BR0116084A - Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio - Google Patents
Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássioInfo
- Publication number
- BR0116084A BR0116084A BR0116084-2A BR0116084A BR0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A
- Authority
- BR
- Brazil
- Prior art keywords
- acid amides
- atrial
- arylated
- potassium channel
- furanecarboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
"AMIDAS DE áCIDO FURANOCARBOXìLICO E TIOFENOCARBOXìLICO ARILADAS COM EFEITO BLOQUEADOR DE CANAL DE POTáSSIO". Amidas de ácido furanocarboxílico e tiofenocarboxílico ariladas, processo para sua preparação, seu emprego como medicamento, assim como preparados farmacêuticos contendo-as. Compostos de fórmula (Ia) e (Ib) nas quais X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), e R(30) e R(31) têm os significados indicados nas reivindicações, são muito particularmente apropriados como substâncias ativas anti-arrítmicas novas, particularmente para tratamento e profilaxia de arritmias do átrio, por exemplo, vibração atrial (fibrilação atrial, AF) ou instabilidade atrial (instabilidade do átrio).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10061876A DE10061876A1 (de) | 2000-12-12 | 2000-12-12 | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
PCT/EP2001/013958 WO2002048131A1 (de) | 2000-12-12 | 2001-11-29 | Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116084A true BR0116084A (pt) | 2003-10-14 |
Family
ID=7666837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0116084-2A BR0116084A (pt) | 2000-12-12 | 2001-11-29 | Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio |
Country Status (30)
Country | Link |
---|---|
US (1) | US6982279B2 (pt) |
EP (1) | EP1349846B1 (pt) |
JP (1) | JP4252798B2 (pt) |
KR (1) | KR20030061846A (pt) |
CN (1) | CN1225463C (pt) |
AR (1) | AR032781A1 (pt) |
AT (1) | ATE288906T1 (pt) |
AU (2) | AU2002235743B2 (pt) |
BR (1) | BR0116084A (pt) |
CA (1) | CA2431095A1 (pt) |
CZ (1) | CZ20031633A3 (pt) |
DE (2) | DE10061876A1 (pt) |
DK (1) | DK1349846T3 (pt) |
EE (1) | EE05306B1 (pt) |
ES (1) | ES2236335T3 (pt) |
HK (1) | HK1061850A1 (pt) |
HR (1) | HRP20030469A2 (pt) |
HU (1) | HUP0303665A3 (pt) |
IL (2) | IL156314A0 (pt) |
MX (1) | MXPA03004770A (pt) |
NO (1) | NO329163B1 (pt) |
NZ (1) | NZ526383A (pt) |
PL (1) | PL362410A1 (pt) |
PT (1) | PT1349846E (pt) |
RS (1) | RS50336B (pt) |
RU (1) | RU2275366C2 (pt) |
SK (1) | SK287464B6 (pt) |
TW (1) | TWI288134B (pt) |
WO (1) | WO2002048131A1 (pt) |
ZA (1) | ZA200304091B (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA12622A (en) * | 2001-06-11 | 2006-06-12 | Shire Biochem Inc | Thiophene derivatives as antiviral agents for flavivirus infection. |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
ES2345438T3 (es) | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
EP1493739A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0412986D0 (en) | 2004-06-10 | 2004-07-14 | Xention Discovery Ltd | Compounds |
US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
CN102718744A (zh) * | 2005-05-13 | 2012-10-10 | Viro化学制药公司 | 治疗或预防黄病毒感染的组合物和方法 |
AU2006276292B2 (en) * | 2005-07-22 | 2010-09-16 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
CN101636154B (zh) * | 2006-04-27 | 2011-12-14 | 塞诺菲-安万特德国有限公司 | Task-1和task-3离子通道抑制剂 |
EP2104674B8 (en) | 2006-11-15 | 2013-10-02 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophene analogues for the treatment or prevention of flavivirus infections |
CA2699157A1 (en) * | 2007-09-10 | 2009-03-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
ITMI20071971A1 (it) * | 2007-10-10 | 2009-04-11 | Altergon Sa | Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione |
WO2009076454A2 (en) | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
MY157445A (en) | 2008-08-27 | 2016-06-15 | Calcimedica Inc | Compounds that modulate intracellular calcium. |
GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
US8143269B2 (en) | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
EA018907B1 (ru) * | 2009-01-30 | 2013-11-29 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Кристаллический гидрохлорид n-{(1s)-2-амино-1-[(3-фторфенил)метил]этил}-5-хлор-4-(4-хлор-1-метил-1h-пиразол-5-ил)-2-тиофенкарбоксамида |
WO2011034962A2 (en) | 2009-09-16 | 2011-03-24 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
