ZA200707342B - Pyrrolopyrimidines useful as inhibitors of protein kinase - Google Patents
Pyrrolopyrimidines useful as inhibitors of protein kinaseInfo
- Publication number
- ZA200707342B ZA200707342B ZA200707342A ZA200707342A ZA200707342B ZA 200707342 B ZA200707342 B ZA 200707342B ZA 200707342 A ZA200707342 A ZA 200707342A ZA 200707342 A ZA200707342 A ZA 200707342A ZA 200707342 B ZA200707342 B ZA 200707342B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- protein kinase
- useful
- pyrrolopyrimidines
- pyrrolopyrimidines useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
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- Pain & Pain Management (AREA)
- Endocrinology (AREA)
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- Psychiatry (AREA)
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- Reproductive Health (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64978105P | 2005-02-03 | 2005-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200707342B true ZA200707342B (en) | 2009-03-25 |
Family
ID=36498734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200707342A ZA200707342B (en) | 2005-02-03 | 2006-02-02 | Pyrrolopyrimidines useful as inhibitors of protein kinase |
Country Status (17)
Country | Link |
---|---|
US (2) | US8633205B2 (ja) |
EP (1) | EP1844050B1 (ja) |
JP (2) | JP5227032B2 (ja) |
KR (1) | KR20070104641A (ja) |
CN (1) | CN101142218B (ja) |
AT (1) | ATE420883T1 (ja) |
AU (1) | AU2006221065A1 (ja) |
CA (1) | CA2596830A1 (ja) |
DE (1) | DE602006004844D1 (ja) |
ES (1) | ES2320487T3 (ja) |
HK (1) | HK1116349A1 (ja) |
IL (1) | IL184898A0 (ja) |
MX (1) | MX2007009429A (ja) |
NO (1) | NO20074431L (ja) |
RU (1) | RU2434871C2 (ja) |
WO (1) | WO2006096270A1 (ja) |
ZA (1) | ZA200707342B (ja) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
EP1881983B1 (en) * | 2005-05-20 | 2012-01-11 | Vertex Pharmaceuticals, Inc. | Pyrrolopyridines useful as inhibitors of protein kinase |
US20070149506A1 (en) * | 2005-09-22 | 2007-06-28 | Arvanitis Argyrios G | Azepine inhibitors of Janus kinases |
AU2015201850B2 (en) * | 2005-12-13 | 2017-03-02 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
HUE030235T2 (en) | 2005-12-13 | 2017-04-28 | Incyte Holdings Corp | Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
EP2537849A3 (en) | 2006-01-17 | 2013-04-03 | Vertex Pharmaceuticals, Inc. | Azaindoles useful as inhibitors of janus kinases |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
JP2009532475A (ja) * | 2006-04-05 | 2009-09-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | ヤヌスキナーゼの阻害剤として有用なデアザプリン |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
US7919490B2 (en) | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
WO2008043019A1 (en) | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc | 8-substituted 2-(benzimidazolyl) purine derivatives for immunosuppression |
KR20090082453A (ko) | 2006-11-01 | 2009-07-30 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나제의 억제제로서 유용한 트리사이클릭 헤테로아릴 화합물 |
JP2010510211A (ja) * | 2006-11-16 | 2010-04-02 | ファーマコペイア・リミテッド・ライアビリティ・カンパニー | 免疫抑制用7−置換プリン誘導体 |
CA2673472A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo) [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
WO2008079965A1 (en) | 2006-12-22 | 2008-07-03 | Incyte Corporation | Substituted heterocycles as janus kinase inhibitors |
RU2009140319A (ru) * | 2007-04-02 | 2011-05-10 | Палау Фарма С.А. (Es) | Производные пирролпиримидина |
EP3070090B1 (en) * | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
WO2009098236A1 (en) | 2008-02-06 | 2009-08-13 | Novartis Ag | Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors |
ES2602577T3 (es) | 2008-03-11 | 2017-02-21 | Incyte Holdings Corporation | Derivados de azetidina y ciclobutano como inhibidores de JAK |
RU2560153C2 (ru) | 2008-06-20 | 2015-08-20 | Дженентек, Инк. | Триазолпиридиновые соединения, ингибирующие jak, и способы |
BRPI0909945A2 (pt) | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
CL2009001884A1 (es) * | 2008-10-02 | 2010-05-14 | Incyte Holdings Corp | Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco. |
JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
US8592415B2 (en) * | 2009-02-11 | 2013-11-26 | Reaction Biology Corp. | Selective kinase inhibitors |
SI2401267T1 (sl) * | 2009-02-27 | 2014-05-30 | Ambit Biosciences Corporation | Derivati kinazolina, ki modulirajo JAK-kinazo, in njihova uporaba v postopkih |
AR076794A1 (es) | 2009-05-22 | 2011-07-06 | Incyte Corp | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen |
EA020494B1 (ru) | 2009-05-22 | 2014-11-28 | Инсайт Корпорейшн | 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ |
EP3141252B8 (en) | 2009-06-17 | 2019-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2011003418A1 (en) | 2009-07-08 | 2011-01-13 | Leo Pharma A/S | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors |
AR078012A1 (es) * | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
WO2011044481A1 (en) * | 2009-10-09 | 2011-04-14 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
BR112012020693B1 (pt) * | 2010-02-18 | 2020-05-12 | Incyte Holdings Corporation | Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende |
MX347851B (es) | 2010-03-10 | 2017-05-16 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
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GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
JP4078074B2 (ja) * | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
DE60134679D1 (de) * | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
CA2515132C (en) * | 2003-02-07 | 2012-01-03 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrroles useful as inhibitors of protein kinases |
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2006
- 2006-02-02 AU AU2006221065A patent/AU2006221065A1/en not_active Abandoned
- 2006-02-02 MX MX2007009429A patent/MX2007009429A/es active IP Right Grant
- 2006-02-02 AT AT06734381T patent/ATE420883T1/de active
- 2006-02-02 WO PCT/US2006/004019 patent/WO2006096270A1/en active Application Filing
- 2006-02-02 JP JP2007554283A patent/JP5227032B2/ja not_active Expired - Fee Related
- 2006-02-02 RU RU2007132908/04A patent/RU2434871C2/ru not_active IP Right Cessation
- 2006-02-02 KR KR1020077020046A patent/KR20070104641A/ko not_active Application Discontinuation
- 2006-02-02 EP EP06734381A patent/EP1844050B1/en not_active Not-in-force
- 2006-02-02 CA CA002596830A patent/CA2596830A1/en not_active Abandoned
- 2006-02-02 ES ES06734381T patent/ES2320487T3/es active Active
- 2006-02-02 DE DE602006004844T patent/DE602006004844D1/de active Active
- 2006-02-02 ZA ZA200707342A patent/ZA200707342B/xx unknown
- 2006-02-02 CN CN2006800087780A patent/CN101142218B/zh not_active Expired - Fee Related
- 2006-02-02 US US11/346,048 patent/US8633205B2/en not_active Expired - Fee Related
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2007
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- 2008-12-22 JP JP2008326447A patent/JP2009102361A/ja not_active Withdrawn
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US20060183761A1 (en) | 2006-08-17 |
NO20074431L (no) | 2007-08-31 |
EP1844050B1 (en) | 2009-01-14 |
JP2009102361A (ja) | 2009-05-14 |
ES2320487T3 (es) | 2009-05-22 |
AU2006221065A1 (en) | 2006-09-14 |
US8633205B2 (en) | 2014-01-21 |
RU2434871C2 (ru) | 2011-11-27 |
MX2007009429A (es) | 2008-03-18 |
DE602006004844D1 (de) | 2009-03-05 |
ATE420883T1 (de) | 2009-01-15 |
CN101142218B (zh) | 2013-02-06 |
IL184898A0 (en) | 2007-12-03 |
KR20070104641A (ko) | 2007-10-26 |
US20140171454A1 (en) | 2014-06-19 |
RU2007132908A (ru) | 2009-03-10 |
EP1844050A1 (en) | 2007-10-17 |
CA2596830A1 (en) | 2006-09-14 |
JP5227032B2 (ja) | 2013-07-03 |
US20070004762A9 (en) | 2007-01-04 |
CN101142218A (zh) | 2008-03-12 |
WO2006096270A1 (en) | 2006-09-14 |
JP2008528705A (ja) | 2008-07-31 |
HK1116349A1 (en) | 2008-12-19 |
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