WO2008114819A1 - 新規アデニン化合物 - Google Patents

新規アデニン化合物 Download PDF

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Publication number
WO2008114819A1
WO2008114819A1 PCT/JP2008/055088 JP2008055088W WO2008114819A1 WO 2008114819 A1 WO2008114819 A1 WO 2008114819A1 JP 2008055088 W JP2008055088 W JP 2008055088W WO 2008114819 A1 WO2008114819 A1 WO 2008114819A1
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WO
WIPO (PCT)
Prior art keywords
substituted
adenine compound
unsubstituted
formula
oxygen atom
Prior art date
Application number
PCT/JP2008/055088
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English (en)
French (fr)
Inventor
Yoshiaki Isobe
Tomoaki Nakamura
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Astrazeneca Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd., Astrazeneca Aktiebolag filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Priority to JP2009505237A priority Critical patent/JPWO2008114819A1/ja
Priority to EP08738681A priority patent/EP2138497A4/en
Priority to US12/531,867 priority patent/US8044056B2/en
Publication of WO2008114819A1 publication Critical patent/WO2008114819A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract

　医薬として有用な下記式 　式（１）： ［式中、Ｒ1は、置換もしくは無置換のアルキル基等を表し、Ｘは、酸素原子等を表し、Ａ1は、１～２個の窒素原子、０～１個の酸素原子および０～１個の硫黄原子から選択される１～２個のヘテロ原子を含む４～８員の置換もしくは無置換の飽和含窒素へテロ環等を表し、Ａ2は、置換もしくは無置換の６～１０員のアリ－ル基等を表し、Ｌ1およびＬ2は、独立して、直鎖もしくは分枝のアルキレン等を表す。］ で表されるアデニン化合物又はその薬学上許容される塩。
PCT/JP2008/055088 2007-03-20 2008-03-19 新規アデニン化合物 WO2008114819A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009505237A JPWO2008114819A1 (ja) 2007-03-20 2008-03-19 新規アデニン化合物
EP08738681A EP2138497A4 (en) 2007-03-20 2008-03-19 NEW ADENINE CONNECTION
US12/531,867 US8044056B2 (en) 2007-03-20 2008-03-19 Adenine compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-071711 2007-03-20
JP2007071711 2007-03-20

Publications (1)

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WO2008114819A1 true WO2008114819A1 (ja) 2008-09-25

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Family Applications (1)

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PCT/JP2008/055088 WO2008114819A1 (ja) 2007-03-20 2008-03-19 新規アデニン化合物

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US (1) US8044056B2 (ja)
EP (1) EP2138497A4 (ja)
JP (1) JPWO2008114819A1 (ja)
WO (1) WO2008114819A1 (ja)

Cited By (32)

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WO2011004778A1 (ja) * 2009-07-08 2011-01-13 住友化学株式会社 光学活性化合物の製造方法
US8063051B2 (en) 2007-03-19 2011-11-22 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7) modulators
US8067413B2 (en) 2007-03-19 2011-11-29 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
US8067411B2 (en) 2006-12-14 2011-11-29 Astrazeneca Ab Compounds
US8268990B2 (en) 2007-11-22 2012-09-18 Astrazeneca Ab Compounds
JP2013508373A (ja) * 2009-10-22 2013-03-07 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体の調節因子
JP2013519644A (ja) * 2010-02-10 2013-05-30 グラクソスミスクライン エルエルシー プリン誘導体およびそれらの薬学的使用
US8476288B2 (en) 2009-05-21 2013-07-02 Astrazeneca Ab Salts 756
US8865896B2 (en) 2008-01-17 2014-10-21 Astrazeneca Aktiebolag Method for preparing adenine compound
US8895570B2 (en) 2010-12-17 2014-11-25 Astrazeneca Ab Purine derivatives
JP2014534231A (ja) * 2011-11-09 2014-12-18 ヤンセン・アールアンドデイ・アイルランド ウイルス感染の治療のためのプリン誘導体
US9045472B2 (en) 2010-12-16 2015-06-02 Astrazeneca Ab Imidazoquinoline compounds
US9050319B2 (en) 2010-04-30 2015-06-09 Telormedix, Sa Phospholipid drug analogs
US9173935B2 (en) 2010-04-30 2015-11-03 Telormedix Sa Phospholipid drug analogs
US9376398B2 (en) 2012-05-18 2016-06-28 Sumitomo Dainippon Pharma Co., Ltd Carboxylic acid compounds
US9533978B2 (en) 2009-05-21 2017-01-03 Sumitomo Dainippon Pharma Co., Ltd Pyrimidine derivatives and their use in the treatment of cancer and further diseases
WO2018181420A1 (ja) 2017-03-29 2018-10-04 大日本住友製薬株式会社 ワクチンアジュバント製剤
US10253003B2 (en) 2012-11-16 2019-04-09 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
US10259814B2 (en) 2012-10-10 2019-04-16 Janssen Sciences Ireland Uc Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
US10259793B2 (en) 2013-02-21 2019-04-16 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
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