SMT201500095B - Forme cristalline di sale cloridrato di (4A-R, 9A-S)-1-(1hbenzoimidazolo-5-carbonil)-2,3,4,4A,9,9A-esaidro-1H-indeno[2,1-B]piridin-6-carbonitrile e loro uso come inibitore della hsd1 - Google Patents

Forme cristalline di sale cloridrato di (4A-R, 9A-S)-1-(1hbenzoimidazolo-5-carbonil)-2,3,4,4A,9,9A-esaidro-1H-indeno[2,1-B]piridin-6-carbonitrile e loro uso come inibitore della hsd1

Info

Publication number
SMT201500095B
SMT201500095B SM201500095T SM201500095T SMT201500095B SM T201500095 B SMT201500095 B SM T201500095B SM 201500095 T SM201500095 T SM 201500095T SM 201500095 T SM201500095 T SM 201500095T SM T201500095 B SMT201500095 B SM T201500095B
Authority
SM
San Marino
Prior art keywords
hexahydroid
indeno
carbonitrile
pyridin
carbonyl
Prior art date
Application number
SM201500095T
Other languages
English (en)
Italian (it)
Inventor
Matthias Eckhardt
Hans-Juergen Martin
Martin Schuehle
Sandra Sick
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201500095(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SMT201500095B publication Critical patent/SMT201500095B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM201500095T 2010-11-05 2015-04-16 Forme cristalline di sale cloridrato di (4A-R, 9A-S)-1-(1hbenzoimidazolo-5-carbonil)-2,3,4,4A,9,9A-esaidro-1H-indeno[2,1-B]piridin-6-carbonitrile e loro uso come inibitore della hsd1 SMT201500095B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2010/055586 WO2011057054A1 (en) 2009-11-06 2010-11-05 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P 2011-05-11 2011-05-11
PCT/US2011/059331 WO2012061708A1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (1)

Publication Number Publication Date
SMT201500095B true SMT201500095B (it) 2015-07-09

Family

ID=44999935

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201500095T SMT201500095B (it) 2010-11-05 2015-04-16 Forme cristalline di sale cloridrato di (4A-R, 9A-S)-1-(1hbenzoimidazolo-5-carbonil)-2,3,4,4A,9,9A-esaidro-1H-indeno[2,1-B]piridin-6-carbonitrile e loro uso come inibitore della hsd1

Country Status (36)

Country Link
US (2) US8686149B2 (sr)
EP (1) EP2635563B1 (sr)
JP (1) JP2013541592A (sr)
KR (1) KR20130119939A (sr)
CN (1) CN103228642B (sr)
AP (1) AP3521A (sr)
AR (1) AR083678A1 (sr)
AU (1) AU2011323164B2 (sr)
BR (1) BR112013011095A2 (sr)
CA (1) CA2816136A1 (sr)
CL (1) CL2013001221A1 (sr)
CO (1) CO6781480A2 (sr)
CY (1) CY1116043T1 (sr)
DK (1) DK2635563T3 (sr)
EA (1) EA022406B1 (sr)
EC (2) ECSP12011788A (sr)
ES (1) ES2533833T3 (sr)
GE (1) GEP20166481B (sr)
HK (1) HK1184144A1 (sr)
HR (1) HRP20150327T1 (sr)
IL (1) IL225647A0 (sr)
ME (1) ME02066B (sr)
MX (1) MX2013005069A (sr)
NZ (1) NZ609281A (sr)
PE (1) PE20140123A1 (sr)
PL (1) PL2635563T3 (sr)
PT (1) PT2635563E (sr)
RS (1) RS53900B1 (sr)
SG (1) SG189859A1 (sr)
SI (1) SI2635563T1 (sr)
SM (1) SMT201500095B (sr)
TN (1) TN2012000117A1 (sr)
TW (1) TWI537258B (sr)
UA (1) UA110807C2 (sr)
UY (1) UY33701A (sr)
WO (1) WO2012061708A1 (sr)

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EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
US20130303446A1 (en) * 2012-05-09 2013-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN111315735B (zh) 2017-09-04 2024-03-08 C4医药公司 二氢苯并咪唑酮
WO2020181232A1 (en) 2019-03-06 2020-09-10 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment

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Also Published As

Publication number Publication date
CN103228642A (zh) 2013-07-31
MX2013005069A (es) 2013-08-29
SI2635563T1 (sl) 2015-04-30
HRP20150327T1 (hr) 2015-04-24
ME02066B (me) 2015-05-20
SG189859A1 (en) 2013-06-28
PE20140123A1 (es) 2014-03-02
DK2635563T3 (en) 2015-02-02
WO2012061708A1 (en) 2012-05-10
US20120157488A1 (en) 2012-06-21
IL225647A0 (en) 2013-06-27
KR20130119939A (ko) 2013-11-01
RS53900B1 (sr) 2015-08-31
US20140249174A1 (en) 2014-09-04
US8686149B2 (en) 2014-04-01
UA110807C2 (uk) 2016-02-25
PL2635563T3 (pl) 2015-06-30
UY33701A (es) 2012-05-31
CY1116043T1 (el) 2017-01-25
CL2013001221A1 (es) 2013-11-08
EP2635563B1 (en) 2015-01-14
AU2011323164A1 (en) 2013-05-02
AU2011323164B2 (en) 2015-07-23
TW201242960A (en) 2012-11-01
GEP20166481B (en) 2016-05-25
CN103228642B (zh) 2015-02-18
CA2816136A1 (en) 2012-05-10
NZ609281A (en) 2015-02-27
BR112013011095A2 (pt) 2016-08-02
CO6781480A2 (es) 2013-10-31
ES2533833T3 (es) 2015-04-15
TWI537258B (zh) 2016-06-11
HK1184144A1 (en) 2014-01-17
EA022406B1 (ru) 2015-12-30
ECSP12011788A (es) 2012-10-30
EA201390643A1 (ru) 2013-11-29
ECSP13012664A (es) 2013-08-30
AP3521A (en) 2016-01-11
US9120769B2 (en) 2015-09-01
TN2012000117A1 (en) 2013-09-19
EP2635563A1 (en) 2013-09-11
PT2635563E (pt) 2015-04-13
AR083678A1 (es) 2013-03-13
JP2013541592A (ja) 2013-11-14
AP2013006902A0 (en) 2013-06-30

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