AR101177A1 - Inhibidores de la syk - Google Patents

Inhibidores de la syk

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Publication number
AR101177A1
AR101177A1 ARP150102203A ARP150102203A AR101177A1 AR 101177 A1 AR101177 A1 AR 101177A1 AR P150102203 A ARP150102203 A AR P150102203A AR P150102203 A ARP150102203 A AR P150102203A AR 101177 A1 AR101177 A1 AR 101177A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
compounds
effective amount
therapeutically effective
formula
Prior art date
Application number
ARP150102203A
Other languages
English (en)
Inventor
Zhao Zhongdong
Xu Jianjun
Xiong Jin
Ming - Swaminathan Sundaramoorthi
C Schmitt Aaron
A Mitchell Scott
R Lo Jennifer
H Lee Seung
e kropf Jeffrey
Di Paolo Julie
S Currie Kevin
Clarke Astrid
A Blomgren Peter
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR101177A1 publication Critical patent/AR101177A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

La presente divulgación se relaciona con compuestos que son inhibidores de Syk y con su uso en el tratamiento de diferentes estados de enfermedad, incluyendo cáncer y condiciones inflamatorias. La presente descripción proporciona además composiciones farmacéuticas que incluyen estos compuesto, o sales farmacéuticamente aceptables de los mismos, y métodos de uso de estos compuestos y composiciones para tratar afecciones mediadas por Syk. En ciertas realizaciones, también se describen métodos para el tratamiento de un cáncer en un sujeto (por ejemplo, un humano) que requiera de los mismos, que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto de los descriptos, o una sal farmacéuticamente aceptable del mismo, en combinación con un alcaloide de la vinca, o una sal farmacéuticamente aceptable del mismo. Reivindicación 1: Un método para tratar una enfermedad o condición en un humano seleccionada de entre el grupo que consiste de un trastorno inflamatorio, un trastorno alérgico, una enfermedad autoinmune, y un cáncer en un sujeto que requiera del mismo, caracterizado porque el método comprende administrar al humano que requiera del mismo una cantidad terapéuticamente efectiva de un alcaloide de la vinca, o una sal farmacéuticamente aceptable del mismo, y una cantidad terapéuticamente efectiva de un compuesto que tiene la estructura de fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde: R¹ se selecciona de entre el grupo que consiste de los restos de fórmula (2), (3), y (4), donde * indica el átomo de carbono del anillo de fenilo indicado de fórmula (1) al cual R¹ está unido; R² es H o 2-hidroxietoxilo; R³ es H o metilo; y R⁴ es H o metilo.
ARP150102203A 2014-07-14 2015-07-10 Inhibidores de la syk AR101177A1 (es)

Applications Claiming Priority (1)

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US201462024284P 2014-07-14 2014-07-14

Publications (1)

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AR101177A1 true AR101177A1 (es) 2016-11-30

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US (3) US9504684B2 (es)
EP (1) EP3169329A1 (es)
JP (2) JP6292691B2 (es)
KR (1) KR20170023186A (es)
CN (1) CN106572999A (es)
AR (1) AR101177A1 (es)
AU (2) AU2015290041B2 (es)
CA (1) CA2955249A1 (es)
EA (1) EA201790088A1 (es)
MA (1) MA40076A (es)
MX (1) MX2017000612A (es)
NZ (1) NZ726366A (es)
SG (1) SG11201610904UA (es)
TW (1) TW201617074A (es)
UY (1) UY36207A (es)
WO (1) WO2016010809A1 (es)

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