YU46189B - Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija" - Google Patents

Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija"

Info

Publication number
YU46189B
YU46189B YU25787A YU25787A YU46189B YU 46189 B YU46189 B YU 46189B YU 25787 A YU25787 A YU 25787A YU 25787 A YU25787 A YU 25787A YU 46189 B YU46189 B YU 46189B
Authority
YU
Yugoslavia
Prior art keywords
small cell
human lung
antigen
belonging
type
Prior art date
Application number
YU25787A
Other languages
English (en)
Other versions
YU25787A (en
Inventor
K.E. Hellstrom
J.P. Brown
I. Hellstrom
H. Marquardt
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of YU25787A publication Critical patent/YU25787A/xx
Publication of YU46189B publication Critical patent/YU46189B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

naznačeno time, što ima mesto za kombinovanje antigena koje se vezuju za proteinski antigen molekulske težine oko 110 000 daltona i sledeću amino-terminalnu sekvencu amino kiselina: 1 5 10 15 20 LI-X-V-Q-V-D-E-X-P-V-V-V-A-L-V-G15-T-D-A-X-L gde X predstavlja neidentifikovanu amino kiselinu, pri čemu proteinski antigen predstavlja determinantu površine humanog kar-cinoma pluća koji ne pripada tipu malih ćelija. -Prijava sadrži 2 nezavisna zahteva + 15 zavisnih zahteva.
YU25787A 1986-02-26 1987-02-20 Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija" YU46189B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/834,172 US5185432A (en) 1986-02-26 1986-02-26 Monoclonal antibodies and antigen for human non-small cell lung carcinoma and other certain human carcinomas

Publications (2)

Publication Number Publication Date
YU25787A YU25787A (en) 1990-12-31
YU46189B true YU46189B (sh) 1993-05-28

Family

ID=25266276

Family Applications (1)

Application Number Title Priority Date Filing Date
YU25787A YU46189B (sh) 1986-02-26 1987-02-20 Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija"

Country Status (28)

Country Link
US (1) US5185432A (sh)
JP (1) JPS62220197A (sh)
KR (2) KR900006338B1 (sh)
CN (1) CN87100927A (sh)
AT (1) AT400577B (sh)
AU (1) AU612967B2 (sh)
BE (1) BE1000611A5 (sh)
CA (1) CA1312025C (sh)
CH (1) CH675880A5 (sh)
DD (2) DD266028A5 (sh)
DE (1) DE3705276A1 (sh)
DK (1) DK98187A (sh)
ES (1) ES2004245A6 (sh)
FI (1) FI870764A (sh)
FR (1) FR2596062B1 (sh)
GB (1) GB2186885B (sh)
GR (1) GR870294B (sh)
IE (1) IE60286B1 (sh)
IT (1) IT1203511B (sh)
LU (1) LU86786A1 (sh)
NL (1) NL8700415A (sh)
NO (1) NO174719C (sh)
NZ (1) NZ219338A (sh)
OA (1) OA08485A (sh)
PT (1) PT84370B (sh)
SE (2) SE467988B (sh)
YU (1) YU46189B (sh)
ZA (1) ZA869494B (sh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (de) * 1985-09-02 1987-03-05 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte glykoproteine, verfahren zu ihrer herstellung sowie ihre verwendung
JPH0813840B2 (ja) * 1987-03-31 1996-02-14 協和醗酵工業株式会社 抗ヒト肺腺癌単クロ−ン性抗体
US5134075A (en) * 1989-02-17 1992-07-28 Oncogen Limited Partnership Monoclonal antibody to novel antigen associated with human tumors
US5171665A (en) * 1989-04-17 1992-12-15 Oncogen Monoclonal antibody to novel antigen associated with human tumors
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5589579A (en) * 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
DE69831522T2 (de) 1997-03-03 2006-06-14 Amersham Biosciences Uk Ltd In-situ Zellextraktion und Assay-Verfahren
DE19725133A1 (de) * 1997-06-13 1998-12-17 Micromet Ges Fuer Biomedizinis Nachweis von seltenen Zellen
US20050089918A1 (en) * 1998-02-23 2005-04-28 Amersham Biosciences Uk Limited In-situ cell extraction and assay method
US6117981A (en) * 1999-06-03 2000-09-12 Cytoclonal Pharmaceutics, Inc. Hybridomas for lung cancer marker and monoclonal antibodies thereof
AU7337400A (en) * 1999-09-03 2001-04-10 Human Genome Sciences, Inc. B7-like polynucleotides, polypeptides, and antibodies
WO2001094413A2 (en) 2000-06-06 2001-12-13 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
TWI317285B (en) * 2000-07-28 2009-11-21 Dainippon Sumitomo Pharma Co New use and kit for remedies for cancer
CN101724072B (zh) * 2008-10-27 2013-10-09 谷为岳 一种抗肿瘤的单克隆抗体的序列及应用
GB0916686D0 (en) * 2009-09-23 2009-11-04 Univ Manchester Metropolitan Treatment of cancer
US8802091B2 (en) 2010-03-04 2014-08-12 Macrogenics, Inc. Antibodies reactive with B7-H3 and uses thereof
SG183847A1 (en) 2010-03-04 2012-10-30 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
CN105424942B (zh) * 2010-09-17 2017-07-18 国立研究开发法人产业技术综合研究所 肺癌鉴定标志物
CN102391992B (zh) * 2011-11-03 2012-08-29 潘世扬 抗人非小细胞肺癌单克隆抗体及其应用
EP3442574A4 (en) 2016-04-15 2019-12-11 MacroGenics, Inc. NOVEL B7-H3 BINDING MOLECULES, THEIR ANTIBODY-MEDICINAL CONJUGATES AND METHODS OF USE
CN111662371B (zh) * 2020-04-30 2023-07-04 美康生物科技股份有限公司 细胞角蛋白19片段抗原及其制备方法和应用
CN112300284B (zh) * 2020-12-29 2021-04-06 慈达(广州)生物技术有限公司 核酸筛选结合抗体检测用于癌症检测中的用途及其制备的试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569788A (en) * 1983-05-18 1986-02-11 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibodies against non small cell lung cancer
ZA858371B (en) * 1984-11-02 1987-03-25 Oncogen Monoclonal antibodies for human non-small cell lung carcinomas
IL76877A (en) * 1984-11-02 1991-11-21 Oncogen Diagnostic method for the determination of human non-small cell lung carcinomas employing novel monoclonal antibodies and compositions containing said antibodies

