HRP20050325A2 - Novel bicyclic inhibitors of hormone sensitive lipaseryl-3-benzylaminoquinuclidine - Google Patents

Novel bicyclic inhibitors of hormone sensitive lipaseryl-3-benzylaminoquinuclidine

Info

Publication number: HRP20050325A2
Authority: HR; Croatia
Prior art keywords: lipaseryl; benzylaminoquinuclidine; hormone sensitive; novel bicyclic; bicyclic inhibitors
Prior art date: 2002-10-12

Application number

HR20050325A

Other languages

English (en)

Inventor

Petry Stefan

Baringhaus Karl-Heinz

Ten-Nagels Norbert

Mueller Guenter

Heuer Hubert

Original Assignee

Aventis Pharma Deutschland Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-12

Filing date

2005-04-11

Publication date

2005-06-30

2005-04-11 Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh

2005-06-30 Publication of HRP20050325A2 publication Critical patent/HRP20050325A2/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

HR20050325A 2002-10-12 2005-04-11 Novel bicyclic inhibitors of hormone sensitive lipaseryl-3-benzylaminoquinuclidine HRP20050325A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10247680A DE10247680B4 (de)	2002-10-12	2002-10-12	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
PCT/EP2003/010765 WO2004035550A1 (de)	2002-10-12	2003-09-27	Neue bicyclische inhibitoren der hormon sensitiven lipase

Publications (1)

Publication Number	Publication Date
HRP20050325A2 true HRP20050325A2 (en)	2005-06-30

Family

ID=32038583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20050325A HRP20050325A2 (en)	2002-10-12	2005-04-11	Novel bicyclic inhibitors of hormone sensitive lipaseryl-3-benzylaminoquinuclidine

Country Status (39)

Country	Link
EP (1)	EP1554259B1 (xx)
JP (2)	JP4658607B2 (xx)
KR (1)	KR20050059254A (xx)
CN (1)	CN100366616C (xx)
AR (1)	AR041565A1 (xx)
AT (1)	ATE349433T1 (xx)
AU (1)	AU2003275997B8 (xx)
BR (1)	BR0315257A (xx)
CA (1)	CA2501734C (xx)
CR (1)	CR7717A (xx)
CY (1)	CY1106358T1 (xx)
DE (2)	DE10247680B4 (xx)
DK (1)	DK1554259T3 (xx)
EC (1)	ECSP055729A (xx)
ES (1)	ES2277152T3 (xx)
GT (1)	GT200300214A (xx)
HK (1)	HK1080473A1 (xx)
HN (1)	HN2003000316A (xx)
HR (1)	HRP20050325A2 (xx)
IL (1)	IL167907A (xx)
JO (1)	JO2497B1 (xx)
MA (1)	MA27404A1 (xx)
MX (1)	MXPA05003359A (xx)
MY (1)	MY138057A (xx)
NO (1)	NO20052291L (xx)
OA (1)	OA12941A (xx)
PA (1)	PA8585101A1 (xx)
PE (1)	PE20040776A1 (xx)
PL (1)	PL374605A1 (xx)
PT (1)	PT1554259E (xx)
RS (1)	RS51543B (xx)
RU (1)	RU2325385C2 (xx)
SV (1)	SV2004001633A (xx)
TN (1)	TNSN05105A1 (xx)
TW (1)	TWI313265B (xx)
UA (1)	UA79994C2 (xx)
UY (1)	UY28015A1 (xx)
WO (1)	WO2004035550A1 (xx)
ZA (1)	ZA200501757B (xx)

Families Citing this family (25)

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Publication number	Priority date	Publication date	Assignee	Title
DE102005002130A1 (de)	2005-01-17	2006-07-27	Sanofi-Aventis Deutschland Gmbh	Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel
DE102005026808A1 (de)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026762A1 (de)	2005-06-09	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026809A1 (de)	2005-06-09	2006-12-14	Sanofi-Aventis Deutschland Gmbh	Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de)	2005-10-12	2007-04-19	Sanofi-Aventis Deutschland Gmbh	Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049953A1 (de)	2005-10-19	2007-04-26	Sanofi-Aventis Deutschland Gmbh	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de) *	2005-10-19	2007-05-31	Sanofi-Aventis Deutschland Gmbh	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
FR2915197B1 (fr) *	2007-04-18	2009-06-12	Sanofi Aventis Sa	Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr)	2007-04-18	2009-12-18	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2915199B1 (fr) *	2007-04-18	2010-01-22	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
US8470841B2 (en)	2008-07-09	2013-06-25	Sanofi	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
CA2747784C (en) *	2008-12-24	2018-07-31	Bial - Portela & Ca, S.A.	Imidazole compounds for use as enzyme inhibitors
US8329904B2 (en)	2009-05-12	2012-12-11	Hoffmann-La Roche Inc.	Azacyclic derivatives
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en)	2010-04-15	2012-01-17	Hoffmann-La Roche Inc.	Azacyclic derivatives
US8450350B2 (en) *	2010-05-05	2013-05-28	Infinity Pharmaceuticals, Inc.	Triazoles as inhibitors of fatty acid synthase
US8722721B2 (en) *	2011-03-16	2014-05-13	Hoffmann-La Roche Inc.	SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) *	2011-03-17	2014-04-22	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
US8809384B2 (en) *	2011-03-25	2014-08-19	Hoffmann-La Roche Inc.	Azaspirodecanone compounds
UA119247C2 (uk)	2013-09-06	2019-05-27	РОЙВЕНТ САЙЕНСИЗ ҐмбГ	Спіроциклічні сполуки як інгібітори триптофангідроксилази
GB201321740D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
WO2015089137A1 (en)	2013-12-11	2015-06-18	Karos Pharmaceuticals, Inc.	Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en)	2014-12-30	2016-07-07	Karos Pharmaceuticals, Inc.	Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en)	2015-03-05	2017-04-04	Karos Pharmaceuticals, Inc.	Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
KR20210102887A (ko)	2018-11-14	2021-08-20	알타반트 사이언시스 게엠베하	말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1124716A (en) *	1978-10-20	1982-06-01	Michael J. Simons	Blocked benzotriazole compounds as development restrainer precursors
DE19942354A1 (de) *	1999-09-04	2001-03-08	Aventis Pharma Gmbh	Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
HUP0400048A3 (en) *	2001-05-05	2008-10-28	Smithkline Beecham Plc	N-aroyl cyclic amines and pharmaceutical compositions containing them
BR0214967A (pt) *	2001-12-14	2005-05-10	Novo Nordisk As	Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente

2002
- 2002-10-12 DE DE10247680A patent/DE10247680B4/de not_active Expired - Fee Related
2003
- 2003-09-27 AU AU2003275997A patent/AU2003275997B8/en not_active Ceased
- 2003-09-27 BR BR0315257-0A patent/BR0315257A/pt not_active IP Right Cessation
- 2003-09-27 PL PL03374605A patent/PL374605A1/xx not_active Application Discontinuation
- 2003-09-27 UA UAA200504422A patent/UA79994C2/uk unknown
- 2003-09-27 KR KR1020057006312A patent/KR20050059254A/ko not_active Application Discontinuation
- 2003-09-27 JP JP2004544048A patent/JP4658607B2/ja not_active Expired - Fee Related
- 2003-09-27 DE DE50306134T patent/DE50306134D1/de not_active Expired - Lifetime
- 2003-09-27 CA CA2501734A patent/CA2501734C/en not_active Expired - Fee Related
- 2003-09-27 EP EP03808700A patent/EP1554259B1/de not_active Expired - Lifetime
- 2003-09-27 PT PT03808700T patent/PT1554259E/pt unknown
- 2003-09-27 OA OA1200500103A patent/OA12941A/en unknown
- 2003-09-27 MX MXPA05003359A patent/MXPA05003359A/es active IP Right Grant
- 2003-09-27 CN CNB038241420A patent/CN100366616C/zh not_active Expired - Fee Related
- 2003-09-27 DK DK03808700T patent/DK1554259T3/da active
- 2003-09-27 ES ES03808700T patent/ES2277152T3/es not_active Expired - Lifetime
- 2003-09-27 RS YUP-2005/0207A patent/RS51543B/en unknown
- 2003-09-27 RU RU2005114394/04A patent/RU2325385C2/ru not_active IP Right Cessation
- 2003-09-27 AT AT03808700T patent/ATE349433T1/de active
- 2003-09-27 WO PCT/EP2003/010765 patent/WO2004035550A1/de active IP Right Grant
- 2003-09-29 JO JO2003123A patent/JO2497B1/en active
- 2003-09-29 GT GT200300214A patent/GT200300214A/es unknown
- 2003-10-08 TW TW092127898A patent/TWI313265B/zh active
- 2003-10-08 SV SV2003001633A patent/SV2004001633A/es not_active Application Discontinuation
- 2003-10-09 PA PA20038585101A patent/PA8585101A1/es unknown
- 2003-10-09 AR ARP030103676A patent/AR041565A1/es unknown
- 2003-10-09 HN HN2003000316A patent/HN2003000316A/es unknown
- 2003-10-09 PE PE2003001028A patent/PE20040776A1/es not_active Application Discontinuation
- 2003-10-10 UY UY28015A patent/UY28015A1/es unknown
- 2003-10-10 MY MYPI20033883A patent/MY138057A/en unknown
2005
- 2005-03-01 ZA ZA200501757A patent/ZA200501757B/en unknown
- 2005-03-07 CR CR7717A patent/CR7717A/es unknown
- 2005-04-07 IL IL167907A patent/IL167907A/en not_active IP Right Cessation
- 2005-04-11 HR HR20050325A patent/HRP20050325A2/xx not_active Application Discontinuation
- 2005-04-11 MA MA28213A patent/MA27404A1/fr unknown
- 2005-04-11 TN TNP2005000105A patent/TNSN05105A1/en unknown
- 2005-04-11 EC EC2005005729A patent/ECSP055729A/es unknown
- 2005-05-10 NO NO20052291A patent/NO20052291L/no not_active Application Discontinuation
2006
- 2006-01-10 HK HK06100358A patent/HK1080473A1/xx not_active IP Right Cessation
2007
- 2007-03-06 CY CY20071100315T patent/CY1106358T1/el unknown
2010
- 2010-10-08 JP JP2010228107A patent/JP2011026342A/ja not_active Abandoned

Also Published As

Publication number	Publication date
DE10247680A1 (de)	2004-04-22
CN1688555A (zh)	2005-10-26
GT200300214A (es)	2007-02-05
MA27404A1 (fr)	2005-06-01
RS20050207A (xx)	2007-08-03
EP1554259A1 (de)	2005-07-20
CR7717A (es)	2007-09-14
HK1080473A1 (en)	2006-04-28
TW200413335A (en)	2004-08-01
KR20050059254A (ko)	2005-06-17
CY1106358T1 (el)	2011-10-12
BR0315257A (pt)	2005-08-23
SV2004001633A (es)	2004-03-19
RU2005114394A (ru)	2006-01-20
AU2003275997B2 (en)	2010-03-25
DK1554259T3 (da)	2007-05-07
JP2006509734A (ja)	2006-03-23
UA79994C2 (en)	2007-08-10
ZA200501757B (en)	2005-09-07
ECSP055729A (es)	2005-07-06
RU2325385C2 (ru)	2008-05-27
AU2003275997B8 (en)	2010-09-30
CA2501734A1 (en)	2004-04-29
WO2004035550A1 (de)	2004-04-29
DE50306134D1 (de)	2007-02-08
TNSN05105A1 (en)	2007-05-14
OA12941A (en)	2006-10-13
JP4658607B2 (ja)	2011-03-23
NO20052291D0 (no)	2005-05-10
CN100366616C (zh)	2008-02-06
EP1554259B1 (de)	2006-12-27
AR041565A1 (es)	2005-05-18
DE10247680B4 (de)	2005-09-01
PL374605A1 (en)	2005-10-31
RS51543B (en)	2011-06-30
HN2003000316A (es)	2006-06-12
PA8585101A1 (es)	2004-09-16
CA2501734C (en)	2011-05-31
ES2277152T3 (es)	2007-07-01
NO20052291L (no)	2005-05-10
PE20040776A1 (es)	2004-12-24
PT1554259E (pt)	2007-02-28
MXPA05003359A (es)	2005-06-22
TWI313265B (en)	2009-08-11
ATE349433T1 (de)	2007-01-15
IL167907A (en)	2010-12-30
JO2497B1 (en)	2009-10-05
MY138057A (en)	2009-04-30
JP2011026342A (ja)	2011-02-10
AU2003275997A1 (en)	2004-05-04
UY28015A1 (es)	2004-04-30

Legal Events

Date	Code	Title	Description
2005-06-30	A1OB	Publication of a patent application
2005-12-27	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-02-09	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2010-09-26	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20100926 Year of fee payment: 8
2012-03-30	OBST	Application withdrawn

Publication	Publication Date	Title
HRP20050325A2 (en)	2005-06-30	Novel bicyclic inhibitors of hormone sensitive lipaseryl-3-benzylaminoquinuclidine
HK1077762A1 (zh)	2006-02-24	TFGß[轉化生長因子]的抑制劑
TWI347849B (en)	2011-09-01	Sustained-release tablet composition of pramipexole
HK1072545A1 (en)	2005-09-02	Novel inhibitors of kinases
HRP20041029A2 (en)	2004-12-31	Therapeutic use of selcetive pde10 inhibitors
PL376575A1 (pl)	2006-01-09	Podstawione związki heterocykliczne oraz sposoby wykorzystania
PL374832A1 (en)	2005-10-31	Novel substituted benzimidazole dosage forms and method of using same
EG23458A (en)	2005-10-02	Set of elements for assemlying structures
HK1080069A1 (zh)	2006-04-21	環氧酶2-抑制劑的硝酰氧基衍生物
AU2003211093A8 (en)	2003-09-09	Inhibitors of rgs proteins
AU2003217105A8 (en)	2003-09-16	Novel of cytokine inhibitors
ZA200409686B (en)	2007-09-26	Bicyclic 6-aklylidene-penems as ?-lactamases inhibitors
GB0502836D0 (en)	2005-03-16	An article of footwear
AU2003295638A8 (en)	2004-06-18	Novel inhibitors of beta-lactamase
AU2003249320A8 (en)	2004-02-09	Novel inhibitors of ubiquitin isopeptidases
AU2003304374A8 (en)	2005-02-14	Peptide inhibitors of beta-lactamases
SI1554259T1 (sl)	2007-04-30	Novi biciklicni inhibitorji hormonsko senzitivne lipaze
EP1545520A4 (en)	2008-07-16	MULTIFUNCTIONAL COX-2 INHIBITORS
PL356853A1 (en)	2004-05-17	Application of bacteriphages
ZA200500492B (en)	2006-08-30	Novel inhibitors of kinases
SI1537210T1 (sl)	2006-08-31	Lazna oligonukleotidna inhibicija ekspresije CD40
GB0204088D0 (en)	2002-04-10	Novel substituted heterocyclic inhibitors of catechol-o-methyl transperase
GB0200617D0 (en)	2002-02-27	Characterisation of analytes
SI1689233T1 (sl)	2012-10-30	Bicikliäśni inhibitorji mek
TW532191U (en)	2003-05-11	Structure of walking device