IL167907A - Bicyclic inhibitors of hormone sensitive lipase, process for their preparation and pharmaceutical compositions comprising them - Google Patents

Bicyclic inhibitors of hormone sensitive lipase, process for their preparation and pharmaceutical compositions comprising them

Info

Publication number: IL167907A
Authority: IL; Israel
Prior art keywords: preparation; pharmaceutical compositions; sensitive lipase; hormone sensitive; bicyclic inhibitors
Prior art date: 2002-10-12

Application number

IL167907A

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-12

Filing date

2005-04-07

Publication date

2010-12-30

2005-04-07 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2010-12-30 Publication of IL167907A publication Critical patent/IL167907A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

IL167907A 2002-10-12 2005-04-07 Bicyclic inhibitors of hormone sensitive lipase, process for their preparation and pharmaceutical compositions comprising them IL167907A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10247680A DE10247680B4 (en)	2002-10-12	2002-10-12	New bicyclic inhibitors of the hormone sensitive lipase
PCT/EP2003/010765 WO2004035550A1 (en)	2002-10-12	2003-09-27	Novel bicyclic inhibitors of hormone sensitive lipase

Publications (1)

Publication Number	Publication Date
IL167907A true IL167907A (en)	2010-12-30

Family

ID=32038583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL167907A IL167907A (en)	2002-10-12	2005-04-07	Bicyclic inhibitors of hormone sensitive lipase, process for their preparation and pharmaceutical compositions comprising them

Country Status (39)

Country	Link
EP (1)	EP1554259B1 (en)
JP (2)	JP4658607B2 (en)
KR (1)	KR20050059254A (en)
CN (1)	CN100366616C (en)
AR (1)	AR041565A1 (en)
AT (1)	ATE349433T1 (en)
AU (1)	AU2003275997B8 (en)
BR (1)	BR0315257A (en)
CA (1)	CA2501734C (en)
CR (1)	CR7717A (en)
CY (1)	CY1106358T1 (en)
DE (2)	DE10247680B4 (en)
DK (1)	DK1554259T3 (en)
EC (1)	ECSP055729A (en)
ES (1)	ES2277152T3 (en)
GT (1)	GT200300214A (en)
HK (1)	HK1080473A1 (en)
HN (1)	HN2003000316A (en)
HR (1)	HRP20050325A2 (en)
IL (1)	IL167907A (en)
JO (1)	JO2497B1 (en)
MA (1)	MA27404A1 (en)
MX (1)	MXPA05003359A (en)
MY (1)	MY138057A (en)
NO (1)	NO20052291L (en)
OA (1)	OA12941A (en)
PA (1)	PA8585101A1 (en)
PE (1)	PE20040776A1 (en)
PL (1)	PL374605A1 (en)
PT (1)	PT1554259E (en)
RS (1)	RS51543B (en)
RU (1)	RU2325385C2 (en)
SV (1)	SV2004001633A (en)
TN (1)	TNSN05105A1 (en)
TW (1)	TWI313265B (en)
UA (1)	UA79994C2 (en)
UY (1)	UY28015A1 (en)
WO (1)	WO2004035550A1 (en)
ZA (1)	ZA200501757B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005002130A1 (en)	2005-01-17	2006-07-27	Sanofi-Aventis Deutschland Gmbh	New substituted aminomethylene sulfonamides useful as hormone sensitive lipase inhibitors in medicaments for treatment and/or prevention of non-insulin dependent diabetes mellitus, diabetic syndrome or obesity
DE102005026762A1 (en)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-one derivatives as inhibitors of lipases and phospholipases
DE102005026809A1 (en)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzothiazol-2-one derivatives as inhibitors of lipases and phospholipases
DE102005026808A1 (en)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases
DE102005048897A1 (en)	2005-10-12	2007-04-19	Sanofi-Aventis Deutschland Gmbh	Diacylindazole derivatives as inhibitors of lipases and phospholipases
DE102005049953A1 (en)	2005-10-19	2007-04-26	Sanofi-Aventis Deutschland Gmbh	Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases
DE102005049954A1 (en) *	2005-10-19	2007-05-31	Sanofi-Aventis Deutschland Gmbh	Triazolopyridine derivatives as inhibitors of lipases and phospholipases
FR2915197B1 (en)	2007-04-18	2009-06-12	Sanofi Aventis Sa	TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF.
FR2915198B1 (en) *	2007-04-18	2009-12-18	Sanofi Aventis	TRIAZOLOPYRIDINE CARBOXAMIDE AND TRIAZOLOPYRIDINE -CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2915199B1 (en) *	2007-04-18	2010-01-22	Sanofi Aventis	TRIAZOLOPYRIDINE-CARBOXAMIDE AND TRIAZOLOPYRIMIDINE-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
AR072707A1 (en)	2008-07-09	2010-09-15	Sanofi Aventis	HETEROCICLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION, DRUGS THAT UNDERSTAND THESE COMPOUNDS AND THE USE OF THEM
JP5657566B2 (en) *	2008-12-24	2015-01-21	バイアルポルテラアンドシーエイエスエイＢＩＡＬ−Ｐｏｒｔｅｌａ＆Ｃａ，Ｓ．Ａ．	Medicine
US8329904B2 (en) *	2009-05-12	2012-12-11	Hoffmann-La Roche Inc.	Azacyclic derivatives
US8440710B2 (en) *	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en)	2010-04-15	2012-01-17	Hoffmann-La Roche Inc.	Azacyclic derivatives
US8450350B2 (en) *	2010-05-05	2013-05-28	Infinity Pharmaceuticals, Inc.	Triazoles as inhibitors of fatty acid synthase
US8722721B2 (en) *	2011-03-16	2014-05-13	Hoffmann-La Roche Inc.	SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) *	2011-03-17	2014-04-22	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
US8809384B2 (en) *	2011-03-25	2014-08-19	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
UA119247C2 (en)	2013-09-06	2019-05-27	РОЙВЕНТ САЙЕНСИЗ ҐмбГ	Spirocyclic compounds as tryptophan hydroxylase inhibitors
GB201321740D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
WO2015089137A1 (en)	2013-12-11	2015-06-18	Karos Pharmaceuticals, Inc.	Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en)	2014-12-30	2016-07-07	Karos Pharmaceuticals, Inc.	Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en)	2015-03-05	2017-04-04	Karos Pharmaceuticals, Inc.	Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
JP2021535192A (en)	2018-11-14	2021-12-16	アルタバント・サイエンシズ・ゲーエムベーハーALTAVANT SCIENCES GmbH	A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (TPH1) for treating diseases or disorders associated with peripheral serotonin.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1124716A (en) *	1978-10-20	1982-06-01	Michael J. Simons	Blocked benzotriazole compounds as development restrainer precursors
DE19942354A1 (en) *	1999-09-04	2001-03-08	Aventis Pharma Gmbh	Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, their manufacture and use in medicinal products
KR20030096348A (en) *	2001-05-05	2003-12-24	스미스클라인비이참피이엘시이	N-aroyl cyclic amines
EP1458374A2 (en) *	2001-12-14	2004-09-22	Novo Nordisk A/S	Compounds and uses thereof for decreasing activity of hormone-sensitive lipase

