HUP0103650A2 - Vírusburok-proteinek epitópjai és az ellenük termelt ellenanyagok alkalmazása HCV-vírusantigén gazdaszövetből történő kimutatására - Google Patents

Vírusburok-proteinek epitópjai és az ellenük termelt ellenanyagok alkalmazása HCV-vírusantigén gazdaszövetből történő kimutatására

Info

Publication number
HUP0103650A2
HUP0103650A2 HU0103650A HUP0103650A HUP0103650A2 HU P0103650 A2 HUP0103650 A2 HU P0103650A2 HU 0103650 A HU0103650 A HU 0103650A HU P0103650 A HUP0103650 A HU P0103650A HU P0103650 A2 HUP0103650 A2 HU P0103650A2
Authority
HU
Hungary
Prior art keywords
epitopes
detection
hcv
protein
directed against
Prior art date
Application number
HU0103650A
Other languages
English (en)
Inventor
Marie-Ange Buyse
Erik Depla
Geert Maertens
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of HUP0103650A2 publication Critical patent/HUP0103650A2/hu
Publication of HUP0103650A3 publication Critical patent/HUP0103650A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C07K16/109—Hepatitis C virus; Hepatitis G virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgya HCV E1 protein C-terminális régiójához (227-383.aminosav) vagy HCV E2 protein N-terminális régiójához (384-450.aminosav), előnyösen az E1 protein 307-326. aminosavainak, illetve azE2 protein 395-415. aminosavainak megfelelő epitópokhoz specifikusankötődő ellenanyagok alkalmazása természetes HCV-proteinantigénkimutatására szolgáló reagenskészlet előállítására. A találmánytárgyát képezi továbbá az ECACC-nél letétbe helyezett 98031214nyilvántartási számú hybridoma-sejtvonal, az általa termeltmonoklonális ellenanyag, eljárás természetes HCV-proteinantigénekkimutatására, továbbá természetes HCV-proteinantigének kimutatásáraszolgáló reagenskészlet. Ó
HU0103650A 1998-03-27 1999-03-29 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue HUP0103650A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870060A EP0947525A1 (en) 1998-03-27 1998-03-27 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue
PCT/EP1999/002154 WO1999050301A2 (en) 1998-03-27 1999-03-29 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue

Publications (2)

Publication Number Publication Date
HUP0103650A2 true HUP0103650A2 (hu) 2002-01-28
HUP0103650A3 HUP0103650A3 (en) 2005-10-28

Family

ID=8237012

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103650A HUP0103650A3 (en) 1998-03-27 1999-03-29 Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of hcv viral antigen in host tissue

Country Status (19)

Country Link
US (2) US6521403B1 (hu)
EP (2) EP0947525A1 (hu)
JP (1) JP3657515B2 (hu)
KR (1) KR20010042225A (hu)
CN (1) CN1294598A (hu)
AT (1) ATE336512T1 (hu)
AU (1) AU756495B2 (hu)
BR (1) BR9909026A (hu)
CA (1) CA2321179A1 (hu)
DE (1) DE69932812T2 (hu)
ES (1) ES2272065T3 (hu)
HU (1) HUP0103650A3 (hu)
IL (1) IL138586A0 (hu)
NZ (1) NZ506553A (hu)
PL (1) PL343638A1 (hu)
PT (1) PT1064309E (hu)
TR (1) TR200002695T2 (hu)
WO (1) WO1999050301A2 (hu)
ZA (1) ZA200004383B (hu)

