EA202092448A1 - Axl-специфичные антитела для лечения онкологических заболеваний - Google Patents
Axl-специфичные антитела для лечения онкологических заболеванийInfo
- Publication number
- EA202092448A1 EA202092448A1 EA202092448A EA202092448A EA202092448A1 EA 202092448 A1 EA202092448 A1 EA 202092448A1 EA 202092448 A EA202092448 A EA 202092448A EA 202092448 A EA202092448 A EA 202092448A EA 202092448 A1 EA202092448 A1 EA 202092448A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- axl
- specific antibodies
- oncological diseases
- cell death
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Настоящее изобретение относится к анти-AXL антителам, иммуноконъюгатам и композициям для лечения рака, который устойчив к лечению ингибитором рецептора 1 запрограммированной гибели клеток/лиганда 1 запрограммированной гибели клеток (PD-1/PD-L1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862655417P | 2018-04-10 | 2018-04-10 | |
PCT/EP2019/059171 WO2019197506A1 (en) | 2018-04-10 | 2019-04-10 | Axl-specific antibodies for cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202092448A1 true EA202092448A1 (ru) | 2021-03-05 |
Family
ID=66182546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092448A EA202092448A1 (ru) | 2018-04-10 | 2019-04-10 | Axl-специфичные антитела для лечения онкологических заболеваний |
Country Status (10)
Country | Link |
---|---|
US (1) | US20210070869A1 (ru) |
EP (1) | EP3774904A1 (ru) |
JP (1) | JP2021521143A (ru) |
CN (1) | CN112218895A (ru) |
AU (1) | AU2019250443A1 (ru) |
CA (1) | CA3095986A1 (ru) |
EA (1) | EA202092448A1 (ru) |
IL (1) | IL277861A (ru) |
MA (1) | MA52657A (ru) |
WO (1) | WO2019197506A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113474360A (zh) | 2019-02-18 | 2021-10-01 | 伊莱利利公司 | 治疗性抗体制剂 |
EP3999542A1 (en) * | 2019-07-19 | 2022-05-25 | Genmab A/S | Axl antibody-drug conjugates for use in treating cancer |
CN115023237A (zh) * | 2020-01-14 | 2022-09-06 | 艾达普特免疫有限公司 | 癌症或肿瘤的治疗方法 |
CA3170975A1 (en) * | 2020-02-28 | 2021-09-02 | Symphogen A/S | Anti-axl antibodies and compositions |
WO2022269605A1 (en) | 2021-06-24 | 2022-12-29 | Yeda Research And Development Co. Ltd. | Combination therapy for the treatment of cancer comprising an anti-egfr antibody and an axl-inhibitor |
IL289525B2 (en) * | 2021-12-30 | 2023-03-01 | B G Negev Technologies And Applications Ltd At Ben Gurion Univ | Conjugated antibodies for cancer treatment |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2631184A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
AR069333A1 (es) | 2007-11-15 | 2010-01-13 | Chugai Pharmaceutical Co Ltd | Anticuerpos monoclonales que se unen al receptor tirosin quinasa anexelekto (axl), hibridomas que los producen y sus usos |
KR20120024763A (ko) | 2009-05-15 | 2012-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항axl 항체 |
CN103080136B (zh) | 2010-06-18 | 2015-08-12 | 霍夫曼-拉罗奇有限公司 | 抗Axl抗体及使用方法 |
KR20140104944A (ko) | 2011-06-22 | 2014-08-29 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 항-axl 항체 및 그의 용도 |
US9409988B2 (en) | 2011-06-22 | 2016-08-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Axl antibodies and uses thereof |
EP2589609A1 (en) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
WO2013090776A1 (en) | 2011-12-15 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl/gas6 signaling in the treatment of disease |
JP2016518382A (ja) | 2013-04-26 | 2016-06-23 | ピエール、ファーブル、メディカマン | Axl抗体薬物複合体および癌の治療のためのその使用 |
UA127198C2 (uk) * | 2014-07-11 | 2023-06-07 | Ґенмаб А/С | Антитіло, яке зв'язує axl |
