ATE257375T1 - Schmelzextrudierte oral verabreichbare opioidformulierungen - Google Patents
Schmelzextrudierte oral verabreichbare opioidformulierungenInfo
- Publication number
- ATE257375T1 ATE257375T1 AT95939928T AT95939928T ATE257375T1 AT E257375 T1 ATE257375 T1 AT E257375T1 AT 95939928 T AT95939928 T AT 95939928T AT 95939928 T AT95939928 T AT 95939928T AT E257375 T1 ATE257375 T1 AT E257375T1
- Authority
- AT
- Austria
- Prior art keywords
- opioid formulations
- oral opioid
- melts extruded
- melts
- extruded oral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/02—Making granules by dividing preformed material
- B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/334,209 US5965161A (en) | 1994-11-04 | 1994-11-04 | Extruded multi-particulates |
PCT/US1995/014745 WO1996014058A1 (en) | 1994-11-04 | 1995-11-03 | Melt-extruded orally administrable opioid formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE257375T1 true ATE257375T1 (de) | 2004-01-15 |
Family
ID=23306123
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04012331T ATE357909T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
AT03015267T ATE452627T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
AT06123277T ATE397441T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare hydromorphoneformulierungen |
AT04012330T ATE356616T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
AT95939928T ATE257375T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04012331T ATE357909T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
AT03015267T ATE452627T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
AT06123277T ATE397441T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare hydromorphoneformulierungen |
AT04012330T ATE356616T1 (de) | 1994-11-04 | 1995-11-03 | Schmelzextrudierte oral verabreichbare opioidformulierungen |
Country Status (17)
Country | Link |
---|---|
US (11) | US5965161A (de) |
EP (7) | EP1488786A1 (de) |
JP (1) | JP3186064B2 (de) |
KR (1) | KR100232945B1 (de) |
AT (5) | ATE357909T1 (de) |
AU (1) | AU705894B2 (de) |
CA (1) | CA2204180C (de) |
DE (5) | DE69535426T2 (de) |
DK (5) | DK1741426T3 (de) |
ES (5) | ES2282756T3 (de) |
HK (3) | HK1069109A1 (de) |
HU (1) | HUT77626A (de) |
IL (5) | IL115871A (de) |
PT (5) | PT1741426E (de) |
TW (1) | TW425288B (de) |
WO (1) | WO1996014058A1 (de) |
ZA (1) | ZA959367B (de) |
Families Citing this family (332)
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US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
US5914131A (en) * | 1994-07-07 | 1999-06-22 | Alza Corporation | Hydromorphone therapy |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US20020006438A1 (en) * | 1998-09-25 | 2002-01-17 | Benjamin Oshlack | Sustained release hydromorphone formulations exhibiting bimodal characteristics |
DE19531277A1 (de) | 1995-08-25 | 1997-02-27 | Basf Ag | Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
DE19539360A1 (de) * | 1995-10-23 | 1997-04-24 | Basf Ag | Verfahren zur Herstellung von festen Arzneiformen |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
JPH1050306A (ja) * | 1996-07-31 | 1998-02-20 | Toyota Autom Loom Works Ltd | 水素吸蔵合金電極の製造方法 |
PL191399B1 (pl) * | 1996-10-28 | 2006-05-31 | Gen Mills Inc | Sposób kapsułkowania lub osadzania składnika w osnowie w procesie ciągłym, sposób kapsułkowania i/lub osadzania składników w osnowie opartej na węglowodanach, sposób kapsułkowania i/lub osadzania składników w osnowie oraz kapsułka |
EP1342548B1 (de) * | 1996-10-28 | 2015-12-23 | General Mills, Inc. | Einbettung und Einkapselung von Teilchen zur kontrollierten Abgabe und eingekapseltes Produkt |
BE1010803A3 (fr) * | 1996-12-16 | 1999-02-02 | Therabel Research Sa | Comprimes pharmaceutiques a liberation prolongee a base de tramadol et leur preparation. |
US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
ES2263211T3 (es) | 1997-07-02 | 2006-12-01 | Euro-Celtique S.A. | Formulaciones de tramadol de liberacion sostenida estabilizada. |
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US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
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US6274591B1 (en) | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
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JP2001526229A (ja) * | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク,エス.エイ. | オピオイド投薬剤形の乱用を防止する方法 |
ES2412409T3 (es) | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
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US6074689A (en) * | 1998-03-10 | 2000-06-13 | Immucell Corporation | Colonic delivery of protein or peptide compositions |
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SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
