TR201904767T4 - (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanması için geliştirilmiş bir işlem. - Google Patents
(3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanması için geliştirilmiş bir işlem. Download PDFInfo
- Publication number
- TR201904767T4 TR201904767T4 TR2019/04767T TR201904767T TR201904767T4 TR 201904767 T4 TR201904767 T4 TR 201904767T4 TR 2019/04767 T TR2019/04767 T TR 2019/04767T TR 201904767 T TR201904767 T TR 201904767T TR 201904767 T4 TR201904767 T4 TR 201904767T4
- Authority
- TR
- Turkey
- Prior art keywords
- methylpiperidin
- methylamine
- benzyl
- preparation
- improved process
- Prior art date
Links
- NVKDDQBZODSEIN-OCCSQVGLSA-N (3r,4r)-1-benzyl-n,4-dimethylpiperidin-3-amine Chemical compound C1C[C@@H](C)[C@@H](NC)CN1CC1=CC=CC=C1 NVKDDQBZODSEIN-OCCSQVGLSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- -1 7H-pyrrolo [2,3-d] pyrimidin-4-yl Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Abstract
Mevcut buluş, (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanmasına yönelik olarak, bir anahtar başlangıç maddesi olan 3-{(3R,4R)-4-metil-3-[metil(7H-pirolo[2,3-d]pirimidin-4-il)amino]piperidin-l-il}-3-okso-propannitril`in sentezi için verimli ve geliştirilmiş bir işlem sağlar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3843MU2013 IN2013MU03843A (tr) | 2013-12-09 | 2014-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201904767T4 true TR201904767T4 (tr) | 2019-05-21 |
Family
ID=53370688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/04767T TR201904767T4 (tr) | 2013-12-09 | 2014-12-02 | (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamin hazırlanması için geliştirilmiş bir işlem. |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9951012B2 (tr) |
| EP (2) | EP3539965B1 (tr) |
| JP (1) | JP6368794B2 (tr) |
| BR (1) | BR112015025543B1 (tr) |
| ES (2) | ES2720066T3 (tr) |
| HU (2) | HUE042911T2 (tr) |
| IN (1) | IN2013MU03843A (tr) |
| MX (1) | MX362290B (tr) |
| PL (2) | PL2994454T3 (tr) |
| PT (2) | PT3539965T (tr) |
| SI (2) | SI3539965T1 (tr) |
| TR (1) | TR201904767T4 (tr) |
| WO (1) | WO2015087201A1 (tr) |
| ZA (1) | ZA201506551B (tr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3539965T1 (sl) * | 2013-12-09 | 2021-07-30 | Unichem Laboratories Limited | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
| UA118149C2 (uk) | 2015-01-20 | 2018-11-26 | Вуксі Фортуне Фармасьютікал Ко., Лтд | Інгібітор jak |
| EA036058B1 (ru) | 2015-04-29 | 2020-09-21 | Уси Форчун Фармасьютикал Ко., Лтд | Ингибитор jak |
| PL3305788T3 (pl) | 2015-05-29 | 2021-03-08 | Wuxi Fortune Pharmaceutical Co., Ltd | Inhibitor kinazy janusowej |
| CN105237463B (zh) * | 2015-10-09 | 2017-10-10 | 刘卫国 | 一种(3r,4r)‑(1‑苄基‑4‑甲基哌啶‑3‑基)甲胺‑l‑二对甲苯甲酰酒石酸盐的制备方法 |
| CN105884781B (zh) * | 2016-04-18 | 2018-04-20 | 山东罗欣药业集团股份有限公司 | 一种枸橼酸托法替布的制备方法 |
| EP3301087A1 (en) * | 2016-09-30 | 2018-04-04 | DPx Fine Chemicals Austria GmbH & Co KG | Process for preparing chiral amines |
| CN107056681B (zh) * | 2017-03-30 | 2019-10-01 | 广州白云山光华制药股份有限公司 | 一种托法替布中间体的制备方法 |
| CN110668995A (zh) * | 2018-07-03 | 2020-01-10 | 江苏海悦康医药科技有限公司 | 一种枸橼酸托法替布中间体及枸橼酸托法替布的制备方法 |
| CN114685515A (zh) * | 2022-03-15 | 2022-07-01 | 上海蓝乐鸟实业有限公司 | 一种托法替尼的制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06145144A (ja) | 1992-11-04 | 1994-05-24 | Ihara Chem Ind Co Ltd | 新規な３−アミノピリジン誘導体第４級アンモニウム塩及びこれを有効成分とする抗癌剤 |
| JP4671079B2 (ja) * | 1999-07-05 | 2011-04-13 | 日本農薬株式会社 | フタラミド誘導体、その中間体及び農園芸用殺虫剤並びにその使用方法 |
| WO2001030781A2 (en) * | 1999-10-20 | 2001-05-03 | Tanabe Seiyaku Co., Ltd. | INHIBITORS OF αLβ2 MEDIATED CELL ADHESION |
| WO2001042246A2 (en) | 1999-12-10 | 2001-06-14 | Pfizer Products Inc. | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
| NZ528216A (en) | 2001-02-24 | 2006-12-22 | Boehringer Ingelheim Pharma | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7301023B2 (en) | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GT200200234A (es) * | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| ATE427946T1 (de) * | 2004-12-22 | 2009-04-15 | Astrazeneca Ab | Pyridincarbonsaureamidderivate zur verwendung als antikrebsmittel |
| US8232394B2 (en) | 2005-07-29 | 2012-07-31 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis |
| WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| WO2010014930A2 (en) * | 2008-08-01 | 2010-02-04 | Biocryst Pharmaceuticals, Inc. | Therapeutic agents |
| US20120034250A1 (en) | 2009-04-14 | 2012-02-09 | Astellas Pharma Inc. | Condensed pyrrolopyridine derivative |
| EP2421867B1 (en) * | 2009-04-20 | 2015-09-02 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
| EP2456435B1 (en) * | 2009-07-21 | 2015-06-24 | The Board of Trustees of the Leland Stanford Junior University | Heteroaryl benzamides, compositions and methods of use |
| EP2483254B1 (en) * | 2009-09-29 | 2014-08-13 | Glaxo Group Limited | Novel compounds |
| SI3539965T1 (sl) * | 2013-12-09 | 2021-07-30 | Unichem Laboratories Limited | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
-
2014
- 2014-12-02 SI SI201431805T patent/SI3539965T1/sl unknown
- 2014-12-02 TR TR2019/04767T patent/TR201904767T4/tr unknown
- 2014-12-02 MX MX2015015432A patent/MX362290B/es active IP Right Grant
- 2014-12-02 WO PCT/IB2014/066510 patent/WO2015087201A1/en active Application Filing
- 2014-12-02 PT PT191509728T patent/PT3539965T/pt unknown
- 2014-12-02 ES ES14869304T patent/ES2720066T3/es active Active
- 2014-12-02 HU HUE14869304A patent/HUE042911T2/hu unknown
- 2014-12-02 IN IN3843MU2013 patent/IN2013MU03843A/en unknown
- 2014-12-02 SI SI201431159T patent/SI2994454T1/sl unknown
- 2014-12-02 US US14/891,028 patent/US9951012B2/en active Active
- 2014-12-02 PL PL14869304T patent/PL2994454T3/pl unknown
- 2014-12-02 EP EP19150972.8A patent/EP3539965B1/en active Active
- 2014-12-02 HU HUE19150972A patent/HUE053975T2/hu unknown
- 2014-12-02 PL PL19150972T patent/PL3539965T3/pl unknown
- 2014-12-02 BR BR112015025543-4A patent/BR112015025543B1/pt active IP Right Grant
- 2014-12-02 ES ES19150972T patent/ES2865058T3/es active Active
- 2014-12-02 JP JP2016557204A patent/JP6368794B2/ja not_active Expired - Fee Related
- 2014-12-02 PT PT14869304T patent/PT2994454T/pt unknown
- 2014-12-02 EP EP14869304.7A patent/EP2994454B1/en active Active
-
2015
- 2015-09-04 ZA ZA2015/06551A patent/ZA201506551B/en unknown
-
2017
- 2017-05-09 US US15/590,408 patent/US20170240510A1/en not_active Abandoned
- 2017-10-17 US US15/786,195 patent/US20180037551A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,331 patent/US10829450B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015025543A2 (pt) | 2017-07-18 |
| ZA201506551B (en) | 2017-02-22 |
| PL2994454T3 (pl) | 2019-09-30 |
| JP6368794B2 (ja) | 2018-08-01 |
| EP2994454A1 (en) | 2016-03-16 |
| EP3539965B1 (en) | 2021-01-20 |
| ES2865058T3 (es) | 2021-10-14 |
| US9951012B2 (en) | 2018-04-24 |
| EP2994454B1 (en) | 2019-03-06 |
| US20170240510A1 (en) | 2017-08-24 |
| EP3539965A1 (en) | 2019-09-18 |
| PL3539965T3 (pl) | 2021-07-05 |
| HUE053975T2 (hu) | 2021-08-30 |
| HUE042911T2 (hu) | 2019-07-29 |
| MX2015015432A (es) | 2016-03-15 |
| EP2994454A4 (en) | 2016-12-21 |
| IN2013MU03843A (tr) | 2015-08-14 |
| BR112015025543B1 (pt) | 2020-11-03 |
| PT2994454T (pt) | 2019-04-02 |
| MX362290B (es) | 2019-01-10 |
| US20160102057A1 (en) | 2016-04-14 |
| WO2015087201A1 (en) | 2015-06-18 |
| JP2017503007A (ja) | 2017-01-26 |
| SI3539965T1 (sl) | 2021-07-30 |
| US20180134661A1 (en) | 2018-05-17 |
| SI2994454T1 (sl) | 2019-05-31 |
| US20180037551A1 (en) | 2018-02-08 |
| US10829450B2 (en) | 2020-11-10 |
| ES2720066T3 (es) | 2019-07-17 |
| PT3539965T (pt) | 2021-04-07 |
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