US10208121B2 (en) * | 2014-12-18 | 2019-02-19 | Bergen Teknologioverforing As | Anti-Axl antagonistic antibodies |
CN108368171A (zh) * | 2015-07-10 | 2018-08-03 | 根马布股份公司 | 用于癌症治疗的axl特异性抗体-药物缀合物 |
JP6885390B2 (ja) * | 2016-02-26 | 2021-06-16 | 小野薬品工業株式会社 | Axl阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬 |
EP3481868A1 (en) * | 2016-07-08 | 2019-05-15 | Genmab A/S | New dosage regimens for antibody drug conjugates based on anti-axl antibodies |
-
2019
- 2019-04-10 MA MA052657A patent/MA52657A/fr unknown
- 2019-04-10 CA CA3095986A patent/CA3095986A1/en active Pending
- 2019-04-10 EP EP19717837.9A patent/EP3774904A1/en active Pending
- 2019-04-10 JP JP2020555310A patent/JP2021521143A/ja active Pending
- 2019-04-10 CN CN201980037687.7A patent/CN112218895A/zh active Pending
- 2019-04-10 EA EA202092448A patent/EA202092448A1/ru unknown
- 2019-04-10 WO PCT/EP2019/059171 patent/WO2019197506A1/en unknown
- 2019-04-10 US US17/046,199 patent/US20210070869A1/en active Pending
- 2019-04-10 AU AU2019250443A patent/AU2019250443A1/en not_active Abandoned
-
2020
- 2020-10-07 IL IL277861A patent/IL277861A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN112218895A (zh) | 2021-01-12 |
JP2021521143A (ja) | 2021-08-26 |
WO2019197506A9 (en) | 2019-12-05 |
EP3774904A1 (en) | 2021-02-17 |
WO2019197506A1 (en) | 2019-10-17 |
AU2019250443A1 (en) | 2020-10-22 |
MA52657A (fr) | 2021-02-17 |
IL277861A (en) | 2020-11-30 |
CA3095986A1 (en) | 2019-10-17 |
US20210070869A1 (en) | 2021-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202092448A1 (ru) | Axl-специфичные антитела для лечения онкологических заболеваний | |
EA201791621A1 (ru) | 3-замещенные-1,2,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов | |
CY1124891T1 (el) | Pd-1/pd-l1 αναστολεις | |
EA201990997A1 (ru) | Двойные ингибиторы vista и путей pd-1 | |
EA201990912A1 (ru) | Анти-lag-3 антитела и их композиции | |
EA201791628A1 (ru) | Терапевтические циклические соединения в качестве иммуномодуляторов | |
EA202092590A1 (ru) | Пиридазиноны в качестве ингибиторов parp7 | |
EA201791634A1 (ru) | 3-замещенные 1,3,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов | |
CO2018003500A2 (es) | Anticuerpos anti-pd-1 y composiciones | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
EA201991214A1 (ru) | Антитела против pd-1 и их композиции | |
EA201791629A1 (ru) | 1,3,4-оксадиазольные и тиадиазольные соединения в качестве иммуномодуляторов | |
EA201691487A1 (ru) | Антитела человека к pd-l1 | |
MA50949B1 (fr) | Anticorps anti-ctla-4 et leurs procédés d'utilisation | |
MA40074A (fr) | Composés liant ras multivalents | |
EA201792231A1 (ru) | Ингибиторы индоламин-2,3-диоксигеназы и способы их применения | |
EA201691725A1 (ru) | Соединения для лечения опосредованных комплементом нарушений | |
MX2017015811A (es) | Tratamiento de cancer por bloqueo combinado de las trayectorias de señalizacion de muerte programada 1 (pd)-1 y receptor 4 de quimiocina c-x-c(cxcr4). | |
MX2019009772A (es) | Anticuerpos anti-pd-1 para el tratamiento del cancer de pulmon. | |
EA202090746A1 (ru) | Двойные ингибиторы путей tim-3 и pd-1 | |
MD3728207T2 (ro) | Chinazolinone ca inhibitori PARP14 | |
EA201791049A1 (ru) | Комбинация анти-cs1 и анти-pd1 антител для лечения рака (миеломы) | |
EA201892475A1 (ru) | Оксабороловые сложные эфиры, их применение | |
EA202190588A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина | |
EA202191476A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина |