AR100809A1 - Inhibidores de fosfatidilinositol 3-quinasa - Google Patents

Inhibidores de fosfatidilinositol 3-quinasa

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Publication number
AR100809A1
AR100809A1 ARP150101859A ARP150101859A AR100809A1 AR 100809 A1 AR100809 A1 AR 100809A1 AR P150101859 A ARP150101859 A AR P150101859A AR P150101859 A ARP150101859 A AR P150101859A AR 100809 A1 AR100809 A1 AR 100809A1
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AR
Argentina
Prior art keywords
optionally substituted
carbon atoms
alkyl
substituted carbon
haloalkyl
Prior art date
Application number
ARP150101859A
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English (en)
Inventor
Chung Yeung Suet
j watkins William
Van Veldhuizen Joshua
Phillips Gary
W Phillips Barton
Naduthambi Devan
A Loyer-Drew Jennifer
Kaplan Joshua
Du Zhimin
Cai Shaopei
Original Assignee
Gilead Sciences Inc
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Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR100809A1 publication Critical patent/AR100809A1/es

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Abstract

Reivindicación 1: Un compuesto caracterizado porque tiene la estructura de fórmula (1), en donde: n es 0, 1, 2, ó 3; m es 0, 1, ó 2; A es un enlace sencillo o C(O); B es heterocicloalquilo de tres a diez miembros que tiene al menos un heteroátomo seleccionado de N ó O, en donde heterocicloalquilo está sustituido opcionalmente con halo, alquilo de uno a seis átomos de carbono sustituido opcionalmente, heterocicloalquilo de tres a ocho átomos de carbono sustituido opcionalmente, C₁₋₆ haloalquilo, y cicloalquilo de tres a ocho átomos de carbono sustituido opcionalmente; cada R¹ es seleccionado independientemente de halo, ciano, alquilo de uno a seis átomos de carbono sustituido opcionalmente, haloalquilo de uno a seis átomos de carbono sustituido opcionalmente, alcoxi de uno a seis átomos de carbono sustituido opcionalmente, sulfonilo sustituido opcionalmente, arilo de tres a ocho átomos de carbono sustituido opcionalmente, heteroarilo de tres a ocho átomos de carbono sustituido opcionalmente, cicloalquilo de tres a ocho átomos de carbono sustituido opcionalmente, y heterocicloalquilo de tres a ocho átomos de carbono sustituido opcionalmente; cada R² es independientemente halo, alquilo de uno a seis átomos de carbono sustituido opcionalmente, haloalquilo de uno a seis átomos de carbono sustituido opcionalmente, y -NH₂; R³ es hidrógeno, alquilo de uno a seis átomos de carbono sustituido opcionalmente, C₃₋₈ cicloalquilo, o C₆₋₁₀ arilo; R⁴ es un heteroarilo de seis a doce miembros que tiene al menos un grupo aromático y al menos dos heteroátomos seleccionados de N, O, o S, en donde el heteroarilo está sustituido opcionalmente con uno, dos o tres miembros seleccionados independientemente de halo, ciano, haloalquilo de uno a seis átomos de carbono sustituido opcionalmente, alquilo de uno a seis átomos de carbono sustituido opcionalmente, alquinilo de dos a cuatro átomos de carbono sustituido opcionalmente, y -NH₂; y R⁵ es hidrógeno o alquilo de uno a seis átomos de carbono sustituido opcionalmente, en donde R⁵ y R³ junto con los átomos a los cuales están enlazados forman un anillo heterocíclico de cuatro a ocho miembros; o una sal, isómero, o una mezcla de los mismos, farmacéuticamente aceptables.
ARP150101859A 2014-06-13 2015-06-11 Inhibidores de fosfatidilinositol 3-quinasa AR100809A1 (es)

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BR112016028818A2 (pt) 2017-08-22
US10092563B2 (en) 2018-10-09
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CA2952037A1 (en) 2015-12-17
EP3154958B1 (en) 2020-10-07
KR20170012557A (ko) 2017-02-02
US20150361054A1 (en) 2015-12-17
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SG11201610095SA (en) 2016-12-29
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