AR102977A1 - Inhibidores de erk - Google Patents
Inhibidores de erkInfo
- Publication number
- AR102977A1 AR102977A1 ARP150104045A ARP150104045A AR102977A1 AR 102977 A1 AR102977 A1 AR 102977A1 AR P150104045 A ARP150104045 A AR P150104045A AR P150104045 A ARP150104045 A AR P150104045A AR 102977 A1 AR102977 A1 AR 102977A1
- Authority
- AR
- Argentina
- Prior art keywords
- erk inhibitors
- formulas
- group
- compound selected
- methyl
- Prior art date
Links
- 239000012824 ERK inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) caracterizado porque: R¹ es un compuesto seleccionado del grupo de fórmulas (2); R² y R³ son independientemente metilo o R² y R³ pueden tomarse en conjunto para formar ciclopropilo; R⁴ es hidrógeno, metilo, cloro, fluoro, o trifluorometilo; y R⁵ es un compuesto seleccionado del grupo de fórmulas (3); o una sal del mismo farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095185P | 2014-12-22 | 2014-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102977A1 true AR102977A1 (es) | 2017-04-05 |
Family
ID=55135525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150104045A AR102977A1 (es) | 2014-12-22 | 2015-12-11 | Inhibidores de erk |
Country Status (44)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6427197B2 (ja) | 2013-10-03 | 2018-11-21 | クラ オンコロジー， インコーポレイテッド | Ｅｒｋの阻害剤および使用方法 |
| US9879029B2 (en) | 2014-12-22 | 2018-01-30 | Eli Lilly And Company | ERK inhibitors |
| TWI704151B (zh) * | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| CA3001799A1 (en) | 2015-10-21 | 2017-04-27 | Otsuka Pharmaceutical Co., Ltd. | Benzolactam compounds as protein kinase inhibitors |
| US20200306254A1 (en) * | 2016-06-29 | 2020-10-01 | Eli Lilly And Company | Combination of erk1/2 inhibitor compound with gemcitabine or with gemcitabine and nab-paclitaxel for use in treatment of pancreatic cancer |
| WO2018081204A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | DEUTERATED N-(5-((4-ETHYLPIPERAZIN-1-YL)METHYL) PYRIDIN-2-YL)-5-FLUORO-4-(4-FLUORO-1-ISOPROPYL-2-METHYL-1H-BENZO[d]IMIDAZOL-6-YL)PYRIMIDIN-2-AMINE |
| GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
| EP3713941B1 (en) | 2017-11-24 | 2022-06-22 | Janssen Pharmaceutica NV | Pyrazolopyridinone compounds |
| CN112218634A (zh) * | 2018-04-09 | 2021-01-12 | G1治疗公司 | 具有驱动致癌突变的癌症的治疗 |
| EP3797109A4 (en) * | 2018-05-22 | 2022-02-23 | JS Innomed Holdings Ltd. | HETEROCYCLIC COMPOUNDS USED AS KINASE INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF |
| EP3903828A4 (en) | 2018-12-21 | 2022-10-05 | Daiichi Sankyo Company, Limited | COMBINATION OF AN ANTIBODY-DRUG CONJUGATE AND A KINASE INHIBITOR |
| ES2944857T3 (es) * | 2019-03-27 | 2023-06-26 | Lilly Co Eli | Sales del compuesto 5,6-dihidro-4H-tieno[2,3-c]pirrol-4-ona como inhibidores de ERK |
| JP2022527744A (ja) * | 2019-03-28 | 2022-06-06 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | チエノ複素環式誘導体、この誘導体のための調製方法及び医療に関するこの誘導体の使用 |
| KR20210146956A (ko) * | 2019-03-29 | 2021-12-06 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 피롤로헤테로고리형 유도체, 이의 제조 방법, 및 의약에서 이의 응용 |
| WO2020231976A1 (en) * | 2019-05-16 | 2020-11-19 | Eli Lilly And Company | Triple combination of an erk1/2 inhibitor with a braf inhibitor and an egfr inhibitor for use in the treatment of brafv600e colorectal cancer |
| CN112457326B (zh) * | 2019-09-06 | 2022-02-15 | 上海凌达生物医药有限公司 | 一类芳香杂环并内酰胺类化合物、制备方法和用途 |
| AU2020394767B2 (en) * | 2019-12-06 | 2023-05-25 | D3 Bio (Wuxi) Co., Ltd. | Spiro compound serving as ERK inhibitor, and application thereof |
| CN110950876B (zh) * | 2019-12-10 | 2021-08-17 | 上海凌达生物医药有限公司 | 一类呋喃并内酰胺类化合物、制备方法和用途 |
| WO2021216777A1 (en) * | 2020-04-21 | 2021-10-28 | The Trustees Of The Stevens Institute Of Technology | Erk inhibitors for cancer therapy |
