AR061380A1 - 2-anilino-4(heterociclo) amino-pirimidinas - Google Patents
2-anilino-4(heterociclo) amino-pirimidinasInfo
- Publication number
- AR061380A1 AR061380A1 ARP070102631A ARP070102631A AR061380A1 AR 061380 A1 AR061380 A1 AR 061380A1 AR P070102631 A ARP070102631 A AR P070102631A AR P070102631 A ARP070102631 A AR P070102631A AR 061380 A1 AR061380 A1 AR 061380A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- formula
- alpha
- aminopyrimidines
- pkc
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente se refiere a inhibidores de 2-arilamino- 4-(heterociclo) aminopirimidinas que inhiben la Proteína Quinasa C-alfa (PKC-alfa). Los inhibidores de PKC-alfa de la presente son importantes para mejorar el ciclo del calcio intracelular en el miocardio, mejorando el comportamiento de contraccion y relajacion del miocardio y ralentizando de esta manera la progresion de la insuficiencia cardiaca. La presente también se refiere a composiciones que comprenden dichas 2-arilamino-4 - (heterociclo) aminopirimidinas y a métodos para controlar, disminuir o retardar de otra manera la progresion de la insuficiencia cardiaca. Reivindicacion 1: Un compuesto que tiene la formula 1 en la que R es una unidad heterocíclica sustituida o sin sustituir que contiene de 3 a 7 átomos; L es un grupo de union que tiene la formula: - [C(R4aR4b)]n-; cada R4a y R4b se elige independientemente entre: i) hidrogeno; o ii) alquilo C1-4 lineal, ramificado o cíclico; el índice n es de 0 a 4; y R1 es fenilo que tiene la formula (2), R5 es hidrogeno o uno o más sustituyentes elegidos independientemente para hidrogeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81395606P | 2006-06-15 | 2006-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061380A1 true AR061380A1 (es) | 2008-08-20 |
Family
ID=38608732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102631A AR061380A1 (es) | 2006-06-15 | 2007-06-15 | 2-anilino-4(heterociclo) amino-pirimidinas |
Country Status (16)
Country | Link |
---|---|
US (2) | US20070293494A1 (es) |
EP (1) | EP2054392A2 (es) |
JP (1) | JP2009540013A (es) |
KR (1) | KR20090019011A (es) |
CN (1) | CN101506175A (es) |
AR (1) | AR061380A1 (es) |
AU (1) | AU2007257650A1 (es) |
BR (1) | BRPI0713696A2 (es) |
CA (1) | CA2653777A1 (es) |
CL (1) | CL2007001749A1 (es) |
IL (1) | IL195864A0 (es) |
MX (1) | MX2008016004A (es) |
RU (1) | RU2008152195A (es) |
TW (1) | TW200815424A (es) |
WO (1) | WO2007146981A2 (es) |
ZA (1) | ZA200809941B (es) |
Families Citing this family (25)
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EP2032543A1 (en) | 2006-06-15 | 2009-03-11 | Boehringer Ingelheim International GmbH | 2-anilino-4-aminoalkyleneaminopyrimidines |
AU2008229151A1 (en) * | 2007-03-20 | 2008-09-25 | Smithkline Beecham Corporation | Chemical compounds |
CA2693594A1 (en) * | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
WO2010083240A2 (en) * | 2009-01-14 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Methods for treating inflammatory disorders using 2,4-pyrimidinediamine compounds |
CA2749157A1 (en) * | 2009-01-14 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for treatment of inflammatory disorders |
ES2555982T3 (es) * | 2009-01-15 | 2016-01-12 | Rigel Pharmaceuticals, Inc. | Inhibidores de la proteína quinasa C y usos de los mismos |
AR076024A1 (es) * | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
CA2774998A1 (en) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
CA2780759A1 (en) * | 2009-12-01 | 2011-06-09 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
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EP3421485A1 (en) | 2017-06-30 | 2019-01-02 | Université de Strasbourg | Peptides for treatment and prevention of hyperglycaemia |
US11013741B1 (en) | 2018-04-05 | 2021-05-25 | Sumitomo Dainippon Pharma Oncology, Inc. | AXL kinase inhibitors and use of the same |
CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
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TW202108573A (zh) | 2019-05-10 | 2021-03-01 | 美商迪賽孚爾製藥有限公司 | 苯基胺基嘧啶醯胺自噬抑制劑及其使用方法 |
PE20221083A1 (es) | 2019-06-17 | 2022-07-05 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso |
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EP2032543A1 (en) * | 2006-06-15 | 2009-03-11 | Boehringer Ingelheim International GmbH | 2-anilino-4-aminoalkyleneaminopyrimidines |
TW200815020A (en) | 2006-06-15 | 2008-04-01 | Serenex Inc | Stabilized tetracycline compositions |
CL2009000600A1 (es) * | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas. |
BRPI0915205A2 (pt) * | 2008-06-11 | 2017-03-21 | Dana Farber Cancer Inst Inc | compostos e composições úteis para o tratamento de malária |
JP2012505899A (ja) * | 2008-10-16 | 2012-03-08 | シェーリング コーポレイション | アジン誘導体およびそれの使用方法 |
US20110071158A1 (en) | 2009-03-18 | 2011-03-24 | Boehringer Ingelheim International Gmbh | New compounds |
US8410126B2 (en) | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
-
2007
- 2007-06-13 US US11/762,394 patent/US20070293494A1/en not_active Abandoned
- 2007-06-13 WO PCT/US2007/071077 patent/WO2007146981A2/en active Application Filing
- 2007-06-13 CN CNA2007800303500A patent/CN101506175A/zh active Pending
- 2007-06-13 RU RU2008152195/04A patent/RU2008152195A/ru unknown
- 2007-06-13 EP EP07798482A patent/EP2054392A2/en not_active Withdrawn
- 2007-06-13 MX MX2008016004A patent/MX2008016004A/es not_active Application Discontinuation
- 2007-06-13 JP JP2009515622A patent/JP2009540013A/ja active Pending
- 2007-06-13 CA CA002653777A patent/CA2653777A1/en not_active Abandoned
- 2007-06-13 BR BRPI0713696-0A patent/BRPI0713696A2/pt not_active IP Right Cessation
- 2007-06-13 KR KR1020097000717A patent/KR20090019011A/ko not_active Application Discontinuation
- 2007-06-13 AU AU2007257650A patent/AU2007257650A1/en not_active Abandoned
- 2007-06-14 TW TW096121541A patent/TW200815424A/zh unknown
- 2007-06-14 CL CL2007001749A patent/CL2007001749A1/es unknown
- 2007-06-15 AR ARP070102631A patent/AR061380A1/es not_active Application Discontinuation
-
2008
- 2008-11-24 ZA ZA200809941A patent/ZA200809941B/xx unknown
- 2008-12-11 IL IL195864A patent/IL195864A0/en unknown
-
2009
- 2009-05-14 US US12/465,704 patent/US8354407B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2008152195A (ru) | 2010-07-20 |
TW200815424A (en) | 2008-04-01 |
ZA200809941B (en) | 2009-07-29 |
IL195864A0 (en) | 2009-09-01 |
WO2007146981A3 (en) | 2008-02-21 |
US20090227586A1 (en) | 2009-09-10 |
CA2653777A1 (en) | 2007-12-21 |
US20070293494A1 (en) | 2007-12-20 |
KR20090019011A (ko) | 2009-02-24 |
MX2008016004A (es) | 2009-01-16 |
AU2007257650A1 (en) | 2007-12-21 |
EP2054392A2 (en) | 2009-05-06 |
JP2009540013A (ja) | 2009-11-19 |
US8354407B2 (en) | 2013-01-15 |
CN101506175A (zh) | 2009-08-12 |
CL2007001749A1 (es) | 2008-01-25 |
BRPI0713696A2 (pt) | 2012-11-06 |
WO2007146981A2 (en) | 2007-12-21 |
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