SI3539965T1 - Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina - Google Patents
Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilaminaInfo
- Publication number
- SI3539965T1 SI3539965T1 SI201431805T SI201431805T SI3539965T1 SI 3539965 T1 SI3539965 T1 SI 3539965T1 SI 201431805 T SI201431805 T SI 201431805T SI 201431805 T SI201431805 T SI 201431805T SI 3539965 T1 SI3539965 T1 SI 3539965T1
- Authority
- SI
- Slovenia
- Prior art keywords
- methylpiperidin
- methylamine
- benzyl
- preparation
- improved process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19150972.8A EP3539965B1 (en) | 2013-12-09 | 2014-12-02 | An improved process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine |
| IN3843MU2013 IN2013MU03843A (sl) | 2013-12-09 | 2014-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3539965T1 true SI3539965T1 (sl) | 2021-07-30 |
Family
ID=53370688
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431159T SI2994454T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metil piperidin-3-il)-metil amina |
| SI201431805T SI3539965T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metilpiperidin-3-il)-metilamina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431159T SI2994454T1 (sl) | 2013-12-09 | 2014-12-02 | Izboljšan postopek za pripravo (3R,4R)-(1-benzil-4-metil piperidin-3-il)-metil amina |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9951012B2 (sl) |
| EP (2) | EP3539965B1 (sl) |
| JP (1) | JP6368794B2 (sl) |
| BR (1) | BR112015025543B1 (sl) |
| ES (2) | ES2865058T3 (sl) |
| HU (2) | HUE053975T2 (sl) |
| IN (1) | IN2013MU03843A (sl) |
| MX (1) | MX362290B (sl) |
| PL (2) | PL2994454T3 (sl) |
| PT (2) | PT3539965T (sl) |
| SI (2) | SI2994454T1 (sl) |
| TR (1) | TR201904767T4 (sl) |
| WO (1) | WO2015087201A1 (sl) |
| ZA (1) | ZA201506551B (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX362290B (es) * | 2013-12-09 | 2019-01-10 | Unichem Lab Ltd | Un proceso mejorado para la preparacion de (3r,4r)-(1-bencilo-4-me tilpiperidina-3-il)-metilamina. |
| JP6742323B2 (ja) | 2015-01-20 | 2020-08-19 | 无▲錫▼福祈制▲薬▼有限公司Ｗｕｘｉ Ｆｏｒｔｕｎｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ | Ｊａｋ阻害剤 |
| US10174036B2 (en) | 2015-04-29 | 2019-01-08 | Wuxi Fortune Pharmaceutical Co., Ltd | Substituted pyrazoles as JAK inhibitors |
| CN107531711B (zh) | 2015-05-29 | 2020-03-31 | 无锡福祈制药有限公司 | Janus激酶抑制剂 |
| CN105237463B (zh) * | 2015-10-09 | 2017-10-10 | 刘卫国 | 一种(3r,4r)‑(1‑苄基‑4‑甲基哌啶‑3‑基)甲胺‑l‑二对甲苯甲酰酒石酸盐的制备方法 |
| CN105884781B (zh) * | 2016-04-18 | 2018-04-20 | 山东罗欣药业集团股份有限公司 | 一种枸橼酸托法替布的制备方法 |
| EP3301087A1 (en) * | 2016-09-30 | 2018-04-04 | DPx Fine Chemicals Austria GmbH & Co KG | Process for preparing chiral amines |
| CN107056681B (zh) * | 2017-03-30 | 2019-10-01 | 广州白云山光华制药股份有限公司 | 一种托法替布中间体的制备方法 |
| CN110668995A (zh) * | 2018-07-03 | 2020-01-10 | 江苏海悦康医药科技有限公司 | 一种枸橼酸托法替布中间体及枸橼酸托法替布的制备方法 |
| CN114685515A (zh) * | 2022-03-15 | 2022-07-01 | 上海蓝乐鸟实业有限公司 | 一种托法替尼的制备方法 |
| CN115872923B (zh) * | 2022-12-29 | 2023-04-28 | 成都泰和伟业生物科技有限公司 | 一种化合物及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06145144A (ja) | 1992-11-04 | 1994-05-24 | Ihara Chem Ind Co Ltd | 新規な３−アミノピリジン誘導体第４級アンモニウム塩及びこれを有効成分とする抗癌剤 |
| JP4671079B2 (ja) * | 1999-07-05 | 2011-04-13 | 日本農薬株式会社 | フタラミド誘導体、その中間体及び農園芸用殺虫剤並びにその使用方法 |
| EP1307455B1 (en) * | 1999-10-20 | 2005-04-06 | Tanabe Seiyaku Co., Ltd. | Inhibitors of alpha-l beta-2 mediated cell adhesion |
| NZ518884A (en) | 1999-12-10 | 2004-02-27 | Pfizer Prod Inc | Pyrrolo[2,3-d]pyrimidine compounds |
| KR100883277B1 (ko) | 2001-02-24 | 2009-02-12 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 크산틴 유도체 및 이의 제조방법 |
| US7301023B2 (en) * | 2001-05-31 | 2007-11-27 | Pfizer Inc. | Chiral salt resolution |
| GT200200234A (es) * | 2001-12-06 | 2003-06-27 | Compuestos cristalinos novedosos | |
| UY29300A1 (es) * | 2004-12-22 | 2006-07-31 | Astrazeneca Ab | Compuestos quimicos |
| ATE540952T1 (de) * | 2005-07-29 | 2012-01-15 | Pfizer Prod Inc | Pyrroloä2,3-düpyrimidinderivate, ihre zwischenprodukte und synthese |
| WO2008029237A2 (en) * | 2006-09-05 | 2008-03-13 | Pfizer Products Inc. | Combination therapies for rheumatoid arthritis |
| RU2011105768A (ru) * | 2008-08-01 | 2012-09-10 | Биокрист Фармасьютикалз, Инк. (Us) | Производные пиперидина в качестве ингибиторов jakз |
| CA2758359A1 (en) | 2009-04-14 | 2010-10-21 | Astellas Pharma Inc. | Fused pyrrolopyridine derivative |
| CA2759026C (en) * | 2009-04-20 | 2019-01-15 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of janus kinase 3 |
| AU2010276215A1 (en) * | 2009-07-21 | 2012-02-16 | Auckland Uniservices Limited | Heteroaryl benzamides, compositions and methods of use |
| AU2010302842B2 (en) * | 2009-09-29 | 2014-05-08 | Glaxo Group Limited | Novel compounds |
| MX362290B (es) * | 2013-12-09 | 2019-01-10 | Unichem Lab Ltd | Un proceso mejorado para la preparacion de (3r,4r)-(1-bencilo-4-me tilpiperidina-3-il)-metilamina. |
-
2014
- 2014-12-02 MX MX2015015432A patent/MX362290B/es active IP Right Grant
- 2014-12-02 ES ES19150972T patent/ES2865058T3/es active Active
- 2014-12-02 PT PT191509728T patent/PT3539965T/pt unknown
- 2014-12-02 PT PT14869304T patent/PT2994454T/pt unknown
- 2014-12-02 SI SI201431159T patent/SI2994454T1/sl unknown
- 2014-12-02 SI SI201431805T patent/SI3539965T1/sl unknown
- 2014-12-02 PL PL14869304T patent/PL2994454T3/pl unknown
- 2014-12-02 JP JP2016557204A patent/JP6368794B2/ja not_active Expired - Fee Related
- 2014-12-02 BR BR112015025543-4A patent/BR112015025543B1/pt active IP Right Grant
- 2014-12-02 WO PCT/IB2014/066510 patent/WO2015087201A1/en active Application Filing
- 2014-12-02 EP EP19150972.8A patent/EP3539965B1/en active Active
- 2014-12-02 HU HUE19150972A patent/HUE053975T2/hu unknown
- 2014-12-02 HU HUE14869304A patent/HUE042911T2/hu unknown
- 2014-12-02 ES ES14869304T patent/ES2720066T3/es active Active
- 2014-12-02 IN IN3843MU2013 patent/IN2013MU03843A/en unknown
- 2014-12-02 US US14/891,028 patent/US9951012B2/en active Active
- 2014-12-02 PL PL19150972T patent/PL3539965T3/pl unknown
- 2014-12-02 TR TR2019/04767T patent/TR201904767T4/tr unknown
- 2014-12-02 EP EP14869304.7A patent/EP2994454B1/en active Active
-
2015
- 2015-09-04 ZA ZA2015/06551A patent/ZA201506551B/en unknown
-
2017
- 2017-05-09 US US15/590,408 patent/US20170240510A1/en not_active Abandoned
- 2017-10-17 US US15/786,195 patent/US20180037551A1/en not_active Abandoned
-
2018
- 2018-01-11 US US15/868,331 patent/US10829450B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TR201904767T4 (tr) | 2019-05-21 |
| SI2994454T1 (sl) | 2019-05-31 |
| ES2720066T3 (es) | 2019-07-17 |
| ZA201506551B (en) | 2017-02-22 |
| BR112015025543A2 (pt) | 2017-07-18 |
| MX362290B (es) | 2019-01-10 |
| JP2017503007A (ja) | 2017-01-26 |
| HUE053975T2 (hu) | 2021-08-30 |
| PL3539965T3 (pl) | 2021-07-05 |
| MX2015015432A (es) | 2016-03-15 |
| US20180037551A1 (en) | 2018-02-08 |
| JP6368794B2 (ja) | 2018-08-01 |
| EP2994454B1 (en) | 2019-03-06 |
| EP2994454A4 (en) | 2016-12-21 |
| IN2013MU03843A (sl) | 2015-08-14 |
| ES2865058T3 (es) | 2021-10-14 |
| EP3539965B1 (en) | 2021-01-20 |
| US9951012B2 (en) | 2018-04-24 |
| PL2994454T3 (pl) | 2019-09-30 |
| PT2994454T (pt) | 2019-04-02 |
| PT3539965T (pt) | 2021-04-07 |
| EP3539965A1 (en) | 2019-09-18 |
| US20160102057A1 (en) | 2016-04-14 |
| US20170240510A1 (en) | 2017-08-24 |
| HUE042911T2 (hu) | 2019-07-29 |
| US20180134661A1 (en) | 2018-05-17 |
| EP2994454A1 (en) | 2016-03-16 |
| US10829450B2 (en) | 2020-11-10 |
| WO2015087201A1 (en) | 2015-06-18 |
| BR112015025543B1 (pt) | 2020-11-03 |
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