TW270149B - - Google Patents

Info

Publication number
TW270149B
TW270149B TW081107399A TW81107399A TW270149B TW 270149 B TW270149 B TW 270149B TW 081107399 A TW081107399 A TW 081107399A TW 81107399 A TW81107399 A TW 81107399A TW 270149 B TW270149 B TW 270149B
Authority
TW
Taiwan
Prior art keywords
adipoyl
adca
strain
activity
apa
Prior art date
Application number
TW081107399A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of TW270149B publication Critical patent/TW270149B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
TW081107399A 1991-09-11 1992-09-19 TW270149B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75787991A 1991-09-11 1991-09-11
US07/933,469 US5318896A (en) 1991-09-11 1992-08-28 Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Publications (1)

Publication Number Publication Date
TW270149B true TW270149B (zh) 1996-02-11

Family

ID=27116462

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081107399A TW270149B (zh) 1991-09-11 1992-09-19

Country Status (25)

Country Link
US (1) US5318896A (zh)
EP (2) EP0843013A3 (zh)
JP (2) JP3027847B2 (zh)
KR (2) KR0132440B1 (zh)
CN (2) CN1066488C (zh)
AT (1) ATE173017T1 (zh)
AU (1) AU657787B2 (zh)
BG (1) BG62177B1 (zh)
CA (1) CA2077921C (zh)
CZ (1) CZ287357B6 (zh)
DE (1) DE69227494T2 (zh)
DK (1) DK0532341T3 (zh)
ES (1) ES2126588T3 (zh)
FI (1) FI108148B (zh)
HU (1) HU217171B (zh)
IL (1) IL103076A (zh)
MX (1) MX9205175A (zh)
NO (1) NO316742B1 (zh)
NZ (1) NZ244236A (zh)
RO (1) RO115886B1 (zh)
RU (1) RU2178808C2 (zh)
SK (1) SK282387B6 (zh)
TW (1) TW270149B (zh)
UA (1) UA41292C2 (zh)
WO (1) WO1993005158A1 (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
US6709859B1 (en) * 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
KR100327881B1 (ko) * 1993-07-30 2002-07-02 한스 발터 라벤 3-(카르복시에틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
HU219259B (en) * 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca, recombinant dna vectrors and transformed host cells
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
WO1997020053A2 (en) * 1995-11-27 1997-06-05 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
US6320069B1 (en) 1996-07-02 2001-11-20 Toray Industries, Inc. Production of optically active ketone
EP0914463A2 (en) 1996-07-16 1999-05-12 Gist-Brocades B.V. NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
AU6400098A (en) * 1997-02-20 1998-09-09 Gist-Brocades B.V. Fermentative production of valuable compounds on an industrial scale using chemically defined media
EP0915988B1 (en) * 1997-04-22 2003-01-29 Dsm N.V. Process for the fermentative production of deacylated cephalosporins
PL330725A1 (en) * 1997-04-22 1999-05-24 Gist Brocades Bv Method of obtaining a beta-lactamic antibiotic
WO1998048034A1 (en) * 1997-04-22 1998-10-29 Gist-Brocades B.V. Process for the fermentative production of deacylated cephalosporins
ES2237840T3 (es) 1997-04-22 2005-08-01 Dsm Ip Assets B.V. Proceso mejorado para la produccion fermentativa de cefalosporina.
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
SK9762000A3 (en) * 1997-12-24 2001-02-12 Isis Innovation Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure
ID26888A (id) 1998-03-27 2001-02-15 Dsm Nv Proses produksi fermentasi cephalosporin
US6383773B2 (en) * 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
CN101353660A (zh) 1998-05-19 2009-01-28 Dsm公司 体内生产头孢菌素的改良
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
ATE273982T1 (de) 2000-05-13 2004-09-15 Smithkline Beecham Plc Verfahren zur reinigung eines salzes der clavulansäure
CN101351549B (zh) 2005-12-28 2013-03-20 中化帝斯曼制药有限公司荷兰公司 突变体Ⅱ型β-内酰胺酰化酶
EP1987041B1 (en) * 2006-02-23 2013-05-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Improved cephalosporin production
EP2123772A1 (en) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-lactam antibiotic producing strains
EP2392649A3 (en) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA producing strains
CN102119213A (zh) * 2008-08-05 2011-07-06 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
CN102131917A (zh) * 2008-08-05 2011-07-20 帝斯曼知识产权资产管理有限公司 生产己二酰基-7-adca的菌株
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
WO2011161004A1 (en) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Air bubble fermentation process
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
BR112013022521B1 (pt) 2011-03-03 2019-05-07 Dsm Sinochem Pharmaceuticals Netherlands B.V. PROCESSO PARA A DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO E USO DE SULFITO NA DEGRADAÇÃO DE UM COMPOSTO ß-LACTÂMICO
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
CN113699209B (zh) * 2021-08-30 2023-05-02 浙江昂利康制药股份有限公司 一种7-adca回收方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1270852A (fr) * 1960-09-20 1961-09-01 Bayer Ag Procédé d'acylation enzymatique d'acide 6-aminopénicillanique
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
IL81555A0 (en) * 1986-11-17 1987-09-16 Baldwin Jack Edward Enzymatic process for 3-substituted cephalosporins
ATE90382T1 (de) * 1987-01-17 1993-06-15 Hoechst Ag Verwendung von gamma-glutamyl-transpeptidase.
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
US5108918A (en) * 1988-08-11 1992-04-28 Gist-Brocades Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
IL95766A (en) * 1989-09-27 1996-12-05 Lilly Co Eli Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Also Published As