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US7429407B2 (en) * | 1998-12-30 | 2008-09-30 | Aeromatic Fielder Ag | Process for coating small bodies, including tablets |
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DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
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1995
- 1995-11-03 ES ES04012330T patent/ES2282756T3/es not_active Expired - Lifetime
- 1995-11-03 IL IL11587195A patent/IL115871A/xx not_active IP Right Cessation
- 1995-11-03 DE DE69535426T patent/DE69535426T2/de not_active Expired - Lifetime
- 1995-11-03 PT PT06123277T patent/PT1741426E/pt unknown
- 1995-11-03 DK DK06123277T patent/DK1741426T3/da active
- 1995-11-03 DE DE69532415T patent/DE69532415T3/de not_active Expired - Lifetime
- 1995-11-03 DK DK03015267.2T patent/DK1348429T3/da active
- 1995-11-03 IL IL14241395A patent/IL142413A/en not_active IP Right Cessation
- 1995-11-03 EP EP04022651A patent/EP1488786A1/de not_active Ceased
- 1995-11-03 WO PCT/US1995/014745 patent/WO1996014058A1/en active IP Right Grant
- 1995-11-03 DE DE69535767T patent/DE69535767D1/de not_active Expired - Lifetime
- 1995-11-03 EP EP04012331A patent/EP1449531B1/de not_active Expired - Lifetime
- 1995-11-03 EP EP10177509A patent/EP2283816A1/de not_active Ceased
- 1995-11-03 ES ES03015267T patent/ES2338641T3/es not_active Expired - Lifetime
- 1995-11-03 DE DE69536035T patent/DE69536035D1/de not_active Expired - Lifetime
- 1995-11-03 ES ES04012331T patent/ES2282757T3/es not_active Expired - Lifetime
- 1995-11-03 AT AT04012331T patent/ATE357909T1/de not_active IP Right Cessation
- 1995-11-03 PT PT04012330T patent/PT1449530E/pt unknown
- 1995-11-03 EP EP03015267A patent/EP1348429B1/de not_active Expired - Lifetime
- 1995-11-03 PT PT95939928T patent/PT785775E/pt unknown
- 1995-11-03 HU HU9800457A patent/HUT77626A/hu active IP Right Revival
- 1995-11-03 PT PT04012331T patent/PT1449531E/pt unknown
- 1995-11-03 PT PT03015267T patent/PT1348429E/pt unknown
- 1995-11-03 DK DK95939928.8T patent/DK0785775T4/da active
- 1995-11-03 EP EP06123277A patent/EP1741426B1/de not_active Expired - Lifetime
- 1995-11-03 ES ES06123277T patent/ES2308675T3/es not_active Expired - Lifetime
- 1995-11-03 AT AT03015267T patent/ATE452627T1/de not_active IP Right Cessation
- 1995-11-03 EP EP04012330A patent/EP1449530B1/de not_active Expired - Lifetime
- 1995-11-03 KR KR1019970702984A patent/KR100232945B1/ko not_active IP Right Cessation
- 1995-11-03 AT AT06123277T patent/ATE397441T1/de not_active IP Right Cessation
- 1995-11-03 CA CA002204180A patent/CA2204180C/en not_active Expired - Lifetime
- 1995-11-03 IL IL12941095A patent/IL129410A/xx not_active IP Right Cessation
- 1995-11-03 IL IL159766A patent/IL159766A/en not_active IP Right Cessation
- 1995-11-03 DE DE69535445T patent/DE69535445T2/de not_active Expired - Lifetime
- 1995-11-03 AU AU41570/96A patent/AU705894B2/en not_active Expired
- 1995-11-03 ES ES95939928T patent/ES2214512T3/es not_active Expired - Lifetime
- 1995-11-03 JP JP51553796A patent/JP3186064B2/ja not_active Expired - Lifetime
- 1995-11-03 EP EP95939928A patent/EP0785775B2/de not_active Expired - Lifetime
- 1995-11-03 AT AT04012330T patent/ATE356616T1/de not_active IP Right Cessation
- 1995-11-03 DK DK04012330T patent/DK1449530T3/da active
- 1995-11-03 AT AT95939928T patent/ATE257375T1/de active
- 1995-11-03 DK DK04012331T patent/DK1449531T3/da active
- 1995-11-06 ZA ZA959367A patent/ZA959367B/xx unknown
-
1996
- 1996-02-09 TW TW085101623A patent/TW425288B/zh not_active IP Right Cessation
-
1997
- 1997-04-10 US US08/833,948 patent/US5958452A/en not_active Expired - Lifetime
-
1999
- 1999-07-22 US US09/358,828 patent/US6335033B2/en not_active Expired - Lifetime
- 1999-07-23 US US09/360,056 patent/US6261599B1/en not_active Expired - Lifetime
-
2001
- 2001-02-06 US US09/777,616 patent/US6743442B2/en not_active Expired - Fee Related
-
2002
- 2002-01-02 US US10/038,867 patent/US6706281B2/en not_active Expired - Fee Related
-
2003
- 2003-09-16 US US10/664,602 patent/US20050089568A1/en not_active Abandoned
- 2003-10-21 US US10/690,389 patent/US20040081694A1/en not_active Abandoned
- 2003-12-23 US US10/745,950 patent/US7510727B2/en not_active Expired - Fee Related
-
2004
- 2004-01-08 IL IL15976604A patent/IL159766A0/xx active IP Right Grant
- 2004-02-27 HK HK05101624A patent/HK1069109A1/xx not_active IP Right Cessation
- 2004-02-27 HK HK05101625A patent/HK1069110A1/xx not_active IP Right Cessation
- 2004-02-27 HK HK04101468.7A patent/HK1059887A1/xx not_active IP Right Cessation
-
2009
- 2009-02-17 US US12/372,460 patent/US20090148517A1/en not_active Abandoned
-
2010
- 2010-03-12 US US12/722,974 patent/US20100172974A1/en not_active Abandoned
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