SV2004001633A - Nuevos inhibidores biciclicos de la lipasa sensible a hormonas - Google Patents

Nuevos inhibidores biciclicos de la lipasa sensible a hormonas

Info

Publication number
SV2004001633A
SV2004001633A SV2003001633A SV2003001633A SV2004001633A SV 2004001633 A SV2004001633 A SV 2004001633A SV 2003001633 A SV2003001633 A SV 2003001633A SV 2003001633 A SV2003001633 A SV 2003001633A SV 2004001633 A SV2004001633 A SV 2004001633A
Authority
SV
El Salvador
Prior art keywords
hormone
inhibitors
sensitive lipase
new bicycle
lipase
Prior art date
Application number
SV2003001633A
Other languages
English (en)
Inventor
Stefan Petry
Karl-Heinz Baringhaus
Norbert Tennagels
Guenter Mueller
Hubert Heuer
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of SV2004001633A publication Critical patent/SV2004001633A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE DESCRIBEN BENZOTRIAZOLES DE LA FORMULA I EN LA QUE R1 A R8 TIENEN LOS SIGNIFICADOS MENCIONADOS ANTERIORMENTE Y PROCEDIMIENTOS PARA SU PREPARACION. LOS COMPUESTOS PRESENTAN UN EFECTO INHIBIDOR SOBRE LA LIPASA SENSIBLE A HORMONAS
SV2003001633A 2002-10-12 2003-10-08 Nuevos inhibidores biciclicos de la lipasa sensible a hormonas SV2004001633A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10247680A DE10247680B4 (de) 2002-10-12 2002-10-12 Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase

Publications (1)

Publication Number Publication Date
SV2004001633A true SV2004001633A (es) 2004-03-19

Family

ID=32038583

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2003001633A SV2004001633A (es) 2002-10-12 2003-10-08 Nuevos inhibidores biciclicos de la lipasa sensible a hormonas

Country Status (39)

Country Link
EP (1) EP1554259B1 (es)
JP (2) JP4658607B2 (es)
KR (1) KR20050059254A (es)
CN (1) CN100366616C (es)
AR (1) AR041565A1 (es)
AT (1) ATE349433T1 (es)
AU (1) AU2003275997B8 (es)
BR (1) BR0315257A (es)
CA (1) CA2501734C (es)
CR (1) CR7717A (es)
CY (1) CY1106358T1 (es)
DE (2) DE10247680B4 (es)
DK (1) DK1554259T3 (es)
EC (1) ECSP055729A (es)
ES (1) ES2277152T3 (es)
GT (1) GT200300214A (es)
HK (1) HK1080473A1 (es)
HN (1) HN2003000316A (es)
HR (1) HRP20050325A2 (es)
IL (1) IL167907A (es)
JO (1) JO2497B1 (es)
MA (1) MA27404A1 (es)
MX (1) MXPA05003359A (es)
MY (1) MY138057A (es)
NO (1) NO20052291L (es)
OA (1) OA12941A (es)
PA (1) PA8585101A1 (es)
PE (1) PE20040776A1 (es)
PL (1) PL374605A1 (es)
PT (1) PT1554259E (es)
RS (1) RS51543B (es)
RU (1) RU2325385C2 (es)
SV (1) SV2004001633A (es)
TN (1) TNSN05105A1 (es)
TW (1) TWI313265B (es)
UA (1) UA79994C2 (es)
UY (1) UY28015A1 (es)
WO (1) WO2004035550A1 (es)
ZA (1) ZA200501757B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002130A1 (de) 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026809A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026808A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de) 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049953A1 (de) 2005-10-19 2007-04-26 Sanofi-Aventis Deutschland Gmbh Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de) * 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
FR2915197B1 (fr) 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr) * 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
JP5657566B2 (ja) * 2008-12-24 2015-01-21 バイアル ポルテラ アンド シーエイ エス エイＢＩＡＬ−Ｐｏｒｔｅｌａ ＆ Ｃａ， Ｓ．Ａ． 医薬品
US8329904B2 (en) * 2009-05-12 2012-12-11 Hoffmann-La Roche Inc. Azacyclic derivatives
US8440710B2 (en) * 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en) 2010-04-15 2012-01-17 Hoffmann-La Roche Inc. Azacyclic derivatives
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8722721B2 (en) * 2011-03-16 2014-05-13 Hoffmann-La Roche Inc. SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) * 2011-03-17 2014-04-22 Hoffmann-La Roche Inc. Azaspirodecanone compounds
US8809384B2 (en) * 2011-03-25 2014-08-19 Hoffmann-La Roche Inc. Azaspirodecanone compounds
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
JP2021535192A (ja) 2018-11-14 2021-12-16 アルタバント・サイエンシズ・ゲーエムベーハーALTAVANT SCIENCES GmbH 末梢セロトニンと関連する疾患または障害を処置するためのトリプトファンヒドロキシラーゼ１（ｔｐｈ１）の結晶性スピロ環式化合物インヒビター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1124716A (en) * 1978-10-20 1982-06-01 Michael J. Simons Blocked benzotriazole compounds as development restrainer precursors
DE19942354A1 (de) * 1999-09-04 2001-03-08 Aventis Pharma Gmbh Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
KR20030096348A (ko) * 2001-05-05 2003-12-24 스미스클라인비이참피이엘시이 Ｎ-아로일 시클릭 아민
EP1458374A2 (en) * 2001-12-14 2004-09-22 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase

Also Published As

Publication number Publication date
PE20040776A1 (es) 2004-12-24
MY138057A (en) 2009-04-30
RS51543B (en) 2011-06-30
EP1554259B1 (de) 2006-12-27
ES2277152T3 (es) 2007-07-01
HK1080473A1 (en) 2006-04-28
DE50306134D1 (de) 2007-02-08
DE10247680A1 (de) 2004-04-22
AU2003275997A1 (en) 2004-05-04
CN1688555A (zh) 2005-10-26
GT200300214A (es) 2007-02-05
DE10247680B4 (de) 2005-09-01
CR7717A (es) 2007-09-14
CA2501734A1 (en) 2004-04-29
ECSP055729A (es) 2005-07-06
EP1554259A1 (de) 2005-07-20
PL374605A1 (en) 2005-10-31
AR041565A1 (es) 2005-05-18
BR0315257A (pt) 2005-08-23
MA27404A1 (fr) 2005-06-01
TW200413335A (en) 2004-08-01
WO2004035550A1 (de) 2004-04-29
JP4658607B2 (ja) 2011-03-23
UY28015A1 (es) 2004-04-30
KR20050059254A (ko) 2005-06-17
IL167907A (en) 2010-12-30
TWI313265B (en) 2009-08-11
ATE349433T1 (de) 2007-01-15
NO20052291D0 (no) 2005-05-10
JP2006509734A (ja) 2006-03-23
HN2003000316A (es) 2006-06-12
RS20050207A (en) 2007-08-03
NO20052291L (no) 2005-05-10
JO2497B1 (en) 2009-10-05
UA79994C2 (en) 2007-08-10
HRP20050325A2 (en) 2005-06-30
CN100366616C (zh) 2008-02-06
JP2011026342A (ja) 2011-02-10
OA12941A (en) 2006-10-13
PT1554259E (pt) 2007-02-28
TNSN05105A1 (en) 2007-05-14
AU2003275997B8 (en) 2010-09-30
RU2325385C2 (ru) 2008-05-27
MXPA05003359A (es) 2005-06-22
RU2005114394A (ru) 2006-01-20
AU2003275997B2 (en) 2010-03-25
CA2501734C (en) 2011-05-31
ZA200501757B (en) 2005-09-07
PA8585101A1 (es) 2004-09-16
CY1106358T1 (el) 2011-10-12
DK1554259T3 (da) 2007-05-07

Similar Documents

Publication Publication Date Title
SV2004001633A (es) Nuevos inhibidores biciclicos de la lipasa sensible a hormonas
ECSP20027480A (es) Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa
CY2016042I2 (el) Νεες ετεροκυκλικες ενωσεις δραστικες ως αναστολεις των βητα-λακταμασων
LTPA2019007I1 (lt) N3 alkilinto benzimidazolo dariniai kaip MEK inhibitoriai
NO20045220L (no) Heterocykliske inhibitorer for kinaser
DE502005011241D1 (de) Indazolderivate als inhibitoren der hormon-sensitiven lipase
DE60103935D1 (de) Imidazol-5-yl-2-anilino-pyrimidine als inhibitoren der zellproliferation
CR11483A (es) Inhibidores de peptido desformilasa
UY29853A1 (es) Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas-
GT200500287A (es) Analogos de 17-hidroxiwortmanina como inhibidores de pi3k
MA31433B1 (fr) Inhibiteurs de la p70 s6 kinase
DE602005025733D1 (de) Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
UY27729A1 (es) Inhibidores de quinasas.
DE602004008303D1 (de) Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3
EA200970486A1 (ru) Соединения для ингибирования митоза
DE60321808D1 (de) Flavon derivate als inhibitoren von cyclin-abhängigen kinasen
ATE471324T1 (de) Triazolophthalazine
CU20100170A7 (es) Inhibidores heterocíclicos de estearoil-coa-desaturasa
CO5261493A1 (es) Procedimiento y compuestos para la inhibicion de la mrp1
UY30787A1 (es) "inhibidores benzoimidazolicos de trpv1"
PA8630801A1 (es) Nuevos imidazoles
ATE382048T1 (de) Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen
CR8340A (es) Pirazolilcarboxanilidas n-sustituidas
UY31000A1 (es) Oxoisoxazoles como inhibidores de lipasas y fosfolipasas
DK2155886T3 (da) Kosmetisk anvendelse af tyrosinaseinhibitorer

Legal Events

Date Code Title Description
FG Grant
FD Lapse