AR072860A1 - Derivados de 3-(3-pirimidin-2-il-bencil)-[1,2,4]triazolo[4,3-b]piridazina - Google Patents
Derivados de 3-(3-pirimidin-2-il-bencil)-[1,2,4]triazolo[4,3-b]piridazinaInfo
- Publication number
- AR072860A1 AR072860A1 ARP090102184A ARP090102184A AR072860A1 AR 072860 A1 AR072860 A1 AR 072860A1 AR P090102184 A ARP090102184 A AR P090102184A AR P090102184 A ARP090102184 A AR P090102184A AR 072860 A1 AR072860 A1 AR 072860A1
- Authority
- AR
- Argentina
- Prior art keywords
- nhet
- hal
- nhet1
- het1
- nhconh
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos de la formula (1), en donde: R1es Ar, Het o A; R2 es H, A, Hal, OR5, N(R5)2, N=CR5N(R5)2, SR5, NO2, CN, COOR5, CON(R5)2, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, Het, -[C(R5)2]nN(R5)2, -[C(R5)2]nHet, O[C(R5)2]nN(R5)2, O[C(R5)2]nHet, S[C(R5)2]nN(R5)2, S[C(R5)2]nHet, -NR5[C(R5)2]nN(R5)2, -NR5[C(R5)2]nHet, NHCON(R5)2, NHCONH[C(R5)2]nN(R5)2, NHCONH[C(R5)2]nHet, NHCO[C(R5)2]nN(R5)2, NHCO[C(R5)2]nHet, CON(R5)2, CONR5[C(R5)2]nN(R5)2, CONR5[C(R5)2]nHet, COHet o COA; R3, R3' son cada uno, de modo independiente entre sí, H, F o A, también juntos son alquileno C2-5; R4 es H, A o Hal; R5 es H o A; A es alquilo C1-10 no ramificado o ramificado, en donde 1-7 átomos de H pueden estar reemplazados por OH, F, Cl y/o Br, y/o en donde uno o dos grupos CH2 pueden estar reemplazados por O, NH, S, SO, SO2 y/o grupos CH=CH, o es alquilo cíclico C3-7; Ar es fenilo, naftilo o bifenilo no sustituido o mono-, di- o trisustituido con Hal, A, OR5, N(R5)2, SR5, NO2, CN, COOR5, CON(R5)2, NR5COA, NR5SO2A, SO2N(R5)2 y/o S(O)mA; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di o trisustituido con Hal, A, OR5, N(R5)2, SR5, NO2, CN, COOR5, CON(R5)2, NR5COA, NR5SO2A, SO2N(R5)2, S(O)mA, CO-Het1, Het1, [C(R5)2]nN(R5)2, -[C(R5)2]nHet1, O[C(R5)2]nN(R5)2, O[C(R5)2]nHet1, NHCOOA, NHCON(R5)2, NHCOO[C(R5)2]nN(R5)2, NHCOO[C(R5)2]nHet1, NHCONH[C(R5)2]nN(R5)2, NHCONH[C(R5)2]nHet1, OCONH[C(R5)2]nN(R5)2, OCONH[C(R5)2]nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo); Het1 es un heterociclo saturado monocíclico con 1 a 2 átomos de N y/u O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo); Hal es F, Cl, Br o I; m es 0, 1 o 2; n es 1, 2, 3 o 4; así como sus sales, tautomeros y estereoisomeros farmacéuticamente aceptables, incluyendo sus mezclas en todas las proporciones. Son inhibidores de la tirosina quinasa, en especial de la Met-quinasa, y pueden utilizarse, por ejemplo, para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008028905A DE102008028905A1 (de) | 2008-06-18 | 2008-06-18 | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072860A1 true AR072860A1 (es) | 2010-09-29 |
Family
ID=40973097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102184A AR072860A1 (es) | 2008-06-18 | 2009-06-17 | Derivados de 3-(3-pirimidin-2-il-bencil)-[1,2,4]triazolo[4,3-b]piridazina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8497266B2 (es) |
| EP (1) | EP2285811B1 (es) |
| JP (1) | JP5662311B2 (es) |
| KR (1) | KR101661777B1 (es) |
| CN (1) | CN102066378B (es) |
| AR (1) | AR072860A1 (es) |
| AU (1) | AU2009259764B2 (es) |
| BR (1) | BRPI0915417B8 (es) |
| CA (1) | CA2728194C (es) |
| DE (1) | DE102008028905A1 (es) |
| DK (1) | DK2285811T3 (es) |
| EA (1) | EA019534B1 (es) |
| ES (1) | ES2400117T3 (es) |
| IL (1) | IL210063A (es) |
| MX (1) | MX2010013649A (es) |
| PL (1) | PL2285811T3 (es) |
| PT (1) | PT2285811E (es) |
| WO (1) | WO2009152920A1 (es) |
| ZA (1) | ZA201100437B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) * | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| DE102008063667A1 (de) * | 2008-12-18 | 2010-07-01 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-°[1,2,4]triazolo[4,3-b]pyrimidin-derivate |
| PL2361250T3 (pl) | 2008-12-22 | 2014-01-31 | Merck Patent Gmbh | Nowe polimorficzne formy diwodorofosforanu 6-(1-metylo-1H-pirazolo-4-ylo)-2-{3-[5-(2-morfolino-4-ylo-etoksy)-pirymidyno-2-ylo]-benzylo}2H-pirydazyno-3-onowego oraz sposoby ich otrzymywania |
| DE102008062825A1 (de) * | 2008-12-23 | 2010-06-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo [4,3-b]pyridazin-derivate |
| CN105339370B (zh) * | 2013-06-19 | 2017-09-15 | 加拉帕戈斯股份有限公司 | 用于治疗炎症性疾病的化合物和及其药物组合物 |
| GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CN111465602B (zh) | 2017-10-17 | 2023-05-23 | 帕劳制药有限公司 | 4-氨基嘧啶化合物的合成 |
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-
2008
- 2008-06-18 DE DE102008028905A patent/DE102008028905A1/de not_active Withdrawn
-
2009
- 2009-05-25 ES ES09765500T patent/ES2400117T3/es active Active
- 2009-05-25 WO PCT/EP2009/003675 patent/WO2009152920A1/de active Application Filing
- 2009-05-25 CN CN200980122766.4A patent/CN102066378B/zh active Active
- 2009-05-25 EA EA201100031A patent/EA019534B1/ru not_active IP Right Cessation
- 2009-05-25 US US12/999,873 patent/US8497266B2/en active Active
- 2009-05-25 CA CA2728194A patent/CA2728194C/en active Active
- 2009-05-25 AU AU2009259764A patent/AU2009259764B2/en active Active
- 2009-05-25 EP EP09765500A patent/EP2285811B1/de active Active
- 2009-05-25 KR KR1020117001150A patent/KR101661777B1/ko active IP Right Grant
- 2009-05-25 PL PL09765500T patent/PL2285811T3/pl unknown
- 2009-05-25 PT PT97655005T patent/PT2285811E/pt unknown
- 2009-05-25 MX MX2010013649A patent/MX2010013649A/es active IP Right Grant
- 2009-05-25 DK DK09765500.5T patent/DK2285811T3/da active
- 2009-05-25 BR BRPI0915417A patent/BRPI0915417B8/pt not_active IP Right Cessation
- 2009-05-25 JP JP2011513897A patent/JP5662311B2/ja active Active
- 2009-06-17 AR ARP090102184A patent/AR072860A1/es active IP Right Grant
-
2010
- 2010-12-16 IL IL210063A patent/IL210063A/en active IP Right Grant
-
2011
- 2011-01-17 ZA ZA2011/00437A patent/ZA201100437B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0915417B8 (pt) | 2021-05-25 |
| EA201100031A1 (ru) | 2011-08-30 |
| CA2728194A1 (en) | 2009-12-23 |
| EA019534B1 (ru) | 2014-04-30 |
| EP2285811B1 (de) | 2012-12-05 |
| WO2009152920A1 (de) | 2009-12-23 |
| EP2285811A1 (de) | 2011-02-23 |
| JP2011524385A (ja) | 2011-09-01 |
| JP5662311B2 (ja) | 2015-01-28 |
| AU2009259764B2 (en) | 2013-09-26 |
| PL2285811T3 (pl) | 2013-04-30 |
| BRPI0915417B1 (pt) | 2020-02-11 |
| US20110092498A1 (en) | 2011-04-21 |
| DK2285811T3 (da) | 2013-03-11 |
| DE102008028905A1 (de) | 2009-12-24 |
| KR20110031329A (ko) | 2011-03-25 |
| CN102066378A (zh) | 2011-05-18 |
| IL210063A0 (en) | 2011-02-28 |
| KR101661777B1 (ko) | 2016-09-30 |
| ZA201100437B (en) | 2011-09-28 |
| CN102066378B (zh) | 2014-04-16 |
| ES2400117T3 (es) | 2013-04-05 |
| IL210063A (en) | 2015-06-30 |
| PT2285811E (pt) | 2013-03-05 |
| BRPI0915417A2 (pt) | 2015-11-03 |
| US8497266B2 (en) | 2013-07-30 |
| CA2728194C (en) | 2016-11-29 |
| AU2009259764A1 (en) | 2009-12-23 |
| MX2010013649A (es) | 2010-12-21 |
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