| CN114315837B (zh) * | 2020-09-29 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 一种erk抑制剂的结晶形式及其制备方法 |
| AU2021354821A1 (en) * | 2020-09-29 | 2023-06-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Crystal form of pyrrolo heterocyclic derivative and preparation method therefor |
| JP2024526242A (ja) * | 2021-06-28 | 2024-07-17 | 徳昇済医薬（無錫）有限公司 | チアゾール－ラクタム－スピロ複素環化合物及びその適用 |
| CA3238655A1 (en) * | 2021-11-15 | 2023-05-19 | Erasca, Inc. | Thiophene ulk1/2 inhibitors and their use thereof |
| WO2023137297A2 (en) * | 2022-01-11 | 2023-07-20 | Suvalent Therapeutics, Inc. | 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo inhibitors and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4023048A1 (de) * | 1990-07-20 | 1992-01-23 | Basf Ag | Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| MXPA03002294A (es) * | 2000-09-15 | 2005-09-08 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de proteina cinasa. |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ATE510561T1 (de) | 2002-03-04 | 2011-06-15 | Imclone Llc | Kdr-spezifische menschliche antikörper und ihre verwendung |
| AU2003295396B2 (en) * | 2002-11-04 | 2009-02-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl-pyramidine derivatives as JAK inhibitors |
| UA80571C2 (en) | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
| JP2009519218A (ja) * | 2005-11-03 | 2009-05-14 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | ピリミジニル−チオフェンキナーゼモジュレータ |
| EP2326627A1 (en) | 2008-08-20 | 2011-06-01 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| EP2346860B1 (en) * | 2008-10-08 | 2012-09-19 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
| PA8852901A1 (es) * | 2008-12-22 | 2010-07-27 | Lilly Co Eli | Inhibidores de proteina cinasa |
| WO2012030990A1 (en) * | 2010-09-01 | 2012-03-08 | Gilead Connecticut, Inc. | Pyridazinones, method of making, and method of use thereof |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| RS61500B1 (sr) | 2012-03-01 | 2021-03-31 | Array Biopharma Inc | Inhibitori serinske/treoninske kinaze |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| MX2015003895A (es) * | 2012-09-28 | 2015-07-17 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden aglutinantes duales de angiopoyetina-2/dll4 y agentes anti-vegf-r. |
| US9879029B2 (en) * | 2014-12-22 | 2018-01-30 | Eli Lilly And Company | ERK inhibitors |
| TWI704151B (zh) * | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
-
2015
- 2015-12-09 TW TW104141368A patent/TWI704151B/zh not_active IP Right Cessation
- 2015-12-10 JO JOP/2015/0310A patent/JO3596B1/ar active
- 2015-12-11 AR ARP150104045A patent/AR102977A1/es unknown
- 2015-12-16 JP JP2017533381A patent/JP6445701B2/ja active Active
- 2015-12-16 TR TR2019/09887T patent/TR201909887T4/tr unknown
- 2015-12-16 NZ NZ731531A patent/NZ731531A/en not_active IP Right Cessation
- 2015-12-16 EA EA201791133A patent/EA031659B1/ru not_active IP Right Cessation
- 2015-12-16 TN TN2017000233A patent/TN2017000233A1/en unknown
- 2015-12-16 ME MEP-2019-201A patent/ME03490B/me unknown
- 2015-12-16 DK DK15823869.1T patent/DK3237423T3/da active
- 2015-12-16 CA CA2966559A patent/CA2966559C/en active Active
- 2015-12-16 PT PT15823869T patent/PT3237423T/pt unknown
- 2015-12-16 PE PE2017001109A patent/PE20171043A1/es unknown
- 2015-12-16 SG SG11201704521SA patent/SG11201704521SA/en unknown
- 2015-12-16 MD MDE20170231 patent/MD3237423T2/ro unknown
- 2015-12-16 SI SI201530773T patent/SI3237423T1/sl unknown
- 2015-12-16 HU HUE15823869A patent/HUE045933T2/hu unknown
- 2015-12-16 WO PCT/US2015/065940 patent/WO2016106029A1/en active Application Filing