Publication number Publication date
NO316742B1 (no) 2004-04-26
IL103076A0 (en) 1993-02-21
FI941135A0 (fi) 1994-03-10
EP0843013A2 (en) 1998-05-20
ES2126588T3 (es) 1999-04-01
HU217171B (hu) 1999-12-28
EP0532341B1 (en) 1998-11-04
RO115886B1 (ro) 2000-07-28
RU2178808C2 (ru) 2002-01-27
DE69227494T2 (de) 1999-04-08
CN1066488C (zh) 2001-05-30
US5318896A (en) 1994-06-07
AU657787B2 (en) 1995-03-23
UA41292C2 (uk) 2001-09-17
FI108148B (fi) 2001-11-30
SK282387B6 (sk) 2002-01-07
HUT69801A (en) 1995-09-28
CN1332247A (zh) 2002-01-23
NZ244236A (en) 1994-03-25
SK28894A3 (en) 1994-09-07
NO940848L (no) 1994-03-10
DK0532341T3 (da) 1999-07-19
CZ287357B6 (cs) 2000-11-15
JP3072101B2 (ja) 2000-07-31
KR0132440B1 (ko) 1998-04-14
JP3027847B2 (ja) 2000-04-04
EP0532341A1 (en) 1993-03-17
BG62177B1 (bg) 1999-04-30
ATE173017T1 (de) 1998-11-15
BG98643A (bg) 1995-03-31
WO1993005158A1 (en) 1993-03-18
AU2354292A (en) 1993-03-18
CN1075336A (zh) 1993-08-18
KR940702544A (ko) 1994-08-20
HU9400715D0 (en) 1994-06-28
FI941135A (fi) 1994-03-10
CZ53294A3 (en) 1994-08-17
JPH07501931A (ja) 1995-03-02
MX9205175A (es) 1994-02-28
CA2077921C (en) 1998-11-24
IL103076A (en) 1996-10-31
JP2000060582A (ja) 2000-02-29
NO940848D0 (no) 1994-03-10
CA2077921A1 (en) 1993-03-12
DE69227494D1 (de) 1998-12-10
EP0843013A3 (en) 1998-06-17

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