DE68918867D1 - Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. - Google Patents
Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.Info
- Publication number
- DE68918867D1 DE68918867D1 DE68918867T DE68918867T DE68918867D1 DE 68918867 D1 DE68918867 D1 DE 68918867D1 DE 68918867 T DE68918867 T DE 68918867T DE 68918867 T DE68918867 T DE 68918867T DE 68918867 D1 DE68918867 D1 DE 68918867D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- mutants
- missing
- coat protein
- hypervariable domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101710132601 Capsid protein Proteins 0.000 title 1
- 101710094648 Coat protein Proteins 0.000 title 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 title 1
- 101710125418 Major capsid protein Proteins 0.000 title 1
- 101710141454 Nucleoprotein Proteins 0.000 title 1
- 101710083689 Probable capsid protein Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24394488A | 1988-09-13 | 1988-09-13 | |
PCT/US1989/003605 WO1990002568A1 (en) | 1988-09-13 | 1989-08-21 | Hiv-1 envelope muteins lacking hypervariable domains |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68918867D1 true DE68918867D1 (de) | 1994-11-17 |
DE68918867T2 DE68918867T2 (de) | 1995-02-16 |
Family
ID=22920746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68918867T Expired - Lifetime DE68918867T2 (de) | 1988-09-13 | 1989-08-21 | Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. |
Country Status (6)
Country | Link |
---|---|
US (3) | US5814458A (de) |
EP (1) | EP0434713B1 (de) |
AT (1) | ATE112687T1 (de) |
DE (1) | DE68918867T2 (de) |
HK (1) | HK166495A (de) |
WO (1) | WO1990002568A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP237A (en) * | 1990-05-29 | 1993-04-29 | Cedars Sinai Medical Center | Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use. |
CA2164505A1 (en) | 1993-06-07 | 1994-12-22 | Phillip W. Berman | Hiv envelope polypeptides |
DE4405810A1 (de) | 1994-02-23 | 1995-08-24 | Behringwerke Ag | Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung |
NL9400384A (nl) * | 1994-03-11 | 1995-10-02 | Smit Victor | Retrovirus-vaccins, vaccinatie en immunotherapie tegen retrovirale infecties. |
US6585979B1 (en) * | 1996-07-08 | 2003-07-01 | Genentech, Inc. | HIV envelope polypeptides and immunogenic composition |
FR2777007B1 (fr) * | 1998-04-01 | 2000-05-26 | Orstom | Mutants de glycoproteines d'enveloppes de retrovirus et leurs applications biologiques |
FR2786488B1 (fr) | 1998-11-27 | 2003-04-25 | Orstom | Mutants de la gp120 et leurs applications biologiques |
US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Hivポリペプチドの改善された発現およびウイルス様粒子の生成 |
US20030194800A1 (en) | 2001-08-31 | 2003-10-16 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
CA2358385C (en) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
PT1141315E (pt) | 1998-12-31 | 2008-05-05 | Novartis Vaccines & Diagnostic | Polipéptidos do envelope (env) de hiv modificados |
CN101586106B (zh) | 1999-11-16 | 2015-04-01 | 真那特股份公司 | Hiv-1亚型间(c/b’)基因组和其用途 |
WO2002080982A2 (en) | 2001-01-12 | 2002-10-17 | Chiron Corporation | Nucleic acid mucosal immunization |
RU2221873C2 (ru) * | 2001-04-24 | 2004-01-20 | Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" | Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность |
EP1411770A4 (de) | 2001-07-05 | 2006-05-10 | Chiron Corp | Polynukleotide, die für antigene hiv-polypeptide des c-typs codieren, polypeptide und ihre verwendung |
CA2452119C (en) | 2001-07-05 | 2013-10-15 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
AU2003300870A1 (en) * | 2002-12-11 | 2004-06-30 | The Scripps Research Institute | Immunogenic mutant human immunodeficiency virus gp120 polypeptides, and methods of using same |
US20040247586A1 (en) * | 2003-03-05 | 2004-12-09 | Asa Abeliovich | Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof |
EP1628680B1 (de) * | 2003-05-15 | 2012-10-24 | Novartis Vaccines and Diagnostics, Inc. | Hiv polynucleotide und polypeptide von botswana mj4 |
WO2006050394A2 (en) | 2004-11-01 | 2006-05-11 | Novartis Vaccines And Diagnostics Inc. | Combination approaches for generating immune responses |
US20110223197A1 (en) | 2005-10-18 | 2011-09-15 | Novartis Vaccines And Diagnostics Inc. | Mucosal and Systemic Immunization with Alphavirus Replicon Particles |
EP2001459B1 (de) * | 2006-03-29 | 2012-07-11 | Dana-Farber Cancer Institute, Inc. | Zusammensetzungen und verfahren zur induzierung einer immunreaktion gegen hiv und testmodelle |
SG173336A1 (en) | 2006-03-31 | 2011-08-29 | Novartis Ag | Combined mucosal and parenteral immunization against hiv |
WO2008039983A2 (en) * | 2006-09-28 | 2008-04-03 | President And Fellows Of Harvard College | Methods and compositions using mutant gp120 |
CA2737026C (en) | 2008-09-26 | 2019-12-24 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
WO2013074696A1 (en) | 2011-11-14 | 2013-05-23 | Novartis Ag | Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof |
EP3423091A4 (de) | 2016-03-03 | 2019-10-30 | Duke University | Zusammensetzungen und verfahren zur induzierung von hiv-1-antikörpern |
US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
CA3039089A1 (en) | 2016-10-03 | 2018-04-12 | Duke University | Methods to identify immunogens by targeting improbable mutations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341423C (en) * | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
AU600658B2 (en) * | 1984-12-24 | 1990-08-23 | Genentech Inc. | Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use |
EP0242216A1 (de) * | 1986-04-16 | 1987-10-21 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Nicht cytopathischer Klon von menschlichem T-Zellen lymphotropen Virus Typ-III |
US5128319A (en) * | 1987-08-28 | 1992-07-07 | Board Of Regents, The University Of Texas System | Prophylaxis and therapy of acquired immunodeficiency syndrome |
-
1989
- 1989-08-21 EP EP89909916A patent/EP0434713B1/de not_active Expired - Lifetime
- 1989-08-21 DE DE68918867T patent/DE68918867T2/de not_active Expired - Lifetime
- 1989-08-21 WO PCT/US1989/003605 patent/WO1990002568A1/en active IP Right Grant
- 1989-08-21 AT AT89909916T patent/ATE112687T1/de not_active IP Right Cessation
-
1995
- 1995-01-12 US US08/371,618 patent/US5814458A/en not_active Expired - Lifetime
- 1995-05-15 US US08/441,356 patent/US5817792A/en not_active Expired - Lifetime
- 1995-05-15 US US08/441,184 patent/US5792459A/en not_active Expired - Lifetime
- 1995-10-26 HK HK166495A patent/HK166495A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0434713B1 (de) | 1994-10-12 |
EP0434713A4 (en) | 1992-05-20 |
US5792459A (en) | 1998-08-11 |
HK166495A (en) | 1995-11-03 |
WO1990002568A1 (en) | 1990-03-22 |
US5814458A (en) | 1998-09-29 |
US5817792A (en) | 1998-10-06 |
EP0434713A1 (de) | 1991-07-03 |
DE68918867T2 (de) | 1995-02-16 |
ATE112687T1 (de) | 1994-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |