AR247403A1 - Procedimiento para la preparacion de nuevos acetilen, ciano y alenil derivados de adenosina, utiles como agentes antivirales y antineoplasicos - Google Patents

Procedimiento para la preparacion de nuevos acetilen, ciano y alenil derivados de adenosina, utiles como agentes antivirales y antineoplasicos

Info

Publication number
AR247403A1
AR247403A1 AR89313479A AR31347989A AR247403A1 AR 247403 A1 AR247403 A1 AR 247403A1 AR 89313479 A AR89313479 A AR 89313479A AR 31347989 A AR31347989 A AR 31347989A AR 247403 A1 AR247403 A1 AR 247403A1
Authority
AR
Argentina
Prior art keywords
hydrogen
hydroxy
cyano
adenosine derivatives
derivatives
Prior art date
Application number
AR89313479A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of AR247403A1 publication Critical patent/AR247403A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ADENOSINA DE FORMULA (1), EN LA QUE R1 ES ETINILO O CIANO Y X ES HIDROGENO O R1 Y X JUNTO CON EL ATOMO DE CARBONO ADYACENTE CORRESPONDEN A UN GRUPO ALQUILIDENO; A1 Y A2, SON HIDROGENO O HIDROXI, CON LAS CONDICIONES DE QUE CUANDO A1 ES HIDROXI A2 SEA HIDROGENO Y QUE CUANDO A2 ES HIDROXI A1 SEA HIDROGENO, O SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE CONSISTE EN TRATAR LOS DERIVADOS DE ADENOSINA DE FORMULA II, DONDE R1, A1, A2, SE DEFINEN COMO ANTES, OB, A1B Y A2B REPRESENTAN GRUPOS HIDROXI PROTEGIDOS POR UN GRUPO 2', 3'-ALQUILIDEN (C2-C4)CON UN REACTIVO ELEGIDO ENTRE ACIDOS, HALUROS DE PALADIO Y TOLUENSULFONATOS DE PIRIDINIO.
AR89313479A 1988-03-25 1989-03-22 Procedimiento para la preparacion de nuevos acetilen, ciano y alenil derivados de adenosina, utiles como agentes antivirales y antineoplasicos AR247403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,782 US4996308A (en) 1988-03-25 1988-03-25 Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (1)

Publication Number Publication Date
AR247403A1 true AR247403A1 (es) 1994-12-29

Family

ID=22633462

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313479A AR247403A1 (es) 1988-03-25 1989-03-22 Procedimiento para la preparacion de nuevos acetilen, ciano y alenil derivados de adenosina, utiles como agentes antivirales y antineoplasicos

Country Status (21)

Country Link
US (1) US4996308A (es)
EP (1) EP0334361B1 (es)
JP (1) JP2829737B2 (es)
KR (1) KR0135529B1 (es)
CN (1) CN1023804C (es)
AR (1) AR247403A1 (es)
AT (1) ATE121415T1 (es)
AU (1) AU606792B2 (es)
CA (1) CA1322195C (es)
DE (1) DE68922235T2 (es)
DK (1) DK171645B1 (es)
ES (1) ES2074060T3 (es)
FI (1) FI90877C (es)
HU (1) HU203561B (es)
IE (1) IE67543B1 (es)
IL (1) IL89689A0 (es)
NO (1) NO171856C (es)
NZ (1) NZ228422A (es)
PH (1) PH26776A (es)
PT (1) PT90080B (es)
ZA (1) ZA892105B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
ZA907994B (en) * 1989-10-11 1991-07-31 Merrell Dow Pharma Novel inosine/guanosine derivatives
ZA907998B (en) * 1989-10-11 1991-07-31 Merrell Dow Pharma Inosine/guanosine derivatives as antineoplastic agents
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
JPH0421682A (ja) * 1990-05-11 1992-01-24 Asahi Chem Ind Co Ltd ２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
WO1994021659A1 (en) * 1993-03-18 1994-09-29 Yamasa Corporation Novel 2'-methylidenenucleotide compound, process for producing the same, and pharmaceutical use thereof
EP0784624A1 (en) * 1994-10-05 1997-07-23 Chiroscience Limited Purine and guanine compounds as inhibitors of pnp
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
JP2003501391A (ja) * 1999-06-09 2003-01-14 アンチキャンサー， インコーポレイテッド 細菌毒力を制御するためのメチル化のモジュレーター
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
KR20030036189A (ko) * 2000-05-26 2003-05-09 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN102746304B (zh) * 2012-06-21 2014-03-19 成都苑东药业有限公司 一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113851A (en) * 1965-05-29 1968-05-15 Upjohn Co Decoyinine derivatives
US3472837A (en) * 1966-10-10 1969-10-14 Syntex Corp Unsaturated nucleosides and process for their preparation
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3585189A (en) * 1969-06-27 1971-06-15 Syntex Corp Unsaturated nucleosides and processes for their preparation
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
ATE92499T1 (de) * 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
PT90080B (pt) 1994-06-30
IE890953L (en) 1989-09-25
FI891339A (fi) 1989-09-26
PH26776A (en) 1992-10-13
ES2074060T3 (es) 1995-09-01
FI891339A0 (fi) 1989-03-21
EP0334361B1 (en) 1995-04-19
DK145289D0 (da) 1989-03-22
NO171856C (no) 1993-05-12
FI90877C (fi) 1994-04-11
HU203561B (en) 1991-08-28
CN1036579A (zh) 1989-10-25
NO891248D0 (no) 1989-03-21
IL89689A0 (en) 1989-09-28
ZA892105B (en) 1989-11-29
NO891248L (no) 1989-09-26
KR0135529B1 (ko) 1998-04-23
DE68922235T2 (de) 1995-08-31
NO171856B (no) 1993-02-01
AU3173789A (en) 1989-09-28
DE68922235D1 (de) 1995-05-24
CA1322195C (en) 1993-09-14
HUT49367A (en) 1989-09-28
IE67543B1 (en) 1996-04-17
FI90877B (fi) 1993-12-31
DK171645B1 (da) 1997-03-03
JPH01283285A (ja) 1989-11-14
ATE121415T1 (de) 1995-05-15
AU606792B2 (en) 1991-02-14
DK145289A (da) 1989-09-26
EP0334361A3 (en) 1991-04-03
US4996308A (en) 1991-02-26
KR890014573A (ko) 1989-10-24
CN1023804C (zh) 1994-02-16
NZ228422A (en) 1991-04-26
PT90080A (pt) 1989-11-10
EP0334361A2 (en) 1989-09-27
JP2829737B2 (ja) 1998-12-02

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