WO2011156321A1 (en) | 2010-06-07 | 2011-12-15 | Novomedix, Llc | Furanyl compounds and the use thereof |
MX337711B (es) | 2010-08-27 | 2016-03-15 | Calcimedica Inc | Compuestos que modulan el calcio intracelular. |
GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
NO3175985T3 (pt) | 2011-07-01 | 2018-04-28 | ||
US20150045305A1 (en) | 2012-01-27 | 2015-02-12 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CN103012381B (zh) * | 2013-01-10 | 2015-01-07 | 山东大学 | 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用 |
KR101721490B1 (ko) * | 2014-07-30 | 2017-03-30 | 한국생명공학연구원 | 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물 |
EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9214120D0 (en) * | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5670504A (en) | 1995-02-23 | 1997-09-23 | Merck & Co. Inc. | 2,6-diaryl pyridazinones with immunosuppressant activity |
US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
US6013664A (en) * | 1996-11-27 | 2000-01-11 | Bayer Aktiengesellschaft | Microbicidal agents based on thiophene-2-carboxylic acid derivatives |
BR9811828A (pt) * | 1997-08-05 | 2000-08-15 | American Home Prod | Análogos do ácido antranìlico |
DK1040108T3 (da) * | 1997-12-19 | 2004-05-24 | Schering Ag | Orthoanthranilamidderivater som antikoagulanter |
US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
AU2300699A (en) * | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
EP0960882A1 (en) * | 1998-05-19 | 1999-12-01 | Hoechst Marion Roussel Deutschland GmbH | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists |
EP1082315A1 (en) | 1998-06-05 | 2001-03-14 | Icagen, Inc. | Potassium channel inhibitors |
EP1109544A4 (en) | 1998-09-01 | 2004-10-27 | Bristol Myers Squibb Co | POTASSIUM CHANNEL INHIBITORS AND THEIR METHOD OF USE |
US6274620B1 (en) * | 1999-06-07 | 2001-08-14 | Biochem Pharma Inc. | Thiophene integrin inhibitors |
WO2003018585A1 (en) * | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease |
-
2000
- 2000-12-12 DE DE10061876A patent/DE10061876A1/de not_active Withdrawn
-
2001
- 2001-11-29 PL PL01362410A patent/PL362410A1/xx not_active IP Right Cessation
- 2001-11-29 MX MXPA03004770A patent/MXPA03004770A/es active IP Right Grant
- 2001-11-29 SK SK725-2003A patent/SK287464B6/sk not_active IP Right Cessation
- 2001-11-29 AU AU2002235743A patent/AU2002235743B2/en not_active Ceased
- 2001-11-29 EE EEP200300240A patent/EE05306B1/xx not_active IP Right Cessation
- 2001-11-29 IL IL15631401A patent/IL156314A0/xx unknown
- 2001-11-29 RU RU2003121236/04A patent/RU2275366C2/ru not_active IP Right Cessation
- 2001-11-29 CZ CZ20031633A patent/CZ20031633A3/cs unknown
- 2001-11-29 KR KR10-2003-7007875A patent/KR20030061846A/ko active IP Right Grant
- 2001-11-29 WO PCT/EP2001/013958 patent/WO2002048131A1/de active IP Right Grant
- 2001-11-29 PT PT01985832T patent/PT1349846E/pt unknown
- 2001-11-29 EP EP01985832A patent/EP1349846B1/de not_active Expired - Lifetime
- 2001-11-29 RS YUP-425/03A patent/RS50336B/sr unknown
- 2001-11-29 HU HU0303665A patent/HUP0303665A3/hu unknown
- 2001-11-29 DE DE50105337T patent/DE50105337D1/de not_active Expired - Lifetime
- 2001-11-29 AU AU3574302A patent/AU3574302A/xx active Pending
- 2001-11-29 NZ NZ526383A patent/NZ526383A/en unknown
- 2001-11-29 JP JP2002549662A patent/JP4252798B2/ja not_active Expired - Fee Related
- 2001-11-29 ES ES01985832T patent/ES2236335T3/es not_active Expired - Lifetime
- 2001-11-29 CN CNB018204007A patent/CN1225463C/zh not_active Expired - Fee Related
- 2001-11-29 DK DK01985832T patent/DK1349846T3/da active
- 2001-11-29 BR BR0116084-2A patent/BR0116084A/pt not_active Application Discontinuation
- 2001-11-29 AT AT01985832T patent/ATE288906T1/de active
- 2001-11-29 CA CA002431095A patent/CA2431095A1/en not_active Abandoned
- 2001-12-10 AR ARP010105720A patent/AR032781A1/es active IP Right Grant
- 2001-12-10 TW TW090130471A patent/TWI288134B/zh not_active IP Right Cessation
- 2001-12-12 US US10/012,338 patent/US6982279B2/en not_active Expired - Fee Related
-
2003
- 2003-05-27 ZA ZA200304091A patent/ZA200304091B/en unknown
- 2003-06-04 NO NO20032535A patent/NO329163B1/no not_active IP Right Cessation
- 2003-06-04 IL IL156314A patent/IL156314A/en not_active IP Right Cessation
- 2003-06-10 HR HR20030469A patent/HRP20030469A2/hr not_active Application Discontinuation
-
2004
- 2004-07-06 HK HK04104841A patent/HK1061850A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |