EA201790062A1 - Спироциклогептаны как ингибиторы rock - Google Patents

Спироциклогептаны как ингибиторы rock

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Publication number
EA201790062A1
EA201790062A1 EA201790062A EA201790062A EA201790062A1 EA 201790062 A1 EA201790062 A1 EA 201790062A1 EA 201790062 A EA201790062 A EA 201790062A EA 201790062 A EA201790062 A EA 201790062A EA 201790062 A1 EA201790062 A1 EA 201790062A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
spirocyclogeptanes
disorders
rock inhibitors
relates
Prior art date
Application number
EA201790062A
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English (en)
Other versions
EA033061B1 (ru
Inventor
Владимир Ладзята
Питер В. Глунц
Зилун Ху
Юфенг Ванг
Original Assignee
Бристол-Майерс Сквибб Компани
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Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201790062A1 publication Critical patent/EA201790062A1/ru
Publication of EA033061B1 publication Critical patent/EA033061B1/ru

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    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Настоящее изобретение относится к соединениям формулы (I)или их стереоизомерам, таутомерам или фармацевтически приемлемым солям, причем все переменные таковы, как определено в описании изобретения. Такие соединения являются селективными ингибиторами ROCK. Настоящее изобретение также относится к фармацевтическим композициям, содержащим такие соединения, и к способам лечения сердечно-сосудистых нарушений, нарушений гладкой мускулатуры, онкологических, невропатических, аутоиммунных, фиброзных и/или воспалительных нарушений с их применением.
EA201790062A 2014-07-15 2015-07-14 Спироциклогептаны как ингибиторы rock EA033061B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024555P 2014-07-15 2014-07-15
US14/797,414 US9902702B2 (en) 2014-07-15 2015-07-13 Spirocycloheptanes as inhibitors of rock
PCT/US2015/040254 WO2016010950A1 (en) 2014-07-15 2015-07-14 Spirocycloheptanes as inhibitors of rock

Publications (2)

Publication Number Publication Date
EA201790062A1 true EA201790062A1 (ru) 2017-08-31
EA033061B1 EA033061B1 (ru) 2019-08-30

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EA201790062A EA033061B1 (ru) 2014-07-15 2015-07-14 Спироциклогептаны как ингибиторы rock

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US (2) US9902702B2 (ru)
EP (1) EP3169682B1 (ru)
JP (2) JP6499749B2 (ru)
KR (1) KR102420938B1 (ru)
CN (1) CN106817899B (ru)
AR (1) AR101208A1 (ru)
AU (1) AU2015289897B2 (ru)
BR (1) BR112017000808A2 (ru)
CA (1) CA2954976A1 (ru)
CL (1) CL2017000089A1 (ru)
CO (1) CO2017001152A2 (ru)
EA (1) EA033061B1 (ru)
ES (1) ES2716415T3 (ru)
IL (1) IL250046B (ru)
MA (1) MA39554B1 (ru)
MX (1) MX2017000485A (ru)
PE (1) PE20170672A1 (ru)
PH (1) PH12017500072A1 (ru)
SG (1) SG11201700251PA (ru)
TN (1) TN2017000009A1 (ru)
TW (1) TW201607933A (ru)
UY (1) UY36215A (ru)
WO (1) WO2016010950A1 (ru)
ZA (1) ZA201700304B (ru)

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