- 2015-12-16 LT LTEP15823869.1T patent/LT3237423T/lt unknown
- 2015-12-16 US US14/970,588 patent/US9469652B2/en not_active Ceased
- 2015-12-16 RS RS20190906A patent/RS59015B1/sr unknown
- 2015-12-16 CN CN201580070315.6A patent/CN107108648B/zh active Active
- 2015-12-16 ES ES15823869T patent/ES2738406T3/es active Active
- 2015-12-16 AU AU2015369983A patent/AU2015369983C1/en not_active Ceased
- 2015-12-16 EP EP15823869.1A patent/EP3237423B1/en active Active
- 2015-12-16 MX MX2017008242A patent/MX371206B/es active IP Right Grant
- 2015-12-16 CR CR20170182A patent/CR20170182A/es unknown
- 2015-12-16 UA UAA201706046A patent/UA119686C2/uk unknown
- 2015-12-16 MY MYPI2017702263A patent/MY178426A/en unknown
- 2015-12-16 PL PL15823869T patent/PL3237423T3/pl unknown
- 2015-12-16 KR KR1020177016748A patent/KR101917972B1/ko active IP Right Grant
- 2015-12-16 BR BR112017011130A patent/BR112017011130A2/pt active Search and Examination
- 2015-12-16 MA MA41251A patent/MA41251B1/fr unknown
-
2016
- 2016-09-08 US US15/259,381 patent/US9526733B1/en active Active
-
2017
- 2017-04-20 ZA ZA2017/02786A patent/ZA201702786B/en unknown
- 2017-05-01 IL IL252065A patent/IL252065B/en active IP Right Grant
- 2017-05-15 SV SV2017005443A patent/SV2017005443A/es unknown
- 2017-05-16 DO DO2017000122A patent/DOP2017000122A/es unknown
- 2017-05-25 CO CONC2017/0005217A patent/CO2017005217A2/es unknown
- 2017-06-13 CL CL2017001514A patent/CL2017001514A1/es unknown
- 2017-06-19 GT GT201700134A patent/GT201700134A/es unknown
- 2017-06-20 PH PH12017501155A patent/PH12017501155B1/en unknown
- 2017-06-22 EC ECIEPI201738500A patent/ECSP17038500A/es unknown
-
2019
- 2019-05-22 US US16/419,141 patent/USRE48635E1/en active Active
- 2019-07-15 HR HRP20191268 patent/HRP20191268T1/hr unknown
- 2019-07-23 CY CY20191100777T patent/CY1121831T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR102977A1 (es) | Inhibidores de erk | |
| FR3020060B1 (fr) | Preparation d'imides contenant un groupement fluorosulfonyle | |
| NI201700020A (es) | Compuestos de aminopirimidinilo como inhibidores de jak | |
| EA201692203A1 (ru) | Соединения, ингибирующие tank-связывающую киназу | |
| CL2017001017A1 (es) | Nuevos compuestos de metil-piperidina útiles para inhibir la sintasa-1 de prostaglandina microsomal e2 | |
| CR20160564A (es) | Dinucleótidos cíclicos como moduladores de sting | |
| TW201613872A (en) | IRAK4 inhibiting agents | |
| AR094918A1 (es) | Compuestos de tetrahidropirrolotiazina como inhibidores de bace | |
| EA201791256A1 (ru) | Производные хиназолина, применяемые для лечения вич | |
| EA201790202A1 (ru) | Фталазиноны и изохинолиноны в качестве ингибиторов rock | |
| EA201790395A1 (ru) | Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы | |
| EA201790062A1 (ru) | Спироциклогептаны как ингибиторы rock | |
| EA201690172A1 (ru) | Полиморф ингибиторов syk | |
| EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
| AR103680A1 (es) | Inhibidores selectivos de bace1 | |
| AR105549A1 (es) | Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo y usos de los mismos | |
| CY1122264T1 (el) | Ppar ενωσεις για χρηση στην αντιμετωπιση των ινωτικων νοσων | |
| AR101815A1 (es) | Compuestos y composiciones como inhibidores de quinasa | |
| EA201500801A1 (ru) | Бензохинолоновые ингибиторы vmat2 | |
| EA201691670A1 (ru) | Тетразолонзамещенные дигидропиридиноновые ингибиторы mgat2 | |
| EA201691983A1 (ru) | Пиридин-2-амиды, пригодные в качестве агонистов cb2 | |
| AR102957A1 (es) | Combinaciones de compuestos activos | |
| AR105821A1 (es) | COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T | |
| AR100439A1 (es) | Derivados de carboxamida | |
| EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |