BR0315257A - Inibidores bicìclicos de lipase sensìvel a hormÈnio - Google Patents

Inibidores bicìclicos de lipase sensìvel a hormÈnio

Info

Publication number
BR0315257A
BR0315257A BR0315257-0A BR0315257A BR0315257A BR 0315257 A BR0315257 A BR 0315257A BR 0315257 A BR0315257 A BR 0315257A BR 0315257 A BR0315257 A BR 0315257A
Authority
BR
Brazil
Prior art keywords
sensitive lipase
bicyclic
lipase inhibitors
hormone sensitive
hormone
Prior art date
Application number
BR0315257-0A
Other languages
English (en)
Inventor
Stefan Petry
Karl-Heinz Baringhaus
Norbert Tennagels
Guenter Mueller
Hubert Heuer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0315257A publication Critical patent/BR0315257A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"INIBIDORES BICìCLICOS DE LIPASE SENSìVEL A HORMÈNIO". A presente invenção refere-se a benzotriazóis da fórmula geral (I), em que R1 até R8 possuem os significados mencionados, bem como processos para sua preparação. Os compostos apresentam efeito inibidor sobre a lipase sensível a hormónio.
BR0315257-0A 2002-10-12 2003-09-27 Inibidores bicìclicos de lipase sensìvel a hormÈnio BR0315257A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10247680A DE10247680B4 (de) 2002-10-12 2002-10-12 Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
PCT/EP2003/010765 WO2004035550A1 (de) 2002-10-12 2003-09-27 Neue bicyclische inhibitoren der hormon sensitiven lipase

Publications (1)

Publication Number Publication Date
BR0315257A true BR0315257A (pt) 2005-08-23

Family

ID=32038583

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315257-0A BR0315257A (pt) 2002-10-12 2003-09-27 Inibidores bicìclicos de lipase sensìvel a hormÈnio

Country Status (39)

Country Link
EP (1) EP1554259B1 (pt)
JP (2) JP4658607B2 (pt)
KR (1) KR20050059254A (pt)
CN (1) CN100366616C (pt)
AR (1) AR041565A1 (pt)
AT (1) ATE349433T1 (pt)
AU (1) AU2003275997B8 (pt)
BR (1) BR0315257A (pt)
CA (1) CA2501734C (pt)
CR (1) CR7717A (pt)
CY (1) CY1106358T1 (pt)
DE (2) DE10247680B4 (pt)
DK (1) DK1554259T3 (pt)
EC (1) ECSP055729A (pt)
ES (1) ES2277152T3 (pt)
GT (1) GT200300214A (pt)
HK (1) HK1080473A1 (pt)
HN (1) HN2003000316A (pt)
HR (1) HRP20050325A2 (pt)
IL (1) IL167907A (pt)
JO (1) JO2497B1 (pt)
MA (1) MA27404A1 (pt)
MX (1) MXPA05003359A (pt)
MY (1) MY138057A (pt)
NO (1) NO20052291L (pt)
OA (1) OA12941A (pt)
PA (1) PA8585101A1 (pt)
PE (1) PE20040776A1 (pt)
PL (1) PL374605A1 (pt)
PT (1) PT1554259E (pt)
RS (1) RS51543B (pt)
RU (1) RU2325385C2 (pt)
SV (1) SV2004001633A (pt)
TN (1) TNSN05105A1 (pt)
TW (1) TWI313265B (pt)
UA (1) UA79994C2 (pt)
UY (1) UY28015A1 (pt)
WO (1) WO2004035550A1 (pt)
ZA (1) ZA200501757B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002130A1 (de) 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026809A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026808A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de) 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049953A1 (de) 2005-10-19 2007-04-26 Sanofi-Aventis Deutschland Gmbh Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de) * 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
FR2915197B1 (fr) 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr) * 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
JP5657566B2 (ja) * 2008-12-24 2015-01-21 バイアル ポルテラ アンド シーエイ エス エイBIAL−Portela & Ca, S.A. 医薬品
US8329904B2 (en) * 2009-05-12 2012-12-11 Hoffmann-La Roche Inc. Azacyclic derivatives
US8440710B2 (en) * 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en) 2010-04-15 2012-01-17 Hoffmann-La Roche Inc. Azacyclic derivatives
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8722721B2 (en) * 2011-03-16 2014-05-13 Hoffmann-La Roche Inc. SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) * 2011-03-17 2014-04-22 Hoffmann-La Roche Inc. Azaspirodecanone compounds
US8809384B2 (en) * 2011-03-25 2014-08-19 Hoffmann-La Roche Inc. Azaspirodecanone compounds
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
JP2021535192A (ja) 2018-11-14 2021-12-16 アルタバント・サイエンシズ・ゲーエムベーハーALTAVANT SCIENCES GmbH 末梢セロトニンと関連する疾患または障害を処置するためのトリプトファンヒドロキシラーゼ1(tph1)の結晶性スピロ環式化合物インヒビター

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1124716A (en) * 1978-10-20 1982-06-01 Michael J. Simons Blocked benzotriazole compounds as development restrainer precursors
DE19942354A1 (de) * 1999-09-04 2001-03-08 Aventis Pharma Gmbh Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
KR20030096348A (ko) * 2001-05-05 2003-12-24 스미스클라인비이참피이엘시이 N-아로일 시클릭 아민
EP1458374A2 (en) * 2001-12-14 2004-09-22 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase

Also Published As

Publication number Publication date
PE20040776A1 (es) 2004-12-24
MY138057A (en) 2009-04-30
RS51543B (en) 2011-06-30
EP1554259B1 (de) 2006-12-27
ES2277152T3 (es) 2007-07-01
HK1080473A1 (en) 2006-04-28
DE50306134D1 (de) 2007-02-08
DE10247680A1 (de) 2004-04-22
AU2003275997A1 (en) 2004-05-04
CN1688555A (zh) 2005-10-26
GT200300214A (es) 2007-02-05
DE10247680B4 (de) 2005-09-01
CR7717A (es) 2007-09-14
CA2501734A1 (en) 2004-04-29
SV2004001633A (es) 2004-03-19
ECSP055729A (es) 2005-07-06
EP1554259A1 (de) 2005-07-20
PL374605A1 (en) 2005-10-31
AR041565A1 (es) 2005-05-18
MA27404A1 (fr) 2005-06-01
TW200413335A (en) 2004-08-01
WO2004035550A1 (de) 2004-04-29
JP4658607B2 (ja) 2011-03-23
UY28015A1 (es) 2004-04-30
KR20050059254A (ko) 2005-06-17
IL167907A (en) 2010-12-30
TWI313265B (en) 2009-08-11
ATE349433T1 (de) 2007-01-15
NO20052291D0 (no) 2005-05-10
JP2006509734A (ja) 2006-03-23
HN2003000316A (es) 2006-06-12
RS20050207A (en) 2007-08-03
NO20052291L (no) 2005-05-10
JO2497B1 (en) 2009-10-05
UA79994C2 (en) 2007-08-10
HRP20050325A2 (en) 2005-06-30
CN100366616C (zh) 2008-02-06
JP2011026342A (ja) 2011-02-10
OA12941A (en) 2006-10-13
PT1554259E (pt) 2007-02-28
TNSN05105A1 (en) 2007-05-14
AU2003275997B8 (en) 2010-09-30
RU2325385C2 (ru) 2008-05-27
MXPA05003359A (es) 2005-06-22
RU2005114394A (ru) 2006-01-20
AU2003275997B2 (en) 2010-03-25
CA2501734C (en) 2011-05-31
ZA200501757B (en) 2005-09-07
PA8585101A1 (es) 2004-09-16
CY1106358T1 (el) 2011-10-12
DK1554259T3 (da) 2007-05-07

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2168 DE 24/07/2012.