DE68918867D1 - Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. - Google Patents

Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.

Info

Publication number
DE68918867D1
DE68918867D1 DE68918867T DE68918867T DE68918867D1 DE 68918867 D1 DE68918867 D1 DE 68918867D1 DE 68918867 T DE68918867 T DE 68918867T DE 68918867 T DE68918867 T DE 68918867T DE 68918867 D1 DE68918867 D1 DE 68918867D1
Authority
DE
Germany
Prior art keywords
hiv
mutants
missing
coat protein
hypervariable domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68918867T
Other languages
English (en)
Other versions
DE68918867T2 (de
Inventor
Nancy Haigwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE68918867D1 publication Critical patent/DE68918867D1/de
Application granted granted Critical
Publication of DE68918867T2 publication Critical patent/DE68918867T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68918867T 1988-09-13 1989-08-21 Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. Expired - Lifetime DE68918867T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24394488A 1988-09-13 1988-09-13
PCT/US1989/003605 WO1990002568A1 (en) 1988-09-13 1989-08-21 Hiv-1 envelope muteins lacking hypervariable domains

Publications (2)

Publication Number Publication Date
DE68918867D1 true DE68918867D1 (de) 1994-11-17
DE68918867T2 DE68918867T2 (de) 1995-02-16

Family

ID=22920746

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918867T Expired - Lifetime DE68918867T2 (de) 1988-09-13 1989-08-21 Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.

Country Status (6)

Country Link
US (3) US5814458A (de)
EP (1) EP0434713B1 (de)
AT (1) ATE112687T1 (de)
DE (1) DE68918867T2 (de)
HK (1) HK166495A (de)
WO (1) WO1990002568A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP237A (en) * 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
CA2164505A1 (en) 1993-06-07 1994-12-22 Phillip W. Berman Hiv envelope polypeptides
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
NL9400384A (nl) * 1994-03-11 1995-10-02 Smit Victor Retrovirus-vaccins, vaccinatie en immunotherapie tegen retrovirale infecties.
US6585979B1 (en) * 1996-07-08 2003-07-01 Genentech, Inc. HIV envelope polypeptides and immunogenic composition
FR2777007B1 (fr) * 1998-04-01 2000-05-26 Orstom Mutants de glycoproteines d'enveloppes de retrovirus et leurs applications biologiques
FR2786488B1 (fr) 1998-11-27 2003-04-25 Orstom Mutants de la gp120 et leurs applications biologiques
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
JP2002533124A (ja) 1998-12-31 2002-10-08 カイロン コーポレイション Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成
US20030194800A1 (en) 2001-08-31 2003-10-16 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
CA2358385C (en) 1998-12-31 2013-08-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
PT1141315E (pt) 1998-12-31 2008-05-05 Novartis Vaccines & Diagnostic Polipéptidos do envelope (env) de hiv modificados
CN101586106B (zh) 1999-11-16 2015-04-01 真那特股份公司 Hiv-1亚型间(c/b’)基因组和其用途
WO2002080982A2 (en) 2001-01-12 2002-10-17 Chiron Corporation Nucleic acid mucosal immunization
RU2221873C2 (ru) * 2001-04-24 2004-01-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность
EP1411770A4 (de) 2001-07-05 2006-05-10 Chiron Corp Polynukleotide, die für antigene hiv-polypeptide des c-typs codieren, polypeptide und ihre verwendung
CA2452119C (en) 2001-07-05 2013-10-15 Chiron Corporation Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
AU2003300870A1 (en) * 2002-12-11 2004-06-30 The Scripps Research Institute Immunogenic mutant human immunodeficiency virus gp120 polypeptides, and methods of using same
US20040247586A1 (en) * 2003-03-05 2004-12-09 Asa Abeliovich Parkin-associated complex for protecting post-mitotic neurons from excitotoxicity and uses thereof
EP1628680B1 (de) * 2003-05-15 2012-10-24 Novartis Vaccines and Diagnostics, Inc. Hiv polynucleotide und polypeptide von botswana mj4
WO2006050394A2 (en) 2004-11-01 2006-05-11 Novartis Vaccines And Diagnostics Inc. Combination approaches for generating immune responses
US20110223197A1 (en) 2005-10-18 2011-09-15 Novartis Vaccines And Diagnostics Inc. Mucosal and Systemic Immunization with Alphavirus Replicon Particles
EP2001459B1 (de) * 2006-03-29 2012-07-11 Dana-Farber Cancer Institute, Inc. Zusammensetzungen und verfahren zur induzierung einer immunreaktion gegen hiv und testmodelle
SG173336A1 (en) 2006-03-31 2011-08-29 Novartis Ag Combined mucosal and parenteral immunization against hiv
WO2008039983A2 (en) * 2006-09-28 2008-04-03 President And Fellows Of Harvard College Methods and compositions using mutant gp120
CA2737026C (en) 2008-09-26 2019-12-24 Ambrx, Inc. Modified animal erythropoietin polypeptides and their uses
WO2013074696A1 (en) 2011-11-14 2013-05-23 Novartis Ag Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof
EP3423091A4 (de) 2016-03-03 2019-10-30 Duke University Zusammensetzungen und verfahren zur induzierung von hiv-1-antikörpern
US11318197B2 (en) 2016-03-03 2022-05-03 Duke University Compositions and methods for inducing HIV-1 antibodies
CA3039089A1 (en) 2016-10-03 2018-04-12 Duke University Methods to identify immunogens by targeting improbable mutations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341423C (en) * 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
AU600658B2 (en) * 1984-12-24 1990-08-23 Genentech Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
EP0242216A1 (de) * 1986-04-16 1987-10-21 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Nicht cytopathischer Klon von menschlichem T-Zellen lymphotropen Virus Typ-III
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome

Also Published As

Publication number Publication date
EP0434713B1 (de) 1994-10-12
EP0434713A4 (en) 1992-05-20
US5792459A (en) 1998-08-11
HK166495A (en) 1995-11-03
WO1990002568A1 (en) 1990-03-22
US5814458A (en) 1998-09-29
US5817792A (en) 1998-10-06
EP0434713A1 (de) 1991-07-03
DE68918867T2 (de) 1995-02-16
ATE112687T1 (de) 1994-10-15

Similar Documents

Publication Publication Date Title
DE68918867D1 (de) Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.
FI873141A0 (fi) Daeggdjurs interleukin-4.
DK0751992T3 (da) Karendotelvækstfaktor 2
NO973848D0 (no) Fremgangsmåte til fremstilling av hemoglobinliknende protein
ATE125362T1 (de) Monoklonale antikörper gegen glykosyliertes albumin, hybride zellinien, die diese antikörper produzieren, sowie deren verwendung.
DE69535719D1 (de) Fas-antigenbindender ligand
EP0431541A3 (en) Toxoplasma gondii antigen, its production and use
DE69317886D1 (de) Neue propoxyphenderivate sowie deren protein-und polypeptidlabels und-konjugate
FI102383B1 (fi) Menetelmä ja plasmidi modifioidun PE40-domeenia sisältävän hybridiproteiinin valmistamiseksi
EP0369816A3 (de) Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper
JPS6461499A (en) Monoclonal antibody to human papilloma viruses 16 type e7 protein, and production and use thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US