AR119624A1 - Sales de un inhibidor de pd-1 / pd-l1 - Google Patents

Sales de un inhibidor de pd-1 / pd-l1

Info

Publication number
AR119624A1
AR119624A1 ARP200102263A ARP200102263A AR119624A1 AR 119624 A1 AR119624 A1 AR 119624A1 AR P200102263 A ARP200102263 A AR P200102263A AR P200102263 A ARP200102263 A AR P200102263A AR 119624 A1 AR119624 A1 AR 119624A1
Authority
AR
Argentina
Prior art keywords
methyl
dimethylbiphenyl
oxazol
ylamino
pyrrolidine
Prior art date
Application number
ARP200102263A
Other languages
English (en)
Inventor
Zhongjiang Jia
Pingli Liu
David J Meloni
Yongchun Pan
Yongzhong Wu
Jiacheng Zhou
Qun Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR119624A1 publication Critical patent/AR119624A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Una sal, caracterizada porque se selecciona de: sal del ácido bromhídrico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico; sal del ácido oxálico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico; sal del ácido clorhídrico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico; sal del ácido L-tartárico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico; sal del ácido malónico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico; y sal del ácido fosfórico del ácido (R)-1-((7-ciano-2-(3’-(3-(((R)-3-hidroxipirrolidin-1-il)metil)-1,7-naftiridin-8-ilamino)-2,2’-dimetilbifenil-3-il)benzo[d]oxazol-5-il)metil)pirrolidin-3-carboxílico.
ARP200102263A 2019-08-09 2020-08-07 Sales de un inhibidor de pd-1 / pd-l1 AR119624A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962884996P 2019-08-09 2019-08-09

Publications (1)

Publication Number Publication Date
AR119624A1 true AR119624A1 (es) 2021-12-29

Family

ID=72179251

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102263A AR119624A1 (es) 2019-08-09 2020-08-07 Sales de un inhibidor de pd-1 / pd-l1

Country Status (8)

Country Link
US (1) US11753406B2 (es)
EP (1) EP4010342A1 (es)
JP (1) JP2022544189A (es)
AR (1) AR119624A1 (es)
CA (1) CA3150434A1 (es)
MX (1) MX2022001671A (es)
TW (1) TW202115059A (es)
WO (1) WO2021030162A1 (es)

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AR108396A1 (es) 2016-05-06 2018-08-15 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
CN109890819B (zh) 2016-06-20 2022-11-22 因赛特公司 作为免疫调节剂的杂环化合物
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3504198B1 (en) 2016-08-29 2023-01-25 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2899402T3 (es) 2016-12-22 2022-03-11 Incyte Corp Derivados de piridina como inmunomoduladores
PE20191532A1 (es) 2016-12-22 2019-10-23 Incyte Corp Compuestos heterociclicos como inmunomoduladores
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
US20190292188A1 (en) 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
MX2020010321A (es) 2018-03-30 2021-01-08 Incyte Corp Compuestos heterociclicos como inmunomoduladores.
MX2020012045A (es) 2018-05-11 2021-03-29 Incyte Corp Derivados de tetrahidro-imidazo[4,5-c]piridina como inmunomoduladores de ligando 1 de muerte programada (pd-l1).
CA3100731A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
CA3105721A1 (en) 2018-07-05 2020-01-09 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶
MX2022001671A (es) 2019-08-09 2022-05-13 Incyte Corp Sales de un inhibidor de pd-1/pd-l1.
AR120109A1 (es) 2019-09-30 2022-02-02 Incyte Corp Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores
CN114829366A (zh) 2019-11-11 2022-07-29 因赛特公司 Pd-1/pd-l1抑制剂的盐及结晶形式
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
WO2022099071A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
WO2022133176A1 (en) * 2020-12-18 2022-06-23 Incyte Corporation Oral formulation for a pd-l1 inhibitor

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