 | Birdie Biopharmaceuticals, Inc. | Anti-egfr combinations for treating tumors |
CN107074958A (zh) * | 2014-07-09 | 2017-08-18 | 博笛生物科技有限公司 | 用于***的抗‑pd‑l1组合 |
CN107149682A (zh) * | 2016-03-04 | 2017-09-12 | 复旦大学 | 一种靶向cd47的免疫检查点抑制剂药物组合物及其制备方法 |
CN107574149A (zh) * | 2016-07-05 | 2018-01-12 | 上海细胞治疗研究院 | 一种树突状细胞的高效促成熟方法及其用途 |
CN108026533A (zh) * | 2015-09-01 | 2018-05-11 | 中央研究院 | 拮抗性pdl1适体及其在癌症治疗中的应用 |
CN108084265A (zh) * | 2016-11-23 | 2018-05-29 | 复旦大学 | 特异性结合人的5t4抗原的全人源单域抗体及其应用 |
CN108148135A (zh) * | 2015-01-06 | 2018-06-12 | 珠海亿胜生物制药有限公司 | 抗vegf抗体 |
CN108264561A (zh) * | 2016-12-30 | 2018-07-10 | 上海近岸生物科技有限公司 | 一种结合cd19、cd3和t细胞负共刺激分子的三功能分子及其应用 |
CN108264558A (zh) * | 2016-12-30 | 2018-07-10 | 上海近岸生物科技有限公司 | 融合抗cd19、抗cd3抗体结构域和t细胞正共刺激分子配体的三特异性分子及应用 |
CN109069630A (zh) * | 2016-03-30 | 2018-12-21 | 中天生物科技股份有限公司 | 使用免疫检测点调节剂和共生微生物菌丛的发酵产物的结合癌症疗法 |
CN109195988A (zh) * | 2016-01-10 | 2019-01-11 | 尼奥克斯医疗有限公司 | 用于增强超抗原介导的癌症免疫疗法效力的方法和组合物 |
CN109790225A (zh) * | 2016-09-04 | 2019-05-21 | 塔尔格免疫治疗有限公司 | 用于靶向dsRNA的嵌合蛋白 |
CN111840541A (zh) * | 2020-07-03 | 2020-10-30 | 中山大学 | 聚肌苷酸胞苷酸联合抗cd47抗体在肿瘤治疗中的应用 |
CN112384231A (zh) * | 2018-08-26 | 2021-02-19 | 奥伊斯细胞生物技术公司 | 用于治疗胶质母细胞瘤的方法 |
CN112546238A (zh) * | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于***的抗-pd-l1结合物 |
CN113663067A (zh) * | 2021-02-22 | 2021-11-19 | 深圳市康居正医药科技有限公司 | 免疫激活型抗体及其应用 |
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CN102713612B (zh) | 2009-07-02 | 2016-10-05 | 斯隆-凯特林癌症研究院 | 基于二氧化硅的荧光纳米颗粒 |
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US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
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US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
WO2013090648A1 (en) | 2011-12-16 | 2013-06-20 | modeRNA Therapeutics | Modified nucleoside, nucleotide, and nucleic acid compositions |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
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CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
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SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
EP2968536B1 (en) | 2013-03-13 | 2023-06-28 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for modulating chemotherapeutic cytotoxicity |
EP2968621B1 (en) | 2013-03-15 | 2022-08-10 | Memorial Sloan-Kettering Cancer Center | Multimodal silica-based nanoparticles |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
US10323076B2 (en) | 2013-10-03 | 2019-06-18 | Modernatx, Inc. | Polynucleotides encoding low density lipoprotein receptor |
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