WO2008105442A1 - スルホンアミド誘導体 - Google Patents

スルホンアミド誘導体 Download PDF

Info

Publication number
WO2008105442A1
WO2008105442A1 PCT/JP2008/053367 JP2008053367W WO2008105442A1 WO 2008105442 A1 WO2008105442 A1 WO 2008105442A1 JP 2008053367 W JP2008053367 W JP 2008053367W WO 2008105442 A1 WO2008105442 A1 WO 2008105442A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
hydrogen atom
atom
alkyl group
hydroxy
Prior art date
Application number
PCT/JP2008/053367
Other languages
English (en)
French (fr)
Inventor
Koki Matsubara
Atsushi Iesato
Akifumi Oomura
Koh Kawasaki
Rintaro Yamada
Minoru Seto
Original Assignee
Asahi Kasei Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corporation filed Critical Asahi Kasei Pharma Corporation
Priority to CA002679263A priority Critical patent/CA2679263A1/en
Priority to EP08720915A priority patent/EP2130828A4/en
Priority to CN2008800064612A priority patent/CN101622243B/zh
Priority to AU2008220104A priority patent/AU2008220104B2/en
Priority to JP2009501263A priority patent/JP5313125B2/ja
Publication of WO2008105442A1 publication Critical patent/WO2008105442A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

　Rho キナーゼを強力に阻害する式（１）［Ａは含窒素飽和環；ｍは０～２；ｎは１～４；Ｇ1 は水素原子、塩素原子、水酸基、アルコキシ基、又はアミノ基；Ｇ2 はハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基等；Ｇ3 は水素原子、ハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基等；Ｙは単結合、又は－Ｃ(Ｒ3)(Ｒ4)－（Ｒ3 及びＲ4 は水素原子、アルキル基、又は互いに結合して飽和炭化水素環基を形成する）；Ｇ4 は水酸基（但し、Ｙは単結合である）、又は－Ｎ(Ｒ1)(Ｒ2)（Ｒ1 及びＲ2 は水素原子、アルキル基、アラルキル基、アルケニル基等）を示し；Ｇ5 はＡの環構成炭素原子における置換基であり、水素原子、フッ素原子、又はアルキル基を示す］で表される化合物又はその塩、あるいはプロドラッグであるそれらの誘導体。
PCT/JP2008/053367 2007-02-28 2008-02-27 スルホンアミド誘導体 WO2008105442A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002679263A CA2679263A1 (en) 2007-02-28 2008-02-27 Sulfonamide compound
EP08720915A EP2130828A4 (en) 2007-02-28 2008-02-27 sulfonamide
CN2008800064612A CN101622243B (zh) 2007-02-28 2008-02-27 磺酰胺衍生物
AU2008220104A AU2008220104B2 (en) 2007-02-28 2008-02-27 Sulfonamide derivative
JP2009501263A JP5313125B2 (ja) 2007-02-28 2008-02-27 スルホンアミド誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007048280 2007-02-28
JP2007-048280 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105442A1 true WO2008105442A1 (ja) 2008-09-04

Family

ID=39721267

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053367 WO2008105442A1 (ja) 2007-02-28 2008-02-27 スルホンアミド誘導体

Country Status (7)

Country Link
US (1) US7964613B2 (ja)
EP (1) EP2130828A4 (ja)
JP (1) JP5313125B2 (ja)
CN (1) CN101622243B (ja)
AU (1) AU2008220104B2 (ja)
CA (1) CA2679263A1 (ja)
WO (1) WO2008105442A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010146881A1 (ja) * 2009-06-19 2010-12-23 株式会社デ・ウエスタン・セラピテクス研究所 置換されたイソキノリン誘導体
EP2413701A4 (en) * 2009-03-31 2012-10-03 Univ Vanderbilt SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGUES AS GLYT1 INHIBITORS, METHODS OF MAKING THEM AND USE THEREOF IN THE TREATMENT OF PSYCHIATRIC DISORDERS
JP2017513919A (ja) * 2014-04-28 2017-06-01 メッドシャイン ディスカバリー インコーポレイテッド Ｒｈｏキナーゼ阻害剤としてのイソキノリンスルホン誘導体
JP2018070562A (ja) * 2016-11-04 2018-05-10 富士アミドケミカル株式会社 ４−フルオロイソキノリンの製法
JP2020502248A (ja) * 2016-12-21 2020-01-23 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
US11701366B2 (en) 2015-01-26 2023-07-18 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11814361B2 (en) 2016-12-21 2023-11-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
WO2008105058A1 (ja) * 2007-02-27 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド化合物
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
WO2009004792A1 (ja) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation スルホンアミド化合物及びその結晶
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
CN102993178A (zh) * 2012-12-04 2013-03-27 天津红日药业股份有限公司 具有Rho激酶抑制活性的异喹啉类化合物、制备方法及用途
CN105085525B (zh) * 2014-04-28 2019-01-04 南京明德新药研发股份有限公司 作为rho激酶抑制剂的异喹啉磺酰衍生物
CN111132983B (zh) * 2017-09-25 2022-05-17 华润医药控股有限公司 一种异喹啉磺酰衍生物的晶型及其制备方法
CN107564048B (zh) * 2017-09-25 2020-08-21 南通大学 基于分叉点特征配准方法
CN108558758A (zh) * 2018-04-12 2018-09-21 苏州康润医药有限公司 一种4-氟异喹啉-5-胺的合成方法
KR20220024868A (ko) * 2019-06-21 2022-03-03 광저우 오쿠순 옵탈믹 바이오테크놀로지 캄파니 리미티드 Rock단백질 키나아제 억제제인 이소퀴놀리논의 유도체 및 그 응용
CN114644618A (zh) * 2020-12-21 2022-06-21 广州润尔眼科生物科技有限公司 一种作为rock蛋白激酶抑制剂的异喹啉酮型化合物的盐型及其制备方法

Citations (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554816A (en) 1950-04-04 1951-05-29 American Cyanamid Co Heterocyclic sulfonamides and methods of preparation thereof
US3809714A (en) 1972-08-31 1974-05-07 Interx Research Corp Novel ester of ((methylamino)methyl) benzyl alcohol
GB1398455A (en) 1972-10-30 1975-06-25 Eisai Co Ltd Quinazoline compounds
US3953456A (en) 1972-12-14 1976-04-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and process for preparing the same
US4122193A (en) 1972-04-20 1978-10-24 Merz & Co. Drugs or medicines for influencing the central nervous system
US4252984A (en) 1975-11-06 1981-02-24 Synthelabo Phenol ethers
US4515977A (en) 1982-03-16 1985-05-07 Kaken Pharmaceutical Co., Ltd. Process for preparing optically active [S]-2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and salts thereof
US4517199A (en) 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
JPS60222472A (ja) 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS6054317B2 (ja) 1980-06-17 1985-11-29 興和株式会社 新規ベンゾピラン誘導体
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
EP0296879A1 (en) 1987-06-26 1988-12-28 Merck & Co. Inc. Substituted aromatic sulfonamides as antiglaucoma agents
JPH05208973A (ja) * 1991-07-31 1993-08-20 Adir 新規なｎ−（イソキノリン−５−イルスルホニル）アザシクロアルカン化合物
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
JPH06100540A (ja) * 1992-09-24 1994-04-12 Asahi Chem Ind Co Ltd ５−イソキノリンスルホン酸アミド誘導体
US5354860A (en) 1988-10-20 1994-10-11 Peraelampi Markku Process for making pure S-timolol hemihydrate
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5426227A (en) 1993-06-24 1995-06-20 Medicham, S.A. Enantioselective process for the preparation of leveobunolol
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5616599A (en) 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5627209A (en) 1993-12-15 1997-05-06 Alcon Laboratories, Inc. Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
WO1997023222A1 (en) 1995-12-21 1997-07-03 Alcon Laboratories, Inc. Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
WO1997028130A1 (fr) 1996-02-02 1997-08-07 Nippon Shinyaku Co., Ltd. Derives de l'isoquinoline et medicaments associes
WO1998006433A1 (fr) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
JPH1087491A (ja) * 1996-07-26 1998-04-07 Asahi Chem Ind Co Ltd 転写調節因子阻害剤
JP2763791B2 (ja) 1988-07-07 1998-06-11 ローン‐プーラン・サント （アザ）ナフタレンスルタムの誘導体類、それらの製造およびそれらを含有している組成物
WO1999064011A1 (fr) 1998-06-11 1999-12-16 Hiroyoshi Hidaka Medicaments
WO2001056988A1 (fr) 2000-02-01 2001-08-09 Kirin Beer Kabushiki Kaisha Composes contenant de l'azote et possedant une activite d'inhibition des kinases, et medicaments comprenant ces composes
US6403649B1 (en) 1992-09-21 2002-06-11 Allergan Sales, Inc. Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents
WO2002076977A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002076976A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002083175A1 (fr) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Agents ameliorant la fonction visuelle
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
JP2003321442A (ja) 2002-04-24 2003-11-11 Santen Pharmaceut Co Ltd 新規なジフルオロプロスタグランジンアミド誘導体
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
WO2004108724A1 (ja) 2003-06-06 2004-12-16 Asahi Kasei Pharma Corporation ３環系化合物
WO2005006988A1 (en) 2003-06-19 2005-01-27 Everest Biomedical Instruments Breath end-tidal gas monitor
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
WO2005080394A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
JP2007048280A (ja) 2005-08-11 2007-02-22 Samsung Electronics Co Ltd バスモニタリングのための集積回路装置及びその方法
WO2007026664A1 (ja) * 2005-08-30 2007-03-08 Asahi Kasei Pharma Corporation スルホンアミド化合物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156463A (en) 1981-03-20 1982-09-27 Asahi Chem Ind Co Ltd Isoquinoline derivative
JPS57200366A (en) 1981-06-01 1982-12-08 Asahi Chem Ind Co Ltd Isoquinoline compound
US4456757A (en) 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
JPH0667926B2 (ja) 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
US5216150A (en) * 1988-12-26 1993-06-01 Hiroyoshi Hidaka Derivatives of isoquinoline (and naphthalene) sulfonamides
JP2886225B2 (ja) 1988-12-26 1999-04-26 弘義 日高 アルキレンジアミン誘導体及びその製造方法
US5245034A (en) 1988-12-26 1993-09-14 Kiroyoshi Hidaka Compound having vessel smooth muscle relaxation activity
CA2005741C (en) * 1988-12-26 1998-06-02 Hiroyoshi Hidaka Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity
US5235034A (en) * 1989-11-06 1993-08-10 Phillips Petroleum Company Treatment of polyarylene sulfide/sulfone polymers with zinc compound and acidic solution
JP3408546B2 (ja) 1991-02-19 2003-05-19 旭化成株式会社 抗喘息剤
JP3176619B2 (ja) 1991-09-05 2001-06-18 ファルノ−ヴェトロファルム ゲゼルシャフト ミット ベシュレンクテル ハフツング 芳香族スルホンアミド化合物、阻害剤及びそれを含有する医薬組成物
CA2240271C (en) 1995-12-21 2005-12-13 Alcon Laboratories, Inc. Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
JP4316794B2 (ja) 1997-10-22 2009-08-19 株式会社デ・ウエスタン・セラピテクス研究所 イソキノリン誘導体及び医薬
CA2327276A1 (en) 1998-04-23 1999-10-28 Hiroshi Muramatsu Isoquinolinesulfonamide derivatives and drugs containing the same as the active ingredient
US7094789B2 (en) * 2002-07-22 2006-08-22 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivatives
JP4482726B2 (ja) 2002-08-29 2010-06-16 参天製薬株式会社 Ｒｈｏキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
ES2382733T3 (es) 2002-08-29 2012-06-13 Santen Pharmaceutical Co., Ltd. Remedio para el glaucoma que comprende un inhibidor de la Rho quinasa y prostaglandinas
EP1550660A1 (en) * 2002-09-12 2005-07-06 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
KR101103141B1 (ko) 2002-11-18 2012-01-04 산텐 세이야꾸 가부시키가이샤 Ｒｈｏ 키나아제 억제제와 β 차단약으로 이루어진 녹내장치료제
MY140618A (en) 2003-02-28 2009-12-31 Kowa Co Method for preparing acid addition salts of polyacidic basic compounds
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
JP2007015928A (ja) 2003-10-15 2007-01-25 Ube Ind Ltd 新規オレフィン誘導体
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
JP2005232175A (ja) 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
US20060247266A1 (en) * 2004-11-26 2006-11-02 Asahi Kasei Pharma Corporation Nitrogen-containing tricyclic compounds
MY139797A (en) 2004-11-29 2009-10-30 Kowa Co (s)-(-)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1, 4-homopiperazine hydrochloride dihydrate
EP1866298A2 (en) * 2005-03-31 2007-12-19 Takeda San Diego, Inc. Hydroxysteroid dehydrogenase inhibitors
WO2006115245A1 (ja) 2005-04-25 2006-11-02 D. Western Therapeutics Institute, Inc. ４－エチニルイソキノリン誘導体及びこれを含有する医薬
WO2006115244A1 (ja) 2005-04-25 2006-11-02 D. Western Therapeutics Institute, Inc. ４－ブロモイソキノリン誘導体及びこれを含有する医薬
ATE423779T1 (de) 2005-04-25 2009-03-15 Western Therapeutics Inst Inc Hochselektiver rho-kinase-inhibitor
JP2006348028A (ja) 2005-05-19 2006-12-28 Kowa Co 緑内障予防又は治療剤
WO2006137368A1 (ja) 2005-06-21 2006-12-28 Kowa Co., Ltd. 緑内障の予防又は治療剤
JP4972552B2 (ja) 2005-07-12 2012-07-11 興和株式会社 緑内障を予防又は治療する薬剤
JP2007238458A (ja) 2006-03-06 2007-09-20 D Western Therapeutics Institute Inc 新規なイソキノリン誘導体及びこれを含有する医薬
WO2008105058A1 (ja) 2007-02-27 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド化合物
WO2009004792A1 (ja) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation スルホンアミド化合物及びその結晶

Patent Citations (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554816A (en) 1950-04-04 1951-05-29 American Cyanamid Co Heterocyclic sulfonamides and methods of preparation thereof
US4122193A (en) 1972-04-20 1978-10-24 Merz & Co. Drugs or medicines for influencing the central nervous system
US3809714A (en) 1972-08-31 1974-05-07 Interx Research Corp Novel ester of ((methylamino)methyl) benzyl alcohol
GB1398455A (en) 1972-10-30 1975-06-25 Eisai Co Ltd Quinazoline compounds
US3953456A (en) 1972-12-14 1976-04-27 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and process for preparing the same
US4252984A (en) 1975-11-06 1981-02-24 Synthelabo Phenol ethers
JPS6054317B2 (ja) 1980-06-17 1985-11-29 興和株式会社 新規ベンゾピラン誘導体
US4517199A (en) 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4515977A (en) 1982-03-16 1985-05-07 Kaken Pharmaceutical Co., Ltd. Process for preparing optically active [S]-2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and salts thereof
JPS60222472A (ja) 1984-03-30 1985-11-07 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
EP0296879A1 (en) 1987-06-26 1988-12-28 Merck & Co. Inc. Substituted aromatic sulfonamides as antiglaucoma agents
JP2763791B2 (ja) 1988-07-07 1998-06-11 ローン‐プーラン・サント （アザ）ナフタレンスルタムの誘導体類、それらの製造およびそれらを含有している組成物
US5296504A (en) 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5354860A (en) 1988-10-20 1994-10-11 Peraelampi Markku Process for making pure S-timolol hemihydrate
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5616599A (en) 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
JPH05208973A (ja) * 1991-07-31 1993-08-20 Adir 新規なｎ−（イソキノリン−５−イルスルホニル）アザシクロアルカン化合物
US6403649B1 (en) 1992-09-21 2002-06-11 Allergan Sales, Inc. Non-acidic cyclopentane heptanoic acid,2-cycloalkyl or arylalkyl derivatives as therapeutic agents
JPH06100540A (ja) * 1992-09-24 1994-04-12 Asahi Chem Ind Co Ltd ５−イソキノリンスルホン酸アミド誘導体
US5426227A (en) 1993-06-24 1995-06-20 Medicham, S.A. Enantioselective process for the preparation of leveobunolol
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5627209A (en) 1993-12-15 1997-05-06 Alcon Laboratories, Inc. Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
WO1997023222A1 (en) 1995-12-21 1997-07-03 Alcon Laboratories, Inc. Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
WO1997028130A1 (fr) 1996-02-02 1997-08-07 Nippon Shinyaku Co., Ltd. Derives de l'isoquinoline et medicaments associes
JPH1087491A (ja) * 1996-07-26 1998-04-07 Asahi Chem Ind Co Ltd 転写調節因子阻害剤
WO1998006433A1 (fr) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
WO1999064011A1 (fr) 1998-06-11 1999-12-16 Hiroyoshi Hidaka Medicaments
WO2001056988A1 (fr) 2000-02-01 2001-08-09 Kirin Beer Kabushiki Kaisha Composes contenant de l'azote et possedant une activite d'inhibition des kinases, et medicaments comprenant ces composes
WO2002076977A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002076976A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002083175A1 (fr) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Agents ameliorant la fonction visuelle
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
JP2003321442A (ja) 2002-04-24 2003-11-11 Santen Pharmaceut Co Ltd 新規なジフルオロプロスタグランジンアミド誘導体
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
WO2004108724A1 (ja) 2003-06-06 2004-12-16 Asahi Kasei Pharma Corporation ３環系化合物
WO2005006988A1 (en) 2003-06-19 2005-01-27 Everest Biomedical Instruments Breath end-tidal gas monitor
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
WO2005080394A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
JP2007048280A (ja) 2005-08-11 2007-02-22 Samsung Electronics Co Ltd バスモニタリングのための集積回路装置及びその方法
WO2007026664A1 (ja) * 2005-08-30 2007-03-08 Asahi Kasei Pharma Corporation スルホンアミド化合物

Non-Patent Citations (172)

* Cited by examiner, † Cited by third party
Title
"Drug Nonclinical Test Guideline Commentary 2002", YAKUJI NIPPO, 2002, pages 1 - 6
"Drug Nonclinical Test Guideline Commentary 2002", YAKUJI NIPPO, 2002, pages 1 - 9
"Electrocardiographic, Echocardiographic, Blood Pressure and Pathological Tests of Animals for Fundamental and Clinical Medicine", 2003, MARUZEN
"Guideline for Drug Toxicity Test", IYAKUSHIN NO. 1834, 2000
"Guideline for Genotoxicity Test", IYAKUSHIN NO. 1604, 1999
"Newest Mass Spectrometry for Life Science", 2002, KODANSHA SCIENTIFIC
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
"Vitreoretinal Diseases", vol. 5, 2003, article "Shin Zusetsu Rinsho Ganka Koza (Illustrative Lecture of Clinical Ophthalmology"
ALLERGY, vol. 50, no. 12, 2001, pages 1152 - 1162
AM. J. RESPIR. CRIT. CARE MED., vol. 163, no. 1, 2001, pages 210 - 217
ANDERSSON, KE. ET AL., WORLD J. VROL., vol. 15, 1997, pages 14 - 20
ARAKAWA, Y. ET AL., BIO CLINICA, vol. 17, no. 13, 2002, pages 26 - 28
BARANY, K. ET AL., BIOCHEMISTRY OF SMOOTH MUSCLE CONTRACTION, 1996, pages 21 - 35
BARANY, M. ET AL., BIOCHEMISTRY OF SMOOTH MUSCLE CONTRACTION, 1996, pages 321 - 339
BENNETT, G.J. ET AL., PAIN, vol. 33, no. 1, 1988, pages 87 - 107
BEVAN, C.D. ET AL., ANAL. CHEM., vol. 72, 2000, pages 1781 - 1787
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 183, 1992, pages 48 - 54
BUCHWALD, S.L., J. ORG. CHEM., 2000, pages 1158
BUCHWALD, S.L., ORGANIC LETTERS, 2000, pages 1101
BUEHLER, E.V., ARCH. DERMATOL., vol. 91, 1965, pages 171 - 177
CANCER RES., vol. 55, 1995, pages 3551 - 3557
CHACHIN, M. ET AL., NIPPON YAKURIGAKU ZASSHI, vol. 119, 2002, pages 345 - 351
CHENG, C.S. ET AL., DRUG DEVELOP. INDUST. PHARM., vol. 28, 2002, pages 177 - 191
CIR. RES., vol. 89, no. 5, 2001, pages 415 - 21
CLIVE, D. ET AL., MUTAT. RES., vol. 31, 1975, pages 17 - 29
COLE, J. ET AL., MUTAT. RES., vol. 111, 1983, pages 371 - 386
CRUB S. ET AL., ACTA NEUROPATHOL., vol. 101, no. 2, 2001, pages 85 - 91
DANIELA, S. ET AL., J. PHARMACOL. EXP. THER., vol. 297, no. 1, 2001, pages 280 - 290
DELIE, F. ET AL., CRIT. REV. THER. DRUG CARRIER SYST., vol. 14, 1997, pages 221 - 286
DORN, A. ET AL., J. BIOMOL. SCREEN., vol. 10, 2005, pages 339 - 347
DRORBAUGH, J.E. ET AL., PEDIATRICS, vol. 16, 1955, pages 81 - 87
DUBREUIL, C.I. ET AL., J. CELL. BIOL., vol. 162, no. 2, 2003, pages 233 - 243
DUCIC, I. ET AL., J. CARDIOVASC. PHARMACOL., vol. 30, no. 1, 1997, pages 42 - 54
EPSTEIN, M.A. ET AL., RESPIR. PHYSIOL., vol. 32, 1978, pages 105 - 120
FENECH M. ET AL., MUTAT. RES., vol. 147, 1985, pages 29 - 36
FENG, J. ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 37385 - 37390
FINNEY, N.S. ET AL., ORG. LETT., vol. 4, 2002, pages 3001
FUCHIGAMI J. ET AL., 73RD MEETING OF JAPANESE PHARMACOLOGICAL SOCIETY, 2000
FUCHIKAMI ET AL., TETRAHEDRON LETT., vol. 32, 1991, pages 91
FUJIMOTO, O. ET AL., JOURNAL OF JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 88, no. 1, 1998, pages 148 - 58
FUKATA, Y. ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 22, 2001, pages 32 - 39
FUKATA, Y. ET AL., TRENDS PHARMACOL. SCI., vol. 22, 2001, pages 32 - 39
FUKUI, N. ET AL., GENDAI NO RINSHO, vol. 4, no. 7, 1970, pages 277 - 289
GERMANN, U.A., METHODS ENZYMOL., vol. 292, 1998, pages 427 - 41
GILBERT, J.D. ET AL., J. PHARM. TOX. METHODS, vol. 50, 2004, pages 187 - 199
GOLUB, L.M. ET AL., ANN. N.Y. ACAD. SCI., vol. 878, 1999, pages 290 - 310
GOMEZ-LECHON, M.J. ET AL., CURR. DRUG METAB., vol. 5, no. 5, 2004, pages 443 - 462
GONZALES DE MORAES, VL. ET AL., BR. J. PHARMACOL., vol. 123, 1998, pages 631 - 6
GRIFFITH, M.M. ET AL., ARTHRITIS RHEUMATISM, vol. 24, 1981, pages 781
GUZMAN, R.E. ET AL., TOXICOL. PATHOL., vol. 31, no. 6, 2003, pages 619 - 624
HAHN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1998, pages 6556
HARBER, L.C., ARCH. DERMATOL., vol. 96, 1967, pages 646 - 653
HARRIS, A. ET AL., J. OCUL. PHARMACOL. THER., vol. 15, 1999, pages 189 - 197
HAYASHI M. ET AL., MUTAT. RES., vol. 312, 1994, pages 293 - 304
HAYASHI, M. ET AL., ENVIRON. MOL. MUTAGEN., vol. 35, 2000, pages 234 - 252
HECK R.F. ET AL., J. ORG. CHEM., 1978, pages 2947
HENDERSON W.R. ET AL., AM. J. RESPIR. CRIT. CARE MED., vol. 165, no. 1, 2002, pages 108 - 16
HENDERSON, W. R. ET AL., AM. J. RESPIR. CRIC. CARE MED., vol. 165, no. 1, 2002, pages 108 - 116
HENGSTLER, J.G. ET AL., DRUG METAB. REV., vol. 32, 2000, pages 81 - 118
HIRAYAMA, K. ET AL., PRELIMINARY PUBLISHED ABSTRACTS OF THE 42ND CONGRESS OF THE VITREORETINA SOCIETY OF JAPAN
HIROSE, T.; KARINO, S.; TADA, T.: "EAE, Clinical Immunology Illustrated", 1994, NANKODO, article "Experimental Autoimmune Encephalomyelitis", pages: 112 - 117
HONJO, M. ET AL., ARCH. OPHTHALMOL., vol. 119, no. 8, 2001, pages 1171 - 8
HONJO, M. ET AL., INVEST. OPHTHALMOL. VIS. SCI., vol. 42, no. 1, 2001, pages 137 - 44
HORIO, T., J. INVEST. DERMATOL., vol. 67, 1976, pages 591 - 593
HOWE, P.H. ET AL., BIOCHEM J., vol. 255, 1988, pages 423 - 429
ICHIKAWA, H. ET AL., J. INVEST. DERMATOL., vol. 76, 1981, pages 498 - 501
INGELS, F.M. ET AL., J. PHAM. SCI., vol. 92, 2003, pages 1545 - 1558
INOUE, M. ET AL., NAT. MED., vol. 10, 2004, pages 712 - 718
INOUE, T. ET AL., CURRENT EYE RES., vol. 23, no. 2, 2001, pages 133 - 8
INOUE, T. ET AL., OPHTHALMIC RES., vol. 35, 2003, pages 351 - 4
IRVINE, J.D. ET AL., J. PHAM. SCI., vol. 88, 1999, pages 28 - 33
IRWIN, S., COMPREHENSIVE OBSERVATIONAL ASSESSMENT, vol. 13, 1968, pages 222 - 257
ITO, K.M. ET AL., AM. J. PHYSIOL., vol. 279, 2000, pages H1786 - H1795
ITO, S. ET AL., GRAEFES ARCH. CLIN. EXP. OPHTHALMOL., vol. 237, no. 8, 1999, pages 691 - 6
ITOH ET AL., ORG. LETT., vol. 6, 2004, pages 4587
ITOH, K. ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 1136, 1992, pages 52 - 56
ITOH, K. ET AL., BIOCHIM. BIOPHYS. ACTA., vol. 1136, 1992, pages 52 - 56
ITOH, K. ET AL., NAT. MED., vol. 5, no. 2, 1999, pages 221 - 5
J. HEPATOL., vol. 35, no. 4, 2001, pages 474 - 81
J. IMMUNOL., vol. 159, 1997, pages 3961 - 3967
J. ORG. CHEM., vol. 63, 1998, pages 7990
J. URO., vol. 151, 1994, pages 797 - 800
JAPANESE JOURNAL OF OPHTHALMOLOGY, vol. 107, no. 3, 2003
JORDAN, W.P., CONTACT DERMATITIS, vol. 8, 1982, pages 109 - 116
K. IIDZUKA ET AL., JPN. J. RESPIROLOGY SOCIETY, vol. 37, 1999, pages 196
K. IIDZUKA, ALLERGY, vol. 47, 1998, pages 943
KAMM, K. ET AL., ANNU. REV. PHYSIOL., vol. 51, 1989, pages 299 - 313
KANEKO S. ET AL., FOLIA PHARMACOL. JAPON, vol. 93, no. 2, 1989, pages 55 - 60
KATO, M. ET AL., DRUG METAB. PHARMACOKINET., vol. 20, no. 4, 2005, pages 236 - 243
KEANE-MYERS A. ET AL., CURR. ALLERGY ASTHMA REP., vol. 1, no. 6, 2001, pages 550 - 557
KEELY, P. ET AL., TRENDS CELL BIOL., vol. 8, no. 3, pages 101 - 6
KI D.W. ET AL., ANTICANCER RES., vol. 22, no. 2A, 2002, pages 777 - 88
KIM, T W. ET AL., KOREAN J. OPHTHALMOL., vol. 16, no. 1, 2002, pages 1 - 7
KIRINO ET AL., BRAIN RES., vol. 239, 1982, pages 57 - 69
KISO TO RINSHO, vol. 30, 1996, pages 511 - 524
KITANI, S. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 183, 1992, pages 48 - 54
KOCHEVER, I.E. ET AL., J. INVEST. DERMATOL., vol. 73, 1979, pages 144 - 146
KOJIMA ET AL., FOLIA. PHARMACOL. JPN., vol. 118, 2001, pages 123 - 130
KUNIHIKO IIZUKA, ALLERGY, vol. 47, 1998, pages 943
KUNIHIKO IIZUKA; AKIHIRO YOSHII, JPN. J. RESPIROL. SOC., vol. 37, 1999, pages 196
KUROSE ET AL., PROTEIN NUCLEIC ACID ENZYME, vol. 42, no. 3, 1997, pages 316 - 26
LEBEL ET AL., ORG. LETT., vol. 7, 2005, pages 4107
LI, C. ET AL., DRUG METAB. DISPOS., vol. 34, no. 6, 2006, pages 901 - 905
LIPINSKI, C.A. ET AL., ADV. DRUG DELIV. REV., vol. 23, 1997, pages 3 - 26
M. SATOH ET AL., 57TH GENERAL MEETING OF JAPANNEUROSURGICAL SOCIETY, vol. 153, pages 1998
MAEKAWA, T. ET AL., TROMBOS. DIATHES. HAEMORRH., vol. 60, 1974, pages 363 - 370
MAGNUSSON B. ET AL., J. INVEST. DERMATOL., vol. 52, 1969, pages 268 - 276
MARVEL, C.S. ET AL., J. AM. CHEM. SOC., vol. 67, 1945, pages 2250
MATTSON, J.L. ET AL.: "Functional Observational Battery", J. AMERICAN COLLEGE OF TECHNOLOGY, vol. 15, no. 3, 1996, pages 239 - 254
MAURER, T. ET AL., BR. J. DERMATOL., vol. 63, 1980, pages 593 - 605
MILLER, B. ET AL., MUTAT. RES., vol. 392, 1997, pages 45 - 59
MILLER, V.P. ET AL., ANN. N.Y. ACAD. SCI., vol. 919, 2000, pages 26 - 32
MILLS, J.C. ET AL., J. CELL BIOL., vol. 140, no. 3, pages 627 - 636
MIYATA, K. ET AL., AM. J. PHYSIOL., vol. 274, 1998, pages G827 - 831
MIYATA, K. ET AL., J. PHARMACOL. EXP. THER., vol. 259, 1991, pages 815 - 819
MOBLEY P.L. ET AL., EXP. CELL RES., vol. 214, 1994, pages 55 - 66
MORIKAWA, F. ET AL.: "Sunlight and Man", 1974, TOKYO UNIV. PRESS, pages: 529 - 557
MURAKI, K. ET AL., AM. J. PHYSIOL., vol. 269, 1995, pages H524 - 532
MURATA T. ET AL., J. HEPATOTOL., vol. 35, 2001, pages 474 - 481
N. ONO ET AL., PHARMACOL. THER., vol. 82, no. 2-3, 1991, pages 123 - 31
NAGUMO, H. ET AL., AM. J. PHYSIOL. CELL PHYSIOL., vol. 278, no. 1, 2000, pages C57 - 65
NAKAI, K. ET AL., ANESTH. ANALG., vol. 94, 2002, pages 1537 - 1541
NAKAI, K. ET AL., BLOOD, vol. 90, no. 10, 1997, pages 3736 - 42
NEWMAN, M.S. ET AL., J. ORG. CHEM., 1961, pages 2525
NIEDIRAU, C. ET AL., GASTROENTEROLOGY, vol. 88, 1985, pages 1192 - 204
NIGGLI, V, FEBS LETT., vol. 445, 1999, pages 69 - 72
NIGGLI, V., FEBS LETT., vol. 445, 1999, pages 69 - 72
NOMURA N. ET AL., FOLIA PHARMACOL. JAPON, vol. 94, no. 3, 1989, pages 173
OCHIAI T. ET AL., TRANSPLANT. PROC., vol. 19, 1987, pages 1284 - 1286
OHNAKA, K. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 287, 2001, pages 337 - 342
ORENGO I.F. ET AL., ARCH DERMATOL., vol. 138, no. 6, 2002, pages 823 - 4
OSHIMA, Y. ET AL., GENE THER., vol. 9, no. 18, 2002, pages 1214 - 20
PIERCE S.M. ET AL., AM. J. PHYSIOL. HEART CIRC. PHYSIOL., vol. 281, no. 1, 2001, pages H67 - 74
PN. J. OPHTHALMOL., vol. 45, no. 4, 2001, pages 359 - 62
RENAUT ET AL., CHEM. PHARM. BULL., vol. 50, 2002, pages 316
RICHARD, M B. ET AL., ANNU. REV. PHARMACOL. TOXICOL., vol. 41, 2001, pages 661 - 90
SAMLYO, A.P. ET AL., REV. PHYSIOL. BIOCHEM. PHARMACOL., vol. 134, 1999, pages 209 - 34
SAMUELSSON ET AL., J. ORG. CHEM., vol. 59, 1994, pages 1779
SATO, Y. ET AL., CONTACT DERMATITIS, vol. 7, 1981, pages 225 - 237
SATOH, H. ET AL., JPN. J. PHARMACOL., vol. 79, 1999, pages 211
SAWADA N. ET AL., CIRCULATION, vol. 101, no. 17, 2000, pages 2030 - 3
SCHLOSSER ET AL., EUR. J. ORG. CHEM., 2002, pages 327
SCHMIDT, J.T. ET AL., J, NEUROBIOL., vol. 52, no. 3, 2002, pages 175 - 188
See also references of EP2130828A4
SHIMOKAWA ET AL., CARDIOVASC. RES., vol. 43, no. 4, 1999, pages 1029 - 39
SHOU, W.Z. ET AL., J. MASS SPECTROM., vol. 40, no. 10, 2005, pages 1347 - 1356
SILVERMAN ET AL., J. MED. CHEM., vol. 49, 2006, pages 6254
SONOGASHIRA, K. ET AL., TETRAHEDRON, 1984, pages 2303
SURV. OPHTHALMOL., vol. 41, 1996, pages 59 - 518
SUZUKI, A. ET AL., BR. J. PHARMACOL., vol. 109, 1993, pages 703 - 712
TAKEYOSHI, M. ET AL., J. APPL. TOXICOL., vol. 25, no. 2, 2005, pages 129 - 34
TAKEYOSHI, M. ET AL., TOXICOL. LETT., vol. 119, no. 3, 2001, pages 203 - 8
TAMAKI, Y. ET AL., J. OCUL. PHARMACOL. THER., vol. 17, no. 5, 2001, pages 403 - 11
TAMAKI, Y. ET AL., SURV. OPHTHALMOL., vol. 42, no. 1, 1997, pages S52 - S63
TETRADERON LETT., vol. 44, 2003, pages 8437
THOMPSON, C.B., SCIENCE, vol. 267, 1995, pages 1456 - 1462
TORIU, N. ET AL., EXP. EYE RES., vol. 70, no. 4, 2000, pages 475 - 84
UEHATA, M. ET AL., NATURE, vol. 389, 1997, pages 990 - 994
UEKI, J. ET AL., GENDAI IRYO, vol. 34, no. 9, 2002, pages 87 - 92
VAUGHAN ET AL., J. ORG. CHEM., vol. 26, 1961, pages 468
VINSON, L.J., J. SOC. COSM. CHEM., vol. 17, 1966, pages 123 - 130
WEISSMAN S.A. ET AL., J. ORG. CHEM., vol. 70, 2005, pages 1508
WEISSMAN, S.A. ET AL., J. ORG. CHEM., vol. 70, 2005, pages 1508
WHEELER, LA. ET AL., EUR. J. OPHTHALMOL., vol. 11, no. 2, 2001, pages 403 - 11
WOOD, J P ET AL., EXP. EYE RES., vol. 76, no. 4, 2003, pages 505 - 16
WOOLEY, P.H. ET AL., J. EXP. MED., vol. 154, 1981, pages 688
WU ET AL., J. ORG. CHEM., vol. 67, 2002, pages 7553
XIA Q.G. ET AL., CARDIOVASC. RES., vol. 49, no. 1, 2001, pages 110 - 7
YAMASHITA, S. ET AL., EUR. J. PHAM. SCI., vol. 10, 2000, pages 195 - 204
YANKNER, B.A. ET AL., SCIENCE, vol. 250, 1990, pages 279 - 282
YUGE, T. ET AL.: "Current Situation of Neuropathic Pain", MEDICAL EXAMINATION PRACTICE IN ANESTHESIOLOGY, vol. 6, 2002
YUHONG, S. ET AL., EXP. CELL RES., vol. 278, 2002, pages 45 - 52

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2413701A4 (en) * 2009-03-31 2012-10-03 Univ Vanderbilt SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGUES AS GLYT1 INHIBITORS, METHODS OF MAKING THEM AND USE THEREOF IN THE TREATMENT OF PSYCHIATRIC DISORDERS
CN102448941B (zh) * 2009-06-19 2016-04-06 株式会社D.西医疗法研究所 取代的异喹啉衍生物
CN102448941A (zh) * 2009-06-19 2012-05-09 株式会社D.西医疗法研究所 取代的异喹啉衍生物
JP4915010B2 (ja) * 2009-06-19 2012-04-11 株式会社デ・ウエスタン・セラピテクス研究所 置換されたイソキノリン誘導体
EA019523B1 (ru) * 2009-06-19 2014-04-30 Д. Вестерн Терапьютикс Инститьют, Инк. Производное замещенного изохинолина, содержащая его фармацевтическая композиция и применение для лечения заболеваний
US8951997B2 (en) 2009-06-19 2015-02-10 D. Western Therapeutics Institute, Inc. Substituted isoquinoline derivative
WO2010146881A1 (ja) * 2009-06-19 2010-12-23 株式会社デ・ウエスタン・セラピテクス研究所 置換されたイソキノリン誘導体
JP2017513919A (ja) * 2014-04-28 2017-06-01 メッドシャイン ディスカバリー インコーポレイテッド Ｒｈｏキナーゼ阻害剤としてのイソキノリンスルホン誘導体
US11701366B2 (en) 2015-01-26 2023-07-18 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
JP2018070562A (ja) * 2016-11-04 2018-05-10 富士アミドケミカル株式会社 ４−フルオロイソキノリンの製法
JP2020502248A (ja) * 2016-12-21 2020-01-23 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
JP7117306B2 (ja) 2016-12-21 2022-08-12 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
US11814361B2 (en) 2016-12-21 2023-11-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
JP7461414B2 (ja) 2016-12-21 2024-04-03 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物

Also Published As

Publication number Publication date
US20090048223A1 (en) 2009-02-19
EP2130828A1 (en) 2009-12-09
JP5313125B2 (ja) 2013-10-09
CA2679263A1 (en) 2008-09-04
EP2130828A4 (en) 2010-12-29
AU2008220104A1 (en) 2008-09-04
US7964613B2 (en) 2011-06-21
CN101622243B (zh) 2013-12-04
JPWO2008105442A1 (ja) 2010-06-03
AU2008220104B2 (en) 2012-09-27
CN101622243A (zh) 2010-01-06

Similar Documents

Publication Publication Date Title
WO2008105442A1 (ja) スルホンアミド誘導体
WO2008105058A1 (ja) スルホンアミド化合物
WO2008096231A8 (en) Antiparasitic agents
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
WO2008058096A3 (en) Azaadamantane derivatives and their uses as nicotinic acetylcholine receptors ligands
WO2007148185A3 (en) Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
WO2005110410A3 (en) Kinase inhibitors as therapeutic agents
TW200833686A (en) Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
WO2006135828A3 (en) Trisubstituted amines as phosphodiesterase 4 inhibitors
WO2005074603A3 (en) Aminobenzoxazoles as therapeutic agents
EP1867331A4 (en) TRIAZOL DERIVATIVE AND ITS USE
WO2008071918A8 (en) Pyrido-pyrazine derivatives useful as herbicidal compounds
WO2005094329A3 (en) Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
WO2007084914A3 (en) Phenoxy-substituted pyrimidines as adenosine receptor antagonists
WO2008126901A1 (ja) 含窒素複素環化合物およびそれを含有する医薬組成物
WO2008108380A3 (en) Pyrrole compounds
WO2006113509A3 (en) Quinobenzoxazine analogs and methods of using thereof
WO2009107850A3 (en) Fused heterocyclic derivative and use thereof
WO2006030211A3 (en) Acyclic sulphonamides
EP1854789A4 (en) CHINAZOLINE DERIVATIVE WITH TYROSINE KINASE HEMMENDER EFFECT
WO2007006409A3 (de) Herbizid-safener-kombination
WO2009017098A1 (ja) トロンボポエチン受容体アゴニスト作用を有する光学活性な化合物を含有する医薬組成物およびその中間体
WO2007061966A3 (en) Amidinylphenyl compounds and their use as fungicides
WO2007017728A3 (en) Novel heterocyclic compounds
MX2010001566A (es) Derivado de aminopirazolamida.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880006461.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08720915

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2679263

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2009501263

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008720915

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008220104

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2008220104

Country of ref document: AU

Date of ref document: 20080227

Kind code of ref document: A