2002
- 2002-10-12 DE DE10247680A patent/DE10247680B4/en not_active Expired - Fee Related
2003
- 2003-09-27 RU RU2005114394/04A patent/RU2325385C2/en not_active IP Right Cessation
- 2003-09-27 MX MXPA05003359A patent/MXPA05003359A/en active IP Right Grant
- 2003-09-27 AT AT03808700T patent/ATE349433T1/en active
- 2003-09-27 KR KR1020057006312A patent/KR20050059254A/en not_active Application Discontinuation
- 2003-09-27 DE DE50306134T patent/DE50306134D1/en not_active Expired - Lifetime
- 2003-09-27 PL PL03374605A patent/PL374605A1/en not_active Application Discontinuation
- 2003-09-27 ES ES03808700T patent/ES2277152T3/en not_active Expired - Lifetime
- 2003-09-27 OA OA1200500103A patent/OA12941A/en unknown
- 2003-09-27 UA UAA200504422A patent/UA79994C2/en unknown
- 2003-09-27 AU AU2003275997A patent/AU2003275997B8/en not_active Ceased
- 2003-09-27 DK DK03808700T patent/DK1554259T3/en active
- 2003-09-27 PT PT03808700T patent/PT1554259E/en unknown
- 2003-09-27 BR BR0315257-0A patent/BR0315257A/en not_active IP Right Cessation
- 2003-09-27 JP JP2004544048A patent/JP4658607B2/en not_active Expired - Fee Related
- 2003-09-27 RS YUP-2005/0207A patent/RS51543B/en unknown
- 2003-09-27 EP EP03808700A patent/EP1554259B1/en not_active Expired - Lifetime
- 2003-09-27 CN CNB038241420A patent/CN100366616C/en not_active Expired - Fee Related
- 2003-09-27 WO PCT/EP2003/010765 patent/WO2004035550A1/en active IP Right Grant
- 2003-09-27 CA CA2501734A patent/CA2501734C/en not_active Expired - Fee Related
- 2003-09-29 GT GT200300214A patent/GT200300214A/en unknown
- 2003-09-29 JO JO2003123A patent/JO2497B1/en active
- 2003-10-08 TW TW092127898A patent/TWI313265B/en active
- 2003-10-08 SV SV2003001633A patent/SV2004001633A/en not_active Application Discontinuation
- 2003-10-09 PA PA20038585101A patent/PA8585101A1/en unknown
- 2003-10-09 PE PE2003001028A patent/PE20040776A1/en not_active Application Discontinuation
- 2003-10-09 AR ARP030103676A patent/AR041565A1/en unknown
- 2003-10-09 HN HN2003000316A patent/HN2003000316A/en unknown
- 2003-10-10 UY UY28015A patent/UY28015A1/en unknown
- 2003-10-10 MY MYPI20033883A patent/MY138057A/en unknown
2005
- 2005-03-01 ZA ZA200501757A patent/ZA200501757B/en unknown
- 2005-03-07 CR CR7717A patent/CR7717A/en unknown
- 2005-04-07 IL IL167907A patent/IL167907A/en not_active IP Right Cessation
- 2005-04-11 HR HR20050325A patent/HRP20050325A2/en not_active Application Discontinuation
- 2005-04-11 MA MA28213A patent/MA27404A1/en unknown
- 2005-04-11 TN TNP2005000105A patent/TNSN05105A1/en unknown
- 2005-04-11 EC EC2005005729A patent/ECSP055729A/en unknown
- 2005-05-10 NO NO20052291A patent/NO20052291L/en not_active Application Discontinuation
2006
- 2006-01-10 HK HK06100358A patent/HK1080473A1/en not_active IP Right Cessation
2007
- 2007-03-06 CY CY20071100315T patent/CY1106358T1/en unknown
2010
- 2010-10-08 JP JP2010228107A patent/JP2011026342A/en not_active Abandoned

Also Published As

Publication number	Publication date
PE20040776A1 (en)	2004-12-24
MY138057A (en)	2009-04-30
RS51543B (en)	2011-06-30
EP1554259B1 (en)	2006-12-27
ES2277152T3 (en)	2007-07-01
HK1080473A1 (en)	2006-04-28
DE50306134D1 (en)	2007-02-08
DE10247680A1 (en)	2004-04-22
AU2003275997A1 (en)	2004-05-04
CN1688555A (en)	2005-10-26
GT200300214A (en)	2007-02-05
DE10247680B4 (en)	2005-09-01
CR7717A (en)	2007-09-14
CA2501734A1 (en)	2004-04-29
SV2004001633A (en)	2004-03-19
ECSP055729A (en)	2005-07-06
EP1554259A1 (en)	2005-07-20
PL374605A1 (en)	2005-10-31
AR041565A1 (en)	2005-05-18
BR0315257A (en)	2005-08-23
MA27404A1 (en)	2005-06-01
TW200413335A (en)	2004-08-01
WO2004035550A1 (en)	2004-04-29
JP4658607B2 (en)	2011-03-23
UY28015A1 (en)	2004-04-30
KR20050059254A (en)	2005-06-17
TWI313265B (en)	2009-08-11
ATE349433T1 (en)	2007-01-15
NO20052291D0 (en)	2005-05-10
JP2006509734A (en)	2006-03-23
HN2003000316A (en)	2006-06-12
RS20050207A (en)	2007-08-03
NO20052291L (en)	2005-05-10
JO2497B1 (en)	2009-10-05
UA79994C2 (en)	2007-08-10
HRP20050325A2 (en)	2005-06-30
CN100366616C (en)	2008-02-06
JP2011026342A (en)	2011-02-10
OA12941A (en)	2006-10-13
PT1554259E (en)	2007-02-28
TNSN05105A1 (en)	2007-05-14
AU2003275997B8 (en)	2010-09-30
RU2325385C2 (en)	2008-05-27
MXPA05003359A (en)	2005-06-22
RU2005114394A (en)	2006-01-20
AU2003275997B2 (en)	2010-03-25
CA2501734C (en)	2011-05-31
ZA200501757B (en)	2005-09-07
PA8585101A1 (en)	2004-09-16
CY1106358T1 (en)	2011-10-12
DK1554259T3 (en)	2007-05-07

Legal Events

Date	Code	Title	Description
2014-05-28	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL167907A (en)	2010-12-30	Bicyclic inhibitors of hormone sensitive lipase, process for their preparation and pharmaceutical compositions comprising them
HUP0401711A3 (en)	2009-07-28	N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them
ZA200501641B (en)	2005-08-31	Methods and dosage forms for controlled delivery of paliperidone
HUP0203564A3 (en)	2004-07-28	Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinease, process for their preparation and pharmaceutical compositions containing them
IL163831A (en)	2010-12-30	Derivatives of aminoindazoles, pharmaceutical compositions comprising them, process for their preparation and use thereof
PL374832A1 (en)	2005-10-31	Novel substituted benzimidazole dosage forms and method of using same
HUP0501011A2 (en)	2006-01-30	Carbamates as hormone-sensitive lipase inhibitors, process for producing them, pharmaceutical compositions containing them and their use
EP1594467A4 (en)	2008-10-22	Abuse-deterrent pharmaceutical compositions of opioids and other drugs
PL357856A1 (en)	2004-05-17	Pharmaceutical granules containing tamsulozine and method of their manufacture
HK1088543A1 (en)	2006-11-10	Pharmaceutical compositions and dosage forms of thalidomide
IL190218A0 (en)	2008-11-03	Novel compounds, pharmaceutical compositions containing same, and methods of use for same
HUP0303724A3 (en)	2007-09-28	Chemokine receptors inhibitor bipiperidinyl-derivatives and pharmaceutical compositions containing them and process for preparation of the compounds
HK1086485A1 (en)	2006-09-22	Novel compounds, pharmaceutical compositions containing same, and methods of use for same
HUP0201909A2 (en)	2002-10-28	Aminobenzophenones as inhibitors of il-1betha and tnf-alpha, process for producing them and pharmaceutical compositions containing them
HK1066459A1 (en)	2005-03-24	Pharmaceutical dosage form and method of making
HUP0201846A3 (en)	2002-11-28	Amonobenzophenones as inhibitors of il-1betha and tnf-alpha and pharmaceutical compositions containing them
AU2003276572A1 (en)	2004-06-15	Pharmaceutical dosage forms of biguanide-sulfonylurea combinations
PL361518A1 (en)	2004-02-09	Application of substance and pharmaceutical composition
IL163959A (en)	2010-12-30	Derivatives of phenyl-sulfonylamino- benzoic acid and pharmaceutical compositions comprising them
AU2003251303A1 (en)	2003-12-12	Pharmaceutical products and methods of manufacture
HUP0401712A3 (en)	2009-06-29	N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them
IL162716A0 (en)	2005-11-20	Oral pharmaceutical compositions for soft capsulescontaining vinorelbine and method of treatment
AU2003295713A8 (en)	2004-06-15	Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions
EP1694242A4 (en)	2011-11-02	Pharmaceutical formulations of camptothecins and process for making same
AU2002241270A1 (en)	2003-10-08	Compositions for delivering biologically active drug and method of using the same