UY27198A1 - Nuevos compuestos antiinflamatorios de bencimidazol - Google Patents
Nuevos compuestos antiinflamatorios de bencimidazolInfo
- Publication number
- UY27198A1 UY27198A1 UY27198A UY27198A UY27198A1 UY 27198 A1 UY27198 A1 UY 27198A1 UY 27198 A UY27198 A UY 27198A UY 27198 A UY27198 A UY 27198A UY 27198 A1 UY27198 A1 UY 27198A1
- Authority
- UY
- Uruguay
- Prior art keywords
- bencimidazol
- new
- inflammatory compounds
- alkyl
- nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Triazolopiridinas de fórmula I, en que Het es heterociclo de 5 miembros opcionalmente sustituido conteniendo uno o dos heteroátomos seleccionados entre nitrógeno, azufre y oxígeno, siendo al menos uno de ellos nitrógeno; R2 selecionado del grupo compuesto por hidrógeno, alquilo (C1-C6) u otros sustituyentes adecuados; R3 selecionado del grupo compuesto por hidrógeno, alquilo (C1-C6) u otros sustituyentes adecuados. S número entero de 0,5. Composiciones conteniéndolos y su uso en medicina, como potentes inhibidores de MAP quinasas, preferiblemente de quinasa P38, y útiles para tratar inflamación, osteoporosis, artritis reumatoide, cáncer, repercusión o isquemia en apoplejía o en ataque cardíaco, enfermedades autoinmunes y otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27479101P | 2001-03-09 | 2001-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27198A1 true UY27198A1 (es) | 2002-11-29 |
Family
ID=23049627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27198A UY27198A1 (es) | 2001-03-09 | 2002-03-06 | Nuevos compuestos antiinflamatorios de bencimidazol |
Country Status (17)
Country | Link |
---|---|
US (1) | US7056918B2 (es) |
EP (1) | EP1370557B1 (es) |
JP (1) | JP2004526727A (es) |
AP (1) | AP2002002460A0 (es) |
AT (1) | ATE309997T1 (es) |
BR (1) | BR0207957A (es) |
CA (1) | CA2440211A1 (es) |
DE (1) | DE60207390T2 (es) |
DO (1) | DOP2002000349A (es) |
ES (1) | ES2251582T3 (es) |
GT (1) | GT200200043A (es) |
MX (1) | MXPA03008142A (es) |
PA (1) | PA8540901A1 (es) |
PE (1) | PE20030200A1 (es) |
TN (1) | TNSN02021A1 (es) |
UY (1) | UY27198A1 (es) |
WO (1) | WO2002072576A1 (es) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7074801B1 (en) * | 2001-04-26 | 2006-07-11 | Eisai Co., Ltd. | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof |
EP1554272B1 (en) * | 2002-08-09 | 2006-10-25 | Eli Lilly And Company | Benzimidazoles and benzothiazoles as inhibitors of map kinase |
CN101870691A (zh) | 2002-08-19 | 2010-10-27 | 劳洛斯治疗公司 | 2,4,5-三取代的咪唑及其作为抗菌剂的用途 |
US7037923B2 (en) | 2002-08-30 | 2006-05-02 | Pfizer, Inc. | Alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines |
PA8579601A1 (es) | 2002-08-30 | 2004-05-07 | Pfizer Prod Inc | Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas |
US6949652B2 (en) | 2002-08-30 | 2005-09-27 | Pfizer, Inc. | Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine |
US7012143B2 (en) | 2002-08-30 | 2006-03-14 | Dombroski Mark A | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines |
US7005523B2 (en) | 2002-08-30 | 2006-02-28 | Pfizer Inc. | Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines |
CA2498047C (en) | 2002-09-18 | 2009-05-19 | Pfizer Products Inc. | Novel imidazole compounds as transforming growth factor (tgf) inhibitors |
EA200500377A1 (ru) | 2002-09-18 | 2005-08-25 | Пфайзер Продактс Инк. | Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf) |
CA2515190A1 (en) | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines as anti-inflammatory compounds |
PA8595001A1 (es) * | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
JP2007500245A (ja) * | 2003-06-10 | 2007-01-11 | スミスクライン ビーチャム コーポレーション | 化合物 |
GB0313915D0 (en) * | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
GB0313914D0 (en) * | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
WO2005047266A1 (en) * | 2003-11-14 | 2005-05-26 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
MXPA06007023A (es) * | 2003-12-18 | 2006-08-31 | Pfizer Prod Inc | Metodos para tratar la inflamacion aguda en animales con inhibidores de p38 map cinasa. |
US7863310B2 (en) | 2004-02-03 | 2011-01-04 | Eli Lilly And Company | Kinase inhibitors |
US7569725B2 (en) * | 2004-10-21 | 2009-08-04 | Britsol-Myers Squibb Company | Anthranilic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7713998B2 (en) | 2004-11-10 | 2010-05-11 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic compound and pharmaceutical use thereof |
TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
US8148392B2 (en) | 2005-05-25 | 2012-04-03 | Lorus Therapeutics Inc. | 2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer |
WO2007015866A2 (en) * | 2005-07-20 | 2007-02-08 | Kalypsys, Inc. | Inhibitors of p38 kinase and methods of treating inflammatory disorders |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
EP1934185A1 (en) | 2005-08-12 | 2008-06-25 | Synta Pharmaceuticals Corporation | Pyrazole compounds that modulate hsp90 activity |
EP1829867A1 (en) * | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Imidazole compounds having pharmaceutical activity towards the sigma receptor |
CA2653217A1 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders associated with protooncogene products |
ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
KR100832747B1 (ko) * | 2006-10-27 | 2008-05-27 | 한국화학연구원 | 아미노피라졸 유도체, 이의 제조 방법 및 이를 함유하는허혈성 질환의 예방 또는 치료용 조성물 |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
CA2747784C (en) * | 2008-12-24 | 2018-07-31 | Bial - Portela & Ca, S.A. | Imidazole compounds for use as enzyme inhibitors |
EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
EP2603079B1 (en) * | 2010-08-12 | 2018-09-19 | Merck Sharp & Dohme Corp. | Positive allosteric modulators of mglur2 |
RU2454235C2 (ru) * | 2010-10-11 | 2012-06-27 | Елена Сергеевна Кипарисова | Способ лечения пациентов с острой цереброваскулярной патологией на фоне посттравматического стрессового расстройства, выполняемый комбинированной психомедикаментозной терапией |
TWI410425B (zh) * | 2010-12-03 | 2013-10-01 | Lilly Co Eli | 唑并[5,4-b]吡啶-5-基化合物 |
KR101316101B1 (ko) * | 2011-05-26 | 2013-10-11 | 연세대학교 산학협력단 | Ptk 6의 활성 억제용 조성물 및 이를 이용한 암 예방 및 치료용 조성물 |
UA114490C2 (uk) | 2011-10-06 | 2017-06-26 | Байєр Інтеллектуал Проперті Гмбх | Гетероциклілпіри(mі)динілпіразоли як фунгіциди |
WO2013067165A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
AU2012332421A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of Hsp90 inhibitors with topoisomerase I inhibitors |
JP2014533299A (ja) | 2011-11-14 | 2014-12-11 | シンタ ファーマシューティカルズ コーポレーション | Braf阻害剤とhsp90阻害剤の組合せ療法 |
EP2858983B1 (en) * | 2012-06-11 | 2018-04-18 | UCB Biopharma SPRL | Tnf-alpha modulating benzimidazoles |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
CN105073744B (zh) | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
CN105308050A (zh) | 2013-03-20 | 2016-02-03 | 艾普托斯生物科学公司 | 2-取代咪唑并[4,5-d]菲咯啉衍生物和其在治疗癌症中的用途 |
AU2014256633B2 (en) | 2013-04-25 | 2017-02-02 | Beigene Switzerland Gmbh | Fused heterocyclic compounds as protein kinase inhibitors |
CA2915622C (en) * | 2013-06-21 | 2020-08-18 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
SG10201710705UA (en) | 2013-06-21 | 2018-02-27 | Zenith Epigenetics Ltd | Novel bicyclic bromodomain inhibitors |
JP6542212B2 (ja) | 2013-07-31 | 2019-07-10 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメイン阻害剤としての新規キナゾリノン |
PL3702373T3 (pl) | 2013-09-13 | 2022-12-05 | Beigene Switzerland Gmbh | Przeciwciała anty-PD1 i ich zastosowanie jako środki terapeutyczne i diagnostyczne |
US20150104392A1 (en) | 2013-10-04 | 2015-04-16 | Aptose Biosciences Inc. | Compositions, biomarkers and their use in the treatment of cancer |
TWI726608B (zh) | 2014-07-03 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
EP3227281A4 (en) | 2014-12-01 | 2018-05-30 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
CA2966449A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
KR20170122799A (ko) | 2015-03-02 | 2017-11-06 | 리겔 파마슈티칼스, 인크. | TGF-β 억제제 |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
CN116478165A (zh) | 2016-08-16 | 2023-07-25 | 百济神州(苏州)生物科技有限公司 | 一种化合物的晶型、其制备和用途 |
CN110087680B (zh) | 2016-08-19 | 2024-03-19 | 百济神州有限公司 | 使用包含btk抑制剂的组合产品治疗癌症 |
US10532986B2 (en) * | 2016-08-22 | 2020-01-14 | Medshine Discovery Inc. | Cyclic compound acting as PDE4 inhibitor |
EP3573989A4 (en) | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF |
CN110799543A (zh) | 2017-06-26 | 2020-02-14 | 百济神州有限公司 | 肝细胞癌的免疫治疗 |
WO2019034009A1 (en) | 2017-08-12 | 2019-02-21 | Beigene, Ltd. | BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY |
CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
