ZA200402753B - Methods for treating ocular neovascular diseases. - Google Patents
Methods for treating ocular neovascular diseases. Download PDFInfo
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- ZA200402753B ZA200402753B ZA200402753A ZA200402753A ZA200402753B ZA 200402753 B ZA200402753 B ZA 200402753B ZA 200402753 A ZA200402753 A ZA 200402753A ZA 200402753 A ZA200402753 A ZA 200402753A ZA 200402753 B ZA200402753 B ZA 200402753B
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- South Africa
- Prior art keywords
- vegf
- nucleic acid
- acid ligand
- aptamer
- eye
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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ZA200402753A ZA200402753B (en) | 2001-11-09 | 2004-04-08 | Methods for treating ocular neovascular diseases. |
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EP (1) | EP1441743A4 (zh) |
JP (1) | JP2005511576A (zh) |
KR (1) | KR20050044372A (zh) |
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AR (1) | AR037307A1 (zh) |
BR (1) | BR0213975A (zh) |
CA (1) | CA2464007A1 (zh) |
CR (1) | CR7330A (zh) |
EA (1) | EA006746B1 (zh) |
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Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001234979B2 (en) * | 2000-02-10 | 2006-07-27 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
US6942655B2 (en) * | 2001-11-13 | 2005-09-13 | Minu, Llc | Method to treat age-related macular degeneration |
US6936043B2 (en) * | 2001-11-13 | 2005-08-30 | Minu, Llc | Method to treat age-related macular degeneration |
EP1605847B1 (en) * | 2003-03-07 | 2009-09-16 | Board Of Regents, The University Of Texas System | Antibody-targeted photodynamic therapy |
CL2004001996A1 (es) * | 2003-08-08 | 2005-05-06 | Eyetech Pharmaceuticals Inc | Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion. |
BRPI0413977A (pt) * | 2003-08-27 | 2006-11-07 | Osi Eyetech Inc | método para suprimir um distúrbio neovascular, e para tratar um paciente diagnosticado com ou em risco de desenvolver um distúrbio neovascular, composição farmacêutica, e, embalagem farmacêutica |
US7575321B2 (en) | 2003-10-30 | 2009-08-18 | Welch Allyn, Inc. | Apparatus and method of diagnosis of optically identifiable ophthalmic conditions |
JP5105578B2 (ja) | 2003-11-05 | 2012-12-26 | サーコード バイオサイエンス インコーポレイテッド | 細胞接着のモジュレーター |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20050101582A1 (en) * | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
AU2005209201B2 (en) | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
EP1732571A4 (en) * | 2004-03-05 | 2009-09-09 | Archemix Corp | CONTROLLED MODULATION OF PHARMACOKINETICS AND BIOLOGICAL DISTRIBUTION OF APTAMERIC THERAPY |
US8147865B2 (en) | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
ATE551060T1 (de) * | 2004-06-04 | 2012-04-15 | Scripps Research Inst | Zusammensetzungen und verfahren zur behandlung von neovaskulären erkrankungen |
JP2008507284A (ja) * | 2004-07-23 | 2008-03-13 | (オーエスアイ)アイテツク・インコーポレーテツド | デュアルハイブリダイゼーションによるオリゴヌクレオチドの検出 |
JP2006056807A (ja) * | 2004-08-18 | 2006-03-02 | Konica Minolta Medical & Graphic Inc | 光線力学療法製剤 |
AU2012200865A1 (en) * | 2004-10-21 | 2012-03-29 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
EP2319492A3 (en) * | 2004-10-21 | 2011-08-10 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
US20060111423A1 (en) * | 2004-10-26 | 2006-05-25 | Zeligs Michael A | Use of diindolylmethane-related indoles and growth factor receptor inhibitors for the treatment of human cytomegalovirus-associated disease |
CA2588449A1 (en) * | 2004-11-24 | 2006-06-01 | Therakine Corporation | An implant for intraocular drug delivery |
US20060134175A1 (en) * | 2004-12-22 | 2006-06-22 | Stephen Bartels | Drug eluting pharmaceutical delivery system for treatment of ocular disease and method of use |
US20060134176A1 (en) * | 2004-12-22 | 2006-06-22 | Bausch & Lomb Incorporated | Pharmaceutical delivery system and method of use |
US20060134174A1 (en) * | 2004-12-22 | 2006-06-22 | Bausch & Lomb Incorporated | Pharmaceutical delivery system and method of use |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
US20060258698A1 (en) | 2005-02-09 | 2006-11-16 | Sreenivasu Mudumba | Liquid formulations for treatment of diseases or conditions |
KR20070121754A (ko) * | 2005-03-21 | 2007-12-27 | 마커사이트, 인코포레이티드 | 질환 또는 상태의 치료를 위한 약물 송달 시스템 |
US20060293270A1 (en) * | 2005-06-22 | 2006-12-28 | Adamis Anthony P | Methods and compositions for treating ocular disorders |
JPWO2007037188A1 (ja) * | 2005-09-27 | 2009-04-09 | 北海道公立大学法人 札幌医科大学 | 血管透過性亢進に起因する眼疾患の予防及び治療のための医薬 |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
JP2009525282A (ja) * | 2006-01-30 | 2009-07-09 | (オーエスアイ)アイテツク・インコーポレーテツド | 血管新生疾患の治療のための組み合わせ療法 |
US8492400B2 (en) * | 2006-02-09 | 2013-07-23 | Santen Pharmaceutical Co., Ltd. | Stable formulations, and methods of their preparation and use |
US20070248646A1 (en) * | 2006-02-16 | 2007-10-25 | Ali Hafezi-Moghadam | Use of azurocidin inhibitors in prevention and treatment of ocular vascular leakage |
US20070218007A1 (en) * | 2006-03-17 | 2007-09-20 | Allergan, Inc. | Ophthalmic visualization compositions and methods of using same |
JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
KR101406811B1 (ko) * | 2006-06-16 | 2014-06-12 | 리제너론 파마슈티칼스 인코포레이티드 | 유리체내 투여에 적당한 vegf 길항제 제형 |
US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US9039761B2 (en) | 2006-08-04 | 2015-05-26 | Allergan, Inc. | Ocular implant delivery assemblies with distal caps |
WO2008103320A1 (en) * | 2007-02-16 | 2008-08-28 | Novacea, Inc. | Methods of treating ophthalmic disorders with anthraquinones |
US20100130569A1 (en) * | 2007-05-11 | 2010-05-27 | Saten Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
WO2009054914A1 (en) * | 2007-10-19 | 2009-04-30 | Sarcode Corporation | Compositions and methods for treatment of diabetic retinopathy |
US8530189B2 (en) * | 2008-10-16 | 2013-09-10 | Kathleen Cogan Farinas | Sustained drug delivery system |
EP2349339A4 (en) * | 2008-10-16 | 2015-01-07 | Kathleen Cogan Farinas | EXTENDED MEDICATION DELIVERY SYSTEM |
AU2009327266B2 (en) | 2008-12-16 | 2015-10-29 | Valeant Pharmaceuticals International, Inc. | Combination of photodynamic therapy and anti-VEGF agents in the treatment of unwanted choroidal neovasculature |
US8545554B2 (en) * | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
WO2010091234A2 (en) | 2009-02-06 | 2010-08-12 | The General Hospital Corporation | Methods of treating vascular lesions |
WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
BR112012017071A2 (pt) * | 2010-01-14 | 2016-04-12 | Univ Nagoya City | produto farmacêutico para prevenir ou tratar distúrbios acompanhados da agiogênese ocular e/ou do aumento da permeabilidade vascular ocular |
WO2012047587A2 (en) * | 2010-09-27 | 2012-04-12 | Serrata, Llc | Mdm2 inhibitors for treatment of ocular conditions |
KR20210030510A (ko) | 2011-01-13 | 2021-03-17 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
CN103391782A (zh) | 2011-02-02 | 2013-11-13 | 公立大学法人名古屋市立大学 | 用于预防或治疗伴有眼内血管新生及/或眼内血管渗透性过高的疾病的药物 |
KR101303920B1 (ko) * | 2011-04-26 | 2013-09-05 | 서울대학교산학협력단 | 프로토포르피린 IX 구조를 갖는 화합물을 포함하는, 저산소상태 유도성인자1α 또는 혈관내피세포성장인자 과다 발현으로 기인하는 질병의 예방 및 치료에 유용한 조성물 |
TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
AU2013100070B4 (en) * | 2012-07-03 | 2013-04-04 | Novartis Ag | Use of device |
CN103721257B (zh) * | 2012-10-16 | 2016-12-21 | 无锡兆真辐射技术有限公司 | 光敏素催化分解过氧化氢系列药物 |
SI3660033T1 (sl) | 2012-11-15 | 2021-09-30 | Apellis Pharmaceuticals, Inc. | Analogi kompstatina z dolgotrajnim delovanjem in sorodni sestavki in postopki |
WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
RU2527360C1 (ru) * | 2013-04-23 | 2014-08-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ комбинированного лечения ретиноваскулярного макулярного отека |
EP3628373A1 (en) | 2013-07-12 | 2020-04-01 | IVERIC bio, Inc. | Methods for treating or preventing opthalmological conditions |
AU2014370404A1 (en) * | 2013-12-24 | 2016-07-07 | Novelmed Therapeutics, Inc. | Compositions and methods of treating ocular diseases |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
JP6968787B2 (ja) | 2015-10-07 | 2021-11-17 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals, Inc. | 投与レジメン |
HRP20231379T1 (hr) | 2015-12-03 | 2024-02-16 | Regeneron Pharmaceuticals, Inc. | Postupci dovođenja u vezu genskih varijanti s kliničkim ishodom kod pacijenata koji pate od starosne makularne degeneracije liječenih anti-vegf-om |
CN108712911A (zh) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | 抗体及其缀合物 |
KR20190139931A (ko) | 2017-04-07 | 2019-12-18 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
DE102017008721A1 (de) | 2017-09-16 | 2019-03-21 | protectismundi GmbH | Verfahren und Vorrichtung zur Hochhausbrandbekämfpung |
WO2019210097A1 (en) * | 2018-04-25 | 2019-10-31 | Vitrisa Therapeutics, Inc. | Aptamers with stability, potency or half-life for enhanced safety and efficacy |
US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
JP2022553640A (ja) | 2019-10-10 | 2022-12-26 | コディアック サイエンシーズ インコーポレイテッド | 眼障害を処置する方法 |
CN113101530B (zh) * | 2021-04-14 | 2022-09-30 | 中国人民解放军陆军特色医学中心 | 一种通过无线充电激活玻璃体腔植入性发光二极管的*** |
CN118108804B (zh) * | 2024-04-26 | 2024-06-25 | 山东大学 | 一种缺氧敏感功能化修饰的抗血管生成多肽、纳米胶束材料及其制备方法与应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770592A (en) * | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5731294A (en) * | 1993-07-27 | 1998-03-24 | Hybridon, Inc. | Inhibition of neovasularization using VEGF-specific oligonucleotides |
US5798349A (en) * | 1994-03-14 | 1998-08-25 | The General Hospital Corporation | Use of green porphyrins to treat neovasculature in the eye |
CA2185644C (en) * | 1994-03-14 | 2011-04-12 | Joan W. Miller | Use of green porphyrins in ocular diagnosis and therapy |
JP3845469B2 (ja) * | 1996-02-21 | 2006-11-15 | 明治製菓株式会社 | 眼底の新生血管の閉塞に用いる投与剤 |
US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
KR100514929B1 (ko) * | 1996-10-25 | 2005-09-15 | 길리애드 사이언시즈, 인코포레이티드 | 혈관내피 성장인자 핵산 리간드 복합체 |
US6123923A (en) * | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US6117862A (en) * | 1998-10-09 | 2000-09-12 | Qlt, Inc. | Model and method for angiogenesis inhibition |
US20020049247A1 (en) * | 2000-01-12 | 2002-04-25 | Chen James C. | Novel treatment for eye disease |
AU2001234979B2 (en) * | 2000-02-10 | 2006-07-27 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
DE60130872T2 (de) * | 2000-03-10 | 2008-07-17 | Insite Vision, Inc., Alameda | Verfahren und mittel zur behandlung und vorbeugung von erkrankungen der hinteren augenkammer |
PL359027A1 (en) * | 2000-03-24 | 2004-08-23 | Novartis Ag | Improved treatment of neovascularization |
US6936043B2 (en) * | 2001-11-13 | 2005-08-30 | Minu, Llc | Method to treat age-related macular degeneration |
WO2004034889A2 (en) * | 2002-10-18 | 2004-04-29 | The Regents Of The University Of California | Photodynamic therapy for ocular neovascularization |
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HRP20040406A2 (en) | 2005-02-28 |
CN1582156A (zh) | 2005-02-16 |
CA2464007A1 (en) | 2003-05-15 |
WO2003039404A2 (en) | 2003-05-15 |
MXPA04004363A (es) | 2005-05-16 |
US20070027101A1 (en) | 2007-02-01 |
OA12720A (en) | 2006-06-27 |
KR20050044372A (ko) | 2005-05-12 |
GEP20063755B (en) | 2006-02-27 |
ECSP045098A (es) | 2004-07-23 |
TW200302226A (en) | 2003-08-01 |
JP2005511576A (ja) | 2005-04-28 |
TWI260327B (en) | 2006-08-21 |
EP1441743A4 (en) | 2009-02-25 |
AP1750A (en) | 2007-06-23 |
EA006746B1 (ru) | 2006-04-28 |
EA200400518A1 (ru) | 2004-12-30 |
US20030171320A1 (en) | 2003-09-11 |
NO20041882L (no) | 2004-05-07 |
US20040167091A1 (en) | 2004-08-26 |
WO2003039404A3 (en) | 2004-02-12 |
TNSN04081A1 (fr) | 2006-06-01 |
EP1441743A2 (en) | 2004-08-04 |
BR0213975A (pt) | 2005-05-10 |
AP2004003026A0 (en) | 2004-06-30 |
CR7330A (es) | 2005-06-15 |
RS35404A (en) | 2006-10-27 |
IS7215A (is) | 2004-04-07 |
PL371929A1 (en) | 2005-07-11 |
IL161327A0 (en) | 2004-09-27 |
MA27145A1 (fr) | 2005-01-03 |
AR037307A1 (es) | 2004-11-03 |
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