ATE337296T1 - Verbindungen für die modulation der proliferation von zellen - Google Patents

Verbindungen für die modulation der proliferation von zellen

Info

Publication number
ATE337296T1
ATE337296T1 AT01921087T AT01921087T ATE337296T1 AT E337296 T1 ATE337296 T1 AT E337296T1 AT 01921087 T AT01921087 T AT 01921087T AT 01921087 T AT01921087 T AT 01921087T AT E337296 T1 ATE337296 T1 AT E337296T1
Authority
AT
Austria
Prior art keywords
compounds
cell proliferation
modulating cell
modulating
styrylacrylonitrile
Prior art date
Application number
AT01921087T
Other languages
English (en)
Inventor
Chaim M Roifman
Thomas Grunberger
Olga Rounova
Peter Demin
Nigel Sharfe
Original Assignee
Hsc Res Dev Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hsc Res Dev Lp filed Critical Hsc Res Dev Lp
Application granted granted Critical
Publication of ATE337296T1 publication Critical patent/ATE337296T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
AT01921087T 2000-04-13 2001-04-12 Verbindungen für die modulation der proliferation von zellen ATE337296T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19693600P 2000-04-13 2000-04-13

Publications (1)

Publication Number Publication Date
ATE337296T1 true ATE337296T1 (de) 2006-09-15

Family

ID=22727358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01921087T ATE337296T1 (de) 2000-04-13 2001-04-12 Verbindungen für die modulation der proliferation von zellen

Country Status (18)

Country Link
US (3) US6800659B2 (de)
EP (1) EP1272457B9 (de)
JP (1) JP2003531133A (de)
CN (1) CN100413845C (de)
AT (1) ATE337296T1 (de)
AU (2) AU2001248201B2 (de)
BR (1) BR0110087A (de)
CA (1) CA2406160A1 (de)
CY (1) CY1106447T1 (de)
DE (1) DE60122484T2 (de)
DK (1) DK1272457T3 (de)
ES (1) ES2267747T3 (de)
GB (1) GB2378948B (de)
HK (1) HK1052496A1 (de)
MX (1) MXPA02010089A (de)
PT (1) PT1272457E (de)
RU (1) RU2277531C9 (de)
WO (1) WO2001079158A2 (de)

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CN100413845C (zh) 2000-04-13 2008-08-27 Hsc研究与开发有限合伙公司 调节细胞增生的化合物
CA2463133A1 (en) * 2001-10-11 2003-04-17 The Hospital For Sick Children Styryl acrylonitrile compounds and their use to promote myelopoiesis
WO2003062190A1 (en) 2002-01-18 2003-07-31 The Hospital For Sick Children Compounds for modulating cell proliferation
AU2003273702A1 (en) * 2002-10-11 2004-05-04 The Hospital For Sick Children Styrylacrylonitrile compounds for inhibition of vascular endothelial growth factor
CH696238A5 (de) * 2003-06-30 2007-02-28 Lymphosign Inc Verfahren zur Herstellung von Zimtaldehydverbindungen.
EP1654220A4 (de) * 2003-07-30 2006-10-25 Hospital For Sick Children Verbindungen zur modulierung der zellproliferation
EP1727822A4 (de) * 2004-03-26 2007-05-09 Hsc Res Dev Lp Neue verbindungen zur modulation der zellproliferation
US7807719B2 (en) 2004-09-14 2010-10-05 Chaim Roifman Compounds useful for modulating abnormal cell proliferation
US7202383B2 (en) 2004-09-14 2007-04-10 The Hospital For Sick Children Compounds useful for modulating abnormal cell proliferation
ES2565929T3 (es) 2004-10-25 2016-04-07 Dekk-Tec, Inc. Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales
WO2007006143A1 (en) * 2005-07-13 2007-01-18 The Hospital For Sick Children Compositions and methods for detecting transformed cells
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
JP2009540010A (ja) * 2006-06-13 2009-11-19 エラン ファーマ インターナショナル，リミティド ナノ粒子状のキナーゼインヒビター製剤
EP2581367B1 (de) 2007-04-06 2015-12-30 Ziopharm Oncology, Inc. Salze von Isophosphoramid-Senf und Analoga davon
US8450337B2 (en) * 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
JPWO2013027694A1 (ja) * 2011-08-24 2015-03-19 国立大学法人京都大学 コンフォメーション病診断用分子イメージングプローブ

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Also Published As

Publication number Publication date
GB2378948A (en) 2003-02-26
MXPA02010089A (es) 2004-08-19
DE60122484T2 (de) 2006-12-21
CA2406160A1 (en) 2001-10-25
CY1106447T1 (el) 2011-10-12
JP2003531133A (ja) 2003-10-21
CN1429202A (zh) 2003-07-09
DE60122484D1 (de) 2006-10-05
RU2277531C9 (ru) 2006-11-20
EP1272457B1 (de) 2006-08-23
GB0226316D0 (en) 2002-12-18
CN100413845C (zh) 2008-08-27
EP1272457B9 (de) 2006-12-20
AU4820101A (en) 2001-10-30
GB2378948B (en) 2004-11-10
ES2267747T3 (es) 2007-03-16
US20040072803A1 (en) 2004-04-15
RU2002127415A (ru) 2004-02-27
RU2277531C2 (ru) 2006-06-10
AU2001248201B2 (en) 2006-12-14
US7012095B2 (en) 2006-03-14
WO2001079158A2 (en) 2001-10-25
WO2001079158A3 (en) 2002-01-31
PT1272457E (pt) 2007-01-31
DK1272457T3 (da) 2007-01-08
US6800659B2 (en) 2004-10-05
HK1052496A1 (en) 2003-09-19
BR0110087A (pt) 2004-02-17
US20040209845A1 (en) 2004-10-21
US20030109502A1 (en) 2003-06-12
EP1272457A2 (de) 2003-01-08

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