DK3691620T3 (da) | 2017-10-05 | 2022-10-03 | Fulcrum Therapeutics Inc | P38-kinaseinhibitor reducerer dux4- og downstream-gen-ekspression til behandling af fshd |
WO2019089511A1 (en) | 2017-10-30 | 2019-05-09 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
WO2019089734A1 (en) * | 2017-10-31 | 2019-05-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for the treatment of influenza |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
CN109134431B (zh) * | 2018-10-10 | 2021-06-04 | 成都理工大学 | 作为囊性纤维化跨膜传导调节因子抑制剂的氨基咪唑偶联吡啶酮衍生物 |
CN113557235A (zh) | 2019-03-06 | 2021-10-26 | C4医药公司 | 用于药物治疗的杂环化合物 |
EP3995490A4 (en) * | 2019-07-04 | 2023-08-09 | Medshine Discovery Inc. | CRYSTAL FORM OF A BENZIMIDAZOLE-2-ONE COMPOUND, ITS SOLVATE, CRYSTAL FORM OR SOLVATE THEREOF AND PROCESS FOR THEIR PRODUCTION |
CN114728168B (zh) | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | ***氨基甲酸酯吡啶基磺酰胺作为lpa受体拮抗剂及其用途 |
CA3185689A1 (en) * | 2020-06-03 | 2021-12-09 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
TW202344504A (zh) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU667560A1 (ru) * | 1977-08-08 | 1979-06-15 | Тюменский государственный университет | Способ получени полиметилметакрилата |
US5716972A (en) | 1993-01-13 | 1998-02-10 | Smithkline Beecham Corporation | Pyridyl substituted imidazoles |
PT724588E (pt) | 1993-09-17 | 2000-05-31 | Smithkline Beecham Corp | Proteina de ligacao a farmacos |
US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
US5717100A (en) | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
KR19990077164A (ko) | 1996-01-11 | 1999-10-25 | 스티븐 베네티아너 | 신규 치환된 이미다졸 화합물 |
GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
TW517055B (en) * | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
JP2002516325A (ja) | 1998-05-26 | 2002-06-04 | スミスクライン・ビーチャム・コーポレイション | 新規な置換イミダゾール化合物 |
US6207687B1 (en) * | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
ES2221426T3 (es) * | 1998-08-20 | 2004-12-16 | Smithkline Beecham Corporation | Nuevos compuestos de triazol sustituidos. |
US6350744B1 (en) | 1998-11-20 | 2002-02-26 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
CA2355075C (en) | 1998-12-16 | 2009-12-08 | Aventis Pharma Limited | Heteroaryl-cyclic acetals |
AU2408300A (en) | 1999-01-08 | 2000-07-24 | Smithkline Beecham Corporation | Novel compounds |
JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
-
2002
- 2002-01-30 DE DE60207390T patent/DE60207390T2/de not_active Expired - Fee Related
- 2002-01-30 AT AT02716257T patent/ATE309997T1/de not_active IP Right Cessation
- 2002-01-30 CA CA002440211A patent/CA2440211A1/en not_active Abandoned
- 2002-01-30 ES ES02716257T patent/ES2251582T3/es not_active Expired - Lifetime
- 2002-01-30 WO PCT/IB2002/000334 patent/WO2002072576A1/en active IP Right Grant
- 2002-01-30 EP EP02716257A patent/EP1370557B1/en not_active Expired - Lifetime
- 2002-01-30 JP JP2002571492A patent/JP2004526727A/ja not_active Withdrawn
- 2002-01-30 AP APAP/P/2002/002460A patent/AP2002002460A0/en unknown
- 2002-01-30 BR BR0207957-7A patent/BR0207957A/pt not_active IP Right Cessation
- 2002-01-30 MX MXPA03008142A patent/MXPA03008142A/es active IP Right Grant
- 2002-02-28 DO DO2002000349A patent/DOP2002000349A/es unknown
- 2002-03-05 GT GT200200043A patent/GT200200043A/es unknown
- 2002-03-06 PE PE2002000180A patent/PE20030200A1/es not_active Application Discontinuation
- 2002-03-06 UY UY27198A patent/UY27198A1/es not_active Application Discontinuation
- 2002-03-08 TN TNTNSN02021A patent/TNSN02021A1/fr unknown
- 2002-03-08 PA PA20028540901A patent/PA8540901A1/es unknown
- 2002-03-11 US US10/094,717 patent/US7056918B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7056918B2 (en) | 2006-06-06 |
JP2004526727A (ja) | 2004-09-02 |
ATE309997T1 (de) | 2005-12-15 |
CA2440211A1 (en) | 2002-09-19 |
ES2251582T3 (es) | 2006-05-01 |
BR0207957A (pt) | 2004-02-25 |
PE20030200A1 (es) | 2003-03-12 |
EP1370557B1 (en) | 2005-11-16 |
PA8540901A1 (es) | 2002-10-28 |
TNSN02021A1 (fr) | 2005-12-23 |
US20030092749A1 (en) | 2003-05-15 |
EP1370557A1 (en) | 2003-12-17 |
GT200200043A (es) | 2003-02-11 |
DE60207390T2 (de) | 2006-07-20 |
DOP2002000349A (es) | 2002-10-15 |
WO2002072576A1 (en) | 2002-09-19 |
AP2002002460A0 (en) | 2002-06-30 |
MXPA03008142A (es) | 2003-12-12 |
DE60207390D1 (de) | 2005-12-22 |
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