Also Published As

Publication number Publication date
YU25787A (en) 1990-12-31
KR870008026A (ko) 1987-09-23
FR2596062B1 (fr) 1990-06-08
NO870770L (no) 1987-08-27
BE1000611A5 (fr) 1989-02-21
AU6927287A (en) 1987-08-27
DK98187A (da) 1987-08-27
NZ219338A (en) 1991-11-26
ATA43587A (de) 1995-06-15
IT1203511B (it) 1989-02-15
AU612967B2 (en) 1991-07-25
GB2186885B (en) 1990-10-03
SE9201529A0 (sv) 1992-05-14
IE870487L (en) 1987-08-26
SE8700805D0 (sv) 1987-02-25
NO174719C (no) 1994-06-22
CN87100927A (zh) 1988-10-05
SE8700805L (sv) 1987-10-22
PT84370A (en) 1987-03-01
NO870770D0 (no) 1987-02-25
SE467988B (sv) 1992-10-12
NO174719B (no) 1994-03-14
GR870294B (en) 1987-06-30
AT400577B (de) 1996-01-25
GB2186885A (en) 1987-08-26
DK98187D0 (da) 1987-02-25
CH675880A5 (sh) 1990-11-15
DD266028A5 (de) 1989-03-22
NL8700415A (nl) 1987-09-16
CA1312025C (en) 1992-12-29
DE3705276A1 (de) 1987-08-27
IT8719491A0 (it) 1987-02-25
FR2596062A1 (fr) 1987-09-25
OA08485A (fr) 1988-07-29
KR880010438A (ko) 1988-10-08
FI870764A (fi) 1987-08-27
ES2004245A6 (es) 1988-12-16
KR900006338B1 (ko) 1990-08-28
JPS62220197A (ja) 1987-09-28
PT84370B (pt) 1989-11-10
LU86786A1 (fr) 1987-09-15
US5185432A (en) 1993-02-09
IE60286B1 (en) 1994-06-29
FI870764A0 (fi) 1987-02-23
GB8703700D0 (en) 1987-03-25
SE9201529D0 (sv) 1992-05-14
ZA869494B (en) 1987-10-28
DD276165A5 (de) 1990-02-14

Similar Documents

Publication Publication Date Title
YU46189B (sh) Monoklonska antitela i antigen za karcinome pluća čoveka koji ne pripadaju tipu "malih ćelija"
DK0554344T3 (da) Farmaceutisk præparat til behandling eller forebyggelse af en malign tumor
DE69028388D1 (de) Monoklonaler antikörper gegen ein neues humanes tumor assoziiertes antigen
DE68918867D1 (de) Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.
KR900013979A (ko) 사람 유두종비루스형 16의 e7 단백질상의 면역원성 영역
ES2113088T3 (es) Metodo de entrega de agentes a celulas diana.
ATE47155T1 (de) Monoklonaler antikoerper.
DK228486D0 (da) Retrovirale polypeptider med tilknytning til human celletransformation
DK0523395T3 (da) Seroreaktive områder på proteinerne E1 og E2 i HPV 16
DK0431541T3 (da) Toxoplasma gondii-antigener, deres fremstilling og deres anvendelse
DE69535719D1 (de) Fas-antigenbindender ligand
EP0284587A3 (en) Synthetic peptide antigens for the detection of hiv-1 infection
HUP0103650A2 (hu) Vírusburok-proteinek epitópjai és az ellenük termelt ellenanyagok alkalmazása HCV-vírusantigén gazdaszövetből történő kimutatására
KR910019641A (ko) 사람 유두종 바이러스(hpv) 18의 단백질상의 혈청 반응성 에피토프
DE69029134D1 (de) Monoklonale antikörper zur induzierung von toleranz
Le et al. Monoclonal antibodies to human immune interferon and their application for affinity chromatography
YU46386B (sh) Monoklonska antitela i antigeni za ljudske karcinome pluća koji ne pripadaju tipu "malih ćelija"
Gitlin et al. A comparison of the peptides released from related rabbit antibodies by enzymatic hydrolysis
ATE51709T1 (de) Antigen im zusammenhang mit der fruehzeitigen feststellung von schwangerschaft bei saeugern.
Deshayes et al. Proteins of bovine leukemia virus. I. Characterization and reactions with natural antibodies
Mason et al. Platelet antigens in chronic idiopathic thrombocytopenic purpura
Jerry et al. Fetal antigens in nonneoplastic conditions
Comoglio et al. Evidence for a membrane carrier molecule common to embryonal and tumour-specific antigenic determinants expressed by a mouse transplantable tumour.
KR930703445A (ko) 톡소플라스마 곤디(toxoplasma gondii)의 단백질 항원의 클로닝 및 발현
DE3881275D1 (de) Monoklonaler antikoerper zur selektiven immunologischen bestimmung von intaktem prokollagen peptid (typ iii) und prokollagen (typ iii) in koerperfluessigkeiten.