AR032781A1 - Amidas ariladas de acidos furan- y tiofencarboxilicos, composiciones farmaceuticas, su utilizacion para la preparacion de medicamento como tambien las composiciones farmaceuticas que las contienen - Google Patents
Amidas ariladas de acidos furan- y tiofencarboxilicos, composiciones farmaceuticas, su utilizacion para la preparacion de medicamento como tambien las composiciones farmaceuticas que las contienenInfo
- Publication number
- AR032781A1 AR032781A1 ARP010105720A ARP010105720A AR032781A1 AR 032781 A1 AR032781 A1 AR 032781A1 AR P010105720 A ARP010105720 A AR P010105720A AR P010105720 A ARP010105720 A AR P010105720A AR 032781 A1 AR032781 A1 AR 032781A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- conh2
- coome
- methylsulfonylamino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Amidas ariladas de ácidos fura- y tiofencarboxílicos, que comprenden compuestos de las formula (1) y (2), donde X representa oxígeno o azufre; R1 representa C(O)OR9, SO2R10, COR11, C(O)NR12R13 o C(S)NR12R13; R9, R10, R11 y R12, independientemente entre sí, representan CxH2x-R14; x representa 0, 1, 2, 3 o 4; no pudiendo x ser igual a cero cuando R14 representa OR15 o SO2Me; R14 representa alquilo C1-6, cicloalquilo C3-10, CF3, C2F5, C3F7, CH2F, CHF2, OR15, SO2Me, fenilo, naftilo, bifenilo, furilo, tienilo o un heteroaromato que contiene nitrogeno C1-9; pudiendo fenilo, naftilo, bifenilo, furilo, tienilo y el heteroaromato que contiene nitrogeno, estar sin sustituir o estar sustituido con 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-4, dimetilamino, sulfamoílo, metil sulfonilo y metilsulfonilamino; R15 representa alquilo C1-5, cicloalquilo C3-5, CF3 o fenilo, que está sin sustituir o está sustituido con 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-4, dimetilamino, sulfamoílo, metil sulfonilo y metilsulfonilamino; R13 representa hidrogeno, alquilo C1-4 o CF3, R2 representa hidrogeno, alquilo C1-4 o CF3; R3 representa CyH2y-R16; y representa 0, 1, 2, 3 o 4; no pudiendo y ser igual a 0 cuando R16 representa OR17 o SO2Me; R16 representa alquilo C1-6, cicloalquilo C3-11, CF3, C2F5, C3F7, CH2F, CHF2, OR17, SO2Me, fenilo, naftilo, furilo, tienilo o un heteroaromato que contiene nitrogeno C1-9; estando fenilo, naftilo, furilo, tienilo y el heteroaromato que contiene nitrogeno, sin sustituir o está sustituido con 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-6, dimetilamino, sulfamoílo, metil sulfonilo y metilsulfonilamino; R17 representa hidrogeno, alquilo C1-5, cicloalqulo C3-6, CF3, fenilo o 2-, 3- o 4-piridilo; estando fenilo o 2-, 3- o 4-piridilo, sin sustituir o está sustituido con 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-4, dimetilamino, sulfamoílo, metil sulfonilo y metilsulfonilamino;o R3 representa CHR18R19; R18 representa hidrogeno o CzH2z-R16, siendo R16 como anteriormente mencionado, z vale 0, 1, 2 o 3; R19 representa COOH, CONH2, CONR20R21 o CH2OH; R20 representa hidrogeno, alquilo C1-5, CvH2v-CF3 o CwH2w-fenilo; estando el anillo fenilo, sin sustituir o está sustituido con 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en F, Cl, Br, I, CF3, OCF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-4, dimetilamino, sulfamoílo, metil sulfonilo y metilsulfonilamino; v vale 0, 1, 2 o 3; w vale 0, 1, 2 o 3; R21 representa hidrogeno o alquilo C1-5; R22 representa alquilo C1-5; R4 representa hidrogeno, alquilo C1-6 o CF3; R3 y R4 representan conjuntamente una cadena de 4 o 5 grupos metileno, de los cuales un grupo metileno puede estar sustituido por -O-, -S-, -NH-, N(metil)- o -N(bencil)-; R5, R6, R7, independientemente entre sí, representan F, Cl, Br, I, CF3, NO2, CN, COOMe, CONH2, COMe, NH2, OH, alquilo C1-4, alcoxi C1-4, dimetilamino, sulfamoílo, metil sulfonilo o metilsulfonilamino; R30 y R31, independientemente entre sí representan hidrogeno o alquilo C1-3; o: R30 y R31, independientemente entre sí, representan oxígeno o una cadena de 2 grupos metileno; como también sus sales farmacéuticamente aceptables, que son muy especialmente adecuados como novedosas sustancias activas como antiarrítmicas, en especial para el tratamiento y profilaxis de las arritmias auriculares, por ejemplo la fibrilacion auricular (atrial Fibrillation, AF) o el aleteo o fluter auricular (atriales Flattern). También se describen composiciones farmacéuticas y el uso de dichas amidas para la preparacion de medicamentos para el tratamiento y profilaxis de las arritmias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10061876A DE10061876A1 (de) | 2000-12-12 | 2000-12-12 | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032781A1 true AR032781A1 (es) | 2003-11-26 |
Family
ID=7666837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010105720A AR032781A1 (es) | 2000-12-12 | 2001-12-10 | Amidas ariladas de acidos furan- y tiofencarboxilicos, composiciones farmaceuticas, su utilizacion para la preparacion de medicamento como tambien las composiciones farmaceuticas que las contienen |
Country Status (30)
Country | Link |
---|---|
US (1) | US6982279B2 (es) |
EP (1) | EP1349846B1 (es) |
JP (1) | JP4252798B2 (es) |
KR (1) | KR20030061846A (es) |
CN (1) | CN1225463C (es) |
AR (1) | AR032781A1 (es) |
AT (1) | ATE288906T1 (es) |
AU (2) | AU2002235743B2 (es) |
BR (1) | BR0116084A (es) |
CA (1) | CA2431095A1 (es) |
CZ (1) | CZ20031633A3 (es) |
DE (2) | DE10061876A1 (es) |
DK (1) | DK1349846T3 (es) |
EE (1) | EE05306B1 (es) |
ES (1) | ES2236335T3 (es) |
HK (1) | HK1061850A1 (es) |
HR (1) | HRP20030469A2 (es) |
HU (1) | HUP0303665A3 (es) |
IL (2) | IL156314A0 (es) |
MX (1) | MXPA03004770A (es) |
NO (1) | NO329163B1 (es) |
NZ (1) | NZ526383A (es) |
PL (1) | PL362410A1 (es) |
PT (1) | PT1349846E (es) |
RS (1) | RS50336B (es) |
RU (1) | RU2275366C2 (es) |
SK (1) | SK287464B6 (es) |
TW (1) | TWI288134B (es) |
WO (1) | WO2002048131A1 (es) |
ZA (1) | ZA200304091B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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ATE438637T1 (de) * | 2001-06-11 | 2009-08-15 | Virochem Pharma Inc | Thiophenderivate als antivirale mittel gegen flavivirus-infektion |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
US7402608B2 (en) * | 2002-12-10 | 2008-07-22 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
EP1493739A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
EP2546246A3 (en) * | 2005-05-13 | 2013-04-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
JP4943429B2 (ja) * | 2005-07-22 | 2012-05-30 | メルク・シャープ・エンド・ドーム・コーポレイション | カリウムチャネル阻害剤 |
GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
NZ572231A (en) * | 2006-04-27 | 2010-12-24 | Sanofi Aventis Deutschland | Inhibitors of the task-1 and task-3 ion channel |
CA2670260A1 (en) | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
CN101854933A (zh) | 2007-09-10 | 2010-10-06 | 钙医学公司 | 调节细胞内钙的化合物 |
ITMI20071971A1 (it) * | 2007-10-10 | 2009-04-11 | Altergon Sa | Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione |
WO2009076454A2 (en) | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
KR101724161B1 (ko) | 2008-08-27 | 2017-04-06 | 칼시메디카, 인크 | 세포내 칼슘을 조절하는 화합물 |
GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
US20110288142A1 (en) * | 2009-01-30 | 2011-11-24 | Chen Pingyun Y | CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
WO2011034962A2 (en) | 2009-09-16 | 2011-03-24 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
JP5855095B2 (ja) | 2010-06-07 | 2016-02-09 | ノボメディックス,エルエルシーNovomedix,Llc | フラニル化合物およびその使用 |
MX337711B (es) | 2010-08-27 | 2016-03-15 | Calcimedica Inc | Compuestos que modulan el calcio intracelular. |
GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
US20150045305A1 (en) | 2012-01-27 | 2015-02-12 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CN103012381B (zh) * | 2013-01-10 | 2015-01-07 | 山东大学 | 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用 |
KR101721490B1 (ko) * | 2014-07-30 | 2017-03-30 | 한국생명공학연구원 | 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물 |
EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9214120D0 (en) * | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
US6013664A (en) * | 1996-11-27 | 2000-01-11 | Bayer Aktiengesellschaft | Microbicidal agents based on thiophene-2-carboxylic acid derivatives |
AU734786B2 (en) * | 1997-08-05 | 2001-06-21 | American Home Products Corporation | Anthranilic acid analogs |
RU2226529C2 (ru) * | 1997-12-19 | 2004-04-10 | Шеринг Акциенгезельшафт | Производные ортоантраниламида в качестве антикоагулянтов, фармацевтическая композиция и способ лечения |
US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
AU2300699A (en) * | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
EP1082315A1 (en) | 1998-06-05 | 2001-03-14 | Icagen, Inc. | Potassium channel inhibitors |
EP1109544A4 (en) | 1998-09-01 | 2004-10-27 | Bristol Myers Squibb Co | POTASSIUM CHANNEL INHIBITORS AND THEIR METHOD OF USE |
AU5379900A (en) * | 1999-06-07 | 2000-12-28 | Shire Biochem Inc. | Thiophene integrin inhibitors |
EP1419161A1 (en) * | 2001-08-24 | 2004-05-19 | PHARMACIA & UPJOHN COMPANY | Substituted-heteroaryl-7-aza 2.2.1]bicycloheptanes for the treatment of disease |
-
2000
- 2000-12-12 DE DE10061876A patent/DE10061876A1/de not_active Withdrawn
-
2001
- 2001-11-29 DE DE50105337T patent/DE50105337D1/de not_active Expired - Lifetime
- 2001-11-29 KR KR10-2003-7007875A patent/KR20030061846A/ko active IP Right Grant
- 2001-11-29 NZ NZ526383A patent/NZ526383A/en unknown
- 2001-11-29 EP EP01985832A patent/EP1349846B1/de not_active Expired - Lifetime
- 2001-11-29 WO PCT/EP2001/013958 patent/WO2002048131A1/de active IP Right Grant
- 2001-11-29 PL PL01362410A patent/PL362410A1/xx not_active IP Right Cessation
- 2001-11-29 IL IL15631401A patent/IL156314A0/xx unknown
- 2001-11-29 BR BR0116084-2A patent/BR0116084A/pt not_active Application Discontinuation
- 2001-11-29 HU HU0303665A patent/HUP0303665A3/hu unknown
- 2001-11-29 AU AU2002235743A patent/AU2002235743B2/en not_active Ceased
- 2001-11-29 JP JP2002549662A patent/JP4252798B2/ja not_active Expired - Fee Related
- 2001-11-29 AT AT01985832T patent/ATE288906T1/de active
- 2001-11-29 MX MXPA03004770A patent/MXPA03004770A/es active IP Right Grant
- 2001-11-29 ES ES01985832T patent/ES2236335T3/es not_active Expired - Lifetime
- 2001-11-29 SK SK725-2003A patent/SK287464B6/sk not_active IP Right Cessation
- 2001-11-29 AU AU3574302A patent/AU3574302A/xx active Pending
- 2001-11-29 CZ CZ20031633A patent/CZ20031633A3/cs unknown
- 2001-11-29 RS YUP-425/03A patent/RS50336B/sr unknown
- 2001-11-29 CN CNB018204007A patent/CN1225463C/zh not_active Expired - Fee Related
- 2001-11-29 CA CA002431095A patent/CA2431095A1/en not_active Abandoned
- 2001-11-29 DK DK01985832T patent/DK1349846T3/da active
- 2001-11-29 PT PT01985832T patent/PT1349846E/pt unknown
- 2001-11-29 EE EEP200300240A patent/EE05306B1/xx not_active IP Right Cessation
- 2001-11-29 RU RU2003121236/04A patent/RU2275366C2/ru not_active IP Right Cessation
- 2001-12-10 AR ARP010105720A patent/AR032781A1/es active IP Right Grant
- 2001-12-10 TW TW090130471A patent/TWI288134B/zh not_active IP Right Cessation
- 2001-12-12 US US10/012,338 patent/US6982279B2/en not_active Expired - Fee Related
-
2003
- 2003-05-27 ZA ZA200304091A patent/ZA200304091B/en unknown
- 2003-06-04 NO NO20032535A patent/NO329163B1/no not_active IP Right Cessation
- 2003-06-04 IL IL156314A patent/IL156314A/en not_active IP Right Cessation
- 2003-06-10 HR HR20030469A patent/HRP20030469A2/hr not_active Application Discontinuation
-
2004
- 2004-07-06 HK HK04104841A patent/HK1061850A1/xx not_active IP Right Cessation
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