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JPH09503396A (ja) * 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
WO2001030815A1 (en) * 1999-10-27 2001-05-03 Innogenetics N.V. Redox reversible hcv proteins with native-like conformation
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
EP1178116A1 (en) * 2000-08-03 2002-02-06 Hybrigenics S.A. Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
JP2004524829A (ja) * 2000-12-01 2004-08-19 アメリカ合衆国 Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用
WO2002060954A1 (en) 2001-01-12 2002-08-08 Karolinska Innovations Ab Materials and methods for treatment of hepatitis c
JP4342519B2 (ja) * 2003-09-22 2009-10-14 株式会社グリーンペプタイド Ｃ型肝炎ウイルス由来ペプチド
EP1574517A1 (en) * 2004-03-09 2005-09-14 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
EP1602664A1 (en) * 2004-03-08 2005-12-07 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
WO2006033012A2 (en) * 2004-09-24 2006-03-30 Pfizer Limited Method of screening for modulators of hepatitis c virus infection
US20090220490A1 (en) * 2006-02-23 2009-09-03 Martina Buck Compositions and Assays for Inhibiting HCV Infection
WO2007111964A2 (en) * 2006-03-22 2007-10-04 Genimmune N.V. Hepatitis c virus neutralizing antibodies
WO2007137456A1 (fr) * 2006-06-01 2007-12-06 Yun Cheng Peptide pour la prévention ou le traitement d'atteinte hépatique et son dérivé ainsi que son utilisation
ES2456961T3 (es) 2007-02-21 2014-04-24 University Of Massachusetts Anticuerpos humanos contra el virus de la hepatitis C (VHC), usos de los mismos
US8993228B2 (en) 2008-09-30 2015-03-31 Toray Industries, Inc. Antibody binding to envelope protein 2 of hepatitis C virus and method for identifying genotype of hepatitis C virus using the same
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
WO2014065822A1 (en) * 2012-10-26 2014-05-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis c virus neutralizing epitopes, antibodies, and methods
CN107636444B (zh) * 2015-03-23 2020-07-10 以埃森生物科学股份有限公司的名义经营的埃森仪器股份有限公司 用于评估生物材料中的流感病毒类型的非缔合的病毒尺寸颗粒的流式细胞术方法
CN109232722B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段317-325及其用途
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
KR20230050761A (ko) 2021-10-08 2023-04-17 김민준 과제기한 자동알림

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Publication number Priority date Publication date Assignee Title
US5308750A (en) 1989-12-22 1994-05-03 Abbott Laboratories Monoclonal antibodies to putative HCV E2/NS1 proteins and methods for using same
SK285623B6 (sk) 1990-11-08 2007-05-03 Chiron Corporation Spôsob produkcie asialoglykoproteínu hepatitis C vírusu
AU662517B2 (en) * 1991-01-31 1995-09-07 Abbott Laboratories Monoclonal antibodies to putative HCV envelope region and methods for using same
FR2677372B1 (fr) 1991-06-06 1994-11-10 Pasteur Institut Sequences nucleotidiques et peptidiques d'un isolat de virus de l'hepatite c, applications diagnostiques et therapeutiques.
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
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DE69333269T2 (de) 1992-01-31 2004-07-29 Abbott Laboratories, Abbott Park Expressionssystem in säugetieren für hcv-proteine
KR20030096423A (ko) * 1992-03-06 2003-12-31 엔. 브이. 이노제네틱스 소시에떼아노님 면역학적으로 중요한 에피토프에 상응하는 펩티드의 측정방법 및 면역학적으로 중요한 에피토프에 상응하는 항체또는 비오티닐화된 펩티드의 측정 방법에 상기 펩티드를사용하는 방법, 상기 펩티드의 제조방법 및 상기 펩티드를함유하는 조성물
JPH05344899A (ja) 1992-06-11 1993-12-27 Kokuritsu Yobou Eisei Kenkyusho Ｃ型肝炎ウイルス外被タンパク質の産生法
EP0667786B1 (en) * 1992-08-27 2004-01-21 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
US5514539A (en) 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5610009A (en) 1994-01-28 1997-03-11 Abbott Laboratories Mammalian expression systems for hepatitis C virus envelope genes
JPH09503396A (ja) 1994-07-29 1997-04-08 インノジェネティクス・エヌ・ブイ 診断用及び治療用の精製ｃ型肝炎ウイルスエンベロープ蛋白
US6110465A (en) * 1995-06-07 2000-08-29 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines

Also Published As

Publication number Publication date
NZ506553A (en) 2002-11-26
KR20010042225A (ko) 2001-05-25
ATE336512T1 (de) 2006-09-15
AU756495B2 (en) 2003-01-16
EP0947525A1 (en) 1999-10-06
EP1064309B1 (en) 2006-08-16
JP2002510038A (ja) 2002-04-02
WO1999050301A3 (en) 1999-11-25
TR200002695T2 (tr) 2000-12-21
DE69932812D1 (de) 2006-09-28
ZA200004383B (en) 2003-01-28
BR9909026A (pt) 2000-12-05
EP1064309A2 (en) 2001-01-03
WO1999050301A2 (en) 1999-10-07
ES2272065T3 (es) 2007-04-16
US6521403B1 (en) 2003-02-18
DE69932812T2 (de) 2007-04-12
AU3602299A (en) 1999-10-18
CA2321179A1 (en) 1999-10-07
US6841353B2 (en) 2005-01-11
IL138586A0 (en) 2001-10-31
JP3657515B2 (ja) 2005-06-08
US20030129746A1 (en) 2003-07-10
CN1294598A (zh) 2001-05-09
PT1064309E (pt) 2006-12-29
HUP0103650A3 (en) 2005-10-28
PL343638A1 (en) 2001-08-27

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