WO2009015557A1 - Composition pharmaceutique destinée au traitement du diabète et son procédé de préparation - Google Patents
Composition pharmaceutique destinée au traitement du diabète et son procédé de préparation Download PDFInfo
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- WO2009015557A1 WO2009015557A1 PCT/CN2008/001383 CN2008001383W WO2009015557A1 WO 2009015557 A1 WO2009015557 A1 WO 2009015557A1 CN 2008001383 W CN2008001383 W CN 2008001383W WO 2009015557 A1 WO2009015557 A1 WO 2009015557A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Definitions
- the present invention relates to a process for the preparation of a pharmaceutical composition for treating diabetes, and a pharmaceutical composition prepared by the method. Background technique
- Diabetes is a chronic progressive life-threatening disorder caused by disorders of sugar, protein and fat metabolism in the body, characterized by hyperglycemia and diabetes. This disease can lead to heart and kidney complications, blindness and amputation. In recent years, clinical observations have shown that the incidence of diabetes is increasing year by year. At present, there are about 150 million diabetes patients in the world, and the number of diabetes in China is over 40 million. Among the cases of diabetes, a small number are insulin-dependent diabetes mellitus (type I), and most are non-insulin-dependent diabetes mellitus (sputum type). Most people with diabetes need to take medication for life.
- type I insulin-dependent diabetes mellitus
- Sputum type non-insulin-dependent diabetes mellitus
- diabetes treatment is still dominated by chemical synthetic drugs, such as sulfonamides, biguanides, glucosidase inhibitors, glinides and insulin sensitizers.
- chemical synthetic drugs such as sulfonamides, biguanides, glucosidase inhibitors, glinides and insulin sensitizers.
- traditional Chinese medicine has a long history of preventing and treating diabetes. After thousands of years of practice, it has accumulated a lot of valuable experience and formed a unique academic system.
- Chinese medicine classics record many traditional Chinese medicines with hypoglycemic effects, such as Zexie, Zhimu, American ginseng, Pueraria, Rehmannia, and pollen.
- Traditional Chinese medicine treatment of diabetes is based on clinical symptoms and treatment. However, there is no good treatment in the period of impaired glucose tolerance and early onset of diabetes.
- Diabetes is the first to be responsible for the liver and stomach.
- the stagnation of heat is the pathological basis of diabetes, "Mu Yu Da Zhi”, “Tu Yu Yu Zhi”, so when it is based on dredging, SP "will be the owner of the disease, and First, because of it.”
- Sugar-sensitive spirits open the stomach and clear the stomach, nourishing yin and reducing fire, phlegm and phlegm, and treating both the symptoms and the symptoms.
- the stagnation is clear, the qi is self-recovering.
- An object of the present invention is to provide a pharmaceutical composition for treating diabetes which has the following composition, which is produced by the following method of the present invention, thereby solving the above-mentioned problems existing in the prior art. problem.
- a further object of the present invention is to provide a process for the preparation of a pharmaceutical composition of the present invention, which comprises the following extracts prepared from raw materials: 5-40 parts of trichosanthin, 10-30 parts of Bupleurum, and medlar 3-15 parts, 1-6 parts of rhubarb, 1-12 parts of Pinellia, 3-15 parts of astragalus, 1-12 parts of berberine, 3-15 parts of white peony and 5-20 parts of ebony, and optionally containing pharmacy An acceptable excipient; the composition is prepared by one of the following methods:
- Method one includes the following steps:
- adding an excipient to the above-mentioned extract to prepare a pharmaceutically acceptable dosage form includes the following steps:
- the preferred weight ratios of various raw materials are: 9 parts of trichosanthin, 12 parts of Bupleurum, 9 parts of medlar, 3 parts of rhubarb, 6 parts of Pinellia, 9 parts of astragalus, and berberine 6 Servings, 9 white peony and 9 ebony.
- the pharmaceutical composition of the present invention can also be added to the hawthorn in the formula, because the behenic acid is succulent and yin, which can prevent the spleen from being too suffocating and the bitter acid. sweet. It has a good effect in combination with Kaiyuqing.
- the ratio of parts by weight of various raw materials is: 5-40 parts of trichosanthin, 10-30 parts of Bupleurum, 3-15 parts of medlar, 1-6 parts of rhubarb, 1-12 parts of Pinellia ternata 3-15 parts of astragalus, 1-12 parts of berberine, 3-15 parts of white peony, 5-20 parts of ebony and 3-15 parts of hawthorn.
- the weight ratio of various raw materials in the pharmaceutical composition of the present invention is: 10-30 parts of trichosanthin, 10-30 parts of Bupleurum, 3-15 parts of medlar, 1-6 parts of rhubarb, and Pinellia 1 -12 parts, 3-15 parts of astragalus, 1-12 parts of berberine, 3-15 parts of white peony, 5-20 parts of ebony and 3-15 parts of hawthorn.
- the weight ratio of various raw materials in the pharmaceutical composition of the present invention is: 30 parts of trichosanthin, 12 parts of Bupleurum, 9 parts of medlar, 3 parts of rhubarb, 6 parts of Pinellia, 9 parts of astragalus, and berberine 6 Parts, 9 times of white peony, ebony 15 parts and 9 parts of hawthorn; or 15 parts of trichosanthin, 12 parts of Bupleurum, 9 parts of medlar, 3 parts of rhubarb, 6 parts of Pinellia, 9 parts of Astragalus, 6 parts of Coptis, 9 parts of white peony, 15 parts of ebony and hawthorn 9 copies.
- the following operating conditions are preferably employed:
- step (2) it is preferred to extract twice by reflux, using water 10 times the weight of the medicinal material for 1.5 hours each time.
- the extract is concentrated to a ratio of the original medicinal weight (kg) to the volume (L) of the concentrate of 1:1.
- the concentration of ethanol added is preferably from 90 to 100%, preferably 95%.
- the resulting concentrate preferably has an alcohol content of 70%. Since the above-mentioned water extraction and alcohol precipitation method of the present invention is employed, the content of the active ingredient in the traditional Chinese medicine composition prepared by the method is remarkably improved, and the content of impurities is remarkably reduced, thereby reducing the dose to be administered.
- step (2) it is preferred to add water twice to reflux, and use 10 times of water per weight of the medicinal material for one hour each time.
- the macroporous resin is preferably of the AB-8 type.
- the weight ratio of the resin to the medicinal material is preferably from 1:1.5 to 1:3, more preferably 1:2.
- the loading rate of the extract is preferably 4-6 column volumes per hour.
- the amount of water washing is preferably 4-6 column volumes.
- the concentration of ethanol used for elution is preferably from 80% to 95%, further preferably 90%.
- the amount of ethanol used is preferably 2 to 5 column volumes.
- the temperature at which ethanol is recovered under reduced pressure is preferably 60-80 ° C, and ethanol is recovered under reduced pressure to obtain an extract having a relative density of 1.25-1.35, preferably a relative density of 1.30.
- the above preparation method of the invention adopts a water extraction process to ensure that the water-soluble active ingredients, such as saikosaponin, berberine (berberine hydrochloride), baicalin, chrysophanol, paeoniflorin, synephrine, etc., are maximized.
- the content of the active ingredient in the traditional Chinese medicine composition of the present invention is remarkably improved, the content of impurities is greatly reduced, thereby reducing the dose of administration, and also ensuring the stability between product batches.
- the following operating conditions are preferably employed:
- the concentration of the ethanol used is 75-90%, preferably 80%; preferably, the extract is refluxed twice, each time using 10 times the weight of the medicinal material of the step (2), each extraction 1.5 hours.
- step (3) it is preferred to add the other medicinal materials to the dregs obtained in the previous step, and extract them twice with water, each time the amount of water is the other medicinal materials added in the step (3) and the step (2).
- the extract is concentrated to a ratio of the original medicinal weight (kg) to the volume (L) of the concentrate of 1:1.
- concentration of ethanol added is preferably from 90 to 100%, more preferably 95%, and the alcohol content of the concentrate is from 65 to 75%, preferably 70%.
- the raw materials such as Bupleurum, Radix Paeoniae Alba, Radix Paeoniae Alba, Rhubarb, Radix Astragali, Rhizoma Coptidis, etc. are firstly extracted, and the residue is combined with other herbs to extract water, thereby ensuring that the active ingredients of the six herbs are fully extracted;
- Other medicinal materials extract only the active ingredient therein by water because the active ingredients therein are all water-soluble.
- step (2) it is preferred to extract twice with water under reflux, using 10 times the weight of scutellaria each time for 1 hour.
- the holding temperature is preferably 75 to 85 ⁇ , and more preferably 80 °C.
- step (3) it is preferably extracted twice with ethanol under reflux, each time using 10 times the weight of berberine in ethanol for 2 hours each time.
- the concentration of ethanol used is preferably 70-85%, more preferably 75%.
- the pH adjuster is preferably concentrated hydrochloric acid.
- the step (4) it is preferred to extract the remaining medicinal materials twice with water, and add 10 times the water of the medicinal material in the step (4) for 1 hour each time.
- the combined extracts are concentrated to a relative density of 1.03-1.07, preferably a relative density of 1.05.
- the ethanol extract is concentrated to an extract having a relative density of 1.25 to 1.35, preferably having a relative density of 1.30.
- the astragalus, berberine and other medicinal materials are separately extracted, and respectively subjected to water extraction or alcohol extraction under a certain pH condition according to their own properties, so as to make the active ingredient in the traditional Chinese medicine composition of the present invention.
- the content is significantly increased, and the amount of impurities is greatly reduced, thereby reducing the dose administered.
- the pharmaceutical composition for treating diabetes having the above composition can be prepared by the above method of the present invention, and the pharmaceutical composition of the present invention can be prepared into any conventional preparation by a conventional method of a traditional Chinese medicine preparation using conventional excipients in the art. .
- the above-mentioned raw material medicine is ground into a powder, or the prepared extract is dried, pulverized, sieved, ground into a powder, or it is made into a tablet or a capsule orally, or it is made into an injection or the like.
- the pharmaceutical composition prepared by the method of the present invention has a blood sugar lowering effect and has a good therapeutic effect on diabetes.
- ethanol concentration or the alcohol content that is, the amount of ethanol contained in the system
- a percentage it means a volume percentage concentration or a volume percentage unless otherwise specified.
- Example 1 The drug of the present invention and its beneficial effects are further illustrated by the following examples and test examples, but the scope of the present invention is not limited in any way.
- Example 1 The drug of the present invention and its beneficial effects are further illustrated by the following examples and test examples, but the scope of the present invention is not limited in any way.
- Drug formula 750g of trichosanthin, 1500g of Bupleurum, 450g of medlar, 150g of rhubarb, 150g of Pinellia, 450g of Radix Scutellariae, 150g of Rhizoma Coptidis, 450g of Radix Paeoniae Alba and 750g of ebony.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 9-flavored medicinal material is extracted twice with 10 times its weight of water, and the extract is filtered for 1.5 hours each time.
- the extract is concentrated under reduced pressure to the original medicinal material weight (kg) and the volume of the concentrated liquid (L).
- the ratio is 1: 1, adding 90% ethanol to 65% alcohol content, filtering, and concentrating into a thick paste under reduced pressure.
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, white peony root, medlar, rhubarb, astragalus, and berberine were extracted twice with 10 times the weight of 75% ethanol, and the extract was filtered for use for 1.5 hours each time;
- the extract is concentrated under reduced pressure to the original
- the ratio of the weight of the medicinal material (kg) to the volume (L) of the concentrated solution is 1: 1, 90% ethanol is added to the alcohol content of 65%, filtered, and used;
- the pharmaceutical composition of the present invention was prepared by the following method:
- Example 4 Using the same formulation as in Example 1, the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 7 herbs were added with 10 times their weight of water and refluxed twice for 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.03, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; After standing, filtered, the ethanol was recovered to a relative density of 1.25, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula Trichosanthin 1200g, Bupleurum 900g, medlar 450g, rhubarb 180g, Pinellia 360g, Radix Scutellariae 450g, Coptis 360g, Angelica sinensis 450g and ebony 600g.
- the pharmaceutical composition of the present invention is prepared as follows:
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica, Rhizoma, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times their weight and 90% ethanol, 1.5 hours each time, and the extract is filtered and used;
- the ratio of the initial medicinal material weight (kg) to the volume (L) of the concentrate is 1: 1, adding absolute ethanol to the alcohol content of 75%, filtered, and set aside;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 9 herbs were added to the water for 2 times, and each time 49.5 kg of water was added, one hour each time. Let the extract cool down, Filter, merge.
- the AB-8 type macroporous adsorption resin has a macroporous adsorption resin dosage of 1.7 kg and a loading speed of 6 column volumes per hour. First elute with 6 column volumes of water and discard the aqueous eluent. Then, it was eluted with 5 column volumes of 95% ethanol, and the alcohol eluates were combined. The ethanol was recovered under reduced pressure at 70 Torr to a relative density of 1.35, dried under vacuum at 90 Torr, and pulverized through a 80 mesh sieve.
- Starch is compressed into tablets in the obtained dry paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 7 herbs were added with 10 times their weight of water for 2 times, 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.07, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and ethanol was recovered to a relative density of 1.35, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula 630g of gerbera, 840g of Bupleurum, 630g of medlar, 210g of rhubarb, 420g of Pinellia, 630g of astragalus, 420g of berberine, 630g of white peony and 630g of ebony.
- the pharmaceutical composition of the present invention is prepared as follows:
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica sinensis, Radix Paeoniae Alba, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times their weight of 80% ethanol, 1.5 hours each time, and the extract is filtered and used;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 9 herbs were added to the water for 2 times, and 50.4 kg of water was added each time for 1 hour. Let the extract cool down, filter, and combine.
- the AB-8 type macroporous adsorption resin has a macroporous adsorption resin dosage of 2.52 kg and a loading rate of 5 column volumes per hour. First elute with 5 column volumes of water. The water eluate was discarded. Then, it was eluted with 3 column volumes of 90% ethanol, and the alcohol eluates were combined. The ethanol was recovered under reduced pressure at 70 ° C to a relative density of 1.30, dried under vacuum at 80 Torr, and the dry paste was pulverized through an 80 mesh sieve.
- a concentrated pellet was prepared by adding microcrystalline cellulose to the obtained dry paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 7 herbs were added with 10 times their weight of water for 2 times, one hour each time; the extract was concentrated under reduced pressure to a relative density of 1.05, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and the ethanol was recovered to a relative density of 1.30, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula 750g of trichosanthin, 1500g of Bupleurum, 450g of medlar, 150g of rhubarb, 150g of Pinellia, 450g of Radix Scutellariae, 150g of Rhizoma Coptidis, 450g of Radix Paeoniae, 750g of ebony and 450g of Hawthorn.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water, and the extract was filtered for 1.5 hours each time.
- the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1, add 90% B
- the alcohol was added to an alcohol content of 65%, filtered, and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica sinensis, Radix Paeoniae Alba, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times the weight of 75% ethanol, 1.5 hours each time, the extract is filtered, and used;
- the extract is concentrated under reduced pressure.
- the ratio of the original medicinal material weight (kg) to the volume (L) of the concentrate is 1:1, 90% ethanol is added to the alcohol content of 65%, filtered, and set aside;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method - the above 10 herbs were refluxed twice with water, and 52.5 kg of water was added each time for 1 hour. The extract will be allowed to cool, filtered, and combined.
- the AB-8 type macroporous adsorption resin has a macroporous adsorption resin dosage of 3.5 kg and a loading rate of 4 column volumes per hour. First elute with 4 column volumes of water. The water eluate was discarded. Then, it was eluted with 2 column volumes of 80% ethanol, and the alcohol eluates were combined. The ethanol was recovered under reduced pressure at 80 Torr to a relative density of 1.35, dried under vacuum at 70 Torr, and the dried paste was pulverized through an 80 mesh sieve.
- Lactose was added to the obtained dry paste to prepare a capsule.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 8 herbs were added with 10 times their weight of water for 2 times, 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.07, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and the ethanol was recovered to a relative density of 1.25, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula Trichosanthin 1200g, Bupleurum 900g, medlar 450g, Rhubarb 180g, Pinellia 360g, Radix Scutellaria 450g, Coptis 360g, White peony 450g, Wumei 600g and Hawthorn 450g.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water, and the extract was filtered for 1.5 hours each time.
- the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1, add anhydrous ethanol to 75% alcohol content, filter, and concentrate to a thick paste under reduced pressure.
- the pharmaceutical composition of the present invention was prepared by the following method - Bupleurum, Angelica, Rhizoma, Rhubarb, Astragalus, and Coptis were refluxed twice with 10 times the weight of 90% ethanol, each time. 1.5 hours, the extract was filtered and used;
- the ratio of the initial medicinal material weight (kg) to the volume (L) of the concentrate is 1: 1, adding absolute ethanol to the alcohol content of 75%, filtered, and set aside;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 10 herbs were added to the water for 2 times, and each time, 54 kg of water was added, one hour each time. Let the extract cool down, filter, and combine. Through the AB-8 type macroporous adsorption resin, the amount of macroporous adsorption resin is 1.8kg, and the loading speed is 6 times column volume/hour. First elute with 6 column volumes of water. The water eluate was discarded. Then, the column was eluted with 5 column volumes of 95% ethanol, and the alcohol eluate was combined. The ethanol was recovered under reduced pressure at 70 Torr to a relative density of 1.25, dried under vacuum, and the dry paste was pulverized through an 80 mesh sieve.
- Lactose was added to the obtained dry paste to prepare a capsule.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the precipitate was washed with water to a pH of 5-6, dried, and the granules were pulverized through an 80 mesh sieve to obtain a Coptidis extract.
- the remaining 8 herbs were added with 10 times their weight and refluxed twice for 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.03, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and ethanol was recovered to a relative density of 1.35, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula 833g of Tianhua powder, 667g of Bupleurum, 500g of medlar, 167g of rhubarb, 333g of Pinellia, 500g of Radix Astragali, 333g of Rhizoma Coptidis, 500g of Radix Paeoniae, 833g of ebony and 500g of Hawthorn.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water, and the extract was filtered for 1.5 hours each time.
- the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1 , Add 95% ethanol to 70% alcohol content, filter, and concentrate to a thick paste under reduced pressure.
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica sinensis, Radix Paeoniae Alba, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times their weight of 80% ethanol, 1.5 hours each time, and the extract is filtered and used;
- the ratio of the original medicinal material weight (kg) to the volume (L) of the concentrate is 1: 1, adding 95% ethanol to 70% alcohol content, filtered, and set aside;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 10 herbs were added to the water for 2 times, and 51.7 kg of water was added each time for 1 hour each time. Let the extract cool down, filter, and combine.
- the AB-8 type macroporous adsorption resin has a macroporous adsorption resin dosage of 2.6 kg and a loading speed of 5 column volumes per hour. First elute with 5 column volumes of water. The water eluate was discarded. Then, the column was eluted with 3 column volumes of 90% ethanol, and the alcohol eluate was combined. The ethanol was recovered under reduced pressure at 70 ° C to a relative density of 1.30, and vacuum dried at 80 ° C. The dry paste is pulverized through an 80 mesh sieve.
- a concentrated pellet was prepared by adding microcrystalline cellulose to the obtained dry paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 8 herbs were added with 10 times their weight of water for 2 times, one hour each time; the extract was concentrated under reduced pressure to a relative density of 1.05, let cool, add 95% ethanol, and make the alcohol content 70%; The solution was filtered, and the ethanol was recovered to a relative density of 1.30, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula 500g of trichosanthes, 750g of Bupleurum, 500g of medlar, 250g of rhubarb, 500g of Pinellia, 500g of Radix Astragali, 500g of Rhizoma Coptidis, 500g of Radix Paeoniae, 500g of Wumei, 500g of Hawthorn and 500g of Hawthorn.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water, and the extract was filtered for 1.5 hours each time.
- the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1, adding 95% ethanol to 70% alcohol content, filtered, concentrated under reduced pressure into a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica sinensis, Radix Paeoniae Alba, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times their weight of 80% ethanol, 1.5 hours each time, and the extract is filtered and used;
- the extract is decompressed and concentrated.
- the ratio of the original medicinal material weight (kg) to the volume (L) of the concentrate is 1:1, 95% ethanol is added to the alcohol content 70%, filtered, and used; The two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 10 herbs were added to the water for 2 times, and 50 kg of water was added each time for 1 hour. Let the extract cool down, filter, and combine. After the AB-8 type macroporous adsorption resin, the amount of the macroporous adsorption resin is 2.5 kg, and the loading speed is 4 times the column volume/hour. First elute with 5 column volumes of water. The water eluate was discarded. Then, the column was eluted with 4 column volumes of 92% ethanol, and the alcohol eluate was combined. The ethanol was recovered under reduced pressure at 75 ° C to a relative density of 1.25, vacuum dried at 85 ° C, and the dry paste was pulverized through an 80 mesh sieve.
- a dextrin was added to the obtained dry paste to prepare a tablet.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 8 herbs were added with 10 times their weight and refluxed twice for 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.05, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and the ethanol was recovered to a relative density of 1.25, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula Trichosanthin 1200g, Bupleurum 800g, medlar 600g, Rhubarb 200g, Pinellia 400g, Radix Scutellariae 400g, Coptis 200g, Angelica 400g, Wumei 400g and Hawthorn 400g.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water and refluxed for 1.5 hours each time.
- the extract was filtered, and the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1, adding 90% ethanol to 68% alcohol content, filtered, concentrated under reduced pressure into a thick paste.
- Example 30 Using the same formulation as in Example 29, the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica sinensis, Radix Paeoniae Alba, Rhubarb, Astragalus, and Rhizoma Coptidis are refluxed twice with 10 times the weight of 85% ethanol, 1.5 hours each time, the extract is filtered and used;
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method - the above 10 herbs were refluxed twice with water, and 50 kg of water was added each time for 1 hour. Let the extract cool down, filter, and combine. After the AB-8 type macroporous adsorption resin, the amount of the macroporous adsorption resin is 2.0 kg, and the loading speed is 6 times the column volume/hour. First elute with 4 column volumes of water. The water eluate was discarded. Then, the column was eluted with 3 column volumes of 92% ethanol, and the alcohol eluate was combined. The ethanol was recovered under reduced pressure at 65 ° C to a relative density of 1.30, vacuum dried at 75 ° C, and the dry paste was pulverized through an 80 mesh sieve.
- a lactose is added to the obtained dry paste to prepare a capsule.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 8 herbs were added with 10 times their weight and refluxed twice for 1 hour each time; the extract was concentrated under reduced pressure to a relative density of 1.05, allowed to cool, and 95% ethanol was added to make the alcohol content 70%; The solution was filtered, and ethanol was recovered to a relative density of 1.35, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Drug formula Tianhua powder 1000g, Bupleurum 600g, tamping 600g, rhubarb 250g, Pinellia 300g, yellow ⁇ 500g, berberine 300g, white peony 500g, ebony 500g and hawthorn 300g.
- the pharmaceutical composition of the present invention is prepared as follows:
- the 10 herbs were extracted twice with 10 times the weight of water and refluxed for 1.5 hours each time.
- the extract was filtered, and the extract was concentrated under reduced pressure until the ratio of the original drug weight (kg) to the volume (L) of the concentrate was 1 : 1 , Add 99% ethanol to 74% alcohol content, filter, and concentrate to a thick paste under reduced pressure.
- the pharmaceutical composition of the present invention was prepared by the following method:
- Bupleurum, Angelica, Rhizoma, Rhubarb, Astragalus, and Rhizoma Coptidis are extracted twice with 10 times their weight of 90% ethanol, 1.5 hours each time, the extract is filtered and used;
- the extract is concentrated under reduced pressure.
- the ratio of the original medicinal material weight (kg) to the volume (L) of the concentrate is 1: 1, 99% ethanol is added to the alcohol content 74%, filtered, spare
- the two extracts were mixed and concentrated under reduced pressure to a thick paste.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the above 10 herbs were added to the water for 2 times, and each time 48.5 kg of water was added, one hour each time.
- the extract is allowed to cool, filtered, and combined.
- the amount of macroporous adsorption resin is 1.7kg, and the loading speed is 5 times column volume/hour.
- the water eluate was discarded.
- the alcohol eluate was eluted with 5 column volumes of 85% ethanol, and the ethanol was recovered under reduced pressure at 70 Torr to a relative density of 1.35, dried under vacuum at 90 Torr, and the dry paste was pulverized through an 80 mesh sieve.
- a lactose is added to the obtained dry paste to prepare a capsule.
- the pharmaceutical composition of the present invention was prepared by the following method:
- the remaining 8 herbs were added with 10 times their weight of water for 2 times, one hour each time; the extract was concentrated under reduced pressure to a relative density of 1.05, let cool, add 95% ethanol, and make the alcohol content 70%; The solution was filtered, and the ethanol was recovered to a relative density of 1.30, dried, and the dry paste was pulverized through an 80 mesh sieve.
- Streptozotocin American sigma company, batch number 024K1211;
- Anhydrous citric acid (C 6 H 8 O r H 2 0): Tianjin Chemical Reagent No. 1 Plant, batch No. 011121;
- Metformin 250mg/tablet, produced by Tianjin Pacific Pharmaceutical Co., Ltd., batch number 040121;
- the different prescription group drugs of the test examples were the extract powders prepared in accordance with Example 3, Example 8 and Example 9, respectively, and were numbered TL-1, TL-2 and TL-3, respectively.
- the experimental data were expressed as mean ⁇ standard deviation ( ⁇ ), and the significance of the difference between the two groups was t test.
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Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
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NZ581525A NZ581525A (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
RU2009144878/15A RU2485968C2 (ru) | 2007-08-02 | 2008-07-28 | Лекарственный препарат для лечения диабета и способ его изготовления |
BRPI0812792A BRPI0812792B8 (pt) | 2007-08-02 | 2008-07-28 | método para preparar uma composição farmacêutica para o tratamento de diabetes mellitus e dita composição farmacêutica |
US12/601,236 US8637092B2 (en) | 2007-08-02 | 2008-07-28 | Pharmaceutical composition for treating diabetes and its process for preparation |
EP08783574A EP2172207B1 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
CA2687492A CA2687492C (en) | 2007-08-02 | 2008-07-28 | A herbal composition, method for preparing the same and use thereof for treating diabetes mellitus |
AU2008281227A AU2008281227B2 (en) | 2007-08-02 | 2008-07-28 | A pharmaceutical composition for treating diabetes and its process for preparation |
KR1020107003490A KR101462984B1 (ko) | 2007-08-02 | 2008-07-28 | 당뇨병 치료용 약학적 조성물 및 이의 제조 방법 |
DK08783574.0T DK2172207T3 (da) | 2007-08-02 | 2008-07-28 | Farmaceutisk sammensætning til behandling af diabetes og fremgangsmåde til fremstilling heraf |
JP2010518477A JP5508264B2 (ja) | 2007-08-02 | 2008-07-28 | 糖尿病治療のための医薬組成物およびその製造方法 |
HK10104520.9A HK1138206A1 (en) | 2007-08-02 | 2010-05-10 | A pharmaceutical composition for treating diabetes and its process for preparation |
Applications Claiming Priority (8)
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CN200710058571.0 | 2007-08-02 | ||
CN200710058573.X | 2007-08-02 | ||
CNA2007100585710A CN101357180A (zh) | 2007-08-02 | 2007-08-02 | 一种含有天花粉的治疗糖尿病的药物及其制备方法 |
CN200710058573XA CN101357182B (zh) | 2007-08-02 | 2007-08-02 | 一种含有乌梅的治疗糖尿病的药物及其制备方法 |
CN2007100585725A CN101357181B (zh) | 2007-08-02 | 2007-08-02 | 一种含有柴胡的治疗糖尿病的药物及其制备方法 |
CN2007100585744A CN101357183B (zh) | 2007-08-02 | 2007-08-02 | 一种含有枳实的治疗糖尿病的药物及其制备方法 |
CN200710058574.4 | 2007-08-02 | ||
CN200710058572.5 | 2007-08-02 |
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PCT/CN2008/001383 WO2009015557A1 (fr) | 2007-08-02 | 2008-07-28 | Composition pharmaceutique destinée au traitement du diabète et son procédé de préparation |
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US (1) | US8637092B2 (zh) |
EP (1) | EP2172207B1 (zh) |
JP (1) | JP5508264B2 (zh) |
KR (1) | KR101462984B1 (zh) |
AR (1) | AR070306A1 (zh) |
AU (1) | AU2008281227B2 (zh) |
BR (1) | BRPI0812792B8 (zh) |
CA (1) | CA2687492C (zh) |
DK (1) | DK2172207T3 (zh) |
HK (1) | HK1138206A1 (zh) |
MY (1) | MY154567A (zh) |
NZ (1) | NZ581525A (zh) |
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CN103156938B (zh) * | 2013-04-07 | 2014-08-13 | 贵州鸿德中药开发有限公司 | 一种治疗糖尿病的苗药 |
CN103610801B (zh) * | 2013-11-19 | 2015-08-19 | 安徽宝芝堂药业有限公司 | 一种用于治疗伤寒热厥症的中药组合物 |
CN103599215A (zh) * | 2013-11-28 | 2014-02-26 | 成都中医药大学附属医院 | 一种降糖药物 |
CN103784521B (zh) * | 2014-01-21 | 2015-12-09 | 李桂霞 | 一种配合手术治疗腹腔脓肿的中药组合物及其制备方法 |
CN103784515B (zh) * | 2014-02-11 | 2016-02-10 | 王思成 | 一种治疗口腔带状疱疹含漱液 |
CN107648424A (zh) * | 2017-11-07 | 2018-02-02 | 贵州拜特制药有限公司 | 一种杞菊地黄制剂的制作方法 |
CN107875208A (zh) * | 2017-11-29 | 2018-04-06 | 安徽海神寿***业有限公司 | 一种黄连、大黄、黄芩复配的一清浸膏粉的生产方法 |
CN110898170B (zh) * | 2018-09-17 | 2022-04-05 | 江苏九旭药业有限公司 | 一种治疗代谢综合征的中药组合物及其制剂 |
CN110237187A (zh) * | 2019-06-03 | 2019-09-17 | 文山学院 | 一种黄精铁皮石斛口服液及其制备方法 |
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CN1726929A (zh) * | 2004-07-30 | 2006-02-01 | 天津天士力制药股份有限公司 | 一种治疗糖尿病的药物组合物 |
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RU2158600C1 (ru) * | 1999-09-13 | 2000-11-10 | Куркин Владимир Александрович | Способ получения противодиабетического средства |
WO2002058625A2 (en) | 2000-12-22 | 2002-08-01 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Herbal composition for angina pectoris, method to prepare same and uses thereof |
US8486464B2 (en) * | 2000-12-22 | 2013-07-16 | Tasly Pharmaceutical Group Co. Ltd. | Herbal composition for angina pectoris, method to prepare same and uses thereof |
WO2002053164A1 (fr) * | 2000-12-29 | 2002-07-11 | Qihuang Pharmaceutical Technology And Investment Co., Ltd. | Extraits de drynaria pour le traitement de l'osteoporose et leur procede d'extraction |
KR100402421B1 (ko) * | 2001-07-30 | 2003-10-17 | 화천군 | 산사음료의 제조방법 |
RU2234224C2 (ru) * | 2002-07-16 | 2004-08-20 | Шиголаков Петр Васильевич | Сухая питательная смесь "талган" |
CN1725929B (zh) * | 2004-07-21 | 2012-01-25 | 鸿富锦精密工业(深圳)有限公司 | 多灯管驱动*** |
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AU2008281227B2 (en) | 2013-03-28 |
KR20100045478A (ko) | 2010-05-03 |
JP2010535157A (ja) | 2010-11-18 |
DK2172207T3 (da) | 2013-04-08 |
RU2009144878A (ru) | 2011-09-10 |
US20100136150A1 (en) | 2010-06-03 |
EP2172207B1 (en) | 2013-01-02 |
CA2687492A1 (en) | 2009-02-05 |
NZ581525A (en) | 2011-01-28 |
CA2687492C (en) | 2013-08-20 |
BRPI0812792A2 (pt) | 2014-12-02 |
BRPI0812792B1 (pt) | 2019-03-26 |
RU2485968C2 (ru) | 2013-06-27 |
EP2172207A4 (en) | 2010-07-28 |
EP2172207A1 (en) | 2010-04-07 |
US8637092B2 (en) | 2014-01-28 |
AU2008281227A1 (en) | 2009-02-05 |
BRPI0812792B8 (pt) | 2021-05-25 |
KR101462984B1 (ko) | 2014-11-18 |
JP5508264B2 (ja) | 2014-05-28 |
AR070306A1 (es) | 2010-03-31 |
HK1138206A1 (en) | 2010-08-20 |
MY154567A (en) | 2015-06-30 |
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