WO2007084914A3 - Phenoxy-substituted pyrimidines as adenosine receptor antagonists - Google Patents

Phenoxy-substituted pyrimidines as adenosine receptor antagonists Download PDF

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Publication number
WO2007084914A3
WO2007084914A3 PCT/US2007/060632 US2007060632W WO2007084914A3 WO 2007084914 A3 WO2007084914 A3 WO 2007084914A3 US 2007060632 W US2007060632 W US 2007060632W WO 2007084914 A3 WO2007084914 A3 WO 2007084914A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenoxy
receptor antagonists
adenosine receptor
substituted pyrimidines
pyrimidines
Prior art date
Application number
PCT/US2007/060632
Other languages
French (fr)
Other versions
WO2007084914A2 (en
Inventor
Deborah Slee
Xiaohu Zhang
Jaimie K Rueter
Emily Lin
Crespo Maria Isabel Crespo
Palomino Laria Julio Ce Castro
Original Assignee
Neurocrine Biosciences Inc
Almirall Lab
Deborah Slee
Xiaohu Zhang
Jaimie K Rueter
Emily Lin
Crespo Maria Isabel Crespo
Palomino Laria Julio Ce Castro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Almirall Lab, Deborah Slee, Xiaohu Zhang, Jaimie K Rueter, Emily Lin, Crespo Maria Isabel Crespo, Palomino Laria Julio Ce Castro filed Critical Neurocrine Biosciences Inc
Priority to EP07718002A priority Critical patent/EP1976851A2/en
Publication of WO2007084914A2 publication Critical patent/WO2007084914A2/en
Publication of WO2007084914A3 publication Critical patent/WO2007084914A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Compounds of formula (I), including pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof thereof, wherein R1, R2, R3, R4, R5, X, m and n are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
PCT/US2007/060632 2006-01-17 2007-01-17 Phenoxy-substituted pyrimidines as adenosine receptor antagonists WO2007084914A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07718002A EP1976851A2 (en) 2006-01-17 2007-01-17 Phenoxy-substituted pyrimidines as adenosine receptor antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75969206P 2006-01-17 2006-01-17
US60/759,692 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007084914A2 WO2007084914A2 (en) 2007-07-26
WO2007084914A3 true WO2007084914A3 (en) 2007-10-04

Family

ID=38169639

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/060632 WO2007084914A2 (en) 2006-01-17 2007-01-17 Phenoxy-substituted pyrimidines as adenosine receptor antagonists

Country Status (2)

Country Link
EP (1) EP1976851A2 (en)
WO (1) WO2007084914A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

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CL2008003811A1 (en) * 2007-12-21 2009-05-22 Palau Pharma Sa 4-aminopyrimidine-2,6-disubstituted derivative compounds, histamine h4 receptor antagonists; Preparation process; pharmaceutical composition comprising said compound; and use of the compound for the treatment of an allergic, immunological or inflammatory disease, or pain.
ES2790358T3 (en) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Substituted Heteroaryl Aldehyde Compounds and Methods for Their Use in Increasing Tissue Oxygenation
PT2797416T (en) 2011-12-28 2017-10-23 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
CN105073728A (en) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2015031285A1 (en) * 2013-08-27 2015-03-05 Global Blood Therapeutics, Inc. Crystalline 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde ansolvate salts
EA201992707A1 (en) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
WO2015116061A1 (en) * 2014-01-29 2015-08-06 Global Blood Therapeutics, Inc. 1:1 adducts of sickle hemoglobin
US9248199B2 (en) 2014-01-29 2016-02-02 Global Blood Therapeutics, Inc. 1:1 adducts of sickle hemoglobin
MA43373A (en) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc DOSAGE REGIMES FOR 2-HYDROXY-6 - ((2- (1-ISOPROPYL-1H-PYRAZOL-5-YL) PYRIDIN-3-YL) METHOXY) BENZALDEHYDE
AR108435A1 (en) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc PROCESS TO SYNTHETIZE 2-HYDROXI-6 - ((2- (1-ISOPROPIL-1H-PIRAZOL-5-IL) -PIRIDIN-3-IL) METOXI) BENZALDEHYDE
TWI778983B (en) 2016-10-12 2022-10-01 美商全球血液治療公司 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058883A1 (en) * 2003-12-15 2005-06-30 Almirall Prodesfarma Ag 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
WO2006110884A2 (en) * 2005-04-11 2006-10-19 Neurocrine Biosciences, Inc. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058883A1 (en) * 2003-12-15 2005-06-30 Almirall Prodesfarma Ag 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists
WO2006110884A2 (en) * 2005-04-11 2006-10-19 Neurocrine Biosciences, Inc. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Also Published As

Publication number Publication date
WO2007084914A2 (en) 2007-07-26
EP1976851A2 (en) 2008-10-08

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