BR112012027995A2 - anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl - Google Patents
anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axlInfo
- Publication number
- BR112012027995A2 BR112012027995A2 BR112012027995A BR112012027995A BR112012027995A2 BR 112012027995 A2 BR112012027995 A2 BR 112012027995A2 BR 112012027995 A BR112012027995 A BR 112012027995A BR 112012027995 A BR112012027995 A BR 112012027995A BR 112012027995 A2 BR112012027995 A2 BR 112012027995A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- individual
- inhibiting
- axl
- immunoconjugate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35650810P | 2010-06-18 | 2010-06-18 | |
PCT/US2011/040825 WO2011159980A1 (fr) | 2010-06-18 | 2011-06-17 | Anticorps anti-axl, et procédés d'utilisation. |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012027995A2 true BR112012027995A2 (pt) | 2017-01-10 |
Family
ID=45348557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012027995A BR112012027995A2 (pt) | 2010-06-18 | 2011-06-17 | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
Country Status (13)
Country | Link |
---|---|
US (2) | US8853369B2 (fr) |
EP (2) | EP2582729A4 (fr) |
JP (1) | JP5940061B2 (fr) |
KR (1) | KR101885388B1 (fr) |
CN (1) | CN103080136B (fr) |
AR (1) | AR082017A1 (fr) |
BR (1) | BR112012027995A2 (fr) |
CA (1) | CA2794731C (fr) |
HK (1) | HK1179636A1 (fr) |
MX (1) | MX336001B (fr) |
RU (1) | RU2577986C2 (fr) |
TW (1) | TW201204388A (fr) |
WO (1) | WO2011159980A1 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
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US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
PT2525824T (pt) | 2010-01-22 | 2017-07-13 | Univ Leland Stanford Junior | Inibição da sinalização de axl em terapêutica antimetastática |
US9644717B2 (en) | 2011-03-22 | 2017-05-09 | Bombardier Recreational Products Inc. | Continuously variable transmission driving pulley |
JP6033293B2 (ja) * | 2011-06-22 | 2016-11-30 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) | 抗Axl抗体及びその使用 |
KR20140054268A (ko) | 2011-08-26 | 2014-05-08 | 메리맥 파마슈티컬즈, 인크. | 탠덤 fc 이중특이적 항체 |
US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
CN104955842B (zh) * | 2012-11-05 | 2018-04-10 | 皮埃尔法布雷医药公司 | 抗原结合蛋白及其作为定位产品用于治疗癌症的用途 |
JP6195716B2 (ja) * | 2013-02-15 | 2017-09-13 | 富士レビオ株式会社 | 抗癌剤耐性診断マーカー |
JP2016510755A (ja) | 2013-03-06 | 2016-04-11 | メリマック ファーマシューティカルズ インコーポレーティッド | 抗C−METタンデムFc二重特異性抗体 |
EP2970205B1 (fr) | 2013-03-14 | 2019-05-08 | Tolero Pharmaceuticals, Inc. | Inhibiteurs de jak2 et alk2 et leurs procédés d'utilisation |
WO2015030849A1 (fr) * | 2013-08-30 | 2015-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Liaison à haute affinité à gas6 |
GB201410825D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
ES2774428T3 (es) * | 2014-07-11 | 2020-07-21 | Genmab As | Anticuerpos que se unen a AXL |
EP4074735A1 (fr) | 2014-08-28 | 2022-10-19 | BioAtla, Inc. | Récepteurs d'antigène chimérique conditionnellement actifs pour cellules t modifiées |
CA2909669C (fr) | 2014-10-20 | 2023-12-12 | Ruga Corporation | Activite antivirale de l'inhibiteur gas6 |
EP3229836B1 (fr) | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Anticoprs monoclonaux contre 'axl' |
WO2016097370A2 (fr) * | 2014-12-18 | 2016-06-23 | Bergen Teknologioverføring As | Anticorps antagonistes anti-axl |
GB201506409D0 (en) * | 2015-04-15 | 2015-05-27 | Williams David G And Berkel Patricius H C Van And Howard Philip W | Humanized anti-axl antibodies and their conjugates |
GB201506411D0 (en) * | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
JP2018512892A (ja) * | 2015-04-17 | 2018-05-24 | エルサリー バイオテックElsalysbiotech | 抗tyro3抗体及びその使用 |
WO2016187356A1 (fr) * | 2015-05-18 | 2016-11-24 | Agensys, Inc. | Anticorps qui se lient aux protéines axl |
US10787516B2 (en) | 2015-05-18 | 2020-09-29 | Agensys, Inc. | Antibodies that bind to AXL proteins |
GB201509338D0 (en) * | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
EP3319993B1 (fr) | 2015-07-10 | 2020-01-15 | Genmab A/S | Conjugués anticorps-médicament spécifiques d'axl pour le traitement du cancer |
JP2019505520A (ja) | 2016-01-13 | 2019-02-28 | ゲンマブ エー/エス | 抗体およびその薬物コンジュゲートの製剤 |
CA3021086C (fr) | 2016-04-15 | 2023-10-17 | Bioatla, Llc | Anticorps anti-axl, fragments d'anticorps et leurs immunoconjugues et utilisations associees |
HRP20221298T1 (hr) | 2016-05-13 | 2022-12-23 | Bioatla, Inc. | Anti-ror2 protutijela, fragmenti protutijela, njihovi imunokonjugati i njihove uporabe |
US11306153B2 (en) | 2016-05-20 | 2022-04-19 | Agency For Science, Technology And Research | Anti-AXL tyrosine kinase receptor antibodies and uses thereof |
GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
US11249081B2 (en) | 2016-08-31 | 2022-02-15 | Agency For Science, Technology And Research | Methods for the identification, targeting and isolation of human dendritic cell (DC) precursors “pre-DC” and their uses thereof |
JP7280827B2 (ja) | 2017-01-18 | 2023-05-24 | エクスマ バイオテック コーポレイション | Axlまたはror2に対するキメラ抗原受容体およびその使用方法 |
AU2018253948A1 (en) | 2017-04-20 | 2019-09-19 | Adc Therapeutics Sa | Combination therapy with an anti-AXL Antibody-Drug Conjugate |
BR112020020246A8 (pt) * | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
EA202092448A1 (ru) | 2018-04-10 | 2021-03-05 | Генмаб А/С | Axl-специфичные антитела для лечения онкологических заболеваний |
CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
WO2021013746A1 (fr) | 2019-07-19 | 2021-01-28 | Genmab A/S | Conjugués médicament-anticorps anti-axl destinés à être utilisés dans le traitement du cancer |
GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
WO2021154156A1 (fr) * | 2020-01-31 | 2021-08-05 | Agency For Science, Technology And Research | Anticorps anti-axl et leurs utilisations |
KR20220148237A (ko) | 2020-02-28 | 2022-11-04 | 심포젠 에이/에스 | 항-axl 항체 및 조성물 |
GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
WO2021204713A1 (fr) | 2020-04-08 | 2021-10-14 | Bergenbio Asa | Inhibiteurs d'axl pour thérapie antivirale |
GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
CN114075548B (zh) * | 2020-08-13 | 2023-11-21 | 广州医科大学附属第二医院 | 一种靶向axl的car-t细胞及其制备方法和应用 |
JP2023550043A (ja) * | 2020-11-12 | 2023-11-30 | バイオアトラ インコーポレイテッド | 抗Axl抗体、抗体断片およびそれらの免疫コンジュゲートを用いたAxl発現癌の治療方法 |
JPWO2022149609A1 (fr) * | 2021-01-07 | 2022-07-14 | ||
GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
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-
2011
- 2011-06-17 MX MX2012014535A patent/MX336001B/es unknown
- 2011-06-17 AR ARP110102125A patent/AR082017A1/es unknown
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- 2011-06-17 TW TW100121293A patent/TW201204388A/zh unknown
- 2011-06-17 WO PCT/US2011/040825 patent/WO2011159980A1/fr active Application Filing
- 2011-06-17 EP EP11796485.8A patent/EP2582729A4/fr not_active Withdrawn
- 2011-06-17 BR BR112012027995A patent/BR112012027995A2/pt not_active IP Right Cessation
- 2011-06-17 CA CA2794731A patent/CA2794731C/fr active Active
- 2011-06-17 CN CN201180039943.XA patent/CN103080136B/zh active Active
- 2011-06-17 EP EP15199508.1A patent/EP3098240B1/fr active Active
- 2011-06-17 JP JP2013515538A patent/JP5940061B2/ja active Active
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RU2013102225A (ru) | 2014-07-27 |
CN103080136A (zh) | 2013-05-01 |
US8853369B2 (en) | 2014-10-07 |
HK1179636A1 (zh) | 2013-10-04 |
USRE47761E1 (en) | 2019-12-10 |
KR20130032896A (ko) | 2013-04-02 |
TW201204388A (en) | 2012-02-01 |
CA2794731C (fr) | 2019-03-19 |
MX336001B (es) | 2016-01-07 |
JP2013538553A (ja) | 2013-10-17 |
AR082017A1 (es) | 2012-11-07 |
RU2577986C2 (ru) | 2016-03-20 |
CA2794731A1 (fr) | 2011-12-22 |
EP3098240B1 (fr) | 2021-04-07 |
EP3098240A3 (fr) | 2017-04-05 |
KR101885388B1 (ko) | 2018-08-03 |
JP5940061B2 (ja) | 2016-06-29 |
CN103080136B (zh) | 2015-08-12 |
WO2011159980A1 (fr) | 2011-12-22 |
EP2582729A1 (fr) | 2013-04-24 |
US20130243753A1 (en) | 2013-09-19 |
EP2582729A4 (fr) | 2014-05-28 |
MX2012014535A (es) | 2013-01-29 |
EP3098240A2 (fr) | 2016